Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3207501026', 'doi': 'https://doi.org/10.1186/s12985-021-01672-3', 'title': 'A formulated poly (I:C)/CCL21 as an effective mucosal adjuvant for gamma-irradiated influenza vaccine', 'display_name': 'A formulated poly (I:C)/CCL21 as an effective mucosal adjuvant for gamma-irradiated influenza vaccine', 'publication_year': 2021, 'publication_date': '2021-10-09', 'ids': {'openalex': 'https://openalex.org/W3207501026', 'doi': 'https://doi.org/10.1186/s12985-021-01672-3', 'mag': '3207501026', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34627297', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8501930'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12985-021-01672-3', 'pdf_url': 'https://virologyj.biomedcentral.com/track/pdf/10.1186/s12985-021-01672-3', 'source': {'id': 'https://openalex.org/S115714813', 'display_name': 'Virology Journal', 'issn_l': '1743-422X', 'issn': ['1743-422X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://virologyj.biomedcentral.com/track/pdf/10.1186/s12985-021-01672-3', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054555804', 'display_name': 'Ailar Sabbaghi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1301411061', 'display_name': 'Pasteur Institute of Iran', 'ror': 'https://ror.org/00wqczk30', 'country_code': 'IR', 'type': 'facility', 'lineage': ['https://openalex.org/I1301411061']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Ailar Sabbaghi', 'raw_affiliation_strings': ['Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, P.O.Box: 1316943551, Tehran, Iran'], 'affiliations': [{'raw_affiliation_string': 'Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, P.O.Box: 1316943551, Tehran, Iran', 'institution_ids': ['https://openalex.org/I1301411061']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015619035', 'display_name': 'Masoud Malek', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I155419210', 'display_name': 'Islamic Azad University, Science and Research Branch', 'ror': 'https://ror.org/03187yj51', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I155419210']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Masoud Malek', 'raw_affiliation_strings': ['Department of Microbiology, Science and Research Branch, Islamic Azad University, Tehran, Iran'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Science and Research Branch, Islamic Azad University, Tehran, Iran', 'institution_ids': ['https://openalex.org/I155419210']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073128540', 'display_name': 'Sara Abdolahi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210109871', 'display_name': 'Khatam University', 'ror': 'https://ror.org/016tr2g85', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I4210109871']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Sara Abdolahi', 'raw_affiliation_strings': ['Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran'], 'affiliations': [{'raw_affiliation_string': 'Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran', 'institution_ids': ['https://openalex.org/I4210109871']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063180451', 'display_name': 'Seyed Mohammad Miri', 'orcid': 'https://orcid.org/0000-0002-2388-5572'}, 'institutions': [{'id': 'https://openalex.org/I1301411061', 'display_name': 'Pasteur Institute of Iran', 'ror': 'https://ror.org/00wqczk30', 'country_code': 'IR', 'type': 'facility', 'lineage': ['https://openalex.org/I1301411061']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Seyed Mohammad Miri', 'raw_affiliation_strings': ['Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, P.O.Box: 1316943551, Tehran, Iran'], 'affiliations': [{'raw_affiliation_string': 'Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, P.O.Box: 1316943551, Tehran, Iran', 'institution_ids': ['https://openalex.org/I1301411061']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103208962', 'display_name': 'Leila Alizadeh', 'orcid': 'https://orcid.org/0000-0001-9764-7713'}, 'institutions': [{'id': 'https://openalex.org/I4210109871', 'display_name': 'Khatam University', 'ror': 'https://ror.org/016tr2g85', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I4210109871']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Leila Alizadeh', 'raw_affiliation_strings': ['Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran'], 'affiliations': [{'raw_affiliation_string': 'Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran', 'institution_ids': ['https://openalex.org/I4210109871']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101031845', 'display_name': 'Mehdi Samadi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I70640408', 'display_name': 'Tehran University of Medical Sciences', 'ror': 'https://ror.org/01c4pz451', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I70640408']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Mehdi Samadi', 'raw_affiliation_strings': ['Department of Medical Virology, Tehran University of Medical Sciences, Tehran, Iran'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Virology, Tehran University of Medical Sciences, Tehran, Iran', 'institution_ids': ['https://openalex.org/I70640408']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018739716', 'display_name': 'Seyed Reza Mohebbi', 'orcid': 'https://orcid.org/0000-0002-7020-7889'}, 'institutions': [{'id': 'https://openalex.org/I58048189', 'display_name': 'Shahid Beheshti University of Medical Sciences', 'ror': 'https://ror.org/034m2b326', 'country_code': 'IR', 'type': 'education', 'lineage': ['https://openalex.org/I58048189']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Seyed Reza Mohebbi', 'raw_affiliation_strings': ['Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran'], 'affiliations': [{'raw_affiliation_string': 'Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran', 'institution_ids': ['https://openalex.org/I58048189']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039183758', 'display_name': 'Amir Ghaemi', 'orcid': 'https://orcid.org/0000-0001-7793-2920'}, 'institutions': [{'id': 'https://openalex.org/I1301411061', 'display_name': 'Pasteur Institute of Iran', 'ror': 'https://ror.org/00wqczk30', 'country_code': 'IR', 'type': 'facility', 'lineage': ['https://openalex.org/I1301411061']}], 'countries': ['IR'], 'is_corresponding': False, 'raw_author_name': 'Amir Ghaemi', 'raw_affiliation_strings': ['Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, P.O.Box: 1316943551, Tehran, Iran'], 'affiliations': [{'raw_affiliation_string': 'Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, P.O.Box: 1316943551, Tehran, Iran', 'institution_ids': ['https://openalex.org/I1301411061']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'GBP', 'value_usd': 2318, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'GBP', 'value_usd': 2318, 'provenance': 'doaj'}, 'fwci': 1.567, 'has_fulltext': False, 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.999973, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '18', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research and Epidemiology', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research and Epidemiology', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunobiology of Dendritic Cells', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Innate Immune Recognition and Signaling Pathways', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ccl21', 'display_name': 'CCL21', 'score': 0.5874571}, {'id': 'https://openalex.org/keywords/vaccine-adjuvants', 'display_name': 'Vaccine Adjuvants', 'score': 0.521951}], 'concepts': [{'id': 'https://openalex.org/C2777863537', 'wikidata': 'https://www.wikidata.org/wiki/Q357896', 'display_name': 'Adjuvant', 'level': 2, 'score': 0.7796043}, {'id': 'https://openalex.org/C2780868878', 'wikidata': 'https://www.wikidata.org/wiki/Q1660197', 'display_name': 'Immunogenicity', 'level': 3, 'score': 0.6724582}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.6231433}, {'id': 'https://openalex.org/C186382791', 'wikidata': 'https://www.wikidata.org/wiki/Q3648585', 'display_name': 'CCL21', 'level': 5, 'score': 0.5874571}, {'id': 'https://openalex.org/C2780689484', 'wikidata': 'https://www.wikidata.org/wiki/Q383260', 'display_name': 'Influenza vaccine', 'level': 3, 'score': 0.55016017}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5008702}, {'id': 'https://openalex.org/C2779341262', 'wikidata': 'https://www.wikidata.org/wiki/Q182581', 'display_name': 'Immunity', 'level': 3, 'score': 0.47979906}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.4719319}, {'id': 'https://openalex.org/C22070199', 'wikidata': 'https://www.wikidata.org/wiki/Q192995', 'display_name': 'Vaccination', 'level': 2, 'score': 0.41934627}, {'id': 'https://openalex.org/C57992300', 'wikidata': 'https://www.wikidata.org/wiki/Q2066956', 'display_name': 'Potency', 'level': 3, 'score': 0.4166986}, {'id': 'https://openalex.org/C85663871', 'wikidata': 'https://www.wikidata.org/wiki/Q6966562', 'display_name': 'Nasal administration', 'level': 2, 'score': 0.41418597}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.41385558}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.35997522}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.35714418}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.25347048}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.068594575}, {'id': 'https://openalex.org/C12823836', 'wikidata': 'https://www.wikidata.org/wiki/Q24720618', 'display_name': 'Chemokine receptor', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D053118', 'descriptor_name': 'Influenza A Virus, H1N1 Subtype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007252', 'descriptor_name': 'Influenza Vaccines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009976', 'descriptor_name': 'Orthomyxoviridae Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000276', 'descriptor_name': 'Adjuvants, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000281', 'descriptor_name': 'Administration, Intranasal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007111', 'descriptor_name': 'Immunity, Cellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018928', 'descriptor_name': 'Immunity, Mucosal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12985-021-01672-3', 'pdf_url': 'https://virologyj.biomedcentral.com/track/pdf/10.1186/s12985-021-01672-3', 'source': {'id': 'https://openalex.org/S115714813', 'display_name': 'Virology Journal', 'issn_l': '1743-422X', 'issn': ['1743-422X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/06e9513e77bb4ca5880ec246565aa343', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501930', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34627297', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12985-021-01672-3', 'pdf_url': 'https://virologyj.biomedcentral.com/track/pdf/10.1186/s12985-021-01672-3', 'source': {'id': 'https://openalex.org/S115714813', 'display_name': 'Virology Journal', 'issn_l': '1743-422X', 'issn': ['1743-422X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.79}], 'grants': [{'funder': 'https://openalex.org/F4320326567', 'funder_display_name': 'Pasteur Institute of Iran', 'award_id': '1137'}], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W1513080541', 'https://openalex.org/W151943036', 'https://openalex.org/W1583434934', 'https://openalex.org/W1969342260', 'https://openalex.org/W1977294903', 'https://openalex.org/W1987089931', 'https://openalex.org/W1991906425', 'https://openalex.org/W1993687936', 'https://openalex.org/W1995901853', 'https://openalex.org/W2017141690', 'https://openalex.org/W2020627743', 'https://openalex.org/W2028474769', 'https://openalex.org/W2040833320', 'https://openalex.org/W2043145996', 'https://openalex.org/W2044264356', 'https://openalex.org/W2046723039', 'https://openalex.org/W2049995443', 'https://openalex.org/W2056169447', 'https://openalex.org/W2060725986', 'https://openalex.org/W2069770294', 'https://openalex.org/W2072383590', 'https://openalex.org/W2074535746', 'https://openalex.org/W2079495721', 'https://openalex.org/W2087497403', 'https://openalex.org/W2087668602', 'https://openalex.org/W2104845020', 'https://openalex.org/W2107976634', 'https://openalex.org/W2110021087', 'https://openalex.org/W2114860230', 'https://openalex.org/W2119998092', 'https://openalex.org/W2122142559', 'https://openalex.org/W2128270519', 'https://openalex.org/W2131221830', 'https://openalex.org/W2134615815', 'https://openalex.org/W2139149076', 'https://openalex.org/W2145290132', 'https://openalex.org/W2156313733', 'https://openalex.org/W2159133223', 'https://openalex.org/W2161771158', 'https://openalex.org/W2168513578', 'https://openalex.org/W2282170450', 'https://openalex.org/W2395842157', 'https://openalex.org/W2402035185', 'https://openalex.org/W2403812440', 'https://openalex.org/W2404770656', 'https://openalex.org/W2408923629', 'https://openalex.org/W2411530855', 'https://openalex.org/W2469224215', 'https://openalex.org/W2474614962', 'https://openalex.org/W2529223860', 'https://openalex.org/W2552173895', 'https://openalex.org/W2559943160', 'https://openalex.org/W2578227966', 'https://openalex.org/W2579973934', 'https://openalex.org/W2582429810', 'https://openalex.org/W2616719177', 'https://openalex.org/W2802879756', 'https://openalex.org/W2805243275', 'https://openalex.org/W2905110734', 'https://openalex.org/W2948839227', 'https://openalex.org/W2963769984', 'https://openalex.org/W2975251876', 'https://openalex.org/W3119726083', 'https://openalex.org/W4290429886', 'https://openalex.org/W4299684572', 'https://openalex.org/W591557396'], 'related_works': ['https://openalex.org/W4381250869', 'https://openalex.org/W4250292386', 'https://openalex.org/W2792570337', 'https://openalex.org/W2470318958', 'https://openalex.org/W2395948367', 'https://openalex.org/W2111831969', 'https://openalex.org/W2030383191', 'https://openalex.org/W1987173566', 'https://openalex.org/W1581415616', 'https://openalex.org/W1552738310'], 'abstract_inverted_index': {'Several': [0], 'studies': [1], 'on': [2, 66], 'gamma-irradiated': [3, 46], 'influenza': [4, 103], 'A': [5], 'virus': [6], '(γ-Flu)': [7], 'have': [8], 'revealed': [9], 'its': [10], 'superior': [11], 'efficacy': [12], 'for': [13, 245], 'inducing': [14], 'homologous': [15], 'and': [16, 34, 52, 90, 108, 121, 123, 129, 156, 193, 232], 'heterologous': [17], 'virus-specific': [18], 'immunity.': [19], 'However,': [20, 179], 'many': [21], 'inactivated': [22], 'vaccines,': [23], 'notably': [24], 'in': [25, 59, 116, 124, 221], 'nasal': [26], 'delivery,': [27], 'require': [28], 'adjuvants': [29, 65], 'to': [30, 167], 'increase': [31], 'the': [32, 40, 45, 67, 86, 117, 125, 150, 153, 163, 168, 180, 205, 230], 'quality': [33], 'magnitude': [35], 'of': [36, 42, 44, 85, 100, 138, 152, 185, 202], 'vaccine': [37, 48, 68, 155, 164, 207], 'responses.To': [38], 'illustrate': [39], 'impacts': [41], 'co-administration': [43], 'H1N1': [47], 'with': [49, 61, 79, 83, 93, 172, 187, 208, 229], 'poly': [50, 188, 233, 248], '(I:C)': [51, 160, 189, 234, 249], 'recombinant': [53], 'murine': [54], 'CCL21,': [55], 'either': [56], 'alone': [57, 81], 'or': [58, 82, 158], 'combination': [60, 184, 213], 'each': [62, 209], 'other,': [63], 'as': [64, 111, 113, 250], 'potency,': [69], 'mice': [70, 181, 203], 'were': [71, 131, 197], 'inoculated': [72], 'intranasally': [73], '3': [74], 'times': [75], 'at': [76], 'one-week': [77], 'interval': [78], 'γ-Flu': [80, 154, 206], 'any': [84], 'three': [87], 'adjuvant': [88, 210], 'combinations': [89], 'then': [91], 'challenged': [92], 'a': [94, 183, 242, 251], 'high': [95], 'lethal': [96], 'dose': [97], '(10': [98], 'LD50)': [99], 'A/PR/8/34': [101], '(H1N1)': [102], 'virus.': [104], 'Virus-specific': [105], 'humoral,': [106], 'mucosal,': [107], 'cell-mediated': [109, 194], 'immunity,': [110, 195], 'well': [112], 'cytokine': [114], 'profiles': [115], 'spleen': [118], '(IFN-γ,': [119], 'IL-12,': [120], 'IL-4),': [122], 'lung': [126, 222], 'homogenates': [127], '(IL-6': [128], 'IL-10)': [130, 220], 'measured': [132], 'by': [133, 144], 'ELISA.': [134], 'The': [135], 'proliferative': [136], 'response': [137], 'restimulated': [139], 'splenocytes': [140], 'was': [141], 'also': [142, 214], 'determined': [143], 'MTT': [145], 'assay.The': [146], 'findings': [147], 'showed': [148], 'that': [149, 227], 'co-delivery': [151], 'CCL21': [157, 186, 231, 246], 'Poly': [159], 'significantly': [161], 'increased': [162], 'immunogenicity': [165], 'compared': [166], 'non-adjuvanted': [169], 'vaccine,': [170], 'associated': [171], 'more': [173], 'potent': [174, 252], 'protection': [175], 'following': [176], 'challenge': [177], 'infection.': [178], 'given': [182], 'had': [190], 'strong': [191], 'antibody-': [192], 'which': [196], 'considerably': [198], 'higher': [199], 'than': [200], 'responses': [201], 'receiving': [204], 'separately.': [211], 'This': [212], 'reduced': [215], 'inflammatory': [216], 'mediator': [217], 'levels': [218], '(notably': [219], 'homogenate': [223], 'samples.The': [224], 'results': [225], 'indicate': [226], 'adjuvantation': [228], 'can': [235], 'successfully': [236], 'induce': [237], 'vigorous': [238], 'vaccine-mediated': [239], 'protection,': [240], 'suggesting': [241], 'robust': [243], 'propensity': [244], 'plus': [247], 'mucosal': [253], 'adjuvant.': [254]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3207501026', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}], 'updated_date': '2024-09-01T09:27:05.073724', 'created_date': '2021-10-25'}