Abstract 1261: A next generation tri-complex KRASG12C(ON) inhibitor directly targets the active, GTP-bound state of mutant RAS and may overcome resistance to KRASG12C(OFF) inhibition

Name: Work Video:
Duration: 3 min 30 s
Robert J. Nichols; Jim Cregg; Christopher J. Schulze; Zhican Wang; Kevin Yang; Jingjing Jiang; Daniel M. Whalen; Rich Hansen; Lindsay S. Garrenton; Alun Bermingham; John E. Knox; Tiffany J. Choy; Denise F. Reyes; Mayra Rios; Kyle J. Seamon; Michael Longhi; Kang-Jye Chou; Shaoling Li; David Wildes; Mallika Singh; Elena S. Koltun; Adrian L. Gill; Jacqueline A.M. Smith
{'id': 'https://openalex.org/W3181602654', 'doi': 'https://doi.org/10.1158/1538-7445.am2021-1261', 'title': 'Abstract 1261: A next generation tri-complex KRASG12C(ON) inhibitor directly targets the active, GTP-bound state of mutant RAS and may overcome resistance to KRASG12C(OFF) inhibition', 'display_name': 'Abstract 1261: A next generation tri-complex KRASG12C(ON) inhibitor directly targets the active, GTP-bound state of mutant RAS and may overcome resistance to KRASG12C(OFF) inhibition', 'publication_year': 2021, 'publication_date': '2021-07-01', 'ids': {'openalex': 'https://openalex.org/W3181602654', 'doi': 'https://doi.org/10.1158/1538-7445.am2021-1261', 'mag': '3181602654'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2021-1261', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103986436', 'display_name': 'Robert J. Nichols', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert J. Nichols', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078573857', 'display_name': 'Jim Cregg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jim Cregg', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052945974', 'display_name': 'Christopher J. Schulze', 'orcid': 'https://orcid.org/0009-0005-6736-871X'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher J. Schulze', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055357640', 'display_name': 'Zhican Wang', 'orcid': 'https://orcid.org/0000-0002-9411-9349'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhican Wang', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027637263', 'display_name': 'Kevin Yang', 'orcid': 'https://orcid.org/0000-0001-6337-6206'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kevin Yang', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101768843', 'display_name': 'Jingjing Jiang', 'orcid': 'https://orcid.org/0000-0002-5646-6040'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jingjing Jiang', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111780654', 'display_name': 'Daniel M. Whalen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel M. Whalen', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000948839', 'display_name': 'Rich Hansen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rich Hansen', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058881772', 'display_name': 'Lindsay S. Garrenton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lindsay S. Garrenton', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071778044', 'display_name': 'Alun Bermingham', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alun Bermingham', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041603099', 'display_name': 'John E. Knox', 'orcid': 'https://orcid.org/0009-0006-6246-5198'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John E. Knox', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055494036', 'display_name': 'Tiffany J. Choy', 'orcid': 'https://orcid.org/0000-0001-6501-2123'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tiffany Choy', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112578026', 'display_name': 'Denise F. Reyes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Denise Reyes', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071872147', 'display_name': 'Mayra Rios', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mayra Rios', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039694843', 'display_name': 'Kyle J. Seamon', 'orcid': 'https://orcid.org/0009-0005-5028-3752'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kyle Seamon', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007112365', 'display_name': 'Michael Longhi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Longhi', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002869939', 'display_name': 'Kang-Jye Chou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kang-Jye Chou', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026492211', 'display_name': 'Shaoling Li', 'orcid': 'https://orcid.org/0000-0002-7621-3091'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shaoling Li', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038156337', 'display_name': 'David Wildes', 'orcid': 'https://orcid.org/0009-0009-3855-7270'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David P. Wildes', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057362852', 'display_name': 'Mallika Singh', 'orcid': 'https://orcid.org/0009-0003-0234-1589'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mallika Singh', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040036103', 'display_name': 'Elena S. Koltun', 'orcid': 'https://orcid.org/0009-0005-8720-9097'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elena S. Koltun', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022776516', 'display_name': 'Adrian L. Gill', 'orcid': 'https://orcid.org/0009-0003-0914-4860'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Adrian L. Gill', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5027330002', 'display_name': 'Jacqueline A.M. Smith', 'orcid': 'https://orcid.org/0000-0001-5028-8725'}, 'institutions': [{'id': 'https://openalex.org/I4210100604', 'display_name': 'Revolution Medicines (United States)', 'ror': 'https://ror.org/00mny1y94', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100604']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jacqueline A. M. Smith', 'raw_affiliation_strings': ['Revolution Medicines, Redwood City, CA.'], 'affiliations': [{'raw_affiliation_string': 'Revolution Medicines, Redwood City, CA.', 'institution_ids': ['https://openalex.org/I4210100604']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.797, 'has_fulltext': False, 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.999981, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '81', 'issue': '13_Supplement', 'first_page': '1261', 'last_page': '1261'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9875, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9832, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4288348}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.37097996}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22708014}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2021-1261', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.41}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2951063681', 'https://openalex.org/W2403162773', 'https://openalex.org/W2146974279', 'https://openalex.org/W2128654752', 'https://openalex.org/W2110344434', 'https://openalex.org/W2045002748', 'https://openalex.org/W2024075173', 'https://openalex.org/W2021250530', 'https://openalex.org/W2005249481', 'https://openalex.org/W1543380773'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1, 151], 'KRASG12C': [2, 37, 77, 88, 98, 206, 248, 286], 'mutation': [3], 'is': [4, 68, 182, 223, 326], 'found': [5], 'in': [6, 28, 96, 102, 205, 232, 247, 256], '11%': [7], 'of': [8, 15, 21, 46, 48, 55, 66, 87, 105, 135, 161, 172, 178, 195, 197, 236, 243, 281, 316, 332, 338, 354, 430, 443], 'non-small': [9], 'cell': [10, 73, 203], 'lung': [11], 'cancers': [12, 31], 'and': [13, 82, 118, 143, 176, 187, 202, 222, 240, 251, 308, 310, 314, 342, 433, 456], '4%': [14], 'colorectal': [16], 'cancers.': [17], 'Recently,': [18], 'a': [19, 106, 131, 139, 147, 278, 327], 'class': [20, 52], 'KRASG12C(OFF)': [22, 50, 58, 107, 211, 274, 340, 438], 'inhibitors': [23, 341], 'has': [24, 62], 'shown': [25], 'promising': [26], 'activity': [27, 246], 'patients': [29, 347], 'whose': [30], 'bear': [32], 'KRASG12C.': [33], 'These': [34, 93], 'data': [35], 'validate': [36], 'as': [38, 42, 318, 320], 'an': [39, 113], 'oncogenic': [40, 357], 'driver,': [41], 'well': [43, 319], 'the': [44, 49, 84, 90, 103, 110, 120, 351, 426, 444], 'mechanism': [45, 65], 'action': [47, 67], 'inhibitor': [51, 114, 134, 331, 423], '–': [53], 'sequestration': [54], 'inactive,': [56], 'GDP-bound': [57], 'proteins.': [59], 'Previous': [60], 'work': [61], 'demonstrated': [63], 'this': [64, 355], 'vulnerable': [69], 'to': [70, 225, 272, 346, 437], 'adaptive': [71], 'tumor': [72, 207, 249, 254, 263], 'responses': [74], 'that': [75, 115, 137, 334], 'activate': [76], 'by': [78, 348], 'increasing': [79], 'upstream': [80, 305], 'signaling': [81, 157, 201], 'driving': [83], 'cellular': [85], 'pool': [86], 'towards': [89], 'RAS(ON)': [91], 'state.': [92], 'escape': [94], 'mechanisms,': [95], 'which': [97], 'can': [99], 'be': [100, 296], 'reactivated': [101], 'presence': [104], 'inhibitor,': [108], 'highlight': [109], 'potential': [111], 'for': [112, 185, 284, 298, 447], 'directly': [116, 349, 424], 'targets': [117, 425], 'disables': [119], 'KRASG12C(ON)': [121, 136, 142, 155, 179, 186, 267, 293, 333, 422], 'form.': [122], 'Using': [123], 'structure-based': [124], 'drug': [125], 'design,': [126], 'we': [127], 'have': [128], 'discovered': [129], 'RM-032,': [130, 270], 'potent': [132], 'covalent': [133], 'forms': [138], 'tri-complex': [140, 153, 421], 'between': [141], 'cyclophilin': [144], 'A': [145, 418], '(CypA),': [146], 'highly': [148], 'abundant': [149], 'immunophilin.': [150], 'assembled': [152], 'prevents': [154], 'from': [156], 'via': [158], 'steric': [159], 'blockade': [160], 'RAS': [162, 173, 199, 244, 432], 'effector': [163, 174], 'binding.': [164], 'In': [165, 189], 'cells,': [166], 'kinetic': [167], 'analyses': [168], 'demonstrate': [169], 'near-immediate': [170], 'disruption': [171], 'binding': [175], 'extinction': [177], 'signaling.': [180], 'RM-032': [181, 191, 213, 237, 276, 325], 'dual': [183], 'selective': [184], 'NRASG12C(ON).': [188], 'vitro,': [190], 'drives': [192, 252], 'increased': [193], 'durability': [194], 'inhibition': [196, 294, 439], 'both': [198, 304], 'pathway': [200, 245], 'proliferation': [204], 'cells': [208], 'compared': [209], 'with': [210, 300], 'inhibition.': [212], 'displays': [214], 'attractive': [215], 'drug-like': [216], 'properties': [217], 'including': [218, 269], 'cross-species': [219], 'oral': [220, 230], 'bioavailability,': [221], 'predicted': [224], 'achieve': [226], 'adequate': [227], 'exposures': [228], 'following': [229], 'dosing': [231], 'humans.': [233], 'Oral': [234], 'administration': [235], 'produces': [238], 'deep': [239], 'durable': [241], 'suppression': [242], 'models': [250], 'profound': [253], 'regressions': [255], 'vivo': [257], 'at': [258], 'well-tolerated': [259], 'doses.': [260], 'Across': [261], 'multiple': [262], 'xenograft': [264], 'models,': [265], 'advanced': [266], 'inhibitors,': [268], 'appear': [271], 'outperform': [273], 'inhibitors.': [275], 'permits': [277], 'broad': [279], 'array': [280], 'combination': [282], 'opportunities': [283], 'treating': [285], 'mutant': [287, 431], 'cancer': [288], 'types': [289], 'where': [290], 'single': [291], 'agent': [292], 'may': [295, 335, 434], 'insufficient,': [297], 'example': [299], 'agents': [301], 'targeting': [302, 350], 'nodes': [303], '(e.g.,': [306, 312, 323], 'SHP2': [307], 'SOS1)': [309], 'downstream': [311], 'MEK': [313], 'ERK)': [315], 'RAS,': [317], 'parallel': [321], 'pathways': [322], 'mTORC1).': [324], 'next': [328, 419], 'generation': [329, 420], 'mutant-selective': [330], 'overcome': [336, 435], 'liabilities': [337], 'first-generation': [339], 'provide': [343], 'additional': [344], 'benefit': [345], 'active': [352], 'form': [353], 'important': [356], 'driver': [358], 'mutation.': [359], 'Citation': [360], 'Format:': [361], 'Robert': [362], 'J.': [363, 368], 'Nichols,': [364], 'Jim': [365], 'Cregg,': [366], 'Christopher': [367], 'Schulze,': [369], 'Zhican': [370], 'Wang,': [371], 'Kevin': [372], 'Yang,': [373], 'Jingjing': [374], 'Jiang,': [375], 'Daniel': [376], 'M.': [377, 416], 'Whalen,': [378], 'Rich': [379], 'Hansen,': [380], 'Lindsay': [381], 'S.': [382, 409], 'Garrenton,': [383], 'Alun': [384], 'Bermingham,': [385], 'John': [386], 'E.': [387], 'Knox,': [388], 'Tiffany': [389], 'Choy,': [390], 'Denise': [391], 'Reyes,': [392], 'Mayra': [393], 'Rios,': [394], 'Kyle': [395], 'Seamon,': [396], 'Michael': [397], 'Longhi,': [398], 'Kang-Jye': [399], 'Chou,': [400], 'Shaoling': [401], 'Li,': [402], 'David': [403], 'P.': [404], 'Wildes,': [405], 'Mallika': [406], 'Singh,': [407], 'Elena': [408], 'Koltun,': [410], 'Adrian': [411], 'L.': [412], 'Gill,': [413], 'Jacqueline': [414], 'A.': [415], 'Smith.': [417], 'active,': [427], 'GTP-bound': [428], 'state': [429], 'resistance': [436], '[abstract].': [440], 'In:': [441], 'Proceedings': [442], 'American': [445], 'Association': [446], 'Cancer': [448, 462], 'Research': [449], 'Annual': [450], 'Meeting': [451], '2021;': [452], '2021': [453], 'Apr': [454], '10-15': [455], 'May': [457], '17-21.': [458], 'Philadelphia': [459], '(PA):': [460], 'AACR;': [461], 'Res': [463], '2021;81(13_Suppl):Abstract': [464], 'nr': [465], '1261.': [466]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3181602654', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}], 'updated_date': '2024-12-16T09:33:53.902531', 'created_date': '2021-07-19'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
