Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3202402838', 'doi': 'https://doi.org/10.1161/circ.118.suppl_18.s_377-c', 'title': 'Abstract 1727: Apolipoprotein E (ApoE) Induces an Anti-inflammatory Phenotype in Macrophages', 'display_name': 'Abstract 1727: Apolipoprotein E (ApoE) Induces an Anti-inflammatory Phenotype in Macrophages', 'publication_year': 2008, 'publication_date': '2008-10-28', 'ids': {'openalex': 'https://openalex.org/W3202402838', 'doi': 'https://doi.org/10.1161/circ.118.suppl_18.s_377-c', 'mag': '3202402838'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1161/circ.118.suppl_18.s_377-c', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070875001', 'display_name': 'Daniel Baitsch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'funder', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Daniel Baitsch', 'raw_affiliation_strings': ['Daniel Baitsch', 'Univ of Muenster, Muenster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Daniel Baitsch', 'institution_ids': []}, {'raw_affiliation_string': 'Univ of Muenster, Muenster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007370599', 'display_name': 'Ralph Telgmann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'funder', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ralph Telgmann', 'raw_affiliation_strings': ['Ralph Telgmann', 'Univ of Muenster, Muenster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Ralph Telgmann', 'institution_ids': []}, {'raw_affiliation_string': 'Univ of Muenster, Muenster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001208756', 'display_name': 'Georg Varga', 'orcid': 'https://orcid.org/0000-0002-1547-8766'}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'funder', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Georg Varga', 'raw_affiliation_strings': ['Georg Varga', 'Univ of Muenster, Muenster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Georg Varga', 'institution_ids': []}, {'raw_affiliation_string': 'Univ of Muenster, Muenster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028388949', 'display_name': 'Carsten Müller‐Tidow', 'orcid': 'https://orcid.org/0000-0002-7166-5232'}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'funder', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Carsten Muller-Tidow', 'raw_affiliation_strings': ['Carsten Muller-Tidow', 'Univ of Muenster, Muenster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Carsten Muller-Tidow', 'institution_ids': []}, {'raw_affiliation_string': 'Univ of Muenster, Muenster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057079657', 'display_name': 'Martine Bot', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'funder', 'lineage': ['https://openalex.org/I121797337']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Martine Bot', 'raw_affiliation_strings': ['Martine Bot', 'Univ of Leiden, Leiden, Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Martine Bot', 'institution_ids': []}, {'raw_affiliation_string': 'Univ of Leiden, Leiden, Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110307570', 'display_name': 'Jerzy Roch Nofer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'funder', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jerzy Roch Nofer', 'raw_affiliation_strings': ['Jerzy Roch Nofer', 'Univ of Muenster, Muenster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Jerzy Roch Nofer', 'institution_ids': []}, {'raw_affiliation_string': 'Univ of Muenster, Muenster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.439781, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 70, 'max': 74}, 'biblio': {'volume': '118', 'issue': 'suppl_18', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12955', 'display_name': 'Atherosclerosis and Cardiovascular Diseases', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12955', 'display_name': 'Atherosclerosis and Cardiovascular Diseases', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9757, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10027', 'display_name': 'Diabetes, Cardiovascular Risks, and Lipoproteins', 'score': 0.97, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/apolipoprotein-e', 'display_name': 'Apolipoprotein E', 'score': 0.7324263}, {'id': 'https://openalex.org/keywords/foam-cell', 'display_name': 'Foam cell', 'score': 0.4589466}], 'concepts': [{'id': 'https://openalex.org/C57089818', 'wikidata': 'https://www.wikidata.org/wiki/Q424728', 'display_name': 'Apolipoprotein E', 'level': 3, 'score': 0.7324263}, {'id': 'https://openalex.org/C62746215', 'wikidata': 'https://www.wikidata.org/wiki/Q14890615', 'display_name': 'Apolipoprotein B', 'level': 3, 'score': 0.56467783}, {'id': 'https://openalex.org/C8243546', 'wikidata': 'https://www.wikidata.org/wiki/Q419074', 'display_name': 'Very low-density lipoprotein', 'level': 4, 'score': 0.5567258}, {'id': 'https://openalex.org/C2780072125', 'wikidata': 'https://www.wikidata.org/wiki/Q28350', 'display_name': 'Lipoprotein', 'level': 3, 'score': 0.53849006}, {'id': 'https://openalex.org/C43554185', 'wikidata': 'https://www.wikidata.org/wiki/Q425649', 'display_name': 'LDL receptor', 'level': 4, 'score': 0.48412594}, {'id': 'https://openalex.org/C2777895019', 'wikidata': 'https://www.wikidata.org/wiki/Q1425962', 'display_name': 'Foam cell', 'level': 4, 'score': 0.4589466}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.45166543}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.437712}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.40972722}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34918785}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.33349752}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1161/circ.118.suppl_18.s_377-c', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Life below water', 'score': 0.48, 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2607156454', 'https://openalex.org/W2418449123', 'https://openalex.org/W2325611136', 'https://openalex.org/W2287351208', 'https://openalex.org/W2183269159', 'https://openalex.org/W2132802442', 'https://openalex.org/W2088681386', 'https://openalex.org/W2039772954', 'https://openalex.org/W1982789996', 'https://openalex.org/W1856179322'], 'abstract_inverted_index': {'Apolipoprotein': [0], 'E': [1], '(apoE)': [2], 'exerts': [3], 'anti-atherogenic': [4, 277], 'effects': [5, 18, 182], 'by': [6, 154, 190], 'promoting': [7], 'cholesterol': [8, 29, 40], 'efflux': [9], 'and': [10, 88, 102, 144, 160, 164, 168, 170, 178, 196, 249], 'hepatic': [11], 'lipoprotein': [12, 35], 'clearance.': [13], 'However,': [14], 'apoE': [15, 67, 79, 141, 184, 203, 220, 255], 'retains': [16], 'protective': [17], 'even': [19], 'under': [20], 'experimental': [21], 'settings,': [22], 'in': [23, 130, 135, 211, 217], 'which': [24], 'its': [25, 53], 'influence': [26], 'on': [27, 55, 185], 'plasma': [28, 232], 'is': [30], 'negligible': [31], 'suggesting': [32], 'that': [33, 254], 'this': [34], 'inhibits': [36], 'atherosclerosis': [37], 'independently': [38], 'from': [39, 239, 264], 'transport.': [41], 'To': [42], 'gain': [43], 'further': [44], 'insight': [45], 'into': [46], 'mechanisms': [47], 'underlying': [48], 'apoE-mediated': [49], 'atheroprotection,': [50], 'we': [51], 'investigated': [52], 'effect': [54, 272], 'the': [56, 136], 'functional': [57, 85], 'phenotype': [58, 86, 100, 118, 187, 245], 'of': [59, 65, 73, 82, 90, 93, 97, 104, 107, 121, 138, 147, 157, 166, 175, 183, 208, 279], 'RAW': [60], '264.7': [61], 'macrophages': [62, 77, 151, 238], 'overexpressing': [63], 'either': [64], 'two': [66], 'receptors:': [68], 'ApoER2/LRP8': [69, 258], 'or': [70, 75, 132, 149, 213, 259], 'VLDL-R.': [71], 'Incubation': [72], 'ApoER2/LRP8-': [74, 131, 148, 212], 'VLDL-R-expressing': [76, 133, 150, 214], 'with': [78, 224, 230], 'downregulated': [80], 'markers': [81, 96], 'pro-inflammatory': [83, 265], 'M1': [84, 117, 266], '(expression': [87, 101], 'activity': [89, 103, 165, 278], 'iNOS,': [91], 'production': [92, 106, 156, 248], 'IL-12),': [94], 'whereas': [95], 'anti-inflammatory': [98, 268], 'M2': [99, 244, 269], 'arginase-I,': [105], 'IL-1RA)': [108], 'were': [109, 128, 188], 'upregulated.': [110], 'In': [111, 235], 'addition,': [112, 236], 'macrophage': [113, 186, 262], 'responses': [114], 'typical': [115], 'for': [116], '(migration,': [119], 'generation': [120], 'reactive': [122], 'oxygen': [123], 'species,': [124], 'antibody-dependent': [125], 'cell': [126], 'cytotoxicity)': [127], 'suppressed': [129], 'cells': [134], 'presence': [137], 'apoE.': [139, 280], 'Finally,': [140], 'prevented': [142], 'LPS-': [143], 'IFN-γ-induced': [145], 'activation': [146, 172, 207], 'as': [152], 'documented': [153], 'reduced': [155, 162, 171], 'IL-12,': [158], 'TNF-α': [159], 'MCP-1,': [161], 'expression': [163], 'iNOS': [167], 'COX2,': [169], 'and/or': [173], 'phosphorylation': [174], 'NF-κB,': [176], 'IκB': [177], 'STAT1.': [179], 'The': [180], 'modulatory': [181], 'inhibited': [189], 'SB220025,': [191], 'a': [192, 198, 275], 'p38MAP': [193, 209], 'kinase': [194, 200, 210], 'inhibitor,': [195], 'PP1A,': [197], 'tyrosine': [199, 205], 'inhibitor.': [201], 'Accordingly,': [202], 'induced': [204], 'kinase-dependent': [206], 'macrophages.': [215], 'Under': [216], 'vivo': [218], 'conditions,': [219], '−/−': [221], 'mice': [222], 'transplanted': [223, 240], 'apoE-producing': [225], 'wild-type': [226], 'bone': [227], 'marrow': [228], 'presented': [229], 'increased': [231], 'IL-1RA': [233, 247], 'levels.': [234], 'peritoneal': [237], 'animals': [241], 'demonstrated': [242], 'enhanced': [243], '(increased': [246], 'CD206': [250], 'expression).': [251], 'We': [252], 'conclude': [253], 'signalling': [256], 'over': [257], 'VLDL-R': [260], 'promotes': [261], 'conversion': [263], 'to': [267], 'phenotype.': [270], 'This': [271], 'may': [273], 'represent': [274], 'novel': [276]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3202402838', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}], 'updated_date': '2025-01-24T18:16:01.315276', 'created_date': '2021-10-11'}