Abstract: Overexpression of P-glycoprotein genes is one established cause of multidrug resistance in mammalian cells. We are studying P-glycoproteins and their genes in man, in the mouse and in the nematode worm Caenorhabditis elegans in order to understand the normal, physiological role of P-glycoproteins, and the mechanistics of P-glycoprotein function. Our data suggest that one common, and evolutionarily well-conserved function of P-glycoproteins is protection of the organism against naturally occurring xenotoxins present in ingested food. We consider it likely, however, that some P-glycoprotein variants perform a more specialized function in the organism.
Publication Year: 1992
Publication Date: 1992-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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