The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis

Name: Work Video:
Duration: 3 min 30 s
Laura Itzel Quintas‐Granados; Hernán Cortés; Manuel González‐Del Carmen; Gerardo Leyva‐Gómez; Lilia Patricia Bustamante-Montes; Miguel Rodríguez-Morales; Edgar Yebrán Villegas-Vázquez; Israel López-Reyes; Sofía Lizeth Alcaráz‐Estrada; Jorge Sandoval-Basilio; Ernesto Soto‐Reyes; Javad Sharifi‐Rad; Gabriela Figueroa‐González; Octavio D. Reyes‐Hernández
{'id': 'https://openalex.org/W4200236841', 'doi': 'https://doi.org/10.1186/s12935-021-02343-7', 'title': 'The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis', 'display_name': 'The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis', 'publication_year': 2021, 'publication_date': '2021-12-04', 'ids': {'openalex': 'https://openalex.org/W4200236841', 'doi': 'https://doi.org/10.1186/s12935-021-02343-7', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34863151'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12935-021-02343-7', 'pdf_url': 'https://cancerci.biomedcentral.com/track/pdf/10.1186/s12935-021-02343-7', 'source': {'id': 'https://openalex.org/S130214813', 'display_name': 'Cancer Cell International', 'issn_l': '1475-2867', 'issn': ['1475-2867'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://cancerci.biomedcentral.com/track/pdf/10.1186/s12935-021-02343-7', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5025182961', 'display_name': 'Laura Itzel Quintas‐Granados', 'orcid': 'https://orcid.org/0000-0002-8622-2004'}, 'institutions': [{'id': 'https://openalex.org/I4210139122', 'display_name': 'El Colegio Mexiquense', 'ror': 'https://ror.org/03bg52265', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I4210139122']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Laura Itzel Quintas-Granados', 'raw_affiliation_strings': ['Universidad Mexiquense del Bicentenario, Unidad de Estudios Superiores Tultitlán, Mexico, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Universidad Mexiquense del Bicentenario, Unidad de Estudios Superiores Tultitlán, Mexico, Mexico', 'institution_ids': ['https://openalex.org/I4210139122']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016892623', 'display_name': 'Hernán Cortés', 'orcid': 'https://orcid.org/0000-0002-6147-4109'}, 'institutions': [{'id': 'https://openalex.org/I4210124243', 'display_name': 'Instituto Nacional de Rehabilitación', 'ror': 'https://ror.org/03734cd59', 'country_code': 'MX', 'type': 'facility', 'lineage': ['https://openalex.org/I4210124243']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Hernán Cortés', 'raw_affiliation_strings': ['Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, 14389, Mexico City, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, 14389, Mexico City, Mexico', 'institution_ids': ['https://openalex.org/I4210124243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065096784', 'display_name': 'Manuel González‐Del Carmen', 'orcid': 'https://orcid.org/0000-0001-6346-3174'}, 'institutions': [{'id': 'https://openalex.org/I147280213', 'display_name': 'Universidad Veracruzana', 'ror': 'https://ror.org/03efxn362', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I147280213']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Manuel González-Del Carmen', 'raw_affiliation_strings': ['Facultad de Medicina, Universidad Veracruzana, Ciudad Mendoza, 94740, Veracruz, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Facultad de Medicina, Universidad Veracruzana, Ciudad Mendoza, 94740, Veracruz, Mexico', 'institution_ids': ['https://openalex.org/I147280213']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041224036', 'display_name': 'Gerardo Leyva‐Gómez', 'orcid': 'https://orcid.org/0000-0002-7940-1100'}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Gerardo Leyva-Gómez', 'raw_affiliation_strings': ['Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico', 'institution_ids': ['https://openalex.org/I8961855']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005707415', 'display_name': 'Lilia Patricia Bustamante-Montes', 'orcid': 'https://orcid.org/0000-0002-8529-9982'}, 'institutions': [{'id': 'https://openalex.org/I130040446', 'display_name': 'Universidad Autónoma de Guadalajara', 'ror': 'https://ror.org/05ppk0267', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I130040446']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Lilia Patricia Bustamante-Montes', 'raw_affiliation_strings': ['Decanatura Ciencias de la Salud, Universidad Autónoma de Guadalajara, 44670, Guadalajara, Jalisco, México'], 'affiliations': [{'raw_affiliation_string': 'Decanatura Ciencias de la Salud, Universidad Autónoma de Guadalajara, 44670, Guadalajara, Jalisco, México', 'institution_ids': ['https://openalex.org/I130040446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003887683', 'display_name': 'Miguel Rodríguez-Morales', 'orcid': 'https://orcid.org/0000-0002-4302-1069'}, 'institutions': [{'id': 'https://openalex.org/I4210153971', 'display_name': 'Instituto Nacional de Cancerología', 'ror': 'https://ror.org/04z3afh10', 'country_code': 'MX', 'type': 'government', 'lineage': ['https://openalex.org/I4210095685', 'https://openalex.org/I4210153971']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Miguel Rodríguez-Morales', 'raw_affiliation_strings': ['Laboratorio de Genómica, Instituto Nacional de Cancerología, 14080, Mecixo City, México'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Genómica, Instituto Nacional de Cancerología, 14080, Mecixo City, México', 'institution_ids': ['https://openalex.org/I4210153971']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035598439', 'display_name': 'Edgar Yebrán Villegas-Vázquez', 'orcid': 'https://orcid.org/0000-0002-4093-3812'}, 'institutions': [{'id': 'https://openalex.org/I59361560', 'display_name': 'Instituto Politécnico Nacional', 'ror': 'https://ror.org/059sp8j34', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I59361560']}, {'id': 'https://openalex.org/I68368234', 'display_name': 'Center for Research and Advanced Studies of the National Polytechnic Institute', 'ror': 'https://ror.org/009eqmr18', 'country_code': 'MX', 'type': 'facility', 'lineage': ['https://openalex.org/I59361560', 'https://openalex.org/I68368234']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Edgar Yebran Villegas-Vazquez', 'raw_affiliation_strings': ['Departamento de Biotecnología y Bioingeniería del Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Biotecnología y Bioingeniería del Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico', 'institution_ids': ['https://openalex.org/I59361560', 'https://openalex.org/I68368234']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012912559', 'display_name': 'Israel López-Reyes', 'orcid': 'https://orcid.org/0000-0003-2114-1796'}, 'institutions': [{'id': 'https://openalex.org/I167724894', 'display_name': 'Universidad Autónoma de la Ciudad de México', 'ror': 'https://ror.org/04q0r6m34', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I167724894']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Israel López-Reyes', 'raw_affiliation_strings': ['Colegio de Ciencias y Humanidades, Plantel Cuautepec, Universidad Autónoma de la Ciudad de México, Mexico City, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Colegio de Ciencias y Humanidades, Plantel Cuautepec, Universidad Autónoma de la Ciudad de México, Mexico City, Mexico', 'institution_ids': ['https://openalex.org/I167724894']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013906203', 'display_name': 'Sofía Lizeth Alcaráz‐Estrada', 'orcid': 'https://orcid.org/0000-0001-9144-9193'}, 'institutions': [{'id': 'https://openalex.org/I882076700', 'display_name': 'Institute for Social Security and Services for State Workers', 'ror': 'https://ror.org/02d93ae38', 'country_code': 'MX', 'type': 'government', 'lineage': ['https://openalex.org/I882076700']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Sofía Lizeth Alcaraz-Estrada', 'raw_affiliation_strings': ['División de Medicina Genomica, Centro Médico Nacional “20 de Noviembre”-ISSSTE, Mexico, 03100, Mexico City, Mexico'], 'affiliations': [{'raw_affiliation_string': 'División de Medicina Genomica, Centro Médico Nacional “20 de Noviembre”-ISSSTE, Mexico, 03100, Mexico City, Mexico', 'institution_ids': ['https://openalex.org/I882076700']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088911438', 'display_name': 'Jorge Sandoval-Basilio', 'orcid': 'https://orcid.org/0000-0001-9550-492X'}, 'institutions': [{'id': 'https://openalex.org/I4210126384', 'display_name': 'Universidad Hipócrates', 'ror': 'https://ror.org/031kjyq12', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I4210126384']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Jorge Sandoval-Basilio', 'raw_affiliation_strings': ['Laboratorio de Biología Molecular, Universidad Hipócrates, Acapulco, Gro., México'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Biología Molecular, Universidad Hipócrates, Acapulco, Gro., México', 'institution_ids': ['https://openalex.org/I4210126384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027304805', 'display_name': 'Ernesto Soto‐Reyes', 'orcid': 'https://orcid.org/0000-0002-4219-6406'}, 'institutions': [{'id': 'https://openalex.org/I200362191', 'display_name': 'Universidad Autónoma Metropolitana', 'ror': 'https://ror.org/02kta5139', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I200362191']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Ernesto Soto-Reyes', 'raw_affiliation_strings': ['Departamento de Ciencias Naturales, Universidad Autónoma Metropolitana-Cuajimalpa (UAM-C), Mexico City, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Ciencias Naturales, Universidad Autónoma Metropolitana-Cuajimalpa (UAM-C), Mexico City, Mexico', 'institution_ids': ['https://openalex.org/I200362191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042251272', 'display_name': 'Javad Sharifi‐Rad', 'orcid': 'https://orcid.org/0000-0002-7301-8151'}, 'institutions': [{'id': 'https://openalex.org/I4210126183', 'display_name': 'Universidad del Azuay', 'ror': 'https://ror.org/037xrmj59', 'country_code': 'EC', 'type': 'education', 'lineage': ['https://openalex.org/I4210126183']}], 'countries': ['EC'], 'is_corresponding': True, 'raw_author_name': 'Javad Sharifi-Rad', 'raw_affiliation_strings': ['Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador'], 'affiliations': [{'raw_affiliation_string': 'Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador', 'institution_ids': ['https://openalex.org/I4210126183']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076233262', 'display_name': 'Gabriela Figueroa‐González', 'orcid': 'https://orcid.org/0000-0001-8169-4478'}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': True, 'raw_author_name': 'Gabriela Figueroa-González', 'raw_affiliation_strings': ['Laboratorio de Farmacogenética, UMIEZ, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, 09230, Mexico City, México'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Farmacogenética, UMIEZ, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, 09230, Mexico City, México', 'institution_ids': ['https://openalex.org/I8961855']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056002687', 'display_name': 'Octavio D. Reyes‐Hernández', 'orcid': 'https://orcid.org/0000-0002-2767-4799'}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': True, 'raw_author_name': 'Octavio Daniel Reyes-Hernández', 'raw_affiliation_strings': ['Laboratorio de Biología Molecular del Cáncer, UMIEZ, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, 09230, Mexico City, México'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Biología Molecular del Cáncer, UMIEZ, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, 09230, Mexico City, México', 'institution_ids': ['https://openalex.org/I8961855']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 13, 'corresponding_author_ids': ['https://openalex.org/A5042251272', 'https://openalex.org/A5076233262', 'https://openalex.org/A5056002687'], 'corresponding_institution_ids': ['https://openalex.org/I4210126183', 'https://openalex.org/I8961855', 'https://openalex.org/I8961855'], 'apc_list': {'value': 1990, 'currency': 'GBP', 'value_usd': 2440, 'provenance': 'doaj'}, 'apc_paid': {'value': 1990, 'currency': 'GBP', 'value_usd': 2440, 'provenance': 'doaj'}, 'fwci': 0.319, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.469227, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 79}, 'biblio': {'volume': '21', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cpg-site', 'display_name': 'CpG site', 'score': 0.8363749}], 'concepts': [{'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.912644}, {'id': 'https://openalex.org/C140173407', 'wikidata': 'https://www.wikidata.org/wiki/Q1138358', 'display_name': 'CpG site', 'level': 5, 'score': 0.8363749}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.6621633}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6025102}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.599159}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5770916}, {'id': 'https://openalex.org/C2779399171', 'wikidata': 'https://www.wikidata.org/wiki/Q1483951', 'display_name': 'Malignancy', 'level': 2, 'score': 0.575622}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5201326}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.49358642}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.46000865}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.45289508}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4379214}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.34525722}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28724176}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.1509746}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13233113}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12935-021-02343-7', 'pdf_url': 'https://cancerci.biomedcentral.com/track/pdf/10.1186/s12935-021-02343-7', 'source': {'id': 'https://openalex.org/S130214813', 'display_name': 'Cancer Cell International', 'issn_l': '1475-2867', 'issn': ['1475-2867'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/b0c28489a619489d88c83795437c70bd', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645138', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34863151', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12935-021-02343-7', 'pdf_url': 'https://cancerci.biomedcentral.com/track/pdf/10.1186/s12935-021-02343-7', 'source': {'id': 'https://openalex.org/S130214813', 'display_name': 'Cancer Cell International', 'issn_l': '1475-2867', 'issn': ['1475-2867'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1504249692', 'https://openalex.org/W1597681369', 'https://openalex.org/W1658596276', 'https://openalex.org/W1892496998', 'https://openalex.org/W1985543996', 'https://openalex.org/W2007008733', 'https://openalex.org/W2008651555', 'https://openalex.org/W2009816222', 'https://openalex.org/W2014135194', 'https://openalex.org/W2022159715', 'https://openalex.org/W2024962857', 'https://openalex.org/W2073685942', 'https://openalex.org/W2077342365', 'https://openalex.org/W2080783858', 'https://openalex.org/W2085934079', 'https://openalex.org/W2103562997', 'https://openalex.org/W2113493868', 'https://openalex.org/W2122808667', 'https://openalex.org/W2128016314', 'https://openalex.org/W2136959508', 'https://openalex.org/W2141773917', 'https://openalex.org/W2147944526', 'https://openalex.org/W2148064779', 'https://openalex.org/W2148693352', 'https://openalex.org/W2149441684', 'https://openalex.org/W2156157817', 'https://openalex.org/W2156631966', 'https://openalex.org/W2157840751', 'https://openalex.org/W2159379246', 'https://openalex.org/W2168002648', 'https://openalex.org/W2170179858', 'https://openalex.org/W2396517574', 'https://openalex.org/W2431433670', 'https://openalex.org/W2591810315', 'https://openalex.org/W2607435391', 'https://openalex.org/W2735703618', 'https://openalex.org/W2736097031', 'https://openalex.org/W2779584541', 'https://openalex.org/W2779881438', 'https://openalex.org/W2782822491', 'https://openalex.org/W2783109906', 'https://openalex.org/W2790935259', 'https://openalex.org/W2800289222', 'https://openalex.org/W2910445721', 'https://openalex.org/W2912993657', 'https://openalex.org/W2969078102', 'https://openalex.org/W2973987577', 'https://openalex.org/W2979291688', 'https://openalex.org/W2983279499', 'https://openalex.org/W3005612706', 'https://openalex.org/W3027569065', 'https://openalex.org/W3037580763', 'https://openalex.org/W3044605555', 'https://openalex.org/W3134362176', 'https://openalex.org/W4243667708', 'https://openalex.org/W4245290427'], 'related_works': ['https://openalex.org/W3212149434', 'https://openalex.org/W2902329290', 'https://openalex.org/W2291484187', 'https://openalex.org/W2214376880', 'https://openalex.org/W2169344098', 'https://openalex.org/W2139872319', 'https://openalex.org/W2107880877', 'https://openalex.org/W2073893804', 'https://openalex.org/W2052355316', 'https://openalex.org/W2046964473'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'The': [2], 'ESR': [3, 36, 72, 102, 130, 160], '1': [4, 37, 73, 103, 131, 161], 'gene': [5, 74], 'suffers': [6], 'methylation': [7, 58, 68, 106, 127, 141, 162, 175], 'changes': [8], 'in': [9, 23, 29, 42, 75, 96, 112, 147], 'many': [10], 'types': [11], 'of': [12, 35, 44, 54, 100], 'cancers,': [13], 'including': [14], 'breast': [15], 'cancer': [16, 22, 156], '(BC),': [17], 'the': [18, 39, 48, 67, 71, 97, 101, 140], 'most': [19], 'frequently': [20], 'diagnosed': [21], 'women': [24], 'that': [25, 174], 'is': [26, 38], 'also': [27], 'present': [28], 'men.': [30], 'Methylation': [31], 'at': [32, 70, 108, 129, 176], 'promoter': [33, 98], 'A': [34, 99, 168], 'worse': [40], 'prognosis': [41, 185], 'terms': [43], 'overall': [45], 'survival;': [46], 'thus,': [47], 'early': [49], 'detection,': [50], 'prognostic,': [51], 'and': [52, 81], 'prediction': [53], 'therapy': [55], 'involve': [56], 'some': [57], 'biomarkers.': [59], 'Methods': [60], 'Therefore,': [61], 'our': [62], 'study': [63], 'aimed': [64], 'to': [65, 152], 'examine': [66], 'levels': [69, 107, 128, 142, 163], 'samples': [76], 'from': [77], 'Mexican': [78], 'BC': [79], 'patients': [80], 'its': [82], 'possible': [83], 'association': [84], 'with': [85, 134], 'menopausal': [86, 135], 'status.': [87, 136], 'Results': [88], 'We': [89], 'identified': [90], 'a': [91, 183], 'novel': [92, 178], '151-bp': [93], 'CpG': [94, 110, 179], 'island': [95, 111, 180], 'gene.': [104], 'Interestingly,': [105], 'this': [109, 177], 'positive': [113], 'ERα': [114, 122], 'tumors': [115], 'were': [116, 132, 143], 'approximately': [117], '50%': [118], 'less': [119], 'than': [120, 146, 164], 'negative': [121], 'or': [123, 166], 'control': [124], 'samples.': [125], 'Furthermore,': [126], 'associated': [133], 'In': [137], 'postmenopausal': [138], 'patients,': [139], '1.5-fold': [144], 'higher': [145, 159], 'premenopausal': [148], 'patients.': [149], 'Finally,': [150], 'according': [151], 'tumor': [153], 'malignancy,': [154], 'triple-negative': [155], 'subtypes': [157], 'had': [158], 'luminal/HER2+': [165], 'luminal': [167], 'subtypes.': [169], 'Conclusions': [170], 'Our': [171], 'findings': [172], 'suggest': [173], 'might': [181], 'be': [182], 'promising': [184], 'marker': [186]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4200236841', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}], 'updated_date': '2024-12-16T01:30:04.503914', 'created_date': '2021-12-31'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
