Publication Information

{'id': 'https://openalex.org/W3202841036', 'doi': 'https://doi.org/10.1016/j.jcrc.2021.09.011', 'title': 'Trough concentrations of meropenem and piperacillin during slow extended dialysis in critically ill patients with intermittent and continuous infusion: A prospective observational study', 'display_name': 'Trough concentrations of meropenem and piperacillin during slow extended dialysis in critically ill patients with intermittent and continuous infusion: A prospective observational study', 'publication_year': 2021, 'publication_date': '2021-10-07', 'ids': {'openalex': 'https://openalex.org/W3202841036', 'doi': 'https://doi.org/10.1016/j.jcrc.2021.09.011', 'mag': '3202841036', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34628123'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jcrc.2021.09.011', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S126993733', 'display_name': 'Journal of Critical Care', 'issn_l': '0883-9441', 'issn': ['0883-9441', '1557-8615'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5091258386', 'display_name': 'Uwe Liebchen', 'orcid': 'https://orcid.org/0000-0002-4375-0923'}, 'institutions': [{'id': 'https://openalex.org/I3018771216', 'display_name': 'LMU Klinikum', 'ror': 'https://ror.org/02jet3w32', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Uwe Liebchen', 'raw_affiliation_strings': ['Department of Anesthesiology, University Hospital, LMU Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, University Hospital, LMU Munich, Germany', 'institution_ids': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071522112', 'display_name': 'Michael Paal', 'orcid': 'https://orcid.org/0000-0001-8831-0238'}, 'institutions': [{'id': 'https://openalex.org/I3018771216', 'display_name': 'LMU Klinikum', 'ror': 'https://ror.org/02jet3w32', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michael Paal', 'raw_affiliation_strings': ['Institute of Laboratory Medicine, University Hospital, LMU Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Laboratory Medicine, University Hospital, LMU Munich, Germany', 'institution_ids': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036437711', 'display_name': 'Veronika Bucher', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018771216', 'display_name': 'LMU Klinikum', 'ror': 'https://ror.org/02jet3w32', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Veronika Bucher', 'raw_affiliation_strings': ['Department of Anesthesiology, University Hospital, LMU Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, University Hospital, LMU Munich, Germany', 'institution_ids': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062437005', 'display_name': 'Michael Vogeser', 'orcid': 'https://orcid.org/0000-0002-2745-2475'}, 'institutions': [{'id': 'https://openalex.org/I3018771216', 'display_name': 'LMU Klinikum', 'ror': 'https://ror.org/02jet3w32', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michael Vogeser', 'raw_affiliation_strings': ['Institute of Laboratory Medicine, University Hospital, LMU Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Laboratory Medicine, University Hospital, LMU Munich, Germany', 'institution_ids': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042816009', 'display_name': 'Michael Irlbeck', 'orcid': 'https://orcid.org/0000-0002-7868-265X'}, 'institutions': [{'id': 'https://openalex.org/I3018771216', 'display_name': 'LMU Klinikum', 'ror': 'https://ror.org/02jet3w32', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michael Irlbeck', 'raw_affiliation_strings': ['Department of Anesthesiology, University Hospital, LMU Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, University Hospital, LMU Munich, Germany', 'institution_ids': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006687300', 'display_name': 'Ines Schroeder', 'orcid': 'https://orcid.org/0000-0002-7060-3785'}, 'institutions': [{'id': 'https://openalex.org/I3018771216', 'display_name': 'LMU Klinikum', 'ror': 'https://ror.org/02jet3w32', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ines Schroeder', 'raw_affiliation_strings': ['Department of Anesthesiology, University Hospital, LMU Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, University Hospital, LMU Munich, Germany', 'institution_ids': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016854821', 'display_name': 'Michael Zöller', 'orcid': 'https://orcid.org/0000-0002-5337-6509'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I3018771216', 'display_name': 'LMU Klinikum', 'ror': 'https://ror.org/02jet3w32', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michael Zoller', 'raw_affiliation_strings': ['Department of Anesthesiology, University Hospital, LMU Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, University Hospital, LMU Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097', 'https://openalex.org/I3018771216']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065528390', 'display_name': 'Christina Scharf', 'orcid': 'https://orcid.org/0000-0002-5310-4116'}, 'institutions': [{'id': 'https://openalex.org/I3018771216', 'display_name': 'LMU Klinikum', 'ror': 'https://ror.org/02jet3w32', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}, {'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Christina Scharf', 'raw_affiliation_strings': ['Department of Anesthesiology, University Hospital, LMU Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, University Hospital, LMU Munich, Germany', 'institution_ids': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5065528390'], 'corresponding_institution_ids': ['https://openalex.org/I3018771216', 'https://openalex.org/I8204097'], 'apc_list': {'value': 3250, 'currency': 'USD', 'value_usd': 3250, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.674, 'has_fulltext': False, 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.720694, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '67', 'issue': None, 'first_page': '26', 'last_page': '32'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11036', 'display_name': 'Pharmacokinetics of Antibiotics in Critically Ill Patients', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11036', 'display_name': 'Pharmacokinetics of Antibiotics in Critically Ill Patients', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10897', 'display_name': 'Global Burden of Antimicrobial Resistance', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2402', 'display_name': 'Applied Microbiology and Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10147', 'display_name': 'Global Challenge of Antibiotic Resistance in Bacteria', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/piperacillin/tazobactam', 'display_name': 'Piperacillin/tazobactam', 'score': 0.66986656}, {'id': 'https://openalex.org/keywords/therapeutic-drug-monitoring', 'display_name': 'Therapeutic Drug Monitoring', 'score': 0.520845}, {'id': 'https://openalex.org/keywords/trough-level', 'display_name': 'Trough level', 'score': 0.46124807}], 'concepts': [{'id': 'https://openalex.org/C2779375183', 'wikidata': 'https://www.wikidata.org/wiki/Q421670', 'display_name': 'Meropenem', 'level': 4, 'score': 0.93606645}, {'id': 'https://openalex.org/C2778193466', 'wikidata': 'https://www.wikidata.org/wiki/Q423787', 'display_name': 'Piperacillin', 'level': 4, 'score': 0.9100821}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.84881294}, {'id': 'https://openalex.org/C2777858937', 'wikidata': 'https://www.wikidata.org/wiki/Q423376', 'display_name': 'Piperacillin/tazobactam', 'level': 5, 'score': 0.66986656}, {'id': 'https://openalex.org/C2777288759', 'wikidata': 'https://www.wikidata.org/wiki/Q4164182', 'display_name': 'Dosing', 'level': 2, 'score': 0.5746484}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.48278725}, {'id': 'https://openalex.org/C31785415', 'wikidata': 'https://www.wikidata.org/wiki/Q7846541', 'display_name': 'Trough level', 'level': 4, 'score': 0.46124807}, {'id': 'https://openalex.org/C2991859549', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Critically ill', 'level': 2, 'score': 0.4418581}, {'id': 'https://openalex.org/C188816634', 'wikidata': 'https://www.wikidata.org/wiki/Q2113324', 'display_name': 'Prospective cohort study', 'level': 2, 'score': 0.41712588}, {'id': 'https://openalex.org/C2779978075', 'wikidata': 'https://www.wikidata.org/wiki/Q202301', 'display_name': 'Dialysis', 'level': 2, 'score': 0.4162221}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.40859592}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.37914693}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.090985805}, {'id': 'https://openalex.org/C94665300', 'wikidata': 'https://www.wikidata.org/wiki/Q63391344', 'display_name': 'Antibiotic resistance', 'level': 3, 'score': 0.07616082}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2911091166', 'wikidata': 'https://www.wikidata.org/wiki/Q106419912', 'display_name': 'Transplantation', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2777637488', 'wikidata': 'https://www.wikidata.org/wiki/Q31856', 'display_name': 'Pseudomonas aeruginosa', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2909675724', 'wikidata': 'https://www.wikidata.org/wiki/Q411648', 'display_name': 'Tacrolimus', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016638', 'descriptor_name': 'Critical Illness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010878', 'descriptor_name': 'Piperacillin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D016638', 'descriptor_name': 'Critical Illness', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077731', 'descriptor_name': 'Meropenem', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006435', 'descriptor_name': 'Renal Dialysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jcrc.2021.09.011', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S126993733', 'display_name': 'Journal of Critical Care', 'issn_l': '0883-9441', 'issn': ['0883-9441', '1557-8615'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34628123', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.4, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320323390', 'funder_display_name': 'Ludwig-Maximilians-Universität München', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1853945267', 'https://openalex.org/W2051007415', 'https://openalex.org/W2079215889', 'https://openalex.org/W2098013607', 'https://openalex.org/W2100722000', 'https://openalex.org/W2112364034', 'https://openalex.org/W2124431328', 'https://openalex.org/W2133959349', 'https://openalex.org/W2137435784', 'https://openalex.org/W2141559993', 'https://openalex.org/W2164090216', 'https://openalex.org/W2165158988', 'https://openalex.org/W2239960209', 'https://openalex.org/W2319082925', 'https://openalex.org/W2620885642', 'https://openalex.org/W2767005940', 'https://openalex.org/W2792296587', 'https://openalex.org/W2792458838', 'https://openalex.org/W2794244996', 'https://openalex.org/W2883991663', 'https://openalex.org/W2903665340', 'https://openalex.org/W2929478224', 'https://openalex.org/W2964339291', 'https://openalex.org/W2970198296', 'https://openalex.org/W2970215031', 'https://openalex.org/W2992971854', 'https://openalex.org/W3010674765', 'https://openalex.org/W3011496947', 'https://openalex.org/W3012161191', 'https://openalex.org/W3022327571', 'https://openalex.org/W3083032650', 'https://openalex.org/W3106787988', 'https://openalex.org/W4243176461'], 'related_works': ['https://openalex.org/W4386040880', 'https://openalex.org/W4312543117', 'https://openalex.org/W4281633397', 'https://openalex.org/W3202841036', 'https://openalex.org/W2402494363', 'https://openalex.org/W2348497797', 'https://openalex.org/W2092088147', 'https://openalex.org/W2070526767', 'https://openalex.org/W1898677569', 'https://openalex.org/W1898379105'], 'abstract_inverted_index': {'Beta-lactam': [0], 'dosing': [1], 'is': [2, 185], 'challenging': [3], 'in': [4, 30, 169], 'critically': [5], 'ill': [6, 34], 'patients': [7, 35, 85], 'with': [8, 36], 'slow': [9], 'extended': [10], 'daily': [11], 'dialysis': [12], '(SLEDD).': [13], 'This': [14], 'prospective': [15], 'observational': [16], 'study': [17], 'aimed': [18], 'to': [19, 114, 166], 'investigate': [20], 'meropenem': [21, 39, 57, 170], 'and': [22, 25, 29, 38, 53, 58, 65, 100, 109, 171], 'piperacillin': [23, 41, 172], 'concentrations': [24, 99, 159, 173], 'half-lives': [26, 101], 'during': [27, 108, 162], 'SLEDD': [28, 89, 164], 'SLEDD-free': [31, 115], 'intervals.': [32], 'Critically': [33], 'SLEDD-therapy': [37, 112], 'or': [40], 'therapy': [42], 'were': [43, 49, 67, 77, 86, 102, 160], 'included.': [44], 'Breakpoints': [45], 'of': [46, 155, 174, 178, 192], 'target': [47, 193], 'attainment': [48, 194], 'defined': [50], 'as': [51, 187, 189], '2': [52], '20.8': [54], 'mg/L': [55, 125, 137], 'for': [56], 'piperacillin,': [59], 'respectively.': [60], 'Daily': [61], 'TDM': [62], 'was': [63], 'performed': [64], 'therapies': [66], 'adapted': [68], 'based': [69], 'on': [70], 'the': [71, 111, 156, 179, 183, 190], 'measured': [72, 157], 'concentrations.': [73], 'Elimination': [74], 'rate': [75], 'constants': [76], 'determined': [78], 'by': [79], 'using': [80], 'nonlinear': [81], 'regression': [82], 'analysis.': [83], 'Seventeen': [84], 'included': [87], '(48': [88], 'intervals;': [90], 'median': [91, 96, 129], 'SLEDD-duration:': [92], '7.25': [93], 'h).': [94], 'The': [95], 'antibiotic': [97], 'trough': [98, 158], 'significantly': [103], '(p': [104], '<': [105], '0.001)': [106], 'lower': [107], 'after': [110], 'compared': [113], 'intervals': [116], '(median': [117], 'meropenem:': [118, 146], '22.3': [119], '(IQR:': [120, 126, 132, 138], '12.8,': [121], '25.6)': [122], 'vs.': [123, 135], '28.3': [124], '16.9,': [127], '37.4);': [128], 'piperacillin:': [130, 150], '55.8': [131], '45.1,': [133], '84.9)': [134], '130': [136], '91.5,': [139], '154.5);': [140], 'relative': [141], 'change:': [142], '-48.0%': [143], 'each,': [144], 'IQR': [145, 149], '-33.3,': [147], '-58.5%;': [148], '-36.3,': [151], '-52.1%).': [152], 'However,': [153], 'none': [154], 'subtherapeutic': [161, 197], 'SLEDD.': [163], 'leads': [165], 'a': [167], 'reduction': [168], 'approximately': [175], '50%': [176], 'independently': [177], 'initial': [180], 'concentration.': [181], 'If': [182], 'concentration': [184], 'twice': [186], 'high': [188], 'breakpoint': [191], 'before': [195], 'SLEDD-therapy,': [196], 'levels': [198], 'can': [199], 'be': [200], 'avoided.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3202841036', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}], 'updated_date': '2024-09-27T05:33:32.908687', 'created_date': '2021-10-11'}