Title: Analysis of isocitrate dehydrogenase-1/2 gene mutations in gliomas.
Abstract: To highlight recent researches which may show promise for histomolecular classification and new treatments for gliomas.All articles cited in this review were mainly searched from PubMed, which were published in English from 1996 to 2010.Original articles and critical reviews selected were relevant to the isocitrate dehydrogenase-1/2 mutation in gliomas and other tumors.Extraordinary high rates of somatic mutations in isocitrate dehydrogenase-1/2 occur in the majority of World Health Organization grade II and grade III gliomas as well as grade IV secondary glioblastomas. Isocitrate dehydrogenase-1/2 mutations are associated with younger age at diagnosis and a better prognosis in patients with mutated tumors. The functional role of isocitrate dehydrogenase-1/2 mutations in the pathogenesis of gliomas is still unclear.Isocitrate dehydrogenase-1/2 mutations define a specific subtype of gliomas and may have great significance in the diagnosis, prognosis, and treatment of patients with these tumors.
Publication Year: 2010
Publication Date: 2010-12-01
Language: en
Type: article
Indexed In: ['pubmed']
Access and Citation
Cited By Count: 4
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot