Title: Nuclear PRP20 protein is required for mRNA export.
Abstract: Research Article1 January 1993free access Nuclear PRP20 protein is required for mRNA export. D.C. Amberg D.C. Amberg Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755. Search for more papers by this author M. Fleischmann M. Fleischmann Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755. Search for more papers by this author I. Stagljar I. Stagljar Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755. Search for more papers by this author C.N. Cole C.N. Cole Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755. Search for more papers by this author M. Aebi M. Aebi Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755. Search for more papers by this author D.C. Amberg D.C. Amberg Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755. Search for more papers by this author M. Fleischmann M. Fleischmann Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755. Search for more papers by this author I. Stagljar I. Stagljar Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755. Search for more papers by this author C.N. Cole C.N. Cole Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755. Search for more papers by this author M. Aebi M. Aebi Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755. Search for more papers by this author Author Information D.C. Amberg1, M. Fleischmann1, I. Stagljar1, C.N. Cole1 and M. Aebi1 1Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755. The EMBO Journal (1993)12:233-241https://doi.org/10.1002/j.1460-2075.1993.tb05649.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The yeast PRP20 protein is highly homologous in structure and function to the RCC1 protein of higher eukaryotes. The RCC1 protein is involved in the regulation of the onset of mitosis, whereas the PRP20 protein was shown to be required for accurate and efficient mRNA metabolism. The first observable phenotype in mutant prp20 cells when shifted from permissive to non-permissive temperature is a loss of nuclear PRP20 protein. Concomitantly, an accumulation of poly(A)+ RNA in the nucleus is observed. The temperature-sensitive RCC1 allele in the mutant hamster cell line tsBN2 leads to a similar accumulation of mRNA in the nucleus. Previous ArticleNext Article Volume 12Issue 11 January 1993In this issue RelatedDetailsLoading ...