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{'PET製剤である11C-メチオニン(MET)は腫瘍イメージングにおいてアミノ酸薬剤の中では最も多く使用されている薬剤である。がんではアミノ酸代謝は腫瘍が発育するのに好都合な様々な代謝過程に関連している。必須アミノ酸の一つであるL-メチオニンは正常細胞から変化した癌細胞の代謝における中心的な役割をはたしている。特にPETで測定されるMETの集積増加は悪性組織のアミノ酸輸送,メチル基転移反応,蛋白合成の増加を反映しており,また放射線治療後の放射線誘発の炎症には影響されることが少ない。本稿では脳,頭頸部,胸,骨盤,あるいは身体のその他の部位のMET-PET画像の役割を論じている。脳神経膠腫,頭頸部癌,肺癌,卵巣癌,子宮癌,直腸癌,悪性黒色腫,多発性骨髄腫,骨軟部腫瘍などの患者におけるMET-PETの臨床管理上の役割が詳細に再検討されている。要約すると,MET-PETはある種の悪性腫瘍検出において高感度,高特異度を示している。MET取り込みの差が高グレードと低グレードの神経膠腫の間で統計的に有意に異なって認められる。同じグレードの脳神経膠腫であってもMET集積が低ければ予後も良い。治療の評価と治療後の経過観察にMET-PETが有用である。MET-PETは脳腫瘍と放射線由来脳傷害の鑑別に関して感度と特異度が高い。MET-PETは初期診断,腫瘍進展の検出,生検実施の計画,放射線治療計画,治療効果の評価あるいはその他患者の臨床上管理において有用性が示されている。': [0]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W380494903', 'counts_by_year': [], 'updated_date': '2024-09-25T23:46:25.688511', 'created_date': '2016-06-24'}