Abstract: Background: Approximately 30% of patients with renal cell carcinoma present with metastatic disease at the time of diagnosis.Metastasis of renal cell carcinoma to the vagina is rare. Case: A 61 year-old female presented with a vaginal lesion, which was excised anddiagnosed as metastatic clear cell carcinoma. A workup further is done. Radiological studies revealed a left renal mass; A subsequentnephrectomy confirmed renal cell carcinoma. Conclusion: Renal cell carcinoma must be in the differential diagnosis of a vaginal clear cellneoplasm in a postmenopausal woman.