Discrepant Antigen-specific Antibody Responses Causing SARS-CoV-2 Persistence in a Patient Receiving B-cell-targeted Therapy with Rituximab

Name: Work Video:
Duration: 3 min 30 s
Teruhito Takakuwa; Yu Nakagama; Mayo Yasugi; Toshiki Maeda; Kenji Matsuo; Ayako Kiritoshi; Ryo Deguchi; Naohiro Hagawa; Wataru Shibata; Kazuhiro Oshima; Katsumi Yamamoto; Kenichiro Uchida; Tomohiro Noda; Koichi Yamada; T Nishimura; Hiromasa Yamamoto; Yasutoshi Kido; Masayuki Hino; Hiroshi Kakeya; Yasumitsu Mizobata
{'id': 'https://openalex.org/W3215583495', 'doi': 'https://doi.org/10.2169/internalmedicine.7884-21', 'title': 'Discrepant Antigen-specific Antibody Responses Causing SARS-CoV-2 Persistence in a Patient Receiving B-cell-targeted Therapy with Rituximab', 'display_name': 'Discrepant Antigen-specific Antibody Responses Causing SARS-CoV-2 Persistence in a Patient Receiving B-cell-targeted Therapy with Rituximab', 'publication_year': 2021, 'publication_date': '2021-11-30', 'ids': {'openalex': 'https://openalex.org/W3215583495', 'doi': 'https://doi.org/10.2169/internalmedicine.7884-21', 'mag': '3215583495', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34853259'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2169/internalmedicine.7884-21', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S154471048', 'display_name': 'Internal Medicine', 'issn_l': '0918-2918', 'issn': ['0918-2918', '1349-7235'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313351', 'host_organization_name': 'The Japanese Society of Internal Medicine', 'host_organization_lineage': ['https://openalex.org/P4310313351'], 'host_organization_lineage_names': ['The Japanese Society of Internal Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.2169/internalmedicine.7884-21', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5021285250', 'display_name': 'Teruhito Takakuwa', 'orcid': 'https://orcid.org/0000-0001-5259-0450'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Teruhito Takakuwa', 'raw_affiliation_strings': ['Department of Hematology, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031265107', 'display_name': 'Yu Nakagama', 'orcid': 'https://orcid.org/0000-0001-9780-9719'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yu Nakagama', 'raw_affiliation_strings': ['Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020898779', 'display_name': 'Mayo Yasugi', 'orcid': 'https://orcid.org/0000-0002-9688-2006'}, 'institutions': [{'id': 'https://openalex.org/I15807432', 'display_name': 'Osaka Prefecture University', 'ror': 'https://ror.org/02cf1je33', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I15807432']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mayo Yasugi', 'raw_affiliation_strings': ['Department of Veterinary Medicine, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Veterinary Medicine, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan', 'institution_ids': ['https://openalex.org/I15807432']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081465150', 'display_name': 'Toshiki Maeda', 'orcid': 'https://orcid.org/0000-0002-5634-9792'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshiki Maeda', 'raw_affiliation_strings': ['Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103447791', 'display_name': 'Kenji Matsuo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenji Matsuo', 'raw_affiliation_strings': ['Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078092568', 'display_name': 'Ayako Kiritoshi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ayako Kiritoshi', 'raw_affiliation_strings': ['Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038998467', 'display_name': 'Ryo Deguchi', 'orcid': 'https://orcid.org/0000-0002-8831-2388'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryo Deguchi', 'raw_affiliation_strings': ['Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037939158', 'display_name': 'Naohiro Hagawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naohiro Hagawa', 'raw_affiliation_strings': ['Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065756223', 'display_name': 'Wataru Shibata', 'orcid': 'https://orcid.org/0000-0003-0326-6659'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Wataru Shibata', 'raw_affiliation_strings': ['Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016098028', 'display_name': 'Kazuhiro Oshima', 'orcid': 'https://orcid.org/0000-0001-7580-4490'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuhiro Oshima', 'raw_affiliation_strings': ['Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103263360', 'display_name': 'Katsumi Yamamoto', 'orcid': 'https://orcid.org/0000-0003-2503-4170'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Katsumi Yamamoto', 'raw_affiliation_strings': ['Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045094789', 'display_name': 'Kenichiro Uchida', 'orcid': 'https://orcid.org/0000-0002-3673-6007'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenichiro Uchida', 'raw_affiliation_strings': ['Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038866046', 'display_name': 'Tomohiro Noda', 'orcid': 'https://orcid.org/0000-0001-9288-9625'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tomohiro Noda', 'raw_affiliation_strings': ['Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081852652', 'display_name': 'Koichi Yamada', 'orcid': 'https://orcid.org/0000-0002-4766-9380'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Koichi Yamada', 'raw_affiliation_strings': ['Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001844397', 'display_name': 'T Nishimura', 'orcid': 'https://orcid.org/0000-0003-2235-4064'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuro Nishimura', 'raw_affiliation_strings': ['Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021333939', 'display_name': 'Hiromasa Yamamoto', 'orcid': 'https://orcid.org/0000-0002-5330-5460'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiromasa Yamamoto', 'raw_affiliation_strings': ['Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006296380', 'display_name': 'Yasutoshi Kido', 'orcid': 'https://orcid.org/0000-0003-3615-2631'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasutoshi Kido', 'raw_affiliation_strings': ['Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001816724', 'display_name': 'Masayuki Hino', 'orcid': 'https://orcid.org/0000-0002-9128-7750'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masayuki Hino', 'raw_affiliation_strings': ['Department of Hematology, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044497202', 'display_name': 'Hiroshi Kakeya', 'orcid': 'https://orcid.org/0000-0002-6251-1696'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Kakeya', 'raw_affiliation_strings': ['Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082759958', 'display_name': 'Yasumitsu Mizobata', 'orcid': 'https://orcid.org/0000-0001-6279-5441'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasumitsu Mizobata', 'raw_affiliation_strings': ['Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.533, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.587743, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 86}, 'biblio': {'volume': '60', 'issue': '23', 'first_page': '3827', 'last_page': '3831'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10118', 'display_name': 'SARS-CoV-2 and COVID-19 Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10118', 'display_name': 'SARS-CoV-2 and COVID-19 Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10041', 'display_name': 'COVID-19 Clinical Research Studies', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8020093}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.739072}, {'id': 'https://openalex.org/C2780653079', 'wikidata': 'https://www.wikidata.org/wiki/Q412323', 'display_name': 'Rituximab', 'level': 3, 'score': 0.67611325}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.6394243}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.57672054}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.57305413}, {'id': 'https://openalex.org/C45189115', 'wikidata': 'https://www.wikidata.org/wiki/Q502159', 'display_name': 'Serology', 'level': 3, 'score': 0.5616084}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.5406655}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.48357362}, {'id': 'https://openalex.org/C2779261636', 'wikidata': 'https://www.wikidata.org/wiki/Q7003054', 'display_name': 'Neutralizing antibody', 'level': 3, 'score': 0.46576312}, {'id': 'https://openalex.org/C32611913', 'wikidata': 'https://www.wikidata.org/wiki/Q2166189', 'display_name': 'Titer', 'level': 3, 'score': 0.4483968}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000086382', 'descriptor_name': 'COVID-19', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000086402', 'descriptor_name': 'SARS-CoV-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000917', 'descriptor_name': 'Antibody Formation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069283', 'descriptor_name': 'Rituximab', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000069283', 'descriptor_name': 'Rituximab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064370', 'descriptor_name': 'Spike Glycoprotein, Coronavirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2169/internalmedicine.7884-21', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S154471048', 'display_name': 'Internal Medicine', 'issn_l': '0918-2918', 'issn': ['0918-2918', '1349-7235'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313351', 'host_organization_name': 'The Japanese Society of Internal Medicine', 'host_organization_lineage': ['https://openalex.org/P4310313351'], 'host_organization_lineage_names': ['The Japanese Society of Internal Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710376', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34853259', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2169/internalmedicine.7884-21', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S154471048', 'display_name': 'Internal Medicine', 'issn_l': '0918-2918', 'issn': ['0918-2918', '1349-7235'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313351', 'host_organization_name': 'The Japanese Society of Internal Medicine', 'host_organization_lineage': ['https://openalex.org/P4310313351'], 'host_organization_lineage_names': ['The Japanese Society of Internal Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.79, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W3006355661', 'https://openalex.org/W3025631553', 'https://openalex.org/W3036529319', 'https://openalex.org/W3037961558', 'https://openalex.org/W3043294634', 'https://openalex.org/W3045825841', 'https://openalex.org/W3080323991', 'https://openalex.org/W3082513234', 'https://openalex.org/W3112232390', 'https://openalex.org/W3119294059', 'https://openalex.org/W3157877744', 'https://openalex.org/W3167470255'], 'related_works': ['https://openalex.org/W4386402208', 'https://openalex.org/W4307813351', 'https://openalex.org/W4223505415', 'https://openalex.org/W4210369265', 'https://openalex.org/W3204629868', 'https://openalex.org/W3185521317', 'https://openalex.org/W2374971639', 'https://openalex.org/W2271934434', 'https://openalex.org/W2024078487', 'https://openalex.org/W1991270129'], 'abstract_inverted_index': {'A': [0, 24], '73-year-old': [1], 'man': [2], 'previously': [3], 'treated': [4], 'with': [5], 'rituximab': [6], 'for': [7, 92], 'his': [8], 'mucosa-associated': [9], 'lymphoid': [10], 'tissue': [11], 'lymphoma': [12], 'suffered': [13], 'a': [14], 'suboptimal': [15], 'humoral': [16, 31], 'immune': [17, 32], 'response': [18], 'against': [19, 97], 'an': [20], 'acquired': [21], 'SARS-CoV-2': [22], 'infection.': [23], 'detailed': [25], 'serological': [26], 'description': [27], 'revealed': [28], 'discrepant': [29], 'antigen-specific': [30], 'responses.': [33], 'The': [34, 75], 'titer': [35], 'of': [36, 87, 89], 'spike-targeting,': [37], '"viral-neutralizing"': [38], 'antibodies': [39], 'remained': [40], 'below': [41], 'the': [42, 48, 79], 'detection': [43], 'level,': [44], 'in': [45, 56], 'contrast': [46], 'to': [47, 69, 81], 'anti-nucleocapsid,': [49], '"binding"': [50], 'antibody': [51, 95], 'response,': [52], 'which': [53], 'was': [54, 66], 'comparable': [55], 'both': [57], 'magnitude': [58], 'and': [59, 64, 72], 'kinetics.': [60], 'Accordingly,': [61], 'viral': [62], 'neutralizability': [63], 'clearance': [65], 'delayed,': [67], 'leading': [68], 'prolonged': [70], 'RNAemia': [71], 'persistent': [73], 'pneumonia.': [74], 'present': [76], 'case': [77], 'highlights': [78], 'need': [80], 'closely': [82], 'monitor': [83], 'this': [84], 'unique': [85], 'population': [86], 'recipients': [88], 'B-cell-targeted': [90], 'therapies': [91], 'their': [93], 'neutralizing': [94], 'responses': [96], 'SARS-CoV-2.': [98]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3215583495', 'counts_by_year': [{'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2025-01-04T23:09:29.204603', 'created_date': '2021-12-06'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
