Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3185201469', 'doi': 'https://doi.org/10.1093/nar/gkab623', 'title': 'The clinical importance of tandem exon duplication-derived substitutions', 'display_name': 'The clinical importance of tandem exon duplication-derived substitutions', 'publication_year': 2021, 'publication_date': '2021-07-21', 'ids': {'openalex': 'https://openalex.org/W3185201469', 'doi': 'https://doi.org/10.1093/nar/gkab623', 'mag': '3185201469', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34302486', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8373072'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkab623', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/49/14/8232/39802762/gkab623.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://academic.oup.com/nar/article-pdf/49/14/8232/39802762/gkab623.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049510467', 'display_name': 'Laura Martínez Gómez', 'orcid': 'https://orcid.org/0000-0001-9843-1332'}, 'institutions': [{'id': 'https://openalex.org/I4210089594', 'display_name': 'Spanish National Cancer Research Centre', 'ror': 'https://ror.org/00bvhmc43', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210089594']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Laura Martinez\xa0Gomez', 'raw_affiliation_strings': ['Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), C. Melchor Fernandez Almagro, 3, 28029 Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), C. Melchor Fernandez Almagro, 3, 28029 Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210089594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090680921', 'display_name': 'Fernando Campo del Pozo', 'orcid': 'https://orcid.org/0000-0001-7688-6045'}, 'institutions': [{'id': 'https://openalex.org/I4210089594', 'display_name': 'Spanish National Cancer Research Centre', 'ror': 'https://ror.org/00bvhmc43', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210089594']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Fernando Pozo', 'raw_affiliation_strings': ['Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), C. Melchor Fernandez Almagro, 3, 28029 Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), C. Melchor Fernandez Almagro, 3, 28029 Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210089594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006834122', 'display_name': 'Thomas Walsh', 'orcid': 'https://orcid.org/0000-0002-9328-6671'}, 'institutions': [{'id': 'https://openalex.org/I4210089594', 'display_name': 'Spanish National Cancer Research Centre', 'ror': 'https://ror.org/00bvhmc43', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210089594']}, {'id': 'https://openalex.org/I1303153112', 'display_name': 'European Bioinformatics Institute', 'ror': 'https://ror.org/02catss52', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1303153112', 'https://openalex.org/I4210138560']}], 'countries': ['ES', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Thomas\xa0A Walsh', 'raw_affiliation_strings': ['Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), C. Melchor Fernandez Almagro, 3, 28029 Madrid, Spain', 'Eukaryotic Annotation Team, EMBL-EBI, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA. UK'], 'affiliations': [{'raw_affiliation_string': 'Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), C. Melchor Fernandez Almagro, 3, 28029 Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210089594']}, {'raw_affiliation_string': 'Eukaryotic Annotation Team, EMBL-EBI, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA. UK', 'institution_ids': ['https://openalex.org/I1303153112']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025784970', 'display_name': 'Federico Abascal', 'orcid': 'https://orcid.org/0000-0002-6201-1587'}, 'institutions': [{'id': 'https://openalex.org/I2802476451', 'display_name': 'Wellcome Sanger Institute', 'ror': 'https://ror.org/05cy4wa09', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802476451', 'https://openalex.org/I87048295']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Federico Abascal', 'raw_affiliation_strings': ['Somatic Evolution Group, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA,\xa0UK'], 'affiliations': [{'raw_affiliation_string': 'Somatic Evolution Group, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA,\xa0UK', 'institution_ids': ['https://openalex.org/I2802476451']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088945131', 'display_name': 'Michael L. Tress', 'orcid': 'https://orcid.org/0000-0001-9046-6370'}, 'institutions': [{'id': 'https://openalex.org/I4210089594', 'display_name': 'Spanish National Cancer Research Centre', 'ror': 'https://ror.org/00bvhmc43', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210089594']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Michael\xa0L Tress', 'raw_affiliation_strings': ['Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), C. Melchor Fernandez Almagro, 3, 28029 Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), C. Melchor Fernandez Almagro, 3, 28029 Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210089594']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5088945131'], 'corresponding_institution_ids': ['https://openalex.org/I4210089594'], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'fwci': 1.036, 'has_fulltext': False, 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.999981, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '49', 'issue': '14', 'first_page': '8232', 'last_page': '8246'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10015', 'display_name': 'Genomics and Phylogenetic Studies', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10015', 'display_name': 'Genomics and Phylogenetic Studies', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11048', 'display_name': 'Bacteriophages and microbial interactions', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bilateria', 'display_name': 'Bilateria', 'score': 0.6065781}, {'id': 'https://openalex.org/keywords/splice', 'display_name': 'splice', 'score': 0.48844877}, {'id': 'https://openalex.org/keywords/functional-divergence', 'display_name': 'Functional divergence', 'score': 0.44673207}, {'id': 'https://openalex.org/keywords/exon-shuffling', 'display_name': 'Exon shuffling', 'score': 0.41308358}], 'concepts': [{'id': 'https://openalex.org/C156446351', 'wikidata': 'https://www.wikidata.org/wiki/Q7682435', 'display_name': 'Tandem exon duplication', 'level': 4, 'score': 0.97255814}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.90954745}, {'id': 'https://openalex.org/C7602840', 'wikidata': 'https://www.wikidata.org/wiki/Q746284', 'display_name': 'Gene duplication', 'level': 3, 'score': 0.89608306}, {'id': 'https://openalex.org/C36823959', 'wikidata': 'https://www.wikidata.org/wiki/Q373027', 'display_name': 'Exon', 'level': 3, 'score': 0.84347904}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.7044223}, {'id': 'https://openalex.org/C194583182', 'wikidata': 'https://www.wikidata.org/wiki/Q21114084', 'display_name': 'Alternative splicing', 'level': 4, 'score': 0.6119664}, {'id': 'https://openalex.org/C2777738586', 'wikidata': 'https://www.wikidata.org/wiki/Q5173', 'display_name': 'Bilateria', 'level': 4, 'score': 0.6065781}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.5329944}, {'id': 'https://openalex.org/C27149982', 'wikidata': 'https://www.wikidata.org/wiki/Q3456514', 'display_name': 'Tandem repeat', 'level': 4, 'score': 0.49532667}, {'id': 'https://openalex.org/C2780989783', 'wikidata': 'https://www.wikidata.org/wiki/Q7578557', 'display_name': 'splice', 'level': 3, 'score': 0.48844877}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.47462332}, {'id': 'https://openalex.org/C103077935', 'wikidata': 'https://www.wikidata.org/wiki/Q5508811', 'display_name': 'Functional divergence', 'level': 5, 'score': 0.44673207}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.41957387}, {'id': 'https://openalex.org/C190017056', 'wikidata': 'https://www.wikidata.org/wiki/Q5420611', 'display_name': 'Exon shuffling', 'level': 5, 'score': 0.41308358}, {'id': 'https://openalex.org/C5911399', 'wikidata': 'https://www.wikidata.org/wiki/Q2278983', 'display_name': 'Gene family', 'level': 4, 'score': 0.18718565}, {'id': 'https://openalex.org/C90132467', 'wikidata': 'https://www.wikidata.org/wiki/Q171184', 'display_name': 'Phylogenetics', 'level': 3, 'score': 0.1551897}], 'mesh': [{'descriptor_ui': 'D019143', 'descriptor_name': 'Evolution, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005399', 'descriptor_name': 'Fishes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015894', 'descriptor_name': 'Genome, Human', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D017398', 'descriptor_name': 'Alternative Splicing', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017398', 'descriptor_name': 'Alternative Splicing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005091', 'descriptor_name': 'Exons', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005091', 'descriptor_name': 'Exons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005399', 'descriptor_name': 'Fishes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020440', 'descriptor_name': 'Gene Duplication', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020440', 'descriptor_name': 'Gene Duplication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015894', 'descriptor_name': 'Genome, Human', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058977', 'descriptor_name': 'Molecular Sequence Annotation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkab623', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/49/14/8232/39802762/gkab623.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373072', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34302486', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkab623', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/49/14/8232/39802762/gkab623.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/14', 'score': 0.69, 'display_name': 'Life below water'}], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': '3 U41 HG007234'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': '2 U41 HG007234'}], 'datasets': [], 'versions': [], 'referenced_works_count': 75, 'referenced_works': ['https://openalex.org/W1963630241', 'https://openalex.org/W1971301499', 'https://openalex.org/W1971546123', 'https://openalex.org/W1981239255', 'https://openalex.org/W1985519257', 'https://openalex.org/W1986122059', 'https://openalex.org/W1993506738', 'https://openalex.org/W1998591654', 'https://openalex.org/W2005228725', 'https://openalex.org/W2011920499', 'https://openalex.org/W2012034410', 'https://openalex.org/W2020869819', 'https://openalex.org/W2027239974', 'https://openalex.org/W2055043387', 'https://openalex.org/W2056499061', 'https://openalex.org/W2069638671', 'https://openalex.org/W2074468058', 'https://openalex.org/W2085104322', 'https://openalex.org/W2089273345', 'https://openalex.org/W2095712152', 'https://openalex.org/W2096940705', 'https://openalex.org/W2098872898', 'https://openalex.org/W2099326239', 'https://openalex.org/W2105439272', 'https://openalex.org/W2108141237', 'https://openalex.org/W2118132851', 'https://openalex.org/W2119762685', 'https://openalex.org/W2122842112', 'https://openalex.org/W2124772083', 'https://openalex.org/W2128016314', 'https://openalex.org/W2129873761', 'https://openalex.org/W2132340288', 'https://openalex.org/W2132926880', 'https://openalex.org/W2136549416', 'https://openalex.org/W2148090826', 'https://openalex.org/W2154139219', 'https://openalex.org/W2155804510', 'https://openalex.org/W2156052197', 'https://openalex.org/W2169461761', 'https://openalex.org/W2172189660', 'https://openalex.org/W2172581606', 'https://openalex.org/W2173732482', 'https://openalex.org/W2262686766', 'https://openalex.org/W2275150938', 'https://openalex.org/W2322683223', 'https://openalex.org/W2323717928', 'https://openalex.org/W2401478493', 'https://openalex.org/W2417483443', 'https://openalex.org/W2510167837', 'https://openalex.org/W2528511699', 'https://openalex.org/W2537132940', 'https://openalex.org/W2554777987', 'https://openalex.org/W2604308930', 'https://openalex.org/W2610621384', 'https://openalex.org/W2611657348', 'https://openalex.org/W2620998958', 'https://openalex.org/W2766459919', 'https://openalex.org/W2770026599', 'https://openalex.org/W2782373699', 'https://openalex.org/W2810156064', 'https://openalex.org/W2898204371', 'https://openalex.org/W2898598946', 'https://openalex.org/W2912905216', 'https://openalex.org/W2950512597', 'https://openalex.org/W2962597165', 'https://openalex.org/W2982461819', 'https://openalex.org/W2996375460', 'https://openalex.org/W3089350715', 'https://openalex.org/W3096568637', 'https://openalex.org/W3113163651', 'https://openalex.org/W3133569748', 'https://openalex.org/W3164601156', 'https://openalex.org/W4210702584', 'https://openalex.org/W4237403594', 'https://openalex.org/W841301619'], 'related_works': ['https://openalex.org/W4252868546', 'https://openalex.org/W2148090826', 'https://openalex.org/W2093401651', 'https://openalex.org/W2031872306', 'https://openalex.org/W2014546734', 'https://openalex.org/W2006004944', 'https://openalex.org/W1984349060', 'https://openalex.org/W1813070175', 'https://openalex.org/W1610209323', 'https://openalex.org/W1539107620'], 'abstract_inverted_index': {'Most': [0], 'coding': [1], 'genes': [2], 'in': [3, 66, 86, 153, 163], 'the': [4, 17, 21, 59, 67, 79, 104, 154], 'human': [5, 69], 'genome': [6], 'are': [7, 42, 48, 90], 'annotated': [8, 65], 'with': [9], 'multiple': [10], 'alternative': [11, 27, 123, 141], 'transcripts.': [12], 'However,': [13], 'clear': [14], 'evidence': [15], 'for': [16], 'functional': [18, 53, 151], 'relevance': [19], 'of': [20, 78], 'protein': [22], 'isoforms': [23, 35, 108], 'produced': [24], 'by': [25], 'these': [26], 'transcripts': [28], 'is': [29], 'often': [30], 'hard': [31], 'to': [32, 103, 148], 'find.': [33], 'Alternative': [34, 107], 'generated': [36, 109], 'from': [37, 110], 'tandem': [38, 61, 111], 'exon': [39, 62, 112, 126, 144], 'duplication-derived': [40, 63, 113, 127, 145], 'substitutions': [41, 64, 114, 128, 146], 'an': [43], 'exception.': [44], 'These': [45], 'splice': [46], 'events': [47, 80], 'rare,': [49], 'but': [50], 'have': [51, 57, 81, 116, 129, 149, 158], 'important': [52], 'consequences.': [54], 'Here,': [55], 'we': [56], 'catalogued': [58], '236': [60], 'GENCODE': [68], 'reference': [70], 'set.': [71], 'We': [72], 'find': [73], 'that': [74], 'more': [75, 118], 'than': [76, 121], '90%': [77], 'a': [82, 160], 'last': [83], 'common': [84], 'ancestor': [85], 'teleost': [87], 'fish,': [88], 'so': [89], 'at': [91], 'least': [92], '425': [93], 'million': [94], 'years': [95], 'old,': [96], 'and': [97, 135, 156], 'twenty-one': [98], 'can': [99], 'be': [100], 'traced': [101], 'back': [102], 'Bilateria': [105], 'clade.': [106], 'also': [115], 'significantly': [117], 'clinical': [119], 'impact': [120], 'other': [122, 140], 'isoforms.': [124], 'Tandem': [125, 143], '>25': [130], 'times': [131], 'as': [132, 139], 'many': [133], 'pathogenic': [134, 137], 'likely': [136], 'mutations': [138], 'events.': [142], 'appear': [147], 'vital': [150], 'roles': [152], 'cell': [155], 'may': [157], 'played': [159], 'prominent': [161], 'part': [162], 'metazoan': [164], 'evolution.': [165]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3185201469', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}], 'updated_date': '2024-12-25T16:41:33.825806', 'created_date': '2021-08-02'}