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{'id': 'https://openalex.org/W3207894798', 'doi': 'https://doi.org/10.1161/circulationaha.121.054768', 'title': 'PTPMT1 Is Required for Embryonic Cardiac Cardiolipin Biosynthesis to Regulate Mitochondrial Morphogenesis and Heart Development', 'display_name': 'PTPMT1 Is Required for Embryonic Cardiac Cardiolipin Biosynthesis to Regulate Mitochondrial Morphogenesis and Heart Development', 'publication_year': 2021, 'publication_date': '2021-08-02', 'ids': {'openalex': 'https://openalex.org/W3207894798', 'doi': 'https://doi.org/10.1161/circulationaha.121.054768', 'mag': '3207894798', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34339306', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8340985'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circulationaha.121.054768', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.121.054768', 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 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328, 434, 474, 515, 555, 623, 655, 860, 2807], '(Z.C.,': [143, 155, 195, 207, 246, 262, 277, 292, 307, 435, 475, 516, 556, 656, 752, 793, 861], 'S.Z.,': [144, 156, 196, 208, 247, 263, 278, 293, 308, 436, 476, 517, 557, 657, 753, 794, 862], 'H.W.,': [145, 197, 248, 437, 477, 518, 558, 658, 863], 'X.W.,': [146, 198, 249, 438, 478, 519, 559, 659, 864], 'B.X.,': [147, 199, 250, 439, 479, 520, 560, 660, 865], 'S.W.,': [148, 200, 251, 440, 480, 521, 561, 661, 866], 'L.H.,': [149, 201, 252, 441, 481, 522, 562, 662, 867], 'Z.H.,': [150, 202, 253, 442, 482, 523, 563, 663, 868], 'K.O.).': [151, 203, 254, 443, 483, 524, 564, 664, 869], 'Departments': [152, 204, 259, 274, 289, 304, 360, 700, 749, 790], 'Medicine': [154, 206, 261, 276, 291, 306, 751, 792], 'L.W.,': [157, 209, 264, 279, 294, 309, 754, 795], 'J.Z.,': [158, 210, 265, 280, 295, 310, 755, 796], 'Y.G.,': [159, 211, 266, 281, 296, 311, 756, 797], 'C.T.,': [160, 212, 267, 282, 297, 312, 757, 798], 'X.F.,': [161, 213, 268, 283, 298, 313, 758, 799], 'J.C.)': [162, 214, 269, 284, 299, 314, 759, 800], ',': [163, 215, 255, 270, 285, 300, 330, 356, 404, 444, 484, 525, 565, 610, 625, 665, 693, 721, 760], 'ZhuSiting': [165], 'Zhu': [166], 'https://orcid.org/0000-0002-6950-9556': [167], 'WangHong': [217], 'Wang': [218, 258, 407, 487, 3009], 'WangLi': [257], 'ZhangJianlin': [272], 'Zhang': [273, 2991], 'GuYusu': [287], 'Gu': [288], 'TanChangming': [302], 'Tan': [303], 'Cardiothoracic': [317], 'The': [319, 608, 1083, 1114, 1184, 1275, 1367, 1652, 2272, 2472, 2967], 'Second': [320], 'Xiangya': [321], 'Central': [323], 'South': [324], 'University,': [325, 621], 'Changsha,': [326], 'Hunan,': [327], '(C.T.).': [329], 'DhananiMehul': [332], 'Dhanani': [333], 'Anesthesiology': [334, 671], '(M.D.,': [335, 354, 672, 691], 'H.H.P.),': [336, 673, 2837], 'Medicine,': [339, 619, 676, 730, 771, 2900, 2920], 'California': [342, 679, 733, 774, 2903, 2923], 'San': [343, 349, 680, 686, 734, 775, 2904, 2924], 'Diego,': [344, 681, 735, 776, 2905, 2925], 'La': [345, 682, 739, 780, 2909, 2929], 'Jolla.': [346, 683], 'Veterans': [347, 684, 2840], 'Administration': [348, 685, 2841], 'Diego': [350, 687], 'Healthcare': [351, 688], 'System,': [352, 689], 'CA': [353, 690], 'H.H.P.).': [355, 692], 'WeverEric': [358], 'Wever': [359], 'Clinical': [362, 702], 'Chemistry': [363, 703], 'Pediatrics,': [365, 705], 'Amsterdam': [366, 377, 393, 400, 585, 592, 706, 717], 'Gastroenterology': [367, 707], 'Endocrinology': [368, 708], 'Metabolism': [369, 709], '(E.W.,': [370, 375, 398, 590, 710, 715], 'F.M.V.)': [371, 711], 'Core': [372, 712], 'Facility': [373, 713], 'Metabolomics': [374, 714], 'F.M.V.),': [376, 716], 'Universitair': [378, 401, 593, 718], 'Medische': [379, 402, 594, 719], 'Centra': [380, 403, 595, 720], 'Genetic': [382, 574], 'Metabolic': [383, 575], 'Diseases;': [384, 576], 'Bioinformatics': [385, 577], 'Laboratory,': [386, 578], 'Epidemiology': [389, 581], 'Data': [391, 583, 597], 'Science,': [392, 584], 'Public': [394, 586], 'Health': [395, 587, 2834], 'Research': [396, 588, 2814, 2827], 'Institute': [397, 589, 600, 2775, 2822], 'A.H.C.v.K.),': [399, 591], 'WangXinru': [406], 'XieBoyu': [446], 'Xie': [447], 'WangShijia': [486], 'https://orcid.org/0000-0001-5063-6224': [488], 'HuangLei': [527], 'Huang': [528], 'KampenAntoine': [569], 'Kampen': [572], 'Biosystems': [596], 'Analysis,': [598], 'Swammerdam': [599], 'Life': [602], 'Sciences': [603], '(A.H.C.v.K.),': [604], 'Amsterdam,': [607], 'Netherlands.': [609], 'LiuJie': [612], 'Liu': [613], 'Pathophysiology,': [616], '(J.L.).': [624], 'HanZhen': [627], 'Han': [628], 'PatelHemal': [668], 'Patel': [670, 2763], 'VazFrédéric': [696], 'Vaz': [698], 'https://orcid.org/0000-0002-9048-1041': [699], 'FangXi': [723], 'Fang': [724], 'PhD,': [727, 768, 807, 2897, 2917, 2937], '9500': [736, 777, 2906, 2926], 'Gilman': [737, 778, 2907, 2927], 'Drive,': [738, 779, 2908, 2928], 'Jolla,': [740, 781, 2910, 2930], 'CA,': [741, 782, 2911, 2931, 3002], '92093;': [742, 783, 2912, 2932], 'Email': [743, 784, 828, 2913, 2933, 2958], 'E-mail': [744, 785, 829], 'Address:': [745, 786, 830], '[email': [746, 787, 831, 2914, 2934, 2959], 'protected]': [747, 788, 832], 'https://orcid.org/0000-0001-7816-8821': [748], 'ChenJu': [762], 'Correspondence': [764], 'to:': [765, 2894], 'https://orcid.org/0000-0001-7674-4776': [789], 'OuyangKunfu': [803], 'Ouyang': [804], 'Ouyang,': [806, 2936], '518055,': [826, 2956], 'China.': [827, 2957], 'https://orcid.org/0000-0003-0292-375X': [833], 'Originally': [870, 3131], 'published2': [871], 'Aug': [872], '2021https://doi.org/10.1161/CIRCULATIONAHA.121.054768Circulation.': [873], '2021;144:403–406Cardiolipin': [874], 'is': [875, 896, 1002, 1097, 2086, 2354, 2501, 2625, 3016], 'a': [876, 937, 2000, 2014, 2068, 2156, 2257, 2301, 2375, 2718], 'unique': [877], 'glycerol-bridged': [878], 'dimeric': [879], 'phospholipid': [880], 'representing': [881, 1341], 'up': [882], '20%': [884], 'total': [886, 1094, 1117, 2043, 2074, 2657], 'lipids': [887], 'in': [888, 891, 918, 940, 959, 973, 985, 1039, 1125, 1139, 1213, 1307, 1354, 1385, 1430, 1455, 1472, 1492, 1517, 1659, 1681, 1724, 1748, 1989, 2032, 2053, 2071, 2091, 2109, 2129, 2160, 2166, 2183, 2195, 2204, 2217, 2237, 2245, 2276, 2282, 2312, 2344, 2363, 2389, 2392, 2401, 2434, 2467, 2489, 2507, 2515, 2541, 2595, 2636, 2678, 2702, 2707, 2720, 2793, 2972, 2978, 3037], 'mitochondrial': [889, 1011, 1409, 1490, 1513, 1578, 1666, 1896, 1931, 1951, 2011, 2015, 2186, 2193, 2240, 2278, 2331, 2358, 2399, 2422, 2436, 2444, 2455, 2555, 2704, 2755, 2970], 'membranes': [890, 1692], 'cardiomyocytes.': [892, 1474, 2093, 2365], 'Abnormal': [893], 'cardiolipin': [894, 911, 917, 944, 958, 972, 986, 1007, 1027, 1987, 2030, 2044, 2051, 2089, 2275, 2352, 2658, 2661, 2700, 2730, 2971, 3019], 'metabolism': [895, 989, 2728], 'linked': [897], 'heart': [899, 908, 976, 1014, 1382, 2712, 2973], 'diseases,': [900], 'including': [901, 1031, 1413, 1556, 1567, 1582, 1592], 'Barth': [902], 'syndrome,': [903], 'myocardial': [904], 'ischemia-reperfusion': [905], 'injury,': [906], 'failure.1': [909], 'However,': [910], 'profiles': [912], 'specific': [914], 'roles': [915], 'cardiac': [919, 1006, 1990, 1994, 2113, 2161, 2979], 'mitochondria': [920, 1454, 1468, 1500, 1539, 1661, 2255, 2262, 2314, 2335], 'remain': [921], 'largely': [922], 'obscure.We': [923], 'first': [924, 2164], 'performed': [925, 1370, 2288], 'quantitative': [926], 'lipidomic': [927, 1018], 'analysis': [928, 1019, 1404, 1484, 1550, 1609], 'on': [929, 1371, 1405, 2891], 'mouse': [930, 952, 2001, 2095, 2587, 2597, 2709], 'hearts': [931, 953, 961, 1235, 1332, 1358, 1373, 1435, 1700, 2055, 2131, 2171, 2198, 2219, 2247, 2284, 2469, 2491, 2517, 2575], 'at': [932, 1045, 1080, 1128, 1178, 1255, 1289, 1335, 1362, 1378, 1383, 1393, 1400, 1436, 1460, 1522, 1596, 1706, 1729, 1753, 2056, 2132, 2145, 2172, 2269, 2315, 2321, 2470, 2492, 2518, 2576], 'different': [933, 992], 'stages': [934], 'revealed': [936, 2717], 'strong': [938], 'discrepancy': [939], 'molecular': [941], 'compositions': [942], 'cardiolipin-related': [946, 1029, 2077, 2732], 'metabolites': [947, 2078, 2733], 'between': [948, 994, 2118, 2571, 2734], 'embryonic': [949, 960, 995, 1005, 1234, 1434, 1544, 1674, 1836, 1840, 1844, 2033, 2054, 2058, 2063, 2092, 2116, 2119, 2123, 2133, 2197, 2227, 2253, 2283, 2322, 2345, 2708, 2735], 'adult': [951, 975, 997, 2596, 2637, 2682, 2737], '(Figure': [954, 2079, 2136, 2149, 2174, 2224, 2248, 2325, 2347, 2496, 2530, 2578, 2618, 2650, 2666, 2689], '[A]).': [955], 'In': [956], 'particular,': [957], 'displayed': [962], 'more': [963, 1069, 1199, 1671, 2265, 2319], 'diverse': [964], 'acyl': [965], 'compositions,': [966], 'while': [967, 2481], 'the': [968, 974, 982, 1040, 1057, 1063, 1100, 1103, 1170, 1190, 1193, 1302, 1342, 1375, 1406, 1444, 1467, 1493, 1497, 1506, 1512, 1602, 1615, 1627, 1636, 1641, 1655, 1678, 1984, 2019, 2039, 2048, 2100, 2146, 2482, 2493, 2510, 2524, 2542, 2604, 2613, 2630, 2644, 2654, 2679, 2723, 2727, 2769, 2777, 2802, 2811, 2819, 2830, 2839, 2876, 2888, 3038], 'predominant': [969], 'form': [970, 2026], 'was': [977, 1020, 1089, 1369, 1441, 1599, 1662, 1668, 1774, 2298, 2478, 2798], 'tetralinoleoyl': [978], 'cardiolipin,': [979], 'implicating': [980], 'that': [981, 2017, 2084, 2295, 2350, 2503, 2623, 2874], 'pathways': [983], 'involved': [984], 'biosynthesis': [987, 1008, 1988, 2031, 2090, 2353, 2701], 'may': [990], 'have': [991, 2429], 'functions': [993, 2231], 'hearts.Download': [998], 'figureDownload': [999], 'PowerPointFigure.': [1000], 'PTPMT1': [1001, 1639, 1825, 1856, 2007, 2035, 2085, 2108, 2327, 2506, 2594, 2624, 2640, 2688, 2743, 3015], 'required': [1003, 2087, 2355], 'regulate': [1010], 'morphogenesis': [1012, 2359, 2706], 'development.': [1015, 2713], 'A,': [1016, 3066], 'Quantitative': [1017, 1483], 'applied': [1021], 'identify': [1023], 'individual': [1024, 1087, 2076, 2527, 2660], 'species': [1025, 1058, 1067, 1072, 1088, 1197, 1202, 2052, 2617, 2662], 'metabolites,': [1030], 'PA,': [1032, 1118, 1206, 1935], 'PGP,': [1033, 1119, 1207, 1940], 'PG,': [1034, 1120, 1208, 1938], 'CL,': [1035, 1121, 1209, 1827], 'MLCL,': [1036, 1122, 1210, 1886], 'DLCL': [1038, 1124, 1212], 'ventricles': [1041, 1127, 1141, 1157, 1168, 1217], 'control': [1043, 1156, 1225, 1251, 1285, 1315, 1355, 1431, 1456, 1518, 1702, 1725, 1749, 2572], 'mice': [1044, 1254, 1705, 1728, 1742, 1752, 1766, 2683], 'E11.5,': [1046, 1835, 2316], 'E15.5,': [1047, 1181, 1843], '2': [1048, 1372, 1730, 1754, 2460], 'months,': [1049], '10': [1051, 1064, 1071, 1142, 1194, 1201, 1707, 1733, 1757, 1765], 'months': [1052, 1143, 1708, 1731, 1734, 1755, 1758], 'age,': [1054], 'respectively.': [1055, 1182, 1227, 1274, 1366], 'All': [1056, 1769, 2094], 'each': [1060, 1081, 1543], 'metabolite,': [1061], 'or': [1062, 1189, 1380], 'most': [1065, 1195, 2046, 2605, 2614], 'abundant': [1066, 1196, 2606, 2615], 'if': [1068, 1198], 'than': [1070, 1200, 1672], 'were': [1073, 1075, 1150, 1173, 1203, 1218, 1260, 1333, 1352, 1540, 1649, 1693, 2097, 2215, 2232, 2243, 2465, 2676], 'observed,': [1074, 1204], 'selected': [1076], 'further': [1078, 1219, 2233], 'analyzed': [1079, 1151, 1220], 'stage.': [1082], 'abundance': [1084], '(%)': [1085], 'calculated': [1090], 'according': [1091], 'its': [1093, 2976], 'level': [1095], 'represented': [1098], 'by': [1099, 1359, 1688, 1776, 2099, 2199, 2599, 2766, 2801], 'area': [1101, 2377], 'circle': [1104], '(n': [1105, 1130, 1135, 1147, 1158, 1286, 1294, 1316, 1325, 1388, 1524, 1531, 1737, 1761], '=': [1106, 1131, 1136, 1148, 1159, 1266, 1287, 1295, 1317, 1326, 1389, 1396, 1477, 1525, 1532, 1713, 1738, 1762], '3,': [1107, 1108, 1160, 1161, 1318, 1327, 3116], '6,': [1109, 1111], 'respectively).': [1112, 1164], 'B,': [1113, 3090], 'levels': [1115, 1185, 1191, 2072, 2645, 2655], 'CKO': [1126, 1214, 1253, 1293, 1324, 1357, 1433, 1458, 1473, 1520, 1660, 2130, 2170, 2218, 2246, 2313, 2403, 2468, 2490, 2516, 2574], 'E11.5': [1129, 1179, 1363, 1379, 1437, 1461, 1523, 2173, 2223, 2402, 2519, 2577], '3)': [1132], 'E15.5': [1134], '3),': [1137], 'iCKO': [1140, 1216, 1704, 1727, 1751], 'post–tamoxifen-induced': [1144], 'gene': [1145], 'deletion': [1146, 1637, 2005, 2328, 2504, 2592, 2686], '5)': [1149], 'normalized': [1153, 1222], 'their': [1155, 1224], '5,': [1163, 1328, 1330], 'Twenty-five': [1165], '6': [1167, 1397, 1763], 'with': [1169, 1239, 1262, 1374, 1469, 1501, 2003, 2067, 2139, 2260, 2336, 2684], 'same': [1171, 1376, 1679, 2147, 2494], 'genotype': [1172, 1680], 'pooled': [1174], 'as': [1175, 1443, 1575, 1577, 1601, 2220, 2222, 2370], '1': [1176, 1381, 1714, 1930, 2421, 2554, 2566], 'sample': [1177, 1667], 'C,': [1183, 3052], 'every': [1187], 'species,': [1188, 2608], 'ventricles,': [1226], 'D': [1228], 'through': [1229, 1481, 1547], 'H,': [1230], 'Representative': [1231, 1448, 1699], 'images': [1232, 1245, 1452], '(D),': [1236], 'sections': [1237], 'stained': [1238], 'hematoxylin': [1240], 'eosin': [1242], '(E),': [1243], 'EdU': [1247], 'labeling': [1248], '(G)': [1249], 'indicated': [1256, 1336], 'stages.': [1257, 1337], 'cells': [1259], 'costained': [1261], 'α-actinin.': [1263], 'Scale': [1264, 1475, 1711], 'bar': [1265, 1476, 1712], '0.5': [1267, 1478], 'mm,': [1268], '100': [1269], 'μm,': [1270, 1273], '50': [1272, 1673], 'thickness': [1276], 'left': [1278, 1861, 1864, 1871], 'right': [1280, 1954], 'ventricular': [1281, 1308, 1675, 1865, 1872, 2143], 'walls': [1282, 2144], '(F)': [1283], '4': [1288, 1526], 'both': [1290, 2042, 2057, 2185], 'stages)': [1291], '3': [1296, 1533, 1739], '4,': [1298, 1319, 1321], 'respectively)': [1299, 1322, 1331], 'hearts,': [1300], 'ratios': [1303], 'EdU-positive': [1305], 'cardiomyocytes': [1306, 1459, 1521, 2110, 2346, 2508, 2598, 2680, 2710], 'compaction': [1309], 'zone': [1310, 2168], 'trabecular': [1312], '(H)': [1313], 'measured': [1334, 1353, 1541], 'I,': [1338], 'Oxygen': [1339], 'flux': [1340], 'respiratory': [1343, 2205, 2230, 3075, 3080], 'function': [1344, 2187, 2206, 2273, 2974], 'CI': [1346], 'CII,': [1348, 1819], 'mOX,': [1349, 1877], 'mUC': [1351], 'high-resolution': [1360], 'respirometry': [1361], 'E12.5,': [1365, 1839], 'measurement': [1368], 'phenotype': [1377], 'E12.5': [1384, 1530], 'one': [1386], 'chamber': [1387], '8': [1390], 'per': [1391, 1398, 1527, 1534, 1743, 1767], 'group': [1392, 1399, 2022], 'E11.5;': [1394], 'n': [1395], 'E12.5).': [1401], '(J)': [1402], 'Immunoblot': [1403, 1549], 'expression': [1407, 2238], 'oxidative': [1410, 1879, 2212, 2383], 'phosphorylation': [1411, 1880, 2213, 2384], 'subunits': [1412, 1554, 1565], 'NDUFB8': [1414], '(complex': [1415, 1418, 1421, 1424, 1428], 'I),': [1416], 'SDHB': [1417], 'II),': [1419], 'UQCRC2': [1420], 'III),': [1422], 'MTCO1': [1423], 'IV),': [1425], 'ATP5A': [1427, 1787], 'V)': [1429], 'E12.5.': [1439, 1463], 'GAPDH': [1440, 1598], 'used': [1442, 1600, 1993], 'loading': [1445, 1603, 1696], 'control.': [1446, 1604, 1697, 1786], 'K,': [1447], 'transmission': [1449, 2289], 'electron': [1450, 2290], 'microscopic': [1451], 'Red': [1464], 'arrows': [1465], 'indicate': [1466], 'bubble-like': [1470, 2302], 'cristae': [1471, 1488, 1503, 1510, 1900, 2268, 2339, 2342, 2361, 2367, 2393, 2413, 2437, 2705, 2750, 3072], 'μm.': [1479], 'L': [1480], 'O,': [1482], 'length': [1486], '(L),': [1489], 'diameter': [1491, 1867, 1874], 'short': [1494], 'axis': [1495, 1515], '(M),': [1496], 'percentage': [1498], 'lamellar': [1502, 1509, 2267, 2307, 2337], '(N),': [1504], 'number': [1507, 2263], 'along': [1511], 'long': [1514], '(O)': [1516], 'group)': [1528], 'group).': [1535, 1744, 1768], 'At': [1536, 2226], 'least': [1537], '160': [1538], 'heart.': [1545], 'P': [1546], 'T,': [1548, 3056], 'F1F0-ATP': [1552, 1611, 1644, 1971, 1975, 2405, 2463, 2475], 'synthase': [1553, 1612, 1645, 1972, 1976, 2406, 2476], '(P)': [1555], 'ATP5A,': [1557], 'ATP5H,': [1558, 1798], 'ATP5F1,': [1559, 1793], 'ATP5I,': [1560, 1803], 'ATP5L,': [1562], 'MICOS': [1563, 1623, 1656, 1904, 1909, 2408, 2513, 2528], 'complex': [1564, 1613, 1624, 1657, 1790, 1795, 1800, 1805, 1810, 1817, 1820, 1905, 1910, 1966, 2208, 2241, 2477, 2485, 2514], '(R)': [1566], 'MIC60,': [1568, 1903], 'MIC27,': [1569, 1908], 'MIC25,': [1570], 'MIC19,': [1571], 'MIC13,': [1572], 'MIC10,': [1574], 'well': [1576], 'dynamics–related': [1579], 'proteins': [1580, 1591, 2242, 2388, 2570], '(T)': [1581], 'MFN1,': [1583, 1913], 'MFN2,': [1584, 1916], 'OPA1,': [1585, 1926], 'DRP1,': [1586, 1831], 'FIS1': [1588, 2563], 'prohibitin': [1590, 1945, 2427, 2569], 'PHB': [1593], 'PHB2': [1595], 'E11.5.': [1597, 2471], 'Blue': [1605, 1689], 'Native-PAGE': [1606], 'immunoblot': [1608], 'using': [1614, 1626, 2589], 'antibodies': [1616, 1628], 'against': [1617, 1629], 'ATP5F1': [1618], 'ATP5H': [1620], '(Q),': [1621], 'assembly': [1625, 1658, 2483, 2511, 3078], 'MIC10': [1630], 'MIC27': [1632], '(S).': [1633], 'To': [1634], 'note,': [1635], 'reduced': [1640, 2038, 2601], 'formation': [1642], 'dimers,': [1646, 2407], 'whereas': [1647], 'monomers': [1648], 'not': [1650, 2522, 2537, 2721], 'affected.': [1651], 'reduction': [1653], 'also': [1663, 2329, 2479, 2580, 2626, 2642, 2716, 2726, 2799], 'observed.': [1664], 'Each': [1665], 'prepared': [1669], 'from': [1670, 2023, 2632, 2768, 2857, 2887, 3095], 'tissues': [1676], '1%': [1682], 'digitonin-containing': [1683], 'extraction': [1684], 'buffer,': [1685], 'separated': [1687], 'Native-PAGE.': [1690], 'CB-stained': [1691], 'scanned': [1694], 'U,': [1698], 'post–tamoxifen': [1709, 1735, 1759], 'injection.': [1710], 'mm.': [1715], 'V,': [1716, 3064], 'Ratios': [1717], 'ventricle': [1719, 1980], 'weight': [1720, 1723], 'body': [1722], 'injection': [1736, 1760], '7': [1741], 'W,': [1745], 'Echocardiographic': [1746], 'assessment': [1747], 'data': [1770], 'represent': [1771], 'mean±SEM.': [1772], 'Significance': [1773], 'determined': [1775], '2-tailed,': [1777], 'unpaired': [1778], 'Student': [1779], 't': [1780], 'test.': [1781], '*P<0.05,': [1782], '**P<0.01,': [1783], '***P<0.001': [1784], 'vs': [1785], 'indicates': [1788], 'F1': [1789], 'subunit': [1791, 1796, 1801, 1806, 1811, 1906, 1911, 1924, 1961, 1967, 2447, 2458], 'α;': [1792], 'F0': [1794, 1799, 1804, 1809, 2445, 2456], 'b;': [1797], 'd;': [1802], 'e;': [1807], 'ATP5L': [1808, 2450], 'g;': [1812], 'CB,': [1813], 'Coomassie': [1814], 'blue;': [1815], 'CI,': [1816], 'I;': [1818, 1894], 'II;': [1821], 'CKO,': [1822], 'TnT-Cre-mediated': [1823], 'cardiac-specific': [1824, 2004, 2584, 2742], 'knockout;': [1826, 1857], 'cardiolipin;': [1828], 'DLCL,': [1829], 'dilysocardiolipin;': [1830], 'dynamin-related': [1832], 'protein': [1833, 1929, 1948, 2420, 2561], '1;': [1834, 1915, 1952], 'day': [1837, 1841, 1845, 2059, 2064, 2120, 2124, 2134, 2228, 2323, 2745], '11.5;': [1838], '12.5;': [1842], '15.5;': [1846], 'FS,': [1847], 'fractional': [1848], 'shortening;': [1849], 'GAPDH,': [1850], 'glyceraldehyde': [1851], '3-phosphate': [1852], 'dehydrogenase;': [1853], 'iCKO,': [1854], 'αMHC-CreER–mediated': [1855], 'KD,': [1858], 'kilodaltons;': [1859], 'LV,': [1860], 'ventricle;': [1862, 1955], 'LVIDd,': [1863], 'internal': [1866, 1873], 'end': [1868, 1875], 'diastole;': [1869], 'LVIDs,': [1870], 'systole;': [1876], 'maximum': [1878, 1883, 2211], 'capacity;': [1881, 1885], 'mUC,': [1882], 'uncoupled': [1884], 'monolysocardiolipin;': [1887], 'MTCO1,': [1888], 'mitochondrially': [1889], 'encoded': [1890], 'cytochrome': [1891, 1964], 'C': [1892], 'oxidase': [1893], 'MICOS,': [1895], 'contact': [1897, 2410, 2747], 'site': [1898, 2411, 2748], 'organizing': [1901, 2414, 2751], 'system;': [1902], 'Mic60;': [1907], 'Mic27;': [1912], 'mitofusin': [1914, 1917], '2;': [1918, 1946], 'NDUFB8,': [1919], '1,4-dihydronicotinamide': [1920], 'adenine': [1921], 'dinucleotide:ubiquinone': [1922], 'oxidoreductase': [1923], 'B8;': [1925], 'optic': [1927], 'atrophy': [1928, 2419, 2553], 'dynamin-like': [1932, 2423, 2556], 'guanosine': [1933, 2424, 2557], 'triphosphatase;': [1934], 'phosphatidic': [1936], 'acid;': [1937], 'phosphatidylglycerol;': [1939], 'phosphatidylglycerophosphate;': [1941], 'PHB,': [1942], 'prohibitin;': [1943], 'PHB2,': [1944], 'PTPMT1,': [1947], 'tyrosine': [1949, 2009, 2753, 3138], 'phosphatase': [1950, 2010, 2016, 2754, 3014], 'RV,': [1953], 'SDHB,': [1956], 'succinate': [1957], 'dehydrogenase': [1958], '[ubiquinone]': [1959], 'iron-sulfur': [1960], 'B;': [1962], 'UQCRC2,': [1963], 'b-c1': [1965], '2,': [1968, 3133], 'mitochondrial;': [1969], 'Vd,': [1970], 'dimer;': [1973], 'Vm,': [1974], 'monomer;': [1977], 'VW/BW,': [1979], 'weight/body': [1981], 'weight.To': [1982], 'investigate': [1983], 'role': [1985, 2697, 2968], 'development,': [1991], 'we': [1992, 2535], 'Troponin': [1995], 'T': [1996], '(TnT-Cre)': [1997], 'generate': [1999], 'model': [2002, 2588], '([protein': [2008], '1]': [2012], 'CKO),': [2013], 'removes': [2018], 'terminal': [2020], 'phosphate': [2021], 'phosphatidylglycerophosphate': [2024, 2611, 2616, 2633], 'phosphatidylglycerol,2': [2027], 'disrupt': [2029], 'hearts.': [2034, 2638], 'deficiency': [2036, 2641], 'indeed': [2037], 'contents': [2040], 'abundantly': [2049], 'expressed': [2050], '11.5': [2060], '(E11.5)': [2061], '15.5,': [2065], 'accompanied': [2066, 2138], 'broad': [2069], 'alteration': [2070], '[B': [2080, 2651, 2667], 'C]),': [2082, 2621, 2653, 2669], 'demonstrating': [2083], 'protocols': [2096], 'approved': [2098], 'Institutional': [2101], 'Animal': [2102], 'Care': [2103], 'Use': [2105], 'Committee.Deletion': [2106], 'caused': [2111], 'abnormal': [2112], 'development': [2114], 'lethality': [2117], '16.5': [2121], '18.5.': [2125], 'Morphological': [2126], 'changes': [2127, 2236, 2675], 'started': [2128], '12.5': [2135, 2324], '[D]),': [2137], 'decreased': [2140], 'thicknesses': [2141], 'stage': [2148, 2495], '[E': [2150], 'F]),': [2152], 'which': [2153], 'could': [2154, 2395], 'be': [2155, 2309, 2882], 'consequence': [2157], 'defects': [2159], 'cell': [2162], 'proliferation': [2163], 'observed': [2165, 2216, 2244, 2311, 2677], 'compact': [2167], '[G': [2175], 'H]).Cardiolipin': [2177], 'has': [2178, 2850], 'been': [2179, 2430], 'proposed': [2180, 2431], 'participate': [2182, 2433], 'regulating': [2184, 2277, 2435, 2703], 'structure.1': [2189], 'We': [2190, 2287], 'then': [2191], 'evaluated': [2192], 'respiration': [2194, 2400], 'permeabilized': [2196], 'measuring': [2200], 'oxygen': [2201], 'consumption.': [2202], 'Decreases': [2203], 'I': [2209], 'capacity': [2214], 'early': [2221], '[I]).': [2225], '12.5,': [2229], 'impaired,': [2234, 2480], '[I': [2249], 'J]).In': [2251], 'developing': [2252, 2364, 3039], 'cardiomyocytes,': [2254], 'undergo': [2256], 'maturation': [2258], 'process': [2259], 'increased': [2261, 2610], 'organized': [2266], 'later': [2270], 'stages.3': [2271], 'morphology': [2279], 'ultrastructure': [2281], 'remains': [2285], 'unclear.': [2286], 'microscopy': [2291], 'analysis,': [2292], 'found': [2294], 'membrane': [2296, 2304, 2387], 'invagination': [2297], 'impaired': [2299, 2509], 'inner': [2303], 'structure—instead': [2305], 'cristae—could': [2308], 'easily': [2310], 'became': [2318], 'severe': [2320], '[K]).': [2326], 'altered': [2330, 2643], 'diameter,': [2332], 'percentages': [2333], 'cristae,': [2338], 'lengths,': [2340], 'numbers': [2343], '[L–O]),': [2348], 'suggesting': [2349], 'PTPMT1-mediated': [2351, 2699], 'normal': [2357], 'biogenesis': [2362, 2394, 3034, 3096], 'Because': [2366], 'are': [2368, 2764], 'recognized': [2369], 'fundamental': [2371], 'structures': [2372], 'provide': [2374], 'sufficient': [2376], 'proper': [2379], 'spatial': [2380], 'organization': [2381], 'other': [2386, 2885], 'mitochondria,4': [2390], 'abnormalities': [2391], 'account': [2396], 'dysfunctional': [2398], 'hearts.The': [2404], '(mitochondrial': [2409, 2564], 'system)': [2415], 'complex,': [2416, 2446, 2457], 'OPA1': [2417, 2551], '(optic': [2418, 2552], 'triphosphatase),': [2425, 2558], 'proteins,': [2428], 'biogenesis.5': [2438], 'ATP5I': [2439], '(ATP': [2440, 2451], 'synthase,': [2441, 2452, 2464], 'H+': [2442, 2453], 'transporting,': [2443, 2454], 'E)': [2448], 'G),': [2459], 'components': [2461, 2529], 'downregulated': [2466], 'dimerization': [2473], 'monomer': [2486], 'remained': [2487, 2663], 'unaffected': [2488], '[P': [2497], 'Q]).': [2499], 'It': [2500], 'interesting': [2502], 'but': [2520, 2725], 'did': [2521, 2536], 'alter': [2523], 'expressions': [2525, 2543], '[R': [2531], 'S]).': [2533], 'Furthermore,': [2534], 'observe': [2538], 'significant': [2539], 'differences': [2540], 'MFN1': [2545], '(mitofusin': [2546, 2549], '1),': [2547, 2562], 'MFN2': [2548], '2),': [2550], 'DRP1': [2559], '(dynamin-related': [2560], 'fission': [2565], 'protein),': [2567], '[T]).We': [2579], 'generated': [2581], 'an': [2582, 2695, 2787], 'inducible': [2583], 'Ptpmt1': [2585], 'knockout': [2586], 'αMHC-CreER.': [2590], 'Induced': [2591], 'tamoxifen': [2600], 'phosphatidylglycerol': [2602, 2607, 2635], '(34:1),': [2603, 2612], '[A': [2619], 'indicating': [2622], 'responsible': [2627], 'catalyzing': [2629], 'conversion': [2631], 'Although': [2639], 'monolysocardiolipin': [2647], 'dilysocardiolipin': [2649], 'intriguingly': [2664], 'unchanged': [2665], 'no': [2671], 'morphological': [2672], 'functional': [2674, 3098], 'induced': [2685], '[U–W]).Taken': [2690], 'together,': [2691], 'our': [2692], 'results': [2693, 2715], 'demonstrated': [2694], 'essential': [2696, 3017], 'Our': [2714], 'difference': [2719], 'only': [2722], 'composition': [2724], 'hearts.Nonstandard': [2738], 'Abbreviations': [2739], 'AcronymsCKOTnT-Cre-mediated': [2741], 'knockoutE11.5embryonic': [2744], '11.5MICOSmitochondrial': [2746], 'systemPTPMT1protein': [2752], '1Sources': [2756], 'FundingDrs': [2758], 'J.': [2759, 2784, 2848], 'funded': [2765], 'grants': [2767], 'National': [2770, 2779, 2803, 2831], 'Heart,': [2771], 'Lung,': [2772], 'Blood': [2774], 'US': [2778], 'Institutes': [2780, 2832], 'Health.': [2782], 'Dr': [2783, 2847], 'holds': [2786], 'American': [2788, 3126], 'Association': [2790], 'Endowed': [2791], 'Chair': [2792], 'Research.': [2795], 'This': [2796], 'work': [2797], 'supported': [2800], 'Science': [2804], 'Foundation': [2805, 2815], '(81970421': [2808], 'K.O.),': [2810, 2818], 'Basic': [2813], '(JCYJ20190808174001746': [2816], 'Shenzhen-Hong': [2820], 'Kong': [2821], 'Brain': [2824], 'Science-Shenzhen': [2825], 'Fundamental': [2826], 'Institutions': [2828], '(2019SHIBS0004),': [2829], '(HL091071': [2835], '(BX001963': [2842], 'BX005229': [2844], 'H.H.P.).Disclosures': [2846], 'consulted': [2851], 'receives': [2854], 'research': [2855], 'funding': [2856], 'MyoKardia': [2858], 'Inc.Footnoteshttps://www.ahajournals.org/journal/circFor': [2859], 'Sources': [2860], 'Funding': [2862], 'Disclosures,': [2864], 'see': [2865], 'page': [2866], '404.The': [2867], 'data,': [2868], 'analytical': [2869], 'methods,': [2870], 'study': [2872, 2880], 'materials': [2873], 'support': [2875], 'findings': [2877], 'this': [2879], 'will': [2881], 'available': [2883], 'researchers': [2886], 'corresponding': [2889], 'authors': [2890], 'reasonable': [2892], 'request.Correspondence': [2893], 'protected]ucsd.eduXi': [2915], 'protected]ucsd.eduKunfu': [2935], 'protected]edu.cnRefernces1.': [2960], 'Dudek': [2961], 'J,': [2962, 2992], 'Hartmann': [2963], 'M,': [2964, 3060], 'Rehling': [2965], 'P.': [2966], 'implication': [2977], 'disease.Biochim': [2980], 'Biophys': [2981], 'Acta': [2982], 'Mol': [2983, 3101], 'Basis': [2984], 'Dis.': [2985], '2019;': [2986, 3104], '1865:810–821.': [2987], 'doi:': [2988, 3024, 3046, 3084, 3106], '10.1016/j.bbadis.2018.08.025CrossrefMedlineGoogle': [2989], 'Scholar2.': [2990], 'Guan': [2993], 'Z,': [2994], 'Murphy': [2995], 'AN,': [2996], 'Wiley': [2997], 'SE,': [2998], 'Perkins': [2999], 'GA,': [3000], 'Worby': [3001], 'Engel': [3003], 'JL,': [3004], 'Heacock': [3005], 'P,': [3006], 'Nguyen': [3007], 'OK,': [3008], 'JH,': [3010], 'et': [3011, 3069], 'al..': [3012, 3070], 'biosynthesis.Cell': [3020], 'Metab.': [3021], '2011;': [3022], '13:690–700.': [3023], '10.1016/j.cmet.2011.04.007CrossrefMedlineGoogle': [3025], 'Scholar3.': [3026], 'Dorn': [3027], 'GW,': [3028], 'Vega': [3029], 'RB,': [3030], 'Kelly': [3031], 'DP.': [3032], 'dynamics': [3036], 'diseased': [3041], 'heart.Genes': [3042], 'Dev.': [3043], '2015;': [3044], '29:1981–1991.': [3045], '10.1101/gad.269894.115CrossrefMedlineGoogle': [3047], 'Scholar4.': [3048], 'Cogliati': [3049], 'S,': [3050, 3062], 'Frezza': [3051], 'Soriano': [3053], 'ME,': [3054], 'Varanita': [3055], 'Quintana-Cabrera': [3057], 'R,': [3058], 'Corrado': [3059], 'Cipolat': [3061], 'Costa': [3063], 'Casarin': [3065], 'Gomes': [3067], 'LC,': [3068], 'shape': [3073], 'determines': [3074], 'chain': [3076], 'supercomplexes': [3077], 'efficiency.Cell.': [3081], '2013;': [3082], '155:160–171.': [3083], '10.1016/j.cell.2013.08.032CrossrefMedlineGoogle': [3085], 'Scholar5.': [3086], 'Pfanner': [3087], 'N,': [3088], 'Warscheid': [3089], 'Wiedemann': [3091], 'N.': [3092], 'proteins:': [3094], 'networks.Nat': [3099], 'Rev': [3100], 'Cell': [3102], 'Biol.': [3103], '20:267–284.': [3105], '10.1038/s41580-018-0092-0CrossrefMedlineGoogle': [3107], 'Scholar': [3108], 'Previous': [3109], 'Back': [3110], 'top': [3112], 'Next': [3113], 'FiguresReferencesRelatedDetails': [3114], 'August': [3115], '2021Vol': [3117], 'Issue': [3119], '5Article': [3120], 'InformationMetrics': [3121], 'Download:': [3122], '1,002': [3123], '©': [3124], '2021': [3125, 3134], 'Association,': [3128], 'Inc.https://doi.org/10.1161/CIRCULATIONAHA.121.054768PMID:': [3129], '34339306': [3130], 'publishedAugust': [3132], 'Keywordscardiolipinsmitochondriamitochondrial': [3135], 'membranesmyocytes,': [3136], 'cardiacprotein': [3137], 'phosphatasesPDF': [3139], 'download': [3140]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3207894798', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 5}], 'updated_date': '2024-09-20T00:48:26.564248', 'created_date': '2021-10-25'}