Abstract: Vitamin B6 (pyridoxal 5′-phosphate) functions as an enzyme-bound cofactor in a wide variety of reactions, most commonly concerning amino acid metabolism. Two de novo pathways for the biosynthesis of vitamin B6 have been characterized. The first pathway is found predominantly in the γ-subdivision of proteobacteria (DXP pathway) and uses the metabolites glyceraldehyde 3-phosphate, pyruvate, and d-erythrose-4-phosphate as precursors. The second pathway is found in prokaryotes, eukaryotes, and archaea, and involves only two gene products (Pdx1 and Pdx2). This pathway starts with d-ribose-5-phosphate, glutamine, and glyceraldehyde-3-phosphate. This chapter describes the biochemical characterization of each of the enzymes involved in these two pathways and highlights the mechanistic enzymology of the complex pyridine-forming reactions catalyzed by PdxJ and Pdx1.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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