Publication Information

{'id': 'https://openalex.org/W3179585730', 'doi': 'https://doi.org/10.1158/1538-7445.am2021-lb039', 'title': 'Abstract LB039: Oncolytic Seneca Valley Virus (SVV) overcomes resistance to checkpoint inhibitor therapies in neuroendocrine and melanoma murine models expressing the receptor for SVV', 'display_name': 'Abstract LB039: Oncolytic Seneca Valley Virus (SVV) overcomes resistance to checkpoint inhibitor therapies in neuroendocrine and melanoma murine models expressing the receptor for SVV', 'publication_year': 2021, 'publication_date': '2021-07-01', 'ids': {'openalex': 'https://openalex.org/W3179585730', 'doi': 'https://doi.org/10.1158/1538-7445.am2021-lb039', 'mag': '3179585730'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2021-lb039', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5014349709', 'display_name': 'Paul L. Hallenbeck', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Paul L. Hallenbeck', 'raw_affiliation_strings': ['1Seneca Therapeutics, Inc., Blue Bell, PA;'], 'affiliations': [{'raw_affiliation_string': '1Seneca Therapeutics, Inc., Blue Bell, PA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112369989', 'display_name': 'Sunil Chada', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sunil Chada', 'raw_affiliation_strings': ['1Seneca Therapeutics, Inc., Blue Bell, PA;'], 'affiliations': [{'raw_affiliation_string': '1Seneca Therapeutics, Inc., Blue Bell, PA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033803080', 'display_name': 'Zachary S. Morris', 'orcid': 'https://orcid.org/0000-0001-5558-3547'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zachary S. Morris', 'raw_affiliation_strings': ['2University of Wisconsin School of Medicine and Public Health, Madison, WI.'], 'affiliations': [{'raw_affiliation_string': '2University of Wisconsin School of Medicine and Public Health, Madison, WI.', 'institution_ids': ['https://openalex.org/I135310074']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066902661', 'display_name': 'Amber M. Bates', 'orcid': 'https://orcid.org/0000-0002-5184-4532'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amber M. Bates', 'raw_affiliation_strings': ['2University of Wisconsin School of Medicine and Public Health, Madison, WI.'], 'affiliations': [{'raw_affiliation_string': '2University of Wisconsin School of Medicine and Public Health, Madison, WI.', 'institution_ids': ['https://openalex.org/I135310074']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5089532829', 'display_name': 'Amy K. Erbe', 'orcid': 'https://orcid.org/0000-0003-1175-4062'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amy K. Erbe', 'raw_affiliation_strings': ['2University of Wisconsin School of Medicine and Public Health, Madison, WI.'], 'affiliations': [{'raw_affiliation_string': '2University of Wisconsin School of Medicine and Public Health, Madison, WI.', 'institution_ids': ['https://openalex.org/I135310074']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.143, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.453637, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 57, 'max': 67}, 'biblio': {'volume': '81', 'issue': '13_Supplement', 'first_page': 'LB039', 'last_page': 'LB039'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.974, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9681, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/immune-checkpoint', 'display_name': 'Immune checkpoint', 'score': 0.5620495}, {'id': 'https://openalex.org/keywords/oncolytic-adenovirus', 'display_name': 'Oncolytic adenovirus', 'score': 0.44147596}], 'concepts': [{'id': 'https://openalex.org/C82210918', 'wikidata': 'https://www.wikidata.org/wiki/Q1560099', 'display_name': 'Oncolytic virus', 'level': 3, 'score': 0.9848265}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.7068023}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.67218924}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.6445206}, {'id': 'https://openalex.org/C2780851360', 'wikidata': 'https://www.wikidata.org/wiki/Q21686041', 'display_name': 'Immune checkpoint', 'level': 4, 'score': 0.5620495}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.548182}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.5443513}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.49783063}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.46633673}, {'id': 'https://openalex.org/C2777283488', 'wikidata': 'https://www.wikidata.org/wiki/Q7095181', 'display_name': 'Oncolytic adenovirus', 'level': 4, 'score': 0.44147596}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26684716}, {'id': 'https://openalex.org/C3020616263', 'wikidata': 'https://www.wikidata.org/wiki/Q1216998', 'display_name': 'Tumor cells', 'level': 2, 'score': 0.12005672}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2021-lb039', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.76}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W337617016', 'https://openalex.org/W3192445751', 'https://openalex.org/W3155807312', 'https://openalex.org/W3085011113', 'https://openalex.org/W3044984579', 'https://openalex.org/W2765628305', 'https://openalex.org/W2268212512', 'https://openalex.org/W2136742081', 'https://openalex.org/W1998541814', 'https://openalex.org/W1982112663'], 'abstract_inverted_index': {'Abstract': [0], 'Seneca': [1, 463], 'Valley': [2, 464], 'Virus': [3, 465], '(SVV-001)': [4], 'is': [5, 127, 131, 145, 182, 355], 'an': [6, 207], 'oncolytic': [7, 38, 45, 59, 209], 'virus': [8, 60, 257], 'that': [9, 44, 89, 130, 204], 'has': [10, 262], 'only': [11], 'been': [12, 263], 'tested': [13, 78], 'as': [14, 154, 156], 'a': [15, 68, 72, 128], 'single': [16], 'dose': [17], 'intravenous': [18], 'monotherapy': [19, 407], 'in': [20, 36, 50, 54, 65, 98, 115, 125, 136, 147, 159, 265, 277, 290, 413, 436, 473], 'early': [21, 270], 'clinical': [22, 55], 'trials': [23, 56], 'of': [24, 71, 84, 112, 191, 197, 255, 281, 325, 348, 376, 442, 487], 'patients': [25], 'having': [26], 'cancers': [27, 295], 'with': [28, 67, 249, 389, 416, 439], 'neuroendocrine': [29, 294, 474], 'properties': [30], '(e.g.,': [31], 'NET,': [32], 'NEC).': [33], 'Recent': [34], 'data': [35], 'the': [37, 58, 160, 198, 238, 253, 306, 311, 318, 323, 365, 393, 398, 417, 440, 480, 488], 'and': [39, 53, 86, 109, 133, 170, 176, 216, 243, 252, 268, 275, 296, 310, 328, 354, 383, 410, 431, 444, 475, 500], 'immunotherapy': [40, 430], 'fields': [41], 'have': [42, 299, 422, 432], 'demonstrated': [43], 'viruses': [46], 'can': [47, 285], 'enhance': [48], 'efficacy': [49, 111, 276], 'preclinical': [51], 'models': [52, 83, 427, 478], 'when': [57], 'agent': [61], 'was': [62], 'injected': [63, 96], 'intratumorally': [64], 'combination': [66, 418, 441], 'systemic': [69], 'administration': [70], 'checkpoint': [73, 113, 470], 'inhibitor': [74, 471], '(CPI).': [75], 'We': [76], 'therefore': [77], 'two': [79, 424], 'murine': [80, 307, 335, 426, 477], 'syngeneic': [81, 425], 'tumor': [82, 117, 161, 199, 231], 'neuroblastoma': [85, 309], 'melanoma': [87, 313, 476], 'origin': [88], 'are': [90, 337], 'resistant': [91, 338, 357], 'to': [92, 107, 214, 221, 240, 246, 302, 316, 339, 358, 367, 371, 469], 'CPI': [93, 108, 303, 329, 399], 'therapy.': [94, 419], 'When': [95], 'intra-tumorally': [97], 'these': [99, 192], 'immune': [100, 282, 379, 384], 'competent': [101], 'animal': [102], 'models,': [103], 'SVV-001': [104, 172, 185, 201, 248, 261, 327, 372, 381, 391, 406, 429, 443], 'reversed': [105], 'resistance': [106, 468], 'enhanced': [110], 'inhibitors': [114], 'both': [116, 266], 'models.': [118], 'The': [119, 279, 374], 'receptor': [120, 481], 'for': [121, 258, 428, 482, 491], 'SVV-001,': [122], 'TEM8,': [123], '(discovered': [124], '2017)': [126], 'protein': [129], 'highly': [132], 'specifically': [134], 'expressed': [135, 146], 'multiple': [137], 'cell': [138, 195], 'types': [139, 196, 375], 'within': [140], 'solid': [141, 218], 'tumors.': [142], 'Interestingly,': [143], 'TEM8': [144, 235, 319, 349, 361], 'malignant': [148], 'cancer': [149, 151, 167, 174, 177], 'cells,': [150, 166], 'stem': [152, 178], 'cells': [153, 158, 175, 179, 232, 343, 366, 377], 'well': [155], '“normal”': [157], 'microenvironment,': [162], 'including,': [163], 'angiogenic': [164], 'endothelial': [165], 'associated': [168], 'fibroblasts,': [169], 'pericytes.': [171], 'infects': [173, 186], 'while': [180], 'it': [181, 206], 'unknown': [183], 'if': [184], 'or': [187, 403], 'otherwise': [188], 'inhibits': [189], 'growth': [190], 'additional': [193], 'critical': [194], 'microenvironment.': [200], 'possesses': [202], 'features': [203], 'make': [205], 'exemplary': [208], 'virus:': [210], '1)': [211], 'its': [212, 222], 'ability': [213, 239, 245], 'target': [215], 'penetrate': [217], 'tumors': [219, 298], 'due': [220], 'extremely': [223], 'small': [224], '(27': [225], 'nM)': [226], 'size;': [227], '2)': [228], 'specificity': [229], 'toward': [230], 'mediated': [233], 'by': [234], 'expression;': [236], '3)': [237], 'easily': [241], 'manufacture,;': [242], '4)': [244], 'arm': [247], 'anti-tumor': [250, 288, 437], 'transgenes': [251], 'inability': [254], 'this': [256], 'insertional': [259], 'mutagenesis.': [260], 'studied': [264], 'pediatric': [267], 'adult': [269], 'phase': [271], 'studies': [272], 'reporting': [273], 'safety': [274], 'patients.': [278], 'addition': [280], '(CPI)': [283], 'therapies': [284, 472], 'substantially': [286], 'augment': [287], 'effects': [289], 'various': [291], 'cancers,': [292], 'however,': [293], 'SCLC': [297], 'proven': [300], 'refractory': [301], 'monotherapy.': [304], 'Using': [305], 'N1E-115': [308, 342], 'B78': [312, 351, 363], 'model': [314], 'engineered': [315], 'express': [317, 345], 'receptor,': [320], 'we': [321, 421], 'evaluated': [322], 'effect': [324], 'combining': [326], 'therapy': [330], 'using': [331], 'anti-PD-1': [332, 340], 'antibodies.': [333], 'Both': [334], 'lines': [336], 'treatment.': [341], 'endogenously': [344], 'high': [346], 'levels': [347], 'whereas': [350], 'does': [352], 'not': [353], 'thus': [356], 'SVV-001.': [359], 'Transfecting': [360], 'into': [362], 'causes': [364], 'now': [368], 'become': [369], 'susceptible': [370], 'infection.': [373], 'infected,': [378], 'infiltrate,': [380], 'replication,': [382], 'responses': [385], 'were': [386], 'examined': [387], 'along': [388], 'efficacy.': [390], 'increased': [392], 'response': [394, 438], 'rate': [395], '3-6-fold': [396], 'over': [397, 405], 'alone': [400], '(p<0.01': [401], ')': [402], '6-fold': [404], '(': [408], 'p<0.01)': [409], 'improved': [411], 'survival': [412], 'animals': [414], 'treated': [415], 'Thus,': [420], 'developed': [423], 'shown': [433], 'significant': [434], 'improvement': [435], 'anti-PD-1.': [445], 'Citation': [446], 'Format:': [447], 'Paul': [448], 'L.': [449], 'Hallenbeck,': [450], 'Sunil': [451], 'Chada,': [452], 'Zachary': [453], 'S.': [454], 'Morris,': [455], 'Amber': [456], 'M.': [457], 'Bates,': [458], 'Amy': [459], 'K.': [460], 'Erbe.': [461], 'Oncolytic': [462], '(SVV)': [466], 'overcomes': [467], 'expressing': [479], 'SVV': [483], '[abstract].': [484], 'In:': [485], 'Proceedings': [486], 'American': [489], 'Association': [490], 'Cancer': [492, 506], 'Research': [493], 'Annual': [494], 'Meeting': [495], '2021;': [496], '2021': [497], 'Apr': [498], '10-15': [499], 'May': [501], '17-21.': [502], 'Philadelphia': [503], '(PA):': [504], 'AACR;': [505], 'Res': [507], '2021;81(13_Suppl):Abstract': [508], 'nr': [509], 'LB039.': [510]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3179585730', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-12-16T09:39:22.143526', 'created_date': '2021-07-19'}