Publication Information

{'id': 'https://openalex.org/W3182074161', 'doi': 'https://doi.org/10.1158/1538-7445.am2021-917', 'title': 'Abstract 917: The preclinical characterization of TST005, a bi-functional anti-PD-L1 and TGF-β trap fusion protein', 'display_name': 'Abstract 917: The preclinical characterization of TST005, a bi-functional anti-PD-L1 and TGF-β trap fusion protein', 'publication_year': 2021, 'publication_date': '2021-07-01', 'ids': {'openalex': 'https://openalex.org/W3182074161', 'doi': 'https://doi.org/10.1158/1538-7445.am2021-917', 'mag': '3182074161'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2021-917', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5084048563', 'display_name': 'Hongjun Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hongjun Li', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100723780', 'display_name': 'Chunming Wang', 'orcid': 'https://orcid.org/0000-0001-9185-9678'}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunming Wang', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103027471', 'display_name': 'Huanhuan Guo', 'orcid': 'https://orcid.org/0000-0003-0636-6102'}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huanhuan Guo', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010715992', 'display_name': 'Xinlai Yao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xinlai Yao', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101958178', 'display_name': 'Weiwei Sun', 'orcid': 'https://orcid.org/0000-0002-7766-8119'}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weiwei Sun', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102996419', 'display_name': 'Di Sun', 'orcid': 'https://orcid.org/0000-0002-6688-5900'}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Di Sun', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060609537', 'display_name': 'Yupeng Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yupeng Zhu', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049039743', 'display_name': 'Xiangyu Xu', 'orcid': 'https://orcid.org/0000-0002-2485-4671'}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiangyu Xu', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052219257', 'display_name': 'Zhenzhi Yan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhenzhi Yan', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102313110', 'display_name': 'Chengwei Jiang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chengwei Jiang', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101407229', 'display_name': 'Shengjie Zhang', 'orcid': 'https://orcid.org/0000-0001-9910-1976'}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shengjie Zhang', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088431952', 'display_name': 'Xiwen Wu', 'orcid': 'https://orcid.org/0000-0002-0833-7834'}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiwen Wu', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072355065', 'display_name': 'Yingdi Luo', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yingdi Luo', 'raw_affiliation_strings': ['2HJB (Hangzhou) Co., Limited, Hangzhou, China.'], 'affiliations': [{'raw_affiliation_string': '2HJB (Hangzhou) Co., Limited, Hangzhou, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110032862', 'display_name': 'Yadong Dai', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yadong Dai', 'raw_affiliation_strings': ['2HJB (Hangzhou) Co., Limited, Hangzhou, China.'], 'affiliations': [{'raw_affiliation_string': '2HJB (Hangzhou) Co., Limited, Hangzhou, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022517121', 'display_name': 'Lisa Zheng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lisa Zheng', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100403413', 'display_name': 'Fan Zhang', 'orcid': 'https://orcid.org/0000-0001-8927-7089'}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fan Zhang', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100647688', 'display_name': 'Fei Teng', 'orcid': 'https://orcid.org/0000-0001-9076-8862'}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fei Teng', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104113164', 'display_name': 'Xueming Qian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xueming Qian', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102719941', 'display_name': 'Yi Gu', 'orcid': 'https://orcid.org/0000-0003-1589-2665'}, 'institutions': [{'id': 'https://openalex.org/I4210089756', 'display_name': 'Bioscience (China)', 'ror': 'https://ror.org/0072d4h61', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210089756']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi Gu', 'raw_affiliation_strings': ['1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;'], 'affiliations': [{'raw_affiliation_string': '1Mabspace Biosciences (Suzhou) Co., Limited, Suzhou, China;', 'institution_ids': ['https://openalex.org/I4210089756']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.312, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.62596, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 72, 'max': 76}, 'biblio': {'volume': '81', 'issue': '13_Supplement', 'first_page': '917', 'last_page': '917'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9946, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9946, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9924, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/immune-checkpoint', 'display_name': 'Immune checkpoint', 'score': 0.4472778}], 'concepts': [{'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.563176}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.5346455}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.49892902}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.47275314}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.45333156}, {'id': 'https://openalex.org/C2780851360', 'wikidata': 'https://www.wikidata.org/wiki/Q21686041', 'display_name': 'Immune checkpoint', 'level': 4, 'score': 0.4472778}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.43307814}, {'id': 'https://openalex.org/C123894998', 'wikidata': 'https://www.wikidata.org/wiki/Q425158', 'display_name': 'Fusion protein', 'level': 4, 'score': 0.4258624}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4186238}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4152663}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.3919654}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.33628207}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32521367}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.30773354}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09917322}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2021-917', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4285731353', 'https://openalex.org/W4281389645', 'https://openalex.org/W4224222365', 'https://openalex.org/W4206354376', 'https://openalex.org/W3217412908', 'https://openalex.org/W3177607563', 'https://openalex.org/W3153709335', 'https://openalex.org/W3108853735', 'https://openalex.org/W3039388108', 'https://openalex.org/W3029687374'], 'abstract_inverted_index': {'Abstract': [0], 'Treatment': [1], 'with': [2, 15, 23, 61, 114, 125, 149, 166, 217, 247, 341], 'immune': [3, 83, 117], 'checkpoint': [4, 38, 84], 'inhibitors,': [5, 288], 'including': [6], 'anti-PD(L)-1': [7], 'antibodies,': [8], 'has': [9, 307], 'demonstrated': [10, 304], 'durable': [11], 'responses': [12], 'in': [13, 55, 134, 208, 221, 240, 268, 277, 317, 339], 'patients': [14, 22, 340], 'PD-L1': [16, 24, 124, 287], 'expressing': [17], 'tumors.': [18], 'However,': [19], 'not': [20, 198, 323], 'all': [21], 'expression': [25], 'respond': [26], 'to': [27, 31, 37, 82, 106, 122, 143, 187, 286, 325, 349], 'the': [28, 56, 94, 99, 130, 154, 241, 255, 263, 278, 331, 412], 'treatment': [29], 'due': [30], 'de': [32], 'novo': [33], 'or': [34, 65, 190, 250], 'acquired': [35], 'resistance': [36], 'inhibitors.': [39], 'The': [40, 395], 'evidence': [41], 'from': [42, 272, 298], 'a': [43, 62, 88, 107, 135, 162, 212, 224, 400], 'number': [44], 'of': [45, 69, 93, 98, 156, 257, 337, 398, 411], 'studies': [46], 'showed': [47, 211], 'that': [48, 305, 321], 'transforming': [49], 'growth': [50, 293], 'factor': [51], 'β': [52], '(TGF-β)': [53], 'signaling': [54, 71], 'tumor': [57, 74, 80, 269, 292, 319], 'microenvironment': [58], 'is': [59, 87], 'associated': [60], 'poor': [63], 'response': [64, 81, 348], 'resistance,': [66], 'and': [67, 78, 128, 146, 152, 223, 231, 265, 295, 311, 345, 403, 424], 'inhibition': [68, 294], 'TGF-β': [70, 103, 157, 188, 248, 404], 'can': [72, 312], 'induce': [73, 313], 'T': [75, 175, 260], 'cell': [76, 176], 'infiltration/activation': [77], 'potentiate': [79], 'therapy.': [85], 'TST005': [86, 120, 140, 173, 196, 210, 229, 253, 289, 306, 338], 'bifunctional': [89], 'fusion': [90, 406], 'protein': [91, 407], 'composed': [92], 'truncated': [95], 'extracellular': [96], 'domain': [97], 'TGF-βRII': [100], 'receptor': [101, 158], '(a': [102], 'trap)': [104], 'fused': [105], 'humanized': [108], 'anti-PD-L1': [109, 402], 'IgG1': [110], 'antibody': [111], '(AM4B6': [112], 'mAb)': [113], 'ablated': [115], 'Fc': [116], 'effector': [118], 'function.': [119], 'bound': [121, 142], 'human/cyno': [123], 'high': [126, 150], 'affinity': [127, 151], 'blocked': [129], 'PD-1/PD-L1': [131, 326], 'interaction': [132], 'potently': [133], 'cell-based': [136], 'reporter': [137], 'assay.': [138], 'Similarly,': [139], 'also': [141], 'TGF-β1,': [144], '2': [145], '3': [147], 'isoforms': [148], 'inhibited': [153], 'activation': [155, 177], 'mediated': [159], 'signaling.': [160], 'In': [161, 194, 300], 'superantigen': [163], 'stimulation': [164], 'assay': [165], 'human': [167, 205], 'peripheral': [168], 'blood': [169], 'mononuclear': [170], 'cells': [171, 261], '(PBMCs),': [172], 'enhanced': [174, 308], 'significantly': [178], 'as': [179, 185], 'measured': [180], 'by': [181], 'interferon-γ': [182], '(IFN-γ)': [183], 'production,': [184], 'compared': [186, 246], 'trap': [189, 249, 405], 'AM4B6': [191, 251], 'mAb': [192], 'alone.': [193], 'contrast,': [195], 'did': [197], 'exert': [199], 'any': [200], 'cytokine': [201], 'release': [202], 'effect': [203], 'on': [204], 'naïve': [206], 'PBMCs': [207], 'vitro.': [209], 'dose-proportional': [213], 'linear': [214], 'PK': [215], 'profile': [216], 'single': [218], 'IV': [219], 'infusion': [220], 'mice,': [222], 'negative': [225], 'correlation': [226], 'between': [227], 'plasma': [228], 'concentration': [230], 'its': [232], 'pharmacodynamic': [233], 'marker': [234], 'TGF-β1': [235], 'level': [236], 'was': [237], 'established.': [238], 'Furthermore,': [239], 'MC38/hPD-L1': [242], 'xenograft': [243, 280], 'mouse': [244], 'model,': [245], 'mAb,': [252], 'increased': [254], 'infiltration': [256], 'activated': [258], 'CD8+': [259], 'into': [262], 'tumor,': [264], 'it': [266], 'resulted': [267], 'regression': [270, 296], 'starting': [271, 297], '3mg/kg.': [273], 'Of': [274], 'particular': [275], 'interest,': [276], 'EMT6/hPD-L1': [279], 'model': [281], 'which': [282], 'responds': [283], 'only': [284], 'moderately': [285], 'induced': [290], 'significant': [291], '10mg/kg.': [299], 'conclusion,': [301], 'we': [302], 'have': [303], 'immunomodulatory': [309], 'properties': [310], 'potent': [314], 'antitumor': [315], 'activity': [316], 'preclinical': [318, 396], 'models': [320], 'are': [322], 'sensitive': [324], 'monotherapy.': [327], 'These': [328], 'results': [329], 'provide': [330], 'rationale': [332], 'for': [333, 415], 'further': [334], 'clinical': [335], 'evaluation': [336], 'advanced': [342], 'solid': [343], 'tumors': [344], 'less': [346], 'optimal': [347], 'first': [350], 'generation': [351], 'PD(L)-1': [352], 'based': [353], 'immunotherapy.': [354], 'Citation': [355], 'Format:': [356], 'Hongjun': [357], 'Li,': [358], 'Chunming': [359], 'Wang,': [360], 'Huanhuan': [361], 'Guo,': [362], 'Xinlai': [363], 'Yao,': [364], 'Weiwei': [365], 'Sun,': [366, 368], 'Di': [367], 'Yupeng': [369], 'Zhu,': [370], 'Xiangyu': [371], 'Xu,': [372], 'Zhenzhi': [373], 'Yan,': [374], 'Chengwei': [375], 'Jiang,': [376], 'Shengjie': [377], 'Zhang,': [378, 388], 'Xiwen': [379], 'Wu,': [380], 'Yingdi': [381], 'Luo,': [382], 'Yadong': [383], 'Dai,': [384], 'Lisa': [385], 'Zheng,': [386], 'Fan': [387], 'Fei': [389], 'Teng,': [390], 'Xueming': [391], 'Qian,': [392], 'Yi': [393], 'Gu.': [394], 'characterization': [397], 'TST005,': [399], 'bi-functional': [401], '[abstract].': [408], 'In:': [409], 'Proceedings': [410], 'American': [413], 'Association': [414], 'Cancer': [416, 430], 'Research': [417], 'Annual': [418], 'Meeting': [419], '2021;': [420], '2021': [421], 'Apr': [422], '10-15': [423], 'May': [425], '17-21.': [426], 'Philadelphia': [427], '(PA):': [428], 'AACR;': [429], 'Res': [431], '2021;81(13_Suppl):Abstract': [432], 'nr': [433], '917.': [434]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3182074161', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2025-01-12T12:02:41.672866', 'created_date': '2021-07-19'}