Title: Analysis of leukocyte and sperm telomere length in oligozoospermic men
Abstract: AndrologiaVolume 53, Issue 10 e14204 ORIGINAL ARTICLE Analysis of leukocyte and sperm telomere length in oligozoospermic men Masoumeh Amirzadegan, Masoumeh Amirzadegan Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, IranSearch for more papers by this authorNiloofar Sadeghi, Niloofar Sadeghi Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, IranSearch for more papers by this authorMarziyeh Tavalaee, Corresponding Author Marziyeh Tavalaee [email protected] Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran Correspondence Mohammad Hossein Nasr-Esfahani and Marziyeh Tavalaee, Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. Emails: [email protected]; [email protected] (M. H. N); [email protected] (M. T)Search for more papers by this authorMohammad Hossein Nasr-Esfahani, Corresponding Author Mohammad Hossein Nasr-Esfahani [email protected] [email protected] orcid.org/0000-0003-1983-3435 Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran Isfahan Fertility and Infertility Center, Isfahan, Iran Correspondence Mohammad Hossein Nasr-Esfahani and Marziyeh Tavalaee, Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. Emails: [email protected]; [email protected] (M. H. N); [email protected] (M. T)Search for more papers by this author Masoumeh Amirzadegan, Masoumeh Amirzadegan Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, IranSearch for more papers by this authorNiloofar Sadeghi, Niloofar Sadeghi Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, IranSearch for more papers by this authorMarziyeh Tavalaee, Corresponding Author Marziyeh Tavalaee [email protected] Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran Correspondence Mohammad Hossein Nasr-Esfahani and Marziyeh Tavalaee, Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. Emails: [email protected]; [email protected] (M. H. N); [email protected] (M. T)Search for more papers by this authorMohammad Hossein Nasr-Esfahani, Corresponding Author Mohammad Hossein Nasr-Esfahani [email protected] [email protected] orcid.org/0000-0003-1983-3435 Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran Isfahan Fertility and Infertility Center, Isfahan, Iran Correspondence Mohammad Hossein Nasr-Esfahani and Marziyeh Tavalaee, Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. Emails: [email protected]; [email protected] (M. H. N); [email protected] (M. T)Search for more papers by this author First published: 09 August 2021 https://doi.org/10.1111/and.14204Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Telomere length is considered one of the most relevant biological markers of genomic stability since it protects DNA from impairment and also ensures chromosome alignment during DNA replication. The negative impact of telomere shortening on sperm quality has been suggested as an important indicator of male infertility. Therefore, we aimed to assess leucocyte and sperm telomere length (LTL&STL), as well as sperm parameters, DNA damage and protamine deficiency in men with oligozoospermia as compared to fertile men. Our results demonstrated a significant reduction in sperm parameters (concentration, motility, morphology), LTL & STL and a significant increase in sperm DNA damage and protamine deficiency in oligozoospermic men compared with fertile individuals. These outcomes revealed that low sperm concentration in men is possibly a sign of impaired meiotic and/or meiotic division during the spermatogenesis process. It is not only associated with proper chromatin packaging but also with telomere length as a key player in the process of mitosis and meiosis, assisting in chromosomal alignment, pairing, synapsis and crossing over during spermatogenesis. CONFLICT OF INTEREST The authors declare that they have no competing interests. Open Research DATA AVAILABILITY STATEMENT Data are available on request from the authors. Volume53, Issue10November 2021e14204 RelatedInformation