Publication Information

{'id': 'https://openalex.org/W3217697942', 'doi': 'https://doi.org/10.3760/cma.j.cn112338-20210331-00262', 'title': '[Association between a novel regulatory genetic variants and lung cancer risk in Chinese: a two-stage case-control study].', 'display_name': '[Association between a novel regulatory genetic variants and lung cancer risk in Chinese: a two-stage case-control study].', 'publication_year': 2021, 'publication_date': '2021-11-10', 'ids': {'openalex': 'https://openalex.org/W3217697942', 'doi': 'https://doi.org/10.3760/cma.j.cn112338-20210331-00262', 'mag': '3217697942', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34818854'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34818854', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 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'raw_affiliation_strings': ['Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong 226019, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong 226019, China', 'institution_ids': ['https://openalex.org/I199305430']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112942484', 'display_name': 'Narashimha Swamy P', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I199305430', 'display_name': 'Nantong University', 'ror': 'https://ror.org/02afcvw97', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I199305430']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'N P Si', 'raw_affiliation_strings': ['Department of Epidemiology and Biostatistics, School of Public Health, Nantong University, Nantong 226019, China'], 'affiliations': [{'raw_affiliation_string': 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'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W9117736', 'https://openalex.org/W9041372', 'https://openalex.org/W8448932', 'https://openalex.org/W4193887', 'https://openalex.org/W3991422', 'https://openalex.org/W2377452', 'https://openalex.org/W176226', 'https://openalex.org/W13038688', 'https://openalex.org/W11388833', 'https://openalex.org/W1090245'], 'abstract_inverted_index': {'Objective:': [0], 'Regulatory': [1], 'quantitative': [2], 'trait': [3], 'loci': [4], '(regQTL)': [5], 'theory': [6], 'can': [7], 'help': [8], 'to': [9, 33, 110], 'evaluate': [10], 'the': [11, 35, 41, 49, 53, 62, 70, 112, 118, 132, 149, 156, 164, 188, 214, 234, 256, 293, 299], 'regulation': [12], 'function': [13, 66], 'of': [14, 29, 37, 43, 55, 74, 114, 120, 126, 136, 151, 168, 178, 192, 202, 218, 238, 258, 295, 304], 'single': [15], 'nucleotide': [16], 'polymorphisms': [17], '(SNPs)': [18], 'on': [19, 40, 48], 'crucial': [20], 'biological': [21], 'signals': [22], 'from': [23], 'a': [24, 82], 'three-dimensional': [25], 'perspective.': [26], 'The': [27], 'aim': [28], 'this': [30], 'study': [31, 85], 'was': [32, 86, 172, 196], 'investigate': [34], 'effect': [36], 'these': [38], 'regQTL-SNPs': [39, 116, 128, 288], 'susceptibility': [42, 119, 294], 'lung': [44, 57, 75, 92, 103, 121, 137, 152, 179, 203, 222, 242, 260, 296, 305], 'cancer.': [45, 122], 'Methods:': [46], 'Based': [47], 'regQTL': [50, 68], 'theory,': [51], 'using': [52], 'database': [54], 'identified': [56], 'cancer': [58, 76, 93, 104, 138, 153, 180, 204, 261, 297], 'regQTL-SNPs,': [59], 'we': [60], 'screened': [61, 130], 'SNPs': [63, 144], 'that': [64, 163, 213, 255, 289], 'may': [65], 'as': [67], 'in': [69, 131, 155, 170, 194, 265, 298], 'reported': [71, 133, 301], 'susceptible': [72, 134, 302], 'regions': [73, 135, 303], 'by': [77, 139, 263], 'genome-wide': [78], 'association': [79, 113], 'study(GWAS),': [80], 'and': [81, 95, 106], 'two-stage': [83], 'case-control': [84], 'conducted': [87], '(screening': [88], 'stage:': [89, 101], '2': [90], '331': [91], 'cases': [94, 105], '3': [96, 143], '077': [97], 'healthy': [98, 108], 'controls;': [99], 'validation': [100, 160], '626': [102], '667': [107], 'controls)': [109], 'definite': [111], 'related': [115], 'with': [117, 148, 175, 199, 274], 'Results:': [123], 'A': [124], 'total': [125], '8': [127], 'were': [129, 145], 'GWAS.': [140], 'Among': [141], 'which,': [142], 'significantly': [146, 173, 197, 220, 240, 291], 'associated': [147, 174, 198], 'risk': [150, 177, 201, 226, 244, 257], '(P<0.05)': [154], 'screening': [157], 'stage.': [158], 'Further': [159], 'results': [161], 'indicated': [162, 212, 254], 'variant': [165, 189, 215, 235, 270, 281], 'T': [166, 216, 271, 282], 'allele': [167, 191, 217, 237, 272], 'rs6998591': [169, 219, 269, 280], 'ADRA1A': [171], 'increased': [176, 221, 262], '(additive': [181, 227, 245], 'model:': [182, 206, 228, 246], 'OR=1.33,': [183], '95%CI:1.01-1.74,': [184], 'P=0.040).': [185], 'In': [186], 'addition,': [187], 'G': [190, 236], 'rs11202916': [193, 239], 'ACTA2': [195], 'decreased': [200, 241], '(recessive': [205], 'OR=0.71,': [207], '95%CI:0.52-0.96,': [208], 'P=0.026).': [209], 'Stratified': [210], 'analysis': [211, 253], 'squamous': [223], 'cell': [224], 'carcinoma': [225], 'OR=1.53,': [229], '95%CI:': [230, 248], '1.01-2.32,': [231], 'P=0.043),': [232], 'while': [233], 'adenocarcinoma': [243], 'OR=0.83,': [247], '0.69-0.98,': [249], 'P=0.031).': [250], 'Gene-environment': [251], 'interaction': [252], 'developing': [259], '235%': [264], 'smoking': [266], 'individuals': [267, 277], 'carrying': [268, 278], 'compared': [273], 'those': [275], 'non-smoking': [276], 'no': [279], 'allele(OR=3.35,95%CI:2.10-5.34,P<0.001).': [283], 'Conclusion:': [284], 'There': [285], 'are': [286], 'two': [287], 'could': [290], 'affect': [292], 'GWAS': [300], 'cancer.目的：': [306], '调控型数量性状位点（regQTL）理论可以帮助研究者从三维角度评估单核苷酸多态性（SNPs）对重要生物信号的调控作用。本研究拟探讨regQTL-SNPs对肺癌易感性的影响。': [307], '方法：': [308], '基于regQTL理论，利用已知的肺癌regQTL-SNPs数据库，筛选出全基因组关联研究（GWAS）报道的肺癌易感区域中发挥regQTL功能的SNPs。并通过两阶段病例-对照研究（初筛阶段：2': [309], '331例肺癌病例和3': [310], '077例健康对照；验证阶段：626例肺癌病例和667例健康对照），进一步明确上述regQTL-SNPs与肺癌易感性的关联。': [311], '结果：': [312], '在肺癌GWAS已报道的易感区域中，共筛选出8个regQTL-SNPs。人群易感性分析的初筛阶段，研究结果显示3个regQTL-SNPs与肺癌的发病风险存在统计学关联（P<0.05），验证阶段结果显示，位于ADRA1A基因上的rs6998591突变等位基因T可以显著增加肺癌的发病风险（相加模型：OR=1.33，95%CI：1.01~1.74，P=0.040），而位于ACTA2基因上的rs11202916突变等位基因G可以明显降低肺癌的发病风险（隐性模型：OR=0.71，95%CI：0.52~0.96，P=0.026）。分层分析结果显示，rs6998591的突变等位基因T显著增加肺鳞癌的发病风险（相加模型：OR=1.53，95%CI：1.01~2.32，P=0.043），而rs11202916的突变等位基因G显著降低肺腺癌的发病风险（相加模型：OR=0.83，95%CI：0.69~0.98，P=0.031）。基因环境交互作用分析显示携带rs6998591突变等位基因T且吸烟的个体与不携带rs6998591突变等位基因T且不吸烟的个体相比，肺癌的发病风险增加235%（OR=3.35，95%CI：2.10~5.34，P<0.001）。': [313], '结论：': [314], '肺癌GWAS已报道的易感区域中存在2个发挥regQTL功能的SNPs，并且可以显著影响肺癌的易感性。.': [315]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3217697942', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-12-16T07:38:23.606700', 'created_date': '2021-12-06'}