Title: Involvement of polymorphisms of complement lectin pathway serine proteases encoding genes in etiopathogenesis of ischemic stroke
Abstract: Complement is a major part of innate immune system. The complement system is a proteolytic cascade, where serine proteases activate each other by limited proteolysis in a strictly ordered manner. Serine proteases are essential in both the initiation and the amplification of the cascade. The aim of current study was to reveal the possible involvement of complement lectin pathway mannan-binding lectin-associated serine proteases, MASP-1 and MASP-2 in etiopathogenesis of ischemic stroke (IS) by investigating the potential association of single nucleotide polymorphisms (SNPs) in their genes (rs3203210, rs28945070, rs28945073 in MASP1 gene and rs2273343, rs12711521, rs147270785 in MASP2 gene) with IS.
Publication Year: 2021
Publication Date: 2021-10-01
Language: en
Type: article
Indexed In: ['crossref']
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