Title: Ultra-early cancer diagnosis and label-free circulating tumor cell detection by comprehensive analysis of blood and urine using spectroscopy
Abstract: Detecting cancers early on leads to better chances of successful treatment and long-term survival. There is no single test to diagnose cancers but available diagnostic procedures include diagnostic imaging, endoscopic exams and tumour biopsies. Prostate cancer is one of the most frequently diagnosed cancers and a prostate-specific antigen test (PSA) can be used in the detection of this type of cancer. This involves measuring the amount of PSA in the blood, with elevated levels possibly indicating prostate cancer. However, there are risks and limitations associated with existing diagnostic methods. Raman spectroscopy is an optical technique that shows promise in cancer diagnosis but there is room for improvement. At the Digestive Diseases Center, Showa University Koto Toyosu Hospital, Japan, researchers are using surface-enhanced Raman scattering (SERS) in the development of an ultra-early cancer diagnosis technology. Associate Professor Hiroaki Ito is collaborating with Associate Professor Uragami Naoyuki and Professors Noboru Yokoyama and Takashi Fukagai on this work and the researchers have established a high-sensitivity quantitative technology that uses near-infrared lasers as the excitation light source. The researchers have also developed a colorectal cancer prediction model based on Raman spectroscopy and, in another line of work, have developed a method for generating silver nanoscale hexagonal columns (NHCs) for use in SERS. Ultimately, Ito and the team hope their research will lead to enhanced cancer treatment results and improved quality of life for patients.
Publication Year: 2021
Publication Date: 2021-07-15
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot