Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3194237429', 'doi': 'https://doi.org/10.1016/j.ejmech.2021.113767', 'title': 'Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease', 'display_name': 'Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease', 'publication_year': 2021, 'publication_date': '2021-08-14', 'ids': {'openalex': 'https://openalex.org/W3194237429', 'doi': 'https://doi.org/10.1016/j.ejmech.2021.113767', 'mag': '3194237429', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34450494', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8585718'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ejmech.2021.113767', 'pdf_url': 'https://www.sciencedirect.com/science/article/am/pii/S0223523421006164', 'source': {'id': 'https://openalex.org/S4210169613', 'display_name': 'European Journal of Medicinal Chemistry', 'issn_l': '0223-5234', 'issn': ['0223-5234', '1768-3254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.sciencedirect.com/science/article/am/pii/S0223523421006164', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046434677', 'display_name': 'Shenyou Nie', 'orcid': 'https://orcid.org/0000-0002-7396-8114'}, 'institutions': [{'id': 'https://openalex.org/I4210110509', 'display_name': 'Division of Chemistry', 'ror': 'https://ror.org/01ar8dr59', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1311060795', 'https://openalex.org/I4210110509', 'https://openalex.org/I4210112577']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shenyou Nie', 'raw_affiliation_strings': ['Department of Pharmacology and Chemical Biology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Chemical Biology, USA', 'institution_ids': ['https://openalex.org/I4210110509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021648584', 'display_name': 'Jidong Zhao', 'orcid': 'https://orcid.org/0000-0003-1904-935X'}, 'institutions': [{'id': 'https://openalex.org/I4210110509', 'display_name': 'Division of Chemistry', 'ror': 'https://ror.org/01ar8dr59', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1311060795', 'https://openalex.org/I4210110509', 'https://openalex.org/I4210112577']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jidong Zhao', 'raw_affiliation_strings': ['Department of Pharmacology and Chemical Biology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Chemical Biology, USA', 'institution_ids': ['https://openalex.org/I4210110509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057485283', 'display_name': 'Xiaowei Wu', 'orcid': 'https://orcid.org/0000-0001-7248-9149'}, 'institutions': [{'id': 'https://openalex.org/I4210110509', 'display_name': 'Division of Chemistry', 'ror': 'https://ror.org/01ar8dr59', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1311060795', 'https://openalex.org/I4210110509', 'https://openalex.org/I4210112577']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiaowei Wu', 'raw_affiliation_strings': ['Department of Pharmacology and Chemical Biology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Chemical Biology, USA', 'institution_ids': ['https://openalex.org/I4210110509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071566929', 'display_name': 'Yuan Yao', 'orcid': 'https://orcid.org/0000-0002-4543-2988'}, 'institutions': [{'id': 'https://openalex.org/I4210110509', 'display_name': 'Division of Chemistry', 'ror': 'https://ror.org/01ar8dr59', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1311060795', 'https://openalex.org/I4210110509', 'https://openalex.org/I4210112577']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yuan Yao', 'raw_affiliation_strings': ['Department of Pharmacology and Chemical Biology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Chemical Biology, USA', 'institution_ids': ['https://openalex.org/I4210110509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101815367', 'display_name': 'Fangrui Wu', 'orcid': 'https://orcid.org/0000-0001-8141-3584'}, 'institutions': [{'id': 'https://openalex.org/I4210110509', 'display_name': 'Division of Chemistry', 'ror': 'https://ror.org/01ar8dr59', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1311060795', 'https://openalex.org/I4210110509', 'https://openalex.org/I4210112577']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fangrui Wu', 'raw_affiliation_strings': ['Department of Pharmacology and Chemical Biology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Chemical Biology, USA', 'institution_ids': ['https://openalex.org/I4210110509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032091216', 'display_name': 'Yi-Lun Lin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110509', 'display_name': 'Division of Chemistry', 'ror': 'https://ror.org/01ar8dr59', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1311060795', 'https://openalex.org/I4210110509', 'https://openalex.org/I4210112577']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yi-Lun Lin', 'raw_affiliation_strings': ['Department of Pharmacology and Chemical Biology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Chemical Biology, USA', 'institution_ids': ['https://openalex.org/I4210110509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006979014', 'display_name': 'Xin Li', 'orcid': 'https://orcid.org/0000-0002-0189-4371'}, 'institutions': [{'id': 'https://openalex.org/I4210110509', 'display_name': 'Division of Chemistry', 'ror': 'https://ror.org/01ar8dr59', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1311060795', 'https://openalex.org/I4210110509', 'https://openalex.org/I4210112577']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xin Li', 'raw_affiliation_strings': ['Department of Pharmacology and Chemical Biology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Chemical Biology, USA', 'institution_ids': ['https://openalex.org/I4210110509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006282674', 'display_name': 'Alexander R. Kneubehl', 'orcid': 'https://orcid.org/0000-0002-6243-4096'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexander R. Kneubehl', 'raw_affiliation_strings': ['Department of Molecular Virology and Microbiology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Virology and Microbiology, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076912986', 'display_name': 'Megan B. Vogt', 'orcid': 'https://orcid.org/0000-0002-4520-3077'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Megan B. Vogt', 'raw_affiliation_strings': ['Department of Molecular Virology and Microbiology, USA', 'Intragrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA'], 'affiliations': [{'raw_affiliation_string': 'Intragrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA', 'institution_ids': ['https://openalex.org/I181547552']}, {'raw_affiliation_string': 'Department of Molecular Virology and Microbiology, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072495790', 'display_name': 'Rebeca Rico-Hesse', 'orcid': 'https://orcid.org/0000-0001-6216-1000'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rebecca Rico-Hesse', 'raw_affiliation_strings': ['Department of Molecular Virology and Microbiology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Virology and Microbiology, USA', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100728619', 'display_name': 'Yongcheng Song', 'orcid': 'https://orcid.org/0000-0003-2611-2476'}, 'institutions': [{'id': 'https://openalex.org/I4210110509', 'display_name': 'Division of Chemistry', 'ror': 'https://ror.org/01ar8dr59', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1311060795', 'https://openalex.org/I4210110509', 'https://openalex.org/I4210112577']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yongcheng Song', 'raw_affiliation_strings': ['Department of Pharmacology and Chemical Biology, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Chemical Biology, USA', 'institution_ids': ['https://openalex.org/I4210110509']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5100728619'], 'corresponding_institution_ids': ['https://openalex.org/I4210110509'], 'apc_list': {'value': 4710, 'currency': 'USD', 'value_usd': 4710, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.783, 'has_fulltext': False, 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.842231, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '225', 'issue': None, 'first_page': '113767', 'last_page': '113767'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10166', 'display_name': 'Global Impact of Arboviral Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10166', 'display_name': 'Global Impact of Arboviral Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria', 'score': 0.9893, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12134', 'display_name': 'Insect Symbiosis and Microbial Interactions', 'score': 0.9773, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/flavivirus', 'display_name': 'Flavivirus', 'score': 0.8904807}, {'id': 'https://openalex.org/keywords/ns3', 'display_name': 'NS3', 'score': 0.85278124}, {'id': 'https://openalex.org/keywords/zika-virus', 'display_name': 'Zika Virus', 'score': 0.482259}], 'concepts': [{'id': 'https://openalex.org/C2780568436', 'wikidata': 'https://www.wikidata.org/wiki/Q1165479', 'display_name': 'Flavivirus', 'level': 3, 'score': 0.8904807}, {'id': 'https://openalex.org/C132379496', 'wikidata': 'https://www.wikidata.org/wiki/Q83141645', 'display_name': 'NS3', 'level': 4, 'score': 0.85278124}, {'id': 'https://openalex.org/C2779635636', 'wikidata': 'https://www.wikidata.org/wiki/Q476209', 'display_name': 'Dengue virus', 'level': 3, 'score': 0.77116126}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.69653976}, {'id': 'https://openalex.org/C2777053367', 'wikidata': 'https://www.wikidata.org/wiki/Q202864', 'display_name': 'Zika virus', 'level': 3, 'score': 0.6905478}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6527941}, {'id': 'https://openalex.org/C2776714187', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Protease', 'level': 3, 'score': 0.595357}, {'id': 'https://openalex.org/C2777510210', 'wikidata': 'https://www.wikidata.org/wiki/Q1331256', 'display_name': 'Flaviviridae', 'level': 4, 'score': 0.58689725}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.5691154}, {'id': 'https://openalex.org/C533803919', 'wikidata': 'https://www.wikidata.org/wiki/Q30953', 'display_name': 'Dengue fever', 'level': 2, 'score': 0.5684371}, {'id': 'https://openalex.org/C140704245', 'wikidata': 'https://www.wikidata.org/wiki/Q3933202', 'display_name': 'Viral replication', 'level': 3, 'score': 0.52720934}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.39341393}, {'id': 'https://openalex.org/C2776408679', 'wikidata': 'https://www.wikidata.org/wiki/Q708693', 'display_name': 'Hepatitis C virus', 'level': 3, 'score': 0.3335649}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26898265}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.25614566}], 'mesh': [{'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017361', 'descriptor_name': 'Viral Nonstructural Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000071244', 'descriptor_name': 'Zika Virus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020365', 'descriptor_name': 'RNA Helicases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D020365', 'descriptor_name': 'RNA Helicases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020365', 'descriptor_name': 'RNA Helicases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017361', 'descriptor_name': 'Viral Nonstructural Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017361', 'descriptor_name': 'Viral Nonstructural Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071244', 'descriptor_name': 'Zika Virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ejmech.2021.113767', 'pdf_url': 'https://www.sciencedirect.com/science/article/am/pii/S0223523421006164', 'source': {'id': 'https://openalex.org/S4210169613', 'display_name': 'European Journal of Medicinal Chemistry', 'issn_l': '0223-5234', 'issn': ['0223-5234', '1768-3254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585718', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34450494', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ejmech.2021.113767', 'pdf_url': 'https://www.sciencedirect.com/science/article/am/pii/S0223523421006164', 'source': {'id': 'https://openalex.org/S4210169613', 'display_name': 'European Journal of Medicinal Chemistry', 'issn_l': '0223-5234', 'issn': ['0223-5234', '1768-3254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.8, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320306078', 'funder_display_name': 'U.S. Department of Defense', 'award_id': 'W81XWH-18-1-0368'}, {'funder': 'https://openalex.org/F4320306078', 'funder_display_name': 'U.S. Department of Defense', 'award_id': 'RP180177'}, {'funder': 'https://openalex.org/F4320308129', 'funder_display_name': 'Cancer Prevention and Research Institute of Texas', 'award_id': None}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01AI099483'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01AI098715'}, {'funder': 'https://openalex.org/F4320338478', 'funder_display_name': 'U.S. Army Medical Research Acquisition Activity', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1973619678', 'https://openalex.org/W1975120587', 'https://openalex.org/W1981093311', 'https://openalex.org/W1996917543', 'https://openalex.org/W2063302306', 'https://openalex.org/W2085335543', 'https://openalex.org/W2122349387', 'https://openalex.org/W2149682742', 'https://openalex.org/W2162105094', 'https://openalex.org/W2165960748', 'https://openalex.org/W2271569098', 'https://openalex.org/W2285713692', 'https://openalex.org/W2288486409', 'https://openalex.org/W2340291694', 'https://openalex.org/W2474204065', 'https://openalex.org/W2508596867', 'https://openalex.org/W2522132818', 'https://openalex.org/W2535859651', 'https://openalex.org/W2559265740', 'https://openalex.org/W2564044205', 'https://openalex.org/W2568971596', 'https://openalex.org/W2575520328', 'https://openalex.org/W2583070614', 'https://openalex.org/W2594315729', 'https://openalex.org/W2942104049', 'https://openalex.org/W2958054984', 'https://openalex.org/W2991088322', 'https://openalex.org/W2999824980', 'https://openalex.org/W3023251337', 'https://openalex.org/W3033866687', 'https://openalex.org/W3097796182', 'https://openalex.org/W3107473374', 'https://openalex.org/W3130386212', 'https://openalex.org/W4292648090'], 'related_works': ['https://openalex.org/W4385198333', 'https://openalex.org/W3194237429', 'https://openalex.org/W2971491215', 'https://openalex.org/W2945300448', 'https://openalex.org/W2909911222', 'https://openalex.org/W2776626262', 'https://openalex.org/W2498864382', 'https://openalex.org/W2165010374', 'https://openalex.org/W2035062239', 'https://openalex.org/W1519962899'], 'abstract_inverted_index': {'Zika': [0, 74, 141, 163], 'virus': [1, 75, 128, 142], 'belongs': [2], 'to': [3], 'the': [4, 42, 100, 120], 'Flavivirus': [5, 38], 'family': [6], 'of': [7, 37, 44, 65, 73, 89, 109, 115, 123, 149], 'RNA': [8], 'viruses,': [9], 'which': [10], 'include': [11], 'other': [12], 'important': [13], 'human': [14], 'pathogens': [15], 'such': [16], 'as': [17, 81, 83], 'dengue': [18, 124], 'and': [19, 47, 91, 125, 137], 'West': [20, 126], 'Nile': [21, 127], 'virus.': [22, 164], 'There': [23], 'are': [24, 70, 94, 154], 'no': [25], 'approved': [26], 'antiviral': [27], 'drugs': [28], 'for': [29, 41, 158], 'these': [30, 45, 90], 'viruses.': [31], 'The': [32, 86, 132], 'highly': [33], 'conserved': [34], 'NS2B-NS3': [35, 121], 'protease': [36, 76, 122], 'is': [39, 49], 'essential': [40], 'replication': [43, 143], 'viruses': [46], 'it': [48], 'therefore': [50], 'a': [51, 62, 106], 'drug': [52, 160], 'target.': [53], 'Compound': [54], 'screen': [55], 'followed': [56], 'by': [57], 'medicinal': [58], 'chemistry': [59], 'optimization': [60], 'yielded': [61], 'novel': [63, 155], 'series': [64, 114], '2,6-disubstituted': [66], 'indole': [67], 'compounds': [68, 93, 135, 153], 'that': [69], 'potent': [71, 134], 'inhibitors': [72, 117], '(ZVpro)': [77], 'with': [78, 129, 146], 'IC50': [79], 'values': [80, 148], 'low': [82], '320': [84], 'nM.': [85], 'structure-activity': [87], 'relationships': [88], 'related': [92], 'discussed.': [95], 'Enzyme': [96], 'kinetics': [97], 'studies': [98], 'show': [99], 'inhibitor': [101], '66': [102, 136], 'most': [103, 133], 'likely': [104], 'exhibited': [105], 'non-competitive': [107], 'mode': [108], 'inhibition.': [110], 'In': [111], 'addition,': [112], 'this': [113], 'ZVpro': [116], 'also': [118], 'inhibit': [119], 'reduced': [130], 'potencies.': [131], '67': [138], 'strongly': [139], 'inhibited': [140], 'in': [144], 'cells': [145], 'EC68': [147], '1-3': [150], 'μM.': [151], 'These': [152], 'pharmacological': [156], 'leads': [157], 'further': [159], 'development': [161], 'targeting': [162]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3194237429', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 5}], 'updated_date': '2024-09-17T22:15:16.760592', 'created_date': '2021-08-30'}