Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3213359842', 'doi': 'https://doi.org/10.1016/j.eplepsyres.2021.106816', 'title': 'Intravenous kainic acid induces status epilepticus and late onset seizures in mice', 'display_name': 'Intravenous kainic acid induces status epilepticus and late onset seizures in mice', 'publication_year': 2021, 'publication_date': '2021-11-14', 'ids': {'openalex': 'https://openalex.org/W3213359842', 'doi': 'https://doi.org/10.1016/j.eplepsyres.2021.106816', 'mag': '3213359842', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34808484'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.eplepsyres.2021.106816', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S144140688', 'display_name': 'Epilepsy Research', 'issn_l': '0920-1211', 'issn': ['0920-1211', '1872-6844'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.eplepsyres.2021.106816', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047123925', 'display_name': 'Nicolas Drysdale', 'orcid': 'https://orcid.org/0000-0002-1029-0481'}, 'institutions': [{'id': 'https://openalex.org/I170897317', 'display_name': 'Duke University', 'ror': 'https://ror.org/00py81415', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170897317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicolas D. Drysdale', 'raw_affiliation_strings': ['Duke University School of Medicine, USA'], 'affiliations': [{'raw_affiliation_string': 'Duke University School of Medicine, USA', 'institution_ids': ['https://openalex.org/I170897317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043911494', 'display_name': 'Elizabeth Matthews', 'orcid': 'https://orcid.org/0000-0001-9823-9797'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth Matthews', 'raw_affiliation_strings': ['Department of Neurobiology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003470207', 'display_name': 'Elizabeth Schuetz', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth Schuetz', 'raw_affiliation_strings': ['Department of Neurobiology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050683899', 'display_name': 'Enhui Pan', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Enhui Pan', 'raw_affiliation_strings': ['Department of Neurobiology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, USA', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070835383', 'display_name': 'James O McNamara', 'orcid': 'https://orcid.org/0000-0003-4091-618X'}, 'institutions': [{'id': 'https://openalex.org/I4210153043', 'display_name': 'Duke University Hospital', 'ror': 'https://ror.org/04bct7p84', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876', 'https://openalex.org/I4210153043']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'James O. McNamara', 'raw_affiliation_strings': ['Department of Neurobiology, USA', 'Department of Neurology, USA', 'Department of Pharmacology and Molecular Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, USA', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Pharmacology and Molecular Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA', 'institution_ids': ['https://openalex.org/I4210153043', 'https://openalex.org/I4210126298']}, {'raw_affiliation_string': 'Department of Neurology, USA', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5070835383'], 'corresponding_institution_ids': ['https://openalex.org/I4210153043', 'https://openalex.org/I4210126298'], 'apc_list': {'value': 2940, 'currency': 'USD', 'value_usd': 2940, 'provenance': 'doaj'}, 'apc_paid': {'value': 2940, 'currency': 'USD', 'value_usd': 2940, 'provenance': 'doaj'}, 'fwci': 0.374, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.681629, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 73, 'max': 77}, 'biblio': {'volume': '178', 'issue': None, 'first_page': '106816', 'last_page': '106816'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10094', 'display_name': 'Epilepsy and Seizures', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Rafts and Membrane Dynamics', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/seizures', 'display_name': 'Seizures', 'score': 0.506967}, {'id': 'https://openalex.org/keywords/tail-vein', 'display_name': 'Tail vein', 'score': 0.46836957}], 'concepts': [{'id': 'https://openalex.org/C2777341932', 'wikidata': 'https://www.wikidata.org/wiki/Q980709', 'display_name': 'Status epilepticus', 'level': 3, 'score': 0.9642545}, {'id': 'https://openalex.org/C2776108384', 'wikidata': 'https://www.wikidata.org/wiki/Q390239', 'display_name': 'Kainic acid', 'level': 4, 'score': 0.9208386}, {'id': 'https://openalex.org/C2778186239', 'wikidata': 'https://www.wikidata.org/wiki/Q41571', 'display_name': 'Epilepsy', 'level': 2, 'score': 0.8406738}, {'id': 'https://openalex.org/C148762608', 'wikidata': 'https://www.wikidata.org/wiki/Q3748185', 'display_name': 'Hippocampal formation', 'level': 2, 'score': 0.72571486}, {'id': 'https://openalex.org/C2781099131', 'wikidata': 'https://www.wikidata.org/wiki/Q744385', 'display_name': 'Temporal lobe', 'level': 3, 'score': 0.5262881}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.51755375}, {'id': 'https://openalex.org/C2781161787', 'wikidata': 'https://www.wikidata.org/wiki/Q48360', 'display_name': 'Hippocampus', 'level': 2, 'score': 0.49650842}, {'id': 'https://openalex.org/C522805319', 'wikidata': 'https://www.wikidata.org/wiki/Q179965', 'display_name': 'Electroencephalography', 'level': 2, 'score': 0.48371437}, {'id': 'https://openalex.org/C3017562151', 'wikidata': 'https://www.wikidata.org/wiki/Q632901', 'display_name': 'Tail vein', 'level': 3, 'score': 0.46836957}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.43623033}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.39005578}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3891783}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.25590965}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.233854}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22752112}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.15630901}, {'id': 'https://openalex.org/C61174792', 'wikidata': 'https://www.wikidata.org/wiki/Q420510', 'display_name': 'Glutamate receptor', 'level': 3, 'score': 0.11125252}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004833', 'descriptor_name': 'Epilepsy, Temporal Lobe', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013226', 'descriptor_name': 'Status Epilepticus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004569', 'descriptor_name': 'Electroencephalography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004833', 'descriptor_name': 'Epilepsy, Temporal Lobe', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007608', 'descriptor_name': 'Kainic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007608', 'descriptor_name': 'Kainic Acid', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012640', 'descriptor_name': 'Seizures', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012640', 'descriptor_name': 'Seizures', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D013226', 'descriptor_name': 'Status Epilepticus', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.eplepsyres.2021.106816', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S144140688', 'display_name': 'Epilepsy Research', 'issn_l': '0920-1211', 'issn': ['0920-1211', '1872-6844'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657370', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34808484', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.eplepsyres.2021.106816', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S144140688', 'display_name': 'Epilepsy Research', 'issn_l': '0920-1211', 'issn': ['0920-1211', '1872-6844'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320337359', 'funder_display_name': 'National Institute of Neurological Disorders and Stroke', 'award_id': 'NS056217'}, {'funder': 'https://openalex.org/F4320337359', 'funder_display_name': 'National Institute of Neurological Disorders and Stroke', 'award_id': 'NS097717'}], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1612819372', 'https://openalex.org/W1880320779', 'https://openalex.org/W1968678477', 'https://openalex.org/W1992574314', 'https://openalex.org/W2078385314', 'https://openalex.org/W2079239821', 'https://openalex.org/W2081697928', 'https://openalex.org/W2097987464', 'https://openalex.org/W2103946141', 'https://openalex.org/W2119124441', 'https://openalex.org/W2233260261', 'https://openalex.org/W2338445671', 'https://openalex.org/W3150153787'], 'related_works': ['https://openalex.org/W4251746022', 'https://openalex.org/W3213359842', 'https://openalex.org/W2993791493', 'https://openalex.org/W2986580326', 'https://openalex.org/W2734854467', 'https://openalex.org/W2105730096', 'https://openalex.org/W2057460561', 'https://openalex.org/W2056164961', 'https://openalex.org/W2046320735', 'https://openalex.org/W2045221948'], 'abstract_inverted_index': {'We': [0, 16], 'set': [1], 'out': [2], 'to': [3, 18, 65, 138], 'establish': [4], 'a': [5, 14, 126, 144], 'novel': [6], 'model': [7], 'of': [8, 24, 35, 52, 71, 76, 119, 125, 141, 146], 'temporal': [9], 'lobe': [10], 'epilepsy': [11], '(TLE)': [12], 'in': [13, 143], 'mouse.': [15], 'sought': [17], 'induce': [19], 'TLE': [20, 142], 'through': [21, 121], 'the': [22, 29, 74, 95, 122, 139], 'injection': [23, 51], 'kainic': [25], 'acid': [26], '(KA)': [27], 'into': [28], 'tail': [30, 123], 'vein': [31, 124], 'with': [32, 81, 90, 98, 114], 'subsequent': [33], 'development': [34, 70, 140], 'status': [36], 'epilepticus': [37], '(SE).': [38], 'Using': [39], 'C57BL/6': [40], 'mice,': [41], 'we': [42], 'implanted': [43], 'hippocampal': [44], 'EEG': [45, 61], 'recording': [46], 'electrodes': [47], 'before': [48], 'or': [49, 54], 'after': [50], 'KA': [53, 82, 99, 120], 'phosphate': [55], 'buffered': [56], 'saline': [57], '(PBS).': [58], 'Video': [59], 'and': [60, 69, 129, 136], 'analysis': [62], 'were': [63, 88], 'conducted': [64], 'evaluate': [66], 'for': [67, 101], 'SE': [68, 84, 132], 'recurrent': [72, 102, 109], 'seizures,': [73], 'hallmark': [75], 'TLE.': [77], 'All': [78], 'mice': [79], 'injected': [80, 89, 97, 113], 'developed': [83, 107], 'while': [85, 111], 'those': [86, 112], 'who': [87], 'PBS': [91, 115], 'did': [92, 116], 'not.': [93, 117], 'Of': [94], 'animals': [96], 'monitored': [100], 'seizures': [103, 110], 'following': [104], 'SE,': [105], '33%': [106], 'spontaneous': [108], 'Injection': [118], 'mouse': [127], 'reliably': [128], 'rapidly': [130], 'induces': [131], 'which': [133], 'remits': [134], 'spontaneously': [135], 'leads': [137], 'subset': [145], 'mice.': [147]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3213359842', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-09-19T22:57:28.546884', 'created_date': '2021-11-22'}