Title: Accumulation of Radioiodine in Staff Members
Abstract:In our personnel monitoring program we recently found amounts of radioiodine greater than 40 nCi in the thyroids of staff members handling therapeutic radioiodine for our thyroid cancer patients. Inve...In our personnel monitoring program we recently found amounts of radioiodine greater than 40 nCi in the thyroids of staff members handling therapeutic radioiodine for our thyroid cancer patients. Investigation has shown that this occurs when Mallinckrodt's therapeutic radioiodine has been used, but not with Squibb's. The pH of the preparations (Mallinckrodt 2-4, Squibb 7.5-9) suggests that possibly the more acidic Mallinck rodt preparation creates a more favorable milieu for volatiliza tion of the iodine. A few studies were prepared using a sodium sulfite wick held over the vial of the therapeutic 1-131 when opened in a hood. The wicks used for testing demonstrated that the Mallinckrodt dose gave significantly more cpm/mCi than those used for testing the Squibb preparation. Correction was made for total activity in the vial; otherwise the tests were performed similarly. These preliminary but potentially significant observations have been reported to both companies. Representatives have corroborated the difference in pH and its potential effect on volatilization. Dr. Tusing, Medical Director of Mallinckrodt, Inc. , has also stated that they are ‘ in the process of reformu lating this product, and actually have stability studies under way. ‘ ‘ It seems important to share these observations with the nuclear medical community.Read More
Publication Year: 1978
Publication Date: 1978-01-01
Language: en
Type: article
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Cited By Count: 1
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