Abstract: Abstract: Hepatic glycogenolysis and gluconeogenesis, and adipose tissue lipolysis provide most of the fuel for the early stages of starvation. The rate-control of hepatic gluconeogenesis during starvation is governed largely by substrate availability, as well as by the insulin:glucagon ratio. Muscle tissue reduces its dependency upon glucose during starvation as FFAs and KB–s become available. Circulating VLDLs tend to rise during the early-intermediate stages of starvation. As OAA is used for gluconeogenesis in liver tissue, less is available to couple with acetyl-CoA for citrate formation. Excess acetyl-CoA may then be forced into KB-formation. The progressive increase in serum KB- levels during starvation is due largely to reduced oxidation of these substrates by muscle tissue. The brain appears to function well when using predominantly KB-s as fuel. Significant reductions in pituitary gonadotropin output may occur in starved animals.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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