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'August': [258, 2331], '19,': [259, 2347], '2021:': [260], 'Version': [262], 'Record': [264], 'kidney': [266, 296, 434, 453, 514, 583, 1509, 1707], 'disease': [267, 435, 454, 1510, 1566, 1708], 'associated': [269], 'clustering': [272], 'risk': [274, 429, 1572], 'factors': [275, 430], 'that': [276, 324, 344, 490, 597, 657, 685, 775, 789, 810, 831, 847, 849, 866, 926, 1077, 1184, 1208, 1280, 1312, 1345, 1350, 1446, 1452, 1471, 1665, 1697, 1717], 'greatly': [277], 'influence': [278], 'development': [280, 1563], 'cardiovascular': [282, 432], 'complications': [283], 'adults.': [285], 'In': [286, 542, 605, 1257], 'treatment': [287], 'patients': [289, 470, 580, 1447, 1532], 'more': [292, 463, 801, 823, 1370], 'advanced': [293, 748, 1069, 1480, 1948, 2005, 2167], 'forms': [294], 'disease,': [297], 'dialysis': [298, 326, 351, 421, 467, 494, 539, 614, 670, 787, 873, 930, 946, 972, 1023, 1097, 1160, 1186, 1220, 1415, 1426, 1450, 1539, 1587, 1671, 1737, 1900, 1956, 2055, 2097, 2133, 2175, 2212], 'necessary': [301, 1731], 'therapy.Article,': [302], 'see': [303, 1798], 'p': [304], 'e102In': [305], 'current': [307, 444, 1236, 1259, 1443], 'issue': [308], 'Circulation': [310, 2314], 'Research,1': [311], 'authors': [313, 342, 698, 1292, 1478, 1695, 1775], 'study': [314, 445, 655, 1237, 1500], 'known': [316], 'problem': [317], 'peritoneal': [320, 420, 466, 509, 538, 543, 606, 627, 669, 786, 798, 971, 985, 1192, 1219, 1515, 1586, 1648, 1688, 1736, 1852, 1873, 1899, 1955, 1993, 2054, 2132, 2174, 2211, 2217, 2284], 'form': [321], 'dialysis;': [323], 'fluid': [327, 352, 671, 1024, 1427, 1451, 1492, 2134, 2213], 'can': [328, 353, 371, 491, 598, 932, 953, 1008, 1025, 1222, 1428, 1659], 'itself': [330, 1043, 1217, 1658], 'contribute': [331, 812], '(or': [332, 1699], 'it': [333, 370, 521, 843, 975, 1100, 1165, 1175, 1325, 1728], 'least': [336], 'associate': [337], 'with)': [338], 'disease.': [340, 1681], 'The': [341, 481, 513, 1105, 1442, 1499, 1550, 1612, 1773, 2202, 2233], 'discover': [343], 'degradation': [346, 498, 1039, 1440, 1960, 1997, 2138], 'component': [347, 1279], 'glucose': [349, 497, 952, 960, 997, 1000, 1020, 1042, 1090, 1211, 1216, 1229, 1430, 1526, 1546, 1747, 1959, 1996, 2137], 'not': [354, 871, 921, 1033, 1263, 1395, 1667, 1785], 'only': [355, 1396, 1668], 'cause': [356, 373, 599, 694, 1429], 'an': [357, 1114, 1124, 1366, 1661, 1712], 'inflammation': [358, 796], 'peritoneum': [361, 1657], 'as': [362, 974, 1547], 'has': [363, 829], 'been': [364, 688, 830, 1558], 'known,': [365], 'but': [366, 874, 901, 1247, 1369, 1383, 1399, 1628, 1672], 'here': [367, 1377], 'they': [368, 1064, 1576], 'find': [369, 1479], 'also': [372, 844, 1009, 1074, 1121, 1138, 1248, 1400, 1673], 'pathological': [374, 673, 1462, 1599], 'vascular': [375, 674, 1331, 1353, 1418, 1565, 1579, 1663], 'remodeling': [376, 675, 1419, 1463, 1595], 'arteriolar': [379, 510], 'network': [380], 'within': [381], 'omentum': [383, 1468], 'peritoneum.': [386], 'These': [387], 'observations': [388, 806], 'come': [389], 'by': [390, 552, 690, 817, 909, 1131, 1144, 1238, 1290, 1514, 1752, 1995, 2001, 2243], 'way': [391], 'Bartsova': [393, 1132, 1239, 1822], 'et': [394, 1133, 1240, 1242, 1842, 2125, 2277, 2312], 'al': [395], 'from': [396, 408, 416, 447, 645, 717, 771, 795, 876, 894, 998, 1045, 1068, 1210, 1282, 1473, 1485, 1493, 1763], 'University': [398], 'Heidelberg': [400], 'Vienna': [402], 'who': [403, 869, 1511], 'analyzed': [404], 'samples': [405], 'data': [407, 414], 'multi-center': [410], 'international': [411], 'tissue': [412], 'repository': [415], 'these': [417, 457, 805, 956, 1056, 1334, 1389, 1457], 'children': [418, 659, 868, 1495, 1506, 1551, 1849, 1953, 2031], 'undergoing': [419], 'for': [422, 431, 779, 1093, 1233, 1252, 2004], 'duration': [424], '≈2': [426], 'years.While': [427], 'amplify': [436], 'age': [438], 'generic': [441], 'sense,': [442], 'comes': [446], 'sample': [449], 'population': [450], 'chronic': [452, 582, 877, 1508, 1706, 1851, 2033], 'absent': [455, 1560], 'variables:': [458], 'children.': [459], 'Children,': [460], 'general,': [462], 'commonly': [464], 'undergo': [465], '(as': [468], 'do': [469], 'end': [472, 750, 1071, 1950, 2028], 'stage': [473], 'renal': [474, 878, 2034], 'disease1,2),': [475], 'which': [476, 563, 568, 574, 758, 1287, 1739], 'requires': [477], 'less': [478, 1741, 2136], 'in-patient': [479], 'time.': [480], 'resultant': [482], 'findings': [483, 1390], 'inform': [484], 'potentially': [487, 957], 'harmful': [488, 958, 1746], 'components': [489], 'arise': [492, 1080], 'fluids': [495, 788], 'called': [496], 'products': [499, 589, 751, 1482, 1951, 1998, 2029], '(also': [500], 'abbreviated': [501], 'GDPs)': [503, 1486], 'their': [505, 668, 738], 'effects': [506, 2129], 'network.Some': [511], 'basics:': [512], 'our': [516, 529], 'filtration': [517], 'system,': [518], 'when': [520, 1157], 'fails,': [522], 'physicians': [523], 'must': [524], 'mechanically': [525], 'intervene': [526], 'filter': [528], 'blood.': [530], 'There': [531], '2': [533, 944, 1583], 'basic': [534], 'types': [535], 'intervention:': [537], 'hemodialysis.': [541], 'dialysis,': [544, 607], 'filtering': [546, 1051], 'kidneys': [549], 'accomplished': [551], 'catheterization': [554], 'abdominal': [557, 1491, 1677], 'cavity': [558], '(through': [559], 'peritoneum),': [561], 'solution': [565, 615, 991], 'infused,': [567], 'absorbs': [569], 'waste': [570, 588, 621, 642, 988], 'abdomen': [573, 619], 'then': [576], 'collected': [577], 'discarded.In': [579], 'failure,': [584], 'water,': [585], 'electrolytes,': [586], 'accumulate': [590], 'body': [593, 1143, 1164], 'resulting': [594], 'imbalances': [596], 'lethal': [600], 'toxicities': [601], 'patient.': [604], 'infusion': [609], 'concentrated': [612], 'pressure': [613, 638, 981], "patients'": [618, 1271], 'enables': [620], 'exchange': [622], 'disposal': [624], 'across': [625, 983], 'membrane.': [628], 'Glucose': [629, 1844], 'generally': [631, 992], 'used': [632, 1011], 'maintain': [634], 'high': [636, 663, 726, 755, 791, 819, 840, 862, 902, 934, 1213, 1215, 1335, 1455, 1497, 1536, 1622, 1641, 1702, 1722], 'osmotic': [637, 980, 1014], 'withdraw': [640], 'water': [644], 'bloodstream.A': [647], 'key': [648, 966, 1278, 1519], 'part': [649, 1435], 'those': [658, 1108, 1787], 'calculated': [660], 'have': [662, 687, 870, 886, 1557], 'levels': [664, 903, 1230, 1544], 'exhibited': [672], 'omental': [677, 1421], 'arterioles': [678, 715, 1344, 1358, 1465, 1619, 1649], '(peritoneal).': [679], 'To': [680], 'identify': [681], 'novel': [683], 'mechanisms': [684], 'could': [686, 852, 1386], 'triggered': [689], 'GDPs': [692, 905, 935, 941, 1109, 1261, 1363, 1413, 1438, 1458], 'remodeling,': [696], 'implemented': [699], 'profiling': [701, 742], 'approach': [702], 'vessels,': [705], 'doing': [706], 'both': [707], 'microarray': [708], 'proteome': [710], 'analyses': [711, 1254], "children's": [714], 'retrieved': [716], 'bio-bank.': [719], 'Numerous': [720], 'pathways': [721], 'were': [722, 793, 1231, 1378, 1512, 1517], 'dysregulated': [723], 'GDP-exposed': [727], 'arterioles,': [728, 1382], 'including': [729], 'cytoskeletal': [730], 'junctional': [732], 'genes': [733], 'proteins.': [735, 1227], 'Consistent': [736, 864], 'prior': [739], 'observation,3': [740], 'revealed': [743], 'presence': [745], 'increased': [747, 833, 850, 887, 1461], 'glycation': [749, 1070, 1481, 1949, 2006, 2027, 2168], '(AGEs)': [752], 'group,': [757, 773], 'surmised': [760], 'be': [762, 845, 854, 890, 1010, 1026, 1276, 1322, 1327, 1365, 1660, 1711, 1730], 'culprits.': [764], 'This': [765, 1541], 'consistent': [767], 'mouse': [769], 'studies': [770, 802, 1355, 1376, 1385, 1683], 'another': [772, 1609], 'showing': [774], 'AGE': [777, 1167], '(Receptor': [778], 'AGE)': [780], 'deficient': [781], 'mice': [782], 'treated': [783, 1448, 1513], 'lab-made': [785], 'contained': [790], 'protected': [794], 'pathology.4': [799], 'While': [800, 951, 1135, 1273], 'needed,': [804], 'support': [807], 'idea': [809], 'AGEs': [811, 834, 851, 1199], 'pathology': [815, 1580], 'induced': [816, 1846], 'GDP.': [820, 1498], 'From': [821], 'introspective': [824], 'perspective,': [825], 'while': [826, 1003, 1640], 'thinking': [828], 'consequence': [837], 'GDP,': [841, 1336], 'might': [842, 1364], 'possible': [846], 'factors/enzymes': [848], 'themselves': [853], 'impacting': [855], 'elevation': [857], 'or': [858, 1178, 1266, 1535, 1604, 1791], 'toxicity': [859], 'GDPs?': [863, 1057], 'possibility,': [867], 'undergone': [872], 'suffer': [875], 'failure': [879, 2035], 'type': [881, 2037], '1': [882, 2038], 'diabetes': [883], 'may': [884, 889, 1275, 1348, 1644, 1729], 'still': [885], 'AGEs.5This': [888], 'little': [892], 'departure': [893], 'biology': [896, 924], 'human': [899, 1142, 1295, 1343], 'body,': [900], 'mostly': [907], 'generated': [908], 'manufacturing': [911], 'heat': [913], 'sterilization': [914, 1424], 'dialysate': [917], 'solutions.': [918], 'Another': [919], 'aspect': [920], 'related': [922], 'manner': [928], 'delivery,': [931], 'take': [933], 'turn': [937], 'them': [938], 'lower': [940], 'using': [942], 'chamber': [945], 'system': [947], 'versus': [948], 'one': [949, 1286], 'chamber.': [950], 'devolve': [954], 'into': [955, 1162, 1437, 1745], 'GDPs,': [959, 1180, 1190, 1214], 'does': [961], 'course': [963], 'plays': [964], 'positive': [967], 'role': [968], 'fluid,': [973], 'acts': [976], 'produce': [978], 'gradient': [982], 'membrane': [986, 1193, 1470, 1994], 'facilitating': [987], 'filtration.': [989], 'contains': [993], 'range': [995], '1.36%': [999], '4.25%,': [1002], 'dextrose': [1004], 'other': [1006, 1179, 1568, 1774], 'constituents': [1007], 'generate': [1013], 'pressure.6–8': [1015], 'Whether': [1016, 1174, 1592], 'amount': [1018], 'titrated': [1027], 'minimize': [1029], 'formation': [1031, 1168, 1724, 2165], 'fully': [1034], 'clear,': [1035], 'nor,': [1036], 'if': [1037], '(aside': [1044], 'formation),': [1048], 'compromises': [1049], 'its': [1050, 1151, 1171], 'ability.So': [1052], 'what': [1053], 'exactly': [1054], 'For': [1058], 'one,': [1059, 1116], 'despite': [1060], 'similar': [1062], 'name,': [1063], 'chemically': [1066, 1268], 'distinct': [1067, 1075], 'products,': [1072], 'former': [1079], 'bags': [1082, 1161], 'latter': [1085], 'body.': [1088], 'When': [1089], 'heat-sterilized': [1092], 'placement': [1094], 'delivery': [1098], 'bags,': [1099], 'degraded': [1102], 'GDPs.': [1104], 'identity': [1106, 1307], 'include': [1110], 'formaldehyde,': [1111], 'acetylaldehyde,': [1112], 'important': [1115, 1245, 1368, 1630, 1674], '3-deoxyglucosone': [1117], '(3-DG)9,': [1118], '3-DG': [1119, 1136, 1177, 1274], 'was': [1120, 1288, 1528], 'studied': [1122, 1552], 'vitro': [1126], 'arm': [1127], 'work': [1130, 1444, 1555], 'al.': [1134, 2313], 'formed': [1139], 'Maillard': [1146], 'reaction,': [1147], 'characteristic': [1149], 'dicarbonyl': [1152], 'structure': [1153], 'reactivity,': [1155], 'exiting': [1158], 'promotes': [1166], 'because': [1169], 'reactive': [1172], 'nature.10': [1173], 'consensus': [1182], 'solutions': [1187, 1416, 1738], 'low': [1189, 1534, 1958], 'integrity': [1194], 'better': [1196], 'preserved,': [1197], 'reduced.11,12': [1201], 'An': [1202], 'additional': [1203, 1253], 'point': [1204, 1637], 'interest': [1206], 'aside': [1209], 'making': [1212], '(in': [1218], 'fluids)': [1221], 'induce': [1223, 1417], 'glycosylation': [1224], 'substrate': [1226], 'Importantly,': [1228], 'controlled': [1232], 'al.Bartsova': [1241], 'al,': [1243], 'make': [1244, 1349], 'findings,': [1246], 'lay': [1249], 'groundwork': [1251], 'experimentation.': [1256], 'studies,': [1260], 'directly': [1264], 'identified': [1265], 'measured': [1267], 'plasma.': [1272], 'arises': [1281], 'catabolized': [1284], 'glucose,': [1285], 'assessed': [1289], 'cultured': [1294], 'umbilical': [1296], 'artery': [1297], 'endothelial': [1298, 1397], 'cells': [1299, 1406], 'final': [1302, 1636], 'figure,': [1304], 'determining': [1305], 'specific': [1310], 'elevated': [1314], 'toxic': [1317], 'vasculature': [1320, 1689], 'would': [1321, 1326], 'important.': [1323], 'Also,': [1324, 1373], 'interesting': [1328], 'assess': [1330], 'function': [1332, 2281], 'chronically': [1337], 'exposed': [1338, 1360, 1620], 'arterioles.': [1339, 1422], 'However,': [1340], 'attaining': [1341], 'fresh': [1342], 'so-treated': [1347], 'difficult.': [1351], 'Alternatively,': [1352, 1727], 'ring': [1354], 'naive': [1357], 'acutely': [1359], 'different': [1362, 1691], 'equally': [1367], 'feasible': [1371], 'study.': [1372, 1524], 'omics': [1375], 'performed': [1379], 'micro-dissected': [1381], 'future': [1384], 'expand': [1387], 'upon': [1388], 'cell-specific': [1392], 'analysis': [1393, 1616], 'cells,': [1398], 'impact': [1402, 1651], 'smooth': [1404], 'muscle': [1405], 'adipose': [1408], '(Figure).Download': [1409], 'figureDownload': [1410], 'PowerPointFigure.': [1411], 'High': [1412], 'Heat': [1423], '(at': [1432], 'least)': [1433], 'deteriorate': [1436], '(glucose': [1439], 'products).': [1441], 'finds': [1445], 'especially': [1454], 'results': [1459], '(peritoneal': [1469], 'hangs': [1472], 'stomach).': [1475], 'Further,': [1476], '(distinct': [1483], 'biochemically': [1484], 'upregulated': [1488], 'subjects': [1501], 'dialysis.There': [1516], 'many': [1518], 'control': [1520], 'points': [1521, 1624], 'Dialytic': [1525], 'exposure': [1527, 1643], 'same': [1530], 'fluid.': [1540], 'ruled': [1542], 'out': [1543], 'factor.': [1549], 'should': [1556, 1684, 1710], 'largely': [1559], 'age-dependent': [1562], 'CVD': [1569], '(cardiovascular': [1570], 'disease)': [1571], 'factors,': [1573], 'yet': [1575], 'developing': [1578], 'after': [1581, 1906], 'about': [1582], 'years': [1584], '(PD)': [1588], '(high': [1589], 'group).': [1591], 'observed': [1594], 'fact': [1598], 'response,': [1600], 'protective': [1602], 'adaptation,': [1603], 'somewhere': [1605], 'between': [1607], 'story': [1610], 'altogether.': [1611], 'transcriptomic': [1613], 'proteomic': [1615], 'endothelial-specific': [1626], 'effects,': [1627], 'addition': [1629], 'information': [1631], 'likely': [1633], 'therein.': [1634], 'A': [1635], 'commentary:': [1639], 'extend': [1645], 'beyond': [1646], 'major': [1653], 'organ': [1654], 'vasculature,': [1655], 'overlooked': [1662], 'organ/tissue,': [1664], 'affected': [1669], 'metastasis,10': [1676], 'surgery,13': [1678], 'gastrointestinal': [1680], 'More': [1682], 'look': [1685], 'disorders.': [1692], 'Finally,': [1693], 'propose': [1696], 'targeting': [1698], 'interfering)': [1700], 'overload': [1704], '(CKD)': [1709], 'area': [1713], 'focus,': [1715], 'so': [1716], 'new': [1718, 2209], 'strategies': [1719], 'counteract': [1721], 'developed.': [1726], 'administer': [1733], 'process': [1735], 'prone': [1742], 'degrading': [1744], 'metabolites.The': [1748], 'soul': [1749], 'healed': [1751], 'being': [1753], 'children.—Fyodor': [1755], 'DostoyevskyDisclosuresR.D.': [1756], 'Z.': [1759], 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