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{'id': 'https://openalex.org/W3199584386', 'doi': 'https://doi.org/10.1161/circulationaha.121.054846', 'title': 'Adrenergic-Thyroid Hormone Interactions Drive Postnatal Thermogenesis and Loss of Mammalian Heart Regenerative Capacity', 'display_name': 'Adrenergic-Thyroid Hormone Interactions Drive Postnatal Thermogenesis and Loss of Mammalian Heart Regenerative Capacity', 'publication_year': 2021, 'publication_date': '2021-09-21', 'ids': {'openalex': 'https://openalex.org/W3199584386', 'doi': 'https://doi.org/10.1161/circulationaha.121.054846', 'mag': '3199584386', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34543065', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8457303'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circulationaha.121.054846', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.121.054846', 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.121.054846', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5091813762', 'display_name': 'Alexander Y. Payumo', 'orcid': 'https://orcid.org/0000-0002-7733-9622'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}, {'id': 'https://openalex.org/I51504820', 'display_name': 'San Jose State University', 'ror': 'https://ror.org/04qyvz380', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I51504820']}, {'id': 'https://openalex.org/I4210150380', 'display_name': 'Broad Center', 'ror': 'https://ror.org/04tbrah05', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210150380']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexander Y. Payumo', 'raw_affiliation_strings': ['Alexander Y. 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103, 133, 161, 172, 202, 231, 261, 290, 320, 349, 379, 408, 438, 540, 570, 599, 629, 661, 691, 720, 750, 837, 867, 2263], 'Chen,': [48, 54, 69, 75, 104, 107, 134, 137, 173, 176, 203, 206, 232, 235, 262, 265, 291, 294, 321, 324, 350, 353, 380, 383, 409, 412, 439, 442, 541, 544, 571, 574, 600, 603, 630, 633, 662, 665, 692, 695, 721, 724, 751, 754, 838, 841, 868, 871], 'Kentaro': [50, 220], 'Hirose,': [51], 'Xiaoxin': [53, 106, 136, 175, 205, 234, 264, 279, 293, 323, 352, 382, 411, 441, 543, 573, 602, 632, 664, 694, 723, 753, 840, 870], 'Alison': [56, 338], 'Hoang,': [57], 'BA': [58, 61, 73, 80, 83], 'Sheamin': [59, 397], 'Khyeam,': [60], 'Hongyao': [62, 456], 'Yu,': [63], 'Jiajia': [65, 481], 'Wang,': [66], 'Qing': [68, 505], 'Nevan': [71, 529], 'Powers,': [72], 'Li': [74, 588], 'MD': [76], 'Rachel': [77, 647], 'B.': [78, 648, 650], 'Bigley,': [79], 'Jonathan': [81, 709], 'Lovas,': [82], 'Guang': [84, 768], 'Hu,': [85], 'Guo': [87, 792, 799, 2276], 'N.': [88, 793, 795, 800, 2277], 'HuangPhD': [89], 'PayumoAlexander': [92], 'Payumo': [94, 2261, 2332], 'Cardiovascular': [95, 164, 223, 282, 341, 400, 532, 591, 653, 712, 803, 829, 2280], 'Research': [96, 131, 165, 200, 224, 259, 283, 318, 342, 377, 401, 436, 472, 496, 520, 533, 568, 592, 627, 654, 689, 713, 748, 783, 804, 830, 865, 2176, 2200, 2207, 2256, 2281], 'Institute': [97, 166, 225, 284, 343, 402, 467, 491, 515, 534, 593, 655, 714, 778, 831, 2217], '&': [98, 167, 226, 285, 344, 403, 535, 594, 656, 715, 832], 'Department': [99, 150, 168, 227, 286, 345, 404, 536, 595, 657, 716, 833, 2245], 'Physiology': [101, 170, 229, 288, 347, 406, 538, 597, 659, 718, 835], '(A.Y.P.,': [102, 132, 171, 201, 230, 260, 289, 319, 348, 378, 407, 437, 539, 569, 598, 628, 660, 690, 719, 749, 836, 866], 'K.H.,': [105, 135, 174, 204, 233, 263, 292, 322, 351, 381, 410, 440, 542, 572, 601, 631, 663, 693, 722, 752, 839, 869], 'A.H.,': [108, 138, 177, 207, 236, 266, 295, 325, 354, 384, 413, 443, 545, 575, 604, 634, 666, 696, 725, 755, 842, 872], 'S.K.,': [109, 139, 178, 208, 237, 267, 296, 326, 355, 385, 414, 444, 546, 576, 605, 635, 667, 697, 726, 756, 843, 873], 'N.P.,': [110, 140, 179, 209, 238, 268, 297, 327, 356, 386, 415, 445, 547, 577, 606, 636, 668, 698, 727, 757, 844, 874], 'L.C.,': [111, 141, 180, 210, 239, 269, 298, 328, 357, 387, 416, 446, 548, 578, 607, 637, 669, 699, 728, 758, 845, 875], 'R.B.B.,': [112, 142, 181, 211, 240, 270, 299, 329, 358, 388, 417, 447, 549, 579, 608, 638, 670, 700, 729, 759, 846, 876], 'J.L.,': [113, 143, 182, 212, 241, 271, 300, 330, 359, 389, 418, 448, 550, 580, 609, 639, 671, 701, 730, 760, 847, 877], 'G.N.H.),': [114, 144, 183, 213, 242, 272, 301, 331, 360, 390, 419, 449, 551, 581, 610, 640, 672, 702, 731, 761, 848, 878], 'University': [115, 145, 184, 214, 243, 273, 302, 332, 361, 391, 420, 450, 552, 582, 611, 641, 673, 703, 732, 762, 809, 849, 879, 2170, 2286], 'California,': [117, 147, 186, 216, 245, 275, 304, 334, 363, 393, 422, 452, 554, 584, 613, 643, 675, 705, 734, 764, 811, 851, 881, 2288], 'San': [118, 148, 154, 187, 217, 246, 276, 305, 335, 364, 394, 423, 453, 555, 585, 614, 644, 676, 706, 735, 765, 812, 819, 852, 882, 2173, 2289, 2296], 'Francisco.': [119, 149, 188, 218, 247, 277, 306, 336, 365, 395, 424, 454, 556, 586, 615, 645, 677, 707, 736, 766, 853, 883], 'Eli': [120, 189, 248, 307, 366, 425, 557, 616, 678, 737, 854], 'Edythe': [122, 191, 250, 309, 368, 427, 559, 618, 680, 739, 856], 'Broad': [123, 192, 251, 310, 369, 428, 560, 619, 681, 740, 857], 'Center': [124, 193, 252, 311, 370, 429, 561, 620, 682, 741, 858], 'for': [125, 194, 253, 312, 371, 430, 562, 621, 683, 742, 859, 896, 970, 1011, 1624, 2194, 2254, 2352, 2376, 2437], 'Regeneration': [126, 195, 254, 313, 372, 431, 563, 622, 684, 743, 860], 'Medicine': [127, 196, 255, 314, 373, 432, 564, 623, 685, 744, 861], 'Stem': [129, 198, 257, 316, 375, 434, 462, 486, 510, 566, 625, 687, 746, 773, 863], 'Cell': [130, 199, 258, 317, 376, 435, 463, 487, 511, 567, 626, 688, 747, 774, 864], 'Biological': [152], 'Sciences,': [153, 471, 495, 519, 782], 'Jose': [155], 'State': [156], 'University,': [157], 'CA': [158, 821, 2298], '(A.Y.P.).': [159], ',': [160, 219, 278, 337, 396, 455, 480, 504, 528, 587, 646, 708, 767], 'ChenXi': [162], 'Chen': [163, 281, 507, 590, 2264], 'HiroseKentaro': [221], 'Hirose': [222, 1285, 1325, 1403, 1487, 2330], 'ChenXiaoxin': [280], 'HoangAlison': [339], 'Hoang': [340, 2336], 'KhyeamSheamin': [398], 'Khyeam': [399], 'YuHongyao': [457], 'Yu': [458, 2346], 'https://orcid.org/0000-0003-3752-8442': [459], 'Epigenetics': [460, 484, 508, 771], 'Biology': [464, 488, 512, 775, 2483], 'Laboratory,': [465, 489, 513, 776], 'National': [466, 490, 514, 777, 2211, 2216], 'Environmental': [469, 493, 517, 780, 2219], 'Health': [470, 494, 518, 781, 2214, 2220], 'Triangle': [473, 497, 521, 784], 'Park,': [474, 498, 522, 785], 'NC': [475, 499, 523, 786], '(H.Y.,': [476, 500, 524, 787], 'J.W.,': [477, 501, 525, 788], 'Q.C.,': [478, 502, 526, 789], 'G.H.).': [479, 503, 527, 790], 'WangJiajia': [482], 'Wang': [483, 2348], 'ChenQing': [506], 'PowersNevan': [530], 'Powers': [531], 'ChenLi': [589], 'BigleyRachel': [649], 'Bigley': [651, 2344], 'https://orcid.org/0000-0002-1202-2413': [652], 'LovasJonathan': [710], 'Lovas': [711], 'HuGuang': [769], 'Hu': [770], 'HuangGuo': [794], 'Huang': [796], 'Correspondence': [797], 'to:': [798, 2275], 'Huang,': [801, 2278], 'PhD,': [802, 2279], 'Institute,': [805, 2282], 'School': [806, 2283], 'Medicine,': [808, 2285], 'Francisco,': [813, 820, 2290, 2297], '555': [814, 2291], 'Mission': [815, 2292], 'Bay': [816, 2293], 'Blvd': [817, 2294], 'South,': [818, 2295], '94158.': [822, 2299], 'Email': [823, 2300], 'E-mail': [824], 'Address:': [825], '[email': [826], 'protected]': [827], 'https://orcid.org/0000-0002-4335-9123': [828], 'Originally': [884, 2470], 'published20': [885], 'Sep': [886], '2021https://doi.org/10.1161/CIRCULATIONAHA.121.054846Circulation.': [887], '2021;144:1000–1003Newborn': [888], 'mice': [889, 1181, 1214, 1799, 1895], 'possess': [890], 'a': [891, 968, 1742, 1811, 1905, 1910], 'robust': [892, 1882], 'but': [893, 1664, 1861], 'transient': [894], 'capacity': [895, 1893, 1988, 2106, 2358], 'heart': [897, 942, 964, 971, 1071, 1251, 1254, 1421, 1662, 1667, 2013, 2356], 'regeneration': [898, 1794], 'that': [899, 919, 1050, 1140, 1721, 1745, 1754, 1769, 1938, 1965, 1978, 1999, 2025, 2047], 'is': [900, 974, 983, 1001, 1544, 1997, 2045, 2121, 2167], 'lost': [901], 'when': [902], 'cardiomyocytes': [903, 1716, 1839, 2063], 'permanently': [904], 'exit': [905], 'the': [906, 912, 920, 930, 978, 995, 1005, 1017, 1025, 1127, 1170, 1247, 1306, 1428, 1436, 1566, 1577, 1617, 1666, 1708, 1806, 1829, 1898, 2133, 2195, 2205, 2210, 2321, 2377], 'cell': [907, 937, 1064, 1699, 1779, 1825, 1843, 1942, 1973, 1994, 2037, 2054, 2116], 'cycle': [908, 938, 1065, 1302, 1700, 1780, 1826, 1943, 2055, 2117], 'binucleate': [910], 'during': [911, 929, 1024, 2359], 'first': [913, 1429], 'week': [914], 'after': [915, 1258, 1354, 1398, 1473, 1795, 1858, 1863, 1904, 1954, 2008], 'birth.1': [916], 'We': [917, 1672], 'discovered': [918], 'increasing': [921], 'levels': [922], 'circulating': [924], 'thyroid': [925, 1157], 'hormones': [926], '(THs)': [927], 'observed': [928, 1722, 1753, 1909], 'acquisition': [931, 1026], 'endothermy': [933, 2360], 'promote': [934, 1776, 2032], 'postnatal': [935, 1062, 1147, 1162, 1231, 1236, 1678, 1777, 1815, 1950, 1985, 2026, 2100], 'cardiomyocyte': [936, 961, 966, 1044, 1063, 1166, 1273, 1651, 1675, 1693, 1698, 1749, 1762, 1778, 1793, 1824, 1833, 1842, 1874, 1883, 1972, 1993, 2036, 2053, 2068, 2115, 2439], 'arrest': [939, 1781], 'limits': [941], 'regenerative': [943, 972, 1047, 1072, 1174, 1352, 1892, 1987, 2042, 2105, 2318, 2357], 'potential.2': [944], 'In': [945, 1614, 1704, 1929], 'this': [946], 'study,': [947], 'we': [948, 1752, 1797, 1889, 1908], 'describe': [949], 'novel': [950], 'interactions': [951, 1145, 1774, 2031], 'between': [952, 1602], 'adrenergic': [953, 1153], 'receptor': [954, 1154], '(AR)': [955, 1155], 'TH': [957, 1114, 1143, 1648, 1772, 1789, 1852, 1960, 1982, 2029, 2097], 'signaling': [958, 1144, 1160, 1649, 1747, 1758, 1773, 1790, 1853, 1961, 2030, 2098], 'regulating': [959, 2438], 'thermogenesis,': [960, 2034], 'proliferation,': [962], 'regeneration.Diploid': [965], 'abundance,': [967], 'proxy': [969], 'potential,': [973], 'inversely': [975], 'correlated': [976], 'with': [977, 1089, 1110, 1119, 1183, 1260, 1331, 1376, 1440, 1476, 1686, 1707, 1730, 1741, 1800, 1897, 2140], 'standard': [979, 1021], 'metabolic': [980, 987, 999, 1022], 'rate,': [981], 'which': [982, 1112, 2015], 'defined': [984], 'as': [985, 1499, 1537], 'basal': [986], 'rate': [988, 1000, 1009, 1023, 1492], 'divided': [989], 'by': [990, 1279, 1292, 1313, 1372, 1412, 1456, 1465, 1991, 2169, 2431], 'animal': [991, 1659], 'body': [992, 1102, 1133, 1163, 2049], 'mass': [993], '¾': [996], 'power.2': [997], 'Basal': [998], 'directly': [1002, 2051], 'proportional': [1003], 'blood': [1006, 1034], 'volume': [1007], 'flow': [1008, 1035], 'required': [1010], 'oxygen': [1012], 'nutrient': [1014], 'transport.3': [1015], 'Thus,': [1016, 1888], '>10-fold': [1018], 'increase': [1019, 1912], 'in': [1020, 1033, 1052, 1131, 1197, 1204, 1284, 1324, 1329, 1338, 1343, 1393, 1402, 1481, 1525, 1546, 1553, 1561, 1573, 1584, 1595, 1611, 1677, 1723, 1828, 1894, 1913, 1919, 1922, 1941, 1948, 1989, 2107, 2138, 2383, 2398], 'endothermy2': [1028], 'would': [1029], 'require': [1030], 'similar': [1031], 'elevations': [1032, 1051], 'cardiac': [1037, 1040, 1053, 1173, 1351, 1409, 1856, 1891, 1914, 1920, 1986, 2010, 2020, 2041, 2104], 'function.': [1038], 'These': [1039, 1137, 1766, 1975], 'adaptations': [1041], 'may': [1042, 1871, 2016], 'impede': [1043], 'proliferative': [1045, 1369], 'capacity.We': [1048], 'hypothesize': [1049], 'function': [1054, 1857], 'necessary': [1055, 2089], 'support': [1057, 1886], 'mammalian': [1058, 2033, 2112], 'thermogenic': [1059], 'pathways': [1060, 1515, 1967], 'drive': [1061, 1146], 'arrest,': [1066], 'polyploidization,': [1067], 'loss': [1069, 1171, 1875], 'potential.': [1073, 1175], 'Sympathetic': [1074], 'nerves': [1075], 'signal': [1076], 'through': [1077, 1215, 1268, 1347], 'α-ARs': [1078], 'β-ARs': [1080], 'are': [1082, 1244, 1454, 1463, 1516, 1535, 1571, 1968, 2119, 2155], 'critical': [1083], 'regulators': [1084, 1970], 'thermogenesis.4': [1086], 'Mice': [1087], 'administrated': [1088], 'both': [1090, 1120], 'α-AR': [1091], 'β-AR': [1093, 1746, 1757], 'inhibitors,': [1094], 'phenoxybenzamine': [1095], '(α-ARi)': [1096], 'propranolol': [1098], '(β-ARi),': [1099], 'have': [1100], 'reduced': [1101], 'temperatures': [1103, 1178, 2066], '(Figure': [1104, 1116, 1135, 1670, 1695, 1702, 1764, 1818, 1845, 1925, 1962], '[A]),': [1105], 'similarly': [1106], 'those': [1108, 1728], 'treated': [1109, 1182, 1439, 1729, 1798, 1896], 'propylthiouracil,': [1111], 'inhibits': [1113], 'synthesis': [1115], '[A]).': [1117, 1136], 'Treatment': [1118], 'AR': [1121, 1141, 1646, 1770, 1787, 1958, 2027, 2095], 'inhibitors': [1122, 1688, 1802], 'propylthiouracil': [1124, 1194, 1690, 1736], 'together': [1125], 'has': [1126, 1522], 'most': [1128], 'profound': [1129], 'effect': [1130], 'reducing': [1132, 2048], 'temperature': [1134, 1164, 2050], 'results': [1138, 1568, 1767, 2023], 'suggest': [1139, 1768, 1977], 'thermogenesis.Download': [1148], 'figureDownload': [1149], 'PowerPointFigure.': [1150], 'Inhibition': [1151], 'hormone': [1158], '(TH)': [1159], 'delays': [1161], 'elevation,': [1165], 'cell-cycle': [1167], 'exit,': [1168], 'A,': [1176, 2337], 'Body': [1177], 'neonatal': [1180, 2322], 'saline,': [1184], 'α-ARi': [1185, 1224], '(phenoxybenzamine;': [1186], '10': [1187, 1633], 'μg·g–1·d–1),': [1188, 1192], 'β-ARi': [1189, 1226], '(propranolol;': [1190], '40': [1191], '(PTU;': [1195], '0.15%': [1196], 'iodine-deficient': [1198], 'diet,': [1199], 'ad': [1200], 'libitum)': [1201], 'individually': [1202], 'combination.': [1205], 'PTU': [1206, 1264, 1480], 'was': [1207, 1559, 1582, 1593, 1620], 'given': [1208], 'pregnant': [1210], 'nursing': [1212], 'female': [1213], 'food': [1216], 'chow': [1217], 'starting': [1218], 'at': [1219, 1265, 1276, 1424, 1569, 1814, 2064], 'E13.5': [1220], 'maintained': [1222], 'thereafter.': [1223], 'were': [1227, 1497, 1551, 1607, 1945, 2136], 'subcutaneously': [1228], 'injected': [1229], 'from': [1230], 'day': [1232, 1237, 1679, 1816, 1951], '1': [1233], '(P1)': [1234], '14': [1238, 1680, 1817, 1952], '(P14).': [1239], 'Representative': [1240, 1418], 'infrared': [1241], 'thermography': [1242], 'images': [1243, 1419], 'shown': [1245], 'on': [1246, 2071, 2157], 'right.': [1248], 'B,': [1249, 1596], 'Bodyweights,': [1250], 'weights,': [1252], 'weight-to-bodyweight': [1255, 1668], '(HW:BW)': [1256], 'ratios': [1257], 'treatment': [1259, 1475, 1685, 1706], 'α-ARi,': [1261, 1477], 'β-ARi,': [1262, 1478], 'P14.': [1266], 'C': [1267], 'E,': [1269, 1344, 2308], 'Analyses': [1270], 'total': [1272, 1674, 1692], '(CM)': [1274], 'number': [1275, 1531, 1652, 1676], 'P14': [1277, 1355, 1483, 1570], 'determined': [1278, 1291, 1312, 1371, 1644], 'design-based': [1280], 'stereology': [1281], '(as': [1282, 1322, 1400, 1485], 'described': [1283, 1323, 1401, 1486], 'et': [1286, 1326, 1404, 1488], 'al2;': [1287, 1327], 'C),': [1288], 'proliferating': [1289], 'CMs': [1290, 1311, 1337, 1342, 1395], 'colocalization': [1293, 1373], 'PCM1': [1295, 1375], '(CM': [1296], 'perinuclear': [1297], 'marker)': [1298], 'Ki67': [1300, 1378], '(pan-cell': [1301], 'marker;': [1303], 'D),': [1304], 'percentage': [1307], 'diploid': [1309, 1341, 1715, 1761, 1837], 'mononucleated': [1310, 1714], 'quantification': [1314, 1447], 'CM-specific': [1316], 'nuclear': [1317], '4′,6-diamidino-2-phenylindole': [1318], '(DAPI)': [1319], 'fluorescence': [1320], 'intensity': [1321], 'E)': [1328], 'animals': [1330, 1541, 1725, 1924], 'indicated': [1332], 'treatments.': [1333], 'Arrowheads': [1334], 'denote': [1335], 'cycling': [1336], 'D': [1339], 'respectively.': [1345], 'F': [1346], 'J,': [1348, 1414, 1589], 'Assessment': [1349], 'potential': [1353, 2319], 'myocardial': [1356, 1461, 1812, 1864, 1906], 'infarction': [1357, 1813, 1865, 1870], '(MI).': [1358], 'F,': [1359], 'Schematic': [1360], 'presentation': [1361], 'experimental': [1363], 'design.': [1364], 'G,': [1365, 1586], 'Analysis': [1366, 1407], 'CM': [1368, 1390], 'activity': [1370, 1701, 1827], 'either': [1377], 'or': [1379, 1432, 1735], 'phosphohistone': [1380], 'H3': [1381], '(pHH3;': [1382], 'mitosis': [1383], 'marker).': [1384], 'H,': [1385, 1587, 2339, 2347, 2408], '5-Ethynyl-2′-deoxyuridine': [1386], '(EdU)': [1387], 'incorporation': [1388, 2073], 'ploidy': [1391], 'analysis': [1392, 1472, 1567, 1936], 'dissociated': [1394], '28': [1396, 1902], 'days': [1397, 1903], 'MI': [1399], 'al2).': [1405, 1489], 'I,': [1406], 'ejection': [1410, 1915], 'fraction': [1411, 1916], 'echocardiography.': [1413], 'Cardiac': [1415], 'fibrosis': [1416, 1921], 'analysis.': [1417], 'sections': [1422], '(Left)': [1423], '300': [1425], 'μm': [1426, 1434, 1634, 1637], '(for': [1427, 1435], '3': [1430], 'groups)': [1431], '250': [1433], 'fourth': [1437], 'group': [1438], 'αARi,': [1441], 'βARi,': [1442], 'PTU)': [1444], 'intervals': [1445], 'fibrotic': [1449], 'area%': [1450], '(Right).': [1451], 'Fibrotic': [1452], 'tissues': [1453], 'stained': [1455, 1464], 'Sirius': [1457], 'red': [1458], 'viable': [1460], 'cells': [1462], 'Fast': [1466], 'green.': [1467], 'K,': [1468, 2331, 2418], 'Differential': [1469], 'gene': [1470, 1504, 1934], 'expression': [1471, 1935], 'combined': [1474, 1786, 1955, 1979, 2000], 'whole': [1482, 1949], 'hearts': [1484, 1681, 1953], 'False': [1490], 'discovery': [1491], '<0.1': [1493], 'fold-change': [1495], '>2': [1496], 'applied': [1498], 'cutoffs.': [1500], 'K-means': [1501], 'clustering': [1502], 'ontology': [1505], 'classification': [1506], 'differentially': [1508], 'expressed': [1509], 'genes.': [1510], 'Top': [1511], 'upregulated': [1512, 1947], 'downregulated': [1514], 'shown.': [1517], 'The': [1518, 2148], 'RNA-sequencing': [1519, 1931], 'data': [1520, 1976], 'set': [1521], 'been': [1523], 'deposited': [1524], 'Gene': [1526], 'Expression': [1527], 'Omnibus': [1528], 'under': [1529], 'accession': [1530], 'GSE174511.': [1532], 'All': [1533], 'values': [1534], 'reported': [1536], 'mean±SEM.': [1538], 'Number': [1539], '(n)': [1542], 'analyzed': [1543], 'identified': [1545], 'each': [1547], 'figure.': [1548], 'Statistical': [1549], 'analyses': [1550], 'performed': [1552, 1608], 'GraphPad': [1554], 'Prism.': [1555], 'Two-way': [1556, 1580], 'repeated-measures': [1557], 'ANOVA': [1558, 1581, 1592, 1610], 'used': [1560, 1583, 1594, 1621], 'A': [1562, 1574, 2373], 'I.': [1564], 'Only': [1565], 'presented': [1572], 'because': [1575, 2057], 'space': [1578], 'constraint.': [1579], 'C,': [1585, 2416], '3-way': [1591], 'D,': [1597, 2343], 'E.': [1599], 'Pairwise': [1600], 'comparisons': [1601], 'all': [1603, 1615], 'pairs': [1604], 'means': [1606], 'following': [1609], 'multiple': [1612, 1625], 'comparisons.': [1613, 1626], 'analyses,': [1616], 'Tukey': [1618], 'test': [1619, 1784], 'correct': [1623], '*P<0.05;': [1627], '**P<0.01;': [1628], '***P<0.001;': [1629], '****P<0.0001.': [1630], 'Scale': [1631], 'bars:': [1632], '(D),': [1635], '50': [1636], '(E),': [1638], '4': [1640], 'mm': [1641], '(J).We': [1642], 'next': [1643], 'whether': [1645, 1785, 2092], 'regulate': [1650], 'proliferation.': [1654], 'Certain': [1655], 'chemical': [1656], 'combinations': [1657], 'decrease': [1658], 'bodyweight': [1660], 'weight,': [1663], 'not': [1665, 1862, 1867], 'ratio': [1669], '[B]).': [1671], 'quantified': [1673], 'using': [1682], 'stereology.': [1683], 'Combined': [1684, 1820], 'α/β-AR': [1687, 1732, 1980], 'increases': [1691, 1711, 1760, 1823, 2052], 'numbers': [1694], '[C])': [1696], '[D]).': [1703], 'addition,': [1705, 1930], 'inhibitor': [1709, 1899], 'cocktail': [1710], 'retention': [1712], '(59%),': [1717], 'substantially': [1718], 'higher': [1719], 'than': [1720, 1876], 'control': [1724, 2354], '(5.3%)': [1726], 'just': [1731], 'blockers': [1733], '(16%)': [1734], '(21%;': [1737], 'Figure': [1738], '[E]).': [1739, 1765], 'Consistent': [1740], 'recent': [1743], 'report': [1744], 'promotes': [1748], 'cytokinesis': [1750, 2430], 'failure,5': [1751], 'inhibition': [1755, 1791, 1822, 1956, 1983, 2002], 'alone': [1759, 1854], 'abundance': [1763], 'also': [1775, 2003], 'polyploidization.To': [1783], 'enhances': [1792], 'injury,': [1796, 2009], 'pathway': [1801, 1821, 2001], 'then': [1804], 'occluded': [1805], 'coronary': [1807], 'artery': [1808], 'induce': [1810], '[F]).': [1819], 'border': [1830], 'zone,': [1831], 'overall': [1832], '5-ethynyl-2′-deoxyuridine': [1834, 2072], 'incorporation,': [1835], '5-ethynyl-2′-deoxyuridine–positive': [1838], 'indicating': [1840], 'successful': [1841], 'division': [1844], '[G': [1846], 'H]).': [1848], 'Cardiomyocyte-specific': [1849], 'inactivation': [1850], 'improved': [1855], 'ischemia-reperfusion': [1859, 1877], 'injury2': [1860], '(data': [1866], 'shown).': [1868], 'Myocardial': [1869], 'cause': [1872], 'more': [1873], 'injury': [1878], 'likely': [1880, 2122], 'requires': [1881], 'proliferation': [1884, 2069], 'regeneration.': [1887], 'investigated': [1890], 'cocktail.': [1900], 'At': [1901], 'infarction,': [1907], 'significant': [1911], 'reduction': [1918], 'these': [1923, 1966], '[I': [1926], 'J]).': [1928], 'differential': [1933], 'revealed': [1937], 'genes': [1939], 'involved': [1940], 'regulation': [1944], 'significantly': [1946], '[K]),': [1963], 'suggesting': [1964], 'upstream': [1969], 'cycle.': [1974], 'extends': [1984], 'part': [1990], 'promoting': [1992], 'division.': [1995], 'It': [1996, 2044], 'possible': [1998], 'affects': [2004], 'inflammation,': [2005], 'angiogenesis,': [2006], 'revascularization': [2007], 'metabolism,': [2011], 'size': [2014], 'contribute': [2017], 'enhanced': [2019], 'regeneration.Collectively,': [2021], 'our': [2022], 'demonstrate': [2024], 'inhibit': [2035], 'division,': [2038], 'limit': [2040], 'capacity.': [2043], 'unlikely': [2046], 'entry': [2056], 'culturing': [2058], 'embryonic': [2059], 'day18': [2060], 'rat': [2061], 'ventricular': [2062], 'lower': [2065], 'reduces': [2067], 'based': [2070], 'assays': [2074], '(37': [2075], '°C:': [2076, 2079, 2082], '29.26±0.025%;': [2077], '31': [2078], '13.14±0.023%;': [2080], '25': [2081], '0.14±0.002%,': [2083], 'n=3).': [2084], 'Future': [2085], 'studies': [2086], 'will': [2087, 2102], 'be': [2088], 'determine': [2091], 'manipulation': [2093], 'beyond': [2099], 'development': [2101], 'improve': [2103], 'adult': [2108, 2129], 'animals.': [2109], 'Understanding': [2110], 'how': [2111], 'thermogenesis': [2113], 'withdrawal': [2118], 'linked': [2120], 'yield': [2124], 'evolutionary': [2125], 'insights': [2126], 'into': [2127], 'why': [2128], 'mammals': [2130], 'cannot': [2131], 'regenerate': [2132], 'heart.Animal': [2134], 'procedures': [2135], 'conducted': [2137], 'accordance': [2139], 'UCSF': [2141], 'Institutional': [2142, 2175], 'Animal': [2143], 'Care': [2144], 'Use': [2146], 'Committee.': [2147], 'data,': [2149], 'analytical': [2150], 'methods,': [2151], 'study': [2153], 'materials': [2154], 'available': [2156], 'request.Nonstandard': [2158], 'Abbreviations': [2159], 'AcronymsARadrenergic': [2161], 'receptorTHthyroid': [2162], 'hormoneSources': [2163], 'FundingThis': [2165], 'work': [2166], 'supported': [2168], 'California': [2172], 'Francisco': [2174], 'Academic': [2178], 'Career': [2179], 'Development': [2180], 'Award': [2181, 2249], 'postdoctoral': [2182], 'fellowship,': [2183], 'American': [2184, 2235, 2240, 2252, 2465], 'Association': [2186, 2237, 2242], 'Postdoctoral': [2187], 'Fellowship': [2188, 2201], '(to': [2189, 2202, 2223, 2257], 'Dr': [2190, 2203, 2224, 2258], 'Payumo),': [2191], 'Japan': [2192], 'Society': [2193], 'Promotion': [2196], 'Science': [2198], 'Overseas': [2199], 'Hirose),': [2204], 'Intramural': [2206], 'Program': [2208], 'Institutes': [2212], '(NIH),': [2215], 'Sciences': [2221], 'Z01ES102745': [2222], 'Hu),': [2225], 'NIH': [2226], '(R01HL13845),': [2227], 'March': [2228], 'Dimes': [2230], 'Basil': [2231], "O'Conner": [2232], 'Scholar': [2233, 2447], 'Award,': [2234, 2244], 'Beginning': [2238], 'Grant-in-Aid,': [2239], 'Transformation': [2243], 'Defense': [2247], 'Discovery': [2248], '(W81XWH1910206),': [2250], 'Federation': [2253], 'Aging': [2255], 'Huang).Disclosures': [2259], 'None.Footnoteshttps://www.ahajournals.org/journal/circ*A.Y.': [2260], 'contributed': [2265], 'equally.For': [2266], 'Sources': [2267], 'Funding': [2269], 'Disclosures,': [2271], 'see': [2272], 'page': [2273], '1003.Correspondence': [2274], 'Guo.[email': [2301], 'protected]eduReferences1.': [2302], 'Porrello': [2303], 'ER,': [2304], 'Mahmoud': [2305], 'AI,': [2306], 'Simpson': [2307], 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[2453], 'September': [2454], '21,': [2455], '2021Vol': [2456], 'Issue': [2458], '12Article': [2459], 'InformationMetrics': [2460], 'Download:': [2461], '719': [2462], '©': [2463], '2021': [2464, 2473], 'Association,': [2467], 'Inc.https://doi.org/10.1161/CIRCULATIONAHA.121.054846PMID:': [2468], '34543065': [2469], 'publishedSeptember': [2471], '20,': [2472], 'Keywordsmyocytes,': [2474], 'cardiacreceptors,': [2475], 'adrenergicthyroid': [2476], 'hormonescell': [2477], 'cyclePDF': [2478], 'download': [2479], 'SubjectsDevelopmental': [2480], 'BiologyIschemiaMetabolismMyocardial': [2481], 'RegenerationMyocardial': [2482]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3199584386', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 9}], 'updated_date': '2024-08-27T03:43:42.667576', 'created_date': '2021-09-27'}