Cross-talk between CXC chemokine ligand 10-CXC chemokine receptor 3 axis and CC chemokine ligand 17-CC chemokine receptor 4 axis in the pathogenesis of oral lichen planus.

Name: Work Video:
Duration: 3 min 30 s
Nan Tang; Yuyao Zhang; Juehua Cheng; Zhibai Zhao; Fan Yuan
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[118, 156, 201], 'The': [121, 179], 'level': [122], 'anti-CCR4': [127, 168], 'significantly': [130, 149, 171], '(P<0.05),': [132, 158, 173], 'upregulated': [136, 177], 'Ligand': [138], 'analysis': [139], 'results': [140], 'also': [162], 'trend': [180], 'receptors': [182], 'ligands': [184], 'consistent': [188], 'OLP,': [190], 'but': [191], 'no': [192], 'significant': [193], 'difference': [194], 'antagonistic': [198], '(P>0.05).Two': [203], 'axes': [204], 'interact': [205], 'each': [207], 'other': [208], 'may': [215], 'play': [216], 'different': [217], 'roles': [218], 'its': [220], 'occurrence': [221], 'development.目的:': [223], '探讨CXC亚家族趋化因子配体10（CXCL10）-CXC亚家族趋化因子受体3（CXCR3）、CC亚家族趋化因子配体17（CCL17）-CC亚家族趋化因子受体4（CCR4）两轴间在口腔扁平苔藓（OLP）发病机制中的交互关系。方法:': [224], '收集OLP患者（非糜烂、糜烂型）和健康对照者外周血，分离T细胞并鉴定纯度，分为空白（不加拮抗剂）、拮抗CXCR3（加入CXCR3拮抗剂）、拮抗CCR4（加入CCR4拮抗剂）三个组与T细胞共培养，流式细胞术检测各组受体CXCR3、CCR4表达，生物素双抗体夹心酶联免疫吸附法检测相应配体CXCL10、CCL17的表达。结果:': [225], 'T细胞纯度鉴定均>95%且各组间的差异无统计学意义（P>0.05）。受体表达结果显示，OLP中拮抗CXCR3和CCR4组与空白组相比，拮抗CXCR3组的CXCR3和CCR4表达均下调（P>0.05）；拮抗CCR4组的CCR4表达显著下调（P<0.05），CXCR3表达上调（P>0.05）。配体表达结果示，OLP中拮抗组与空白组相比，拮抗CXCR3组的CXCL10表达显著下调（P<0.05），CCL17表达也下调（P>0.05）；拮抗CCR4组的CCL17表达显著下调（P<0.05），CXCL10表达上调（P>0.05）。健康对照者受体和配体趋势与OLP一致，但拮抗组与空白组相比差异无统计学意义（P>0.05）。结论:': [226], '本实验结果提示两轴间在OLP的发病机制中存在相关互作，且可能在OLP的发生发展过程中发挥不同作用。.': [227]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3193942845', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-11T03:09:23.296333', 'created_date': '2021-08-30'}
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