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{'【はじめに】JASPAC-01試験の結果をうけ,現在本邦では膵癌の術後補助化学療法としてはS-1単独療法を行うことが推奨されている.当科では2005年よりadjuvantとしてS-1の投与を行ってきたが,今回はその有効性について無再発生存率(RFS),生存期間(OS)をretrospectiveに解析した.【対象と方法】投与後5年以上経過した浸潤性膵管癌切除19例を対象とした.2週連続・1週休薬を1コースとし,24週(8コース)以上の投与を目標とした.【結果】全19例における2年/5年RFSは42.1/26.3%であった.また2年/5年OSは63.1/36.8%,生存期間中央値(MST)は30.1ヶ月であった.【考察】JASPAC-01では4週投与・2週休薬が選択されていたが,2週投与・1週休薬でもほぼ同等の治療完遂率・有効性・毒性であり,実臨床においてもJASPAC-01を支持する結果が得られたと考えられた.': [0]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W33739088', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-09-15T22:12:12.679115', 'created_date': '2016-06-24'}