Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3198414371', 'doi': 'https://doi.org/10.1016/j.ejphar.2021.174470', 'title': 'Fibroblast growth factor 21 inhibited inflammation and fibrosis after myocardial infarction via EGR1', 'display_name': 'Fibroblast growth factor 21 inhibited inflammation and fibrosis after myocardial infarction via EGR1', 'publication_year': 2021, 'publication_date': '2021-08-31', 'ids': {'openalex': 'https://openalex.org/W3198414371', 'doi': 'https://doi.org/10.1016/j.ejphar.2021.174470', 'mag': '3198414371', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34478691'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejphar.2021.174470', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100730420', 'display_name': 'Jiamin Li', 'orcid': 'https://orcid.org/0009-0003-1157-9177'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiamin Li', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089042011', 'display_name': 'Liling Gong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liling Gong', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101908749', 'display_name': 'Ruijie Zhang', 'orcid': 'https://orcid.org/0000-0001-7894-8705'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ruijie Zhang', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100698039', 'display_name': 'Sijia Li', 'orcid': 'https://orcid.org/0000-0002-9210-3060'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Sijia Li', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101744391', 'display_name': 'Hang Yu', 'orcid': 'https://orcid.org/0000-0001-6652-5465'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hang Yu', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100690527', 'display_name': 'Yining Liu', 'orcid': 'https://orcid.org/0009-0006-4253-0546'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yining Liu', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088082177', 'display_name': 'Yadong Xue', 'orcid': 'https://orcid.org/0000-0002-7254-2939'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yadong Xue', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022715798', 'display_name': 'Di Huang', 'orcid': 'https://orcid.org/0000-0001-7304-4889'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Di Huang', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042215546', 'display_name': 'Ning Xu', 'orcid': 'https://orcid.org/0009-0006-3543-736X'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ning Xu', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100347170', 'display_name': 'Ying Wáng', 'orcid': 'https://orcid.org/0000-0002-8863-554X'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying Wang', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030808563', 'display_name': 'Yan Xu', 'orcid': 'https://orcid.org/0000-0002-1387-8459'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Xu', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087866631', 'display_name': 'Yiming Zhao', 'orcid': 'https://orcid.org/0000-0002-6960-9370'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yiming Zhao', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004952013', 'display_name': 'Qingsui Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qingsui Li', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100351425', 'display_name': 'Ming Li', 'orcid': 'https://orcid.org/0000-0002-4198-8807'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ming Li', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100395618', 'display_name': 'Pengyu Li', 'orcid': 'https://orcid.org/0000-0002-0570-2779'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Pengyu Li', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103256161', 'display_name': 'Mingbin Liu', 'orcid': 'https://orcid.org/0000-0002-9039-5944'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Mingbin Liu', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016131064', 'display_name': 'Zhen Zhang', 'orcid': 'https://orcid.org/0000-0003-4608-0520'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhen Zhang', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100353891', 'display_name': 'Xin Li', 'orcid': 'https://orcid.org/0000-0002-5175-5409'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xin Li', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051567681', 'display_name': 'Weijie Du', 'orcid': 'https://orcid.org/0000-0003-1197-1462'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weijie Du', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100444820', 'display_name': 'Xiaogang Wang', 'orcid': 'https://orcid.org/0000-0001-9109-8020'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Ning Wang', 'raw_affiliation_strings': ['Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5100444820'], 'corresponding_institution_ids': ['https://openalex.org/I156144747'], 'apc_list': {'value': 2790, 'currency': 'USD', 'value_usd': 2790, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.091, 'has_fulltext': False, 'cited_by_count': 38, 'citation_normalized_percentile': {'value': 0.66748, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '910', 'issue': None, 'first_page': '174470', 'last_page': '174470'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Signaling Pathway', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Signaling Pathway', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11586', 'display_name': 'Diagnosis and Management of Congenital Diaphragmatic Hernia', 'score': 0.9149, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cardiac-fibrosis', 'display_name': 'Cardiac fibrosis', 'score': 0.7773122}, {'id': 'https://openalex.org/keywords/fibroblast-growth-factor', 'display_name': 'Fibroblast Growth Factor', 'score': 0.602969}, {'id': 'https://openalex.org/keywords/massons-trichrome-stain', 'display_name': "Masson's trichrome stain", 'score': 0.5479661}, {'id': 'https://openalex.org/keywords/fgf21', 'display_name': 'FGF21', 'score': 0.547392}, {'id': 'https://openalex.org/keywords/myocardial-fibrosis', 'display_name': 'Myocardial fibrosis', 'score': 0.46607566}], 'concepts': [{'id': 'https://openalex.org/C2780559512', 'wikidata': 'https://www.wikidata.org/wiki/Q605709', 'display_name': 'Fibrosis', 'level': 2, 'score': 0.82277906}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.7921595}, {'id': 'https://openalex.org/C2777420927', 'wikidata': 'https://www.wikidata.org/wiki/Q5038318', 'display_name': 'Cardiac fibrosis', 'level': 3, 'score': 0.7773122}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.65473884}, {'id': 'https://openalex.org/C106646824', 'wikidata': 'https://www.wikidata.org/wiki/Q5425475', 'display_name': 'FGF21', 'level': 4, 'score': 0.6199981}, {'id': 'https://openalex.org/C163031210', 'wikidata': 'https://www.wikidata.org/wiki/Q3325848', 'display_name': "Masson's trichrome stain", 'level': 3, 'score': 0.5479661}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5267852}, {'id': 'https://openalex.org/C3018763269', 'wikidata': 'https://www.wikidata.org/wiki/Q5038318', 'display_name': 'Myocardial fibrosis', 'level': 3, 'score': 0.46607566}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.46520454}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.45847678}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.4312864}, {'id': 'https://openalex.org/C74373430', 'wikidata': 'https://www.wikidata.org/wiki/Q24727126', 'display_name': 'Fibroblast growth factor', 'level': 3, 'score': 0.41122496}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.22822973}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19032338}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D051766', 'descriptor_name': 'Early Growth Response Protein 1', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D005346', 'descriptor_name': 'Fibroblast Growth Factors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009203', 'descriptor_name': 'Myocardial Infarction', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051766', 'descriptor_name': 'Early Growth Response Protein 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051766', 'descriptor_name': 'Early Growth Response Protein 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005346', 'descriptor_name': 'Fibroblast Growth Factors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D005346', 'descriptor_name': 'Fibroblast Growth Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005355', 'descriptor_name': 'Fibrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009203', 'descriptor_name': 'Myocardial Infarction', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D009203', 'descriptor_name': 'Myocardial Infarction', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009203', 'descriptor_name': 'Myocardial Infarction', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009203', 'descriptor_name': 'Myocardial Infarction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D032383', 'descriptor_name': 'Myocytes, Cardiac', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061251', 'descriptor_name': 'Primary Cell Culture', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D020257', 'descriptor_name': 'Ventricular Remodeling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020257', 'descriptor_name': 'Ventricular Remodeling', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020257', 'descriptor_name': 'Ventricular Remodeling', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejphar.2021.174470', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34478691', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.82, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1978464513', 'https://openalex.org/W1992389076', 'https://openalex.org/W1994029289', 'https://openalex.org/W2030091856', 'https://openalex.org/W2056983875', 'https://openalex.org/W2063870723', 'https://openalex.org/W2066046884', 'https://openalex.org/W2504425949', 'https://openalex.org/W2799463911', 'https://openalex.org/W2885098536', 'https://openalex.org/W2887773170', 'https://openalex.org/W2916524819', 'https://openalex.org/W2921336580', 'https://openalex.org/W2997510410', 'https://openalex.org/W2999131584', 'https://openalex.org/W2999744331', 'https://openalex.org/W3027708159', 'https://openalex.org/W3042099361', 'https://openalex.org/W3128121530', 'https://openalex.org/W3134107905', 'https://openalex.org/W3136864249'], 'related_works': ['https://openalex.org/W4200248193', 'https://openalex.org/W3121430770', 'https://openalex.org/W3044467369', 'https://openalex.org/W2995381739', 'https://openalex.org/W2214871873', 'https://openalex.org/W2165410364', 'https://openalex.org/W2138955957', 'https://openalex.org/W2110534048', 'https://openalex.org/W2074067577', 'https://openalex.org/W1876107180'], 'abstract_inverted_index': {'Myocardial': [0], 'fibrosis': [1, 47, 88, 145, 159], 'in': [2, 30, 100, 147, 160], 'post-myocardial': [3], 'infarction': [4], 'is': [5], 'a': [6, 98, 104], 'self-healing': [7], 'process': [8], 'of': [9, 40, 103, 106, 120, 132], 'the': [10, 36, 81, 101, 118, 130, 156], 'myocardium,': [11], 'making': [12], 'ventricular': [13], 'remodelling': [14], 'difficult': [15], 'to': [16, 79, 141], 'reverse': [17], 'and': [18, 32, 38, 46, 73, 75, 84, 87, 108, 144, 158], 'develop': [19], 'continuously.': [20], 'Fibroblast': [21], 'growth': [22, 134], 'factor': [23], '21': [24], '(FGF21)': [25], 'plays': [26], 'an': [27], 'essential': [28], 'role': [29], 'cardiovascular': [31], 'metabolic': [33], 'diseases.': [34], 'However,': [35], 'effect': [37], 'mechanism': [39], 'FGF21': [41, 67, 90, 121, 153], 'action': [42], 'on': [43], 'cardiac': [44, 82, 85, 93], 'inflammation': [45, 86, 157], 'caused': [48], 'by': [49, 97, 163], 'myocardial': [50], 'injury': [51], 'have': [52], 'rarely': [53], 'been': [54], 'reported.': [55], 'Adult': [56], 'male': [57], 'Sprague-Dawley': [58], 'rats': [59], 'administered': [60], 'with': [61, 150], 'or': [62], 'without': [63], 'recombinant': [64], 'human': [65], 'basic': [66], '(rhbFGF21)': [68], 'were': [69, 116], 'assessed': [70], 'using': [71], 'echocardiography': [72], 'haematoxylin-eosin': [74], "Masson's": [76], 'trichrome': [77], 'staining': [78], 'determine': [80], 'function': [83], 'levels.': [89], 'might': [91], 'improve': [92], 'remodelling,': [94], 'as': [95], 'characterised': [96], 'decrease': [99], 'expression': [102], 'series': [105], 'inflammatory': [107, 142], 'fibrosis-related': [109], 'factors.': [110], 'Moreover,': [111], 'when': [112], 'FGF': [113], 'receptors': [114], '(FGFRs)': [115], 'blocked,': [117], 'effects': [119], 'disappeared.': [122], 'Mechanistically,': [123], 'we': [124], 'found': [125], 'that': [126], 'oxidative': [127], 'stress': [128], 'induced': [129], 'downregulation': [131], 'early': [133], 'response': [135], 'protein': [136], '1': [137], '(EGR1),': [138], 'which': [139], 'contributed': [140], 'factors': [143], 'reduction': [146], 'cardiomyocytes': [148], 'treated': [149], 'H2O2.': [151], 'Collectively,': [152], 'effectively': [154], 'suppressed': [155], 'post-infarcted': [161], 'hearts': [162], 'regulating': [164], 'FGFR-EGR1.': [165]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3198414371', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 8}], 'updated_date': '2024-09-18T22:28:10.800797', 'created_date': '2021-09-13'}