Asymmetric Access of γ-Amino Acids and γ-Amino Phosphonic Acid Derivatives via Copper-Catalyzed Enantioselective and Regioselective Hydroamination

Name: Work Video:
Duration: 3 min 30 s
Zhi-Ping Yang; Qingwei Du; Yanxin Jiang; Jun Wang
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'system': [131, 279, 762, 1583], 'that': [132, 265, 281, 297, 2072, 2532], 'plays': [133, 282], 'substantial': [135, 284], 'role': [136, 285], 'brain': [138, 287], 'disorders.': [139], 'phosphonic': [141, 164, 184, 218, 411, 428, 462, 559, 699, 782, 947, 2180, 2198], 'unique': [145, 157, 440, 2210], 'surrogate': [146], 'both': [148, 443, 1077, 1136], 'natural': [149, 444, 648], 'unnatural': [151, 446, 650], 'γ-amino': [152, 160, 163, 183, 214, 217, 371, 383, 408, 410, 698, 778, 781, 984, 987, 1437, 1536, 1619, 1677, 1711, 1804, 1807, 1897, 2176, 2179, 2194, 2197], 'acid.': [153], 'Because': [154], 'their': [156, 451, 518, 538, 2209], 'biological': [158, 318, 340, 455, 515], 'activity,': [159], 'derivatives': [166, 186, 220, 315, 430, 949, 959, 978, 1937, 2200], 'have': [167, 316, 362, 431, 525, 563], 'attracted': [168], 'considerable': [169, 434], 'attention.': [170], 'However,': [171], 'an': [172, 333, 503, 607, 686, 792, 1862, 2037, 2046, 2075, 2086, 2120, 2147, 2363, 2408, 3995], 'efficient': [173, 239, 535, 569, 687, 793], 'straightforward': [175], 'method': [176, 380, 688, 798, 940], 'for': [177, 212, 486, 537, 615, 634, 658, 776, 799, 834, 1510, 1855, 2188, 2205, 2257, 2296, 3040, 3677, 3945, 4080, 4141], 'constructing': [178, 928], 'chiral': [179, 541, 557, 576, 581, 620, 626, 651, 662, 691, 697, 713, 725, 777, 838, 929, 1352, 1618, 1803, 1812, 1859, 1896, 1931, 2079, 2193], 'γ-substituted-γ-amino': [180, 943, 946], 'remains': [187], 'long-standing': [189], 'challenge.': [190], 'Herein,': [191, 2144], 'highly': [193, 788, 2171], 'efficient,': [194, 2148], 'versatile,': [195, 2149], 'universal': [197, 795, 2186], 'Cu-catalyzed': [198, 814, 848, 893, 954, 970], 'asymmetric': [199, 368, 550, 679, 738, 796, 910], 'hydroamination': [200, 816, 850, 895, 971, 1570, 1869, 2020, 2152], 'cinnamyl': [202, 204, 207, 958, 1497, 1511, 1523, 1668, 1691, 1699, 2155, 2157, 2160], 'esters,': [203, 882, 1423, 1429, 1498, 1805, 2025, 2156], 'phosphonates,': [205, 2158], 'phosphine': [208, 522, 887, 988, 1512, 1524, 1537, 1611, 1620, 1639, 1669, 1678, 1692, 1808, 1817, 1898, 1928, 1936, 1998, 2161, 4322], 'oxides': [209, 583, 664, 1621, 1679, 2162], 'presented': [211], 'accessing': [213, 800, 2189], 'good': [222, 1360, 1442, 1589], 'yields': [223, 1138, 1358, 1377, 1443, 1576, 1628, 1943], 'with': [224, 599, 625, 766, 855, 1053, 1065, 1322, 1336, 1356, 1364, 1378, 1405, 1445, 1548, 1556, 1577, 1629, 1653, 1682, 1715, 1736, 1877, 1888, 1895, 1984, 2023, 2032, 2119, 2707, 2880, 2932, 3107, 3728, 3750, 3855, 4025, 4287], 'high': [225, 554, 1357, 1446, 1630, 1683, 1947, 2033], 'levels': [226, 1447, 1684], 'enantiocontrol': [228, 1950], 'regioselectivity.': [230], 'Download': [231, 233, 423, 425, 990, 992, 1819, 1821, 2139, 2141], 'figure': [232, 424, 991, 1820, 2140], 'PowerPoint': [234, 426, 993, 1822, 2142], 'Introduction': [235], 'The': [236, 339, 457, 514, 629, 1089, 1453, 1722, 1754, 1867, 1891, 1930, 1978, 2000, 2041, 2111, 2269, 2278, 2428], 'exploration': [237], 'general': [241, 939], 'catalytic': [242, 367, 797, 2137], 'systems': [243], 'construct': [245, 388], 'optically': [246, 574, 2191], 'pure': [247, 575], 'functionalized': [248], 'compounds': [249, 293, 854, 2249], 'from': [250, 647, 721, 1742, 1747, 3259, 4250], 'readily': [251, 807, 858, 1708], 'accessible': [252], 'starting': [253, 812], 'materials': [254, 2258], 'significantly': [256], 'important': [257, 300], 'modern': [259], 'organic': [260], 'chemistry.': [261], 'It': [262], 'well-known': [264], 'γ-aminobutyric': [266], '(GABA)': [268], '(CNS)': [280], 'disorders.1': [288], 'There': [289], 'are': [290, 391, 543, 586, 645, 2226], 'many': [291, 2190], 'bioactive': [292], 'pharmaceutical': [295], 'products': [296, 1353, 1374, 1571], 'contain': [298], 'this': [299, 748, 761, 1434, 1506, 1516, 1581, 2185], 'structural': [301], 'motif,': [302], 'such': [303], 'as': [304, 332, 438, 480, 498, 545, 1010, 1019, 1073, 1109, 1133, 1424, 1426, 1527, 2792, 3221, 3282, 3459], '(R)-baclofen': [305], '(S)-pregabalin': [307], '(Figure': [308], '1).2–4': [309], 'Notably,': [310], 'different': [311, 317], 'enantiomers': [312], 'GABA': [314, 390, 2368], 'activity.': [319], '(R)-Baclofen': [320], 'considerably': [322], 'more': [323], 'active': [324, 504], 'than': [325], 'corresponding': [327, 1320, 1647, 1842, 2264], '(S)-enantiomer,': [328], 'which': [329, 644, 718, 857, 1047], 'used': [331, 496, 1072, 1129, 1275, 1288, 1295], 'antispastic': [334], 'agent': [335], 'muscle': [337], 'relaxant.2': [338], 'activity': [341], 'pregabalin,': [343], 'potent': [345], 'anticonvulsant': [346], 'related': [347], 'GABA,': [352], 'resides': [353], '(S)-enantiomer.3,4': [356], 'Thus,': [357], 'significant': [358], 'numerous': [360], 'efforts': [361], 'been': [363, 564, 707], 'devoted': [364], 'developing': [366, 568], 'synthesis': [369, 617, 660, 695, 745, 974, 1746, 1810, 1857], 'derivatives.': [373, 578, 989, 1513, 1818, 1929, 2182, 3017], 'Michael-type': [375], 'addition': [376, 595], 'classical': [379], 'synthesize': [382], 'acids.5–12': [384], 'Other': [385], 'strategies': [386], 'enantiopure': [389], 'γ-amination': [393], 'carbonyl': [395, 853], 'compounds,13–19': [396], 'three-component': [397], 'radical': [398], 'cascade': [399], 'reactions,20': [400], 'annulation': [402], 'reaction.21,22': [403], 'Figure': [404], '1': [405, 963, 1147, 1161, 1463, 3065], '|': [406, 964, 1148, 1452, 1753, 1795, 2132], 'Representative': [407], 'acids,': [409, 717, 881], 'derivatives,': [413, 561, 701, 784], 'aminophosphine': [415, 577], 'ligands.': [416], 'TBS,': [417], 'tert-butyldimethylsilyl;': [418], 'TBDPS,': [419], 'tert-butyldiphenylsilyl;': [420], 'TIPS,': [421], 'triisopropylsily.': [422], 'also': [432, 685, 1348, 1370, 1415, 1508, 1641, 1671, 2057], 'received': [433], 'continuous': [436, 925], 'attention': [437], 'surrogates': [441], 'amino': [447, 558, 726, 933, 1923, 1927], 'acids': [448, 520, 779, 985], 'due': [449, 530], 'wide': [452, 1585], 'range': [453], 'properties.23,24': [456], 'integration': [458], 'tetrahedral': [461, 468], 'group': [464, 1069, 1591], 'can': [465, 1836], 'imitate': [466], 'transition': [469], 'state': [470], 'peptide': [472, 2216], 'hydrolysis': [473], 'enable': [475], 'these': [476, 573, 2068], 'analogues': [477, 524], 'act': [479], 'inhibitors': [481], 'esterase': [483], 'or': [484, 642, 649, 1420, 1558, 1600, 3284], 'peptidase,': [485], 'instance': [487], 'L-phosphinothricin': [488], 'L-2-amino-4-phosphonobutanoic': [490], '(L-AP4).25–27': [492], 'Bialaphos': [493], 'being': [495], 'commercially': [497], 'herbicide.28': [500], 'Tamiphosphor': [501], 'molecule': [505], 'against': [506], 'oseltamivir': [507], 'resistant': [508], 'strains': [509], 'influenza': [512], 'virus.29–31': [513], 'activities': [516], 'phosphinic': [519], 'oxide': [523, 1525, 1538, 1612, 1640, 1670, 1693, 1899], 'yet': [526], 'be': [528, 787, 1034, 1098, 1731, 1837, 2260], 'studied': [529], 'lack': [533], 'methodologies': [536, 705], 'construction.': [539], 'Furthermore,': [540, 1408], 'aminophosphines': [542], 'perceived': [544], 'powerful': [546, 832], 'ligands': [547, 1026], 'transition-metal-catalyzed': [549], 'reactions.32–36': [551], 'Given': [552], 'demand': [555, 775], 'researchers': [562], 'intensively': [565], 'focused': [566], 'on': [567, 803, 1344, 1606, 1663, 3069], 'methods': [570], 'obtain': [572], 'In': [579, 732, 747, 770, 1636, 1914], 'general,': [580], 'α-aminophosphine': [582], 'phosphonates': [585], 'prepared': [587], 'by': [588, 622, 669, 820, 899, 918, 950, 1268, 1489, 1493, 1733, 1790, 1875, 2008, 2102, 2362, 2557, 2771, 2884, 2906, 2959, 3395, 3625, 3875, 3899, 3972, 4047, 4106], 'Lewis': [590], 'metal-catalyzed': [593], 'nucleophilic': [594, 637], 'reaction': [596, 655, 1302, 1551, 1894, 1958], 'H-P(O)R2': [598], 'imines.37–46': [600], 'Very': [601], 'recently,': [602], 'Huang': [603, 2474, 3204, 3557, 3561, 3616, 3665], 'et': [604, 671, 675, 735, 843, 866, 901], 'al.47': [605], 'reported': [606, 668, 868, 898, 1847], 'elegant': [608, 921], 'enantioselective': [609, 815, 849, 953, 2167, 2172], 'reductive': [610, 2103], 'phosphonylation': [611], 'secondary': [613, 1111], 'amides': [614], 'enantioenriched': [619], 'α-aminophosphonates': [621], 'combining': [623], 'iridium': [624], 'thiourea': [627], 'catalysis.': [628], 'most': [630, 702, 831, 1634], 'established': [631], 'synthetic': [632, 1826], 'protocol': [633, 2187], 'β-aminophosphines': [635, 666], 'phosphide': [638], 'substitution': [639], 'tosylates': [641], 'mesylates,': [643], 'derived': [646, 742], 'aminoalcohols.34': [652], 'phospha-Michael': [654], 'nitroalkenes': [657], 'β-aminophosphine': [663], 'was': [667, 684, 1017, 1071, 1274, 1283, 1287, 1294, 1309, 1403, 1414, 1487, 1540, 1728, 1788, 1872, 1965, 1982], 'Tan': [670, 3507, 3644], 'al.48': [672], 'Duan': [674, 2480, 3563, 3669], 'al.,49': [676], 'respectively.': [677], 'Rh-catalyzed': [678], 'hydrogenation': [680], 'β-phosphorylated': [682], 'enamides': [683], 'access': [690], 'β-aminophosphines.50': [692], 'For': [693, 886, 2235], 'had': [706], 'limited': [708], 'usage': [711], 'auxiliaries': [714], 'α-amino': [716], 'greatly': [719], 'suffered': [720], 'poor': [722], 'diversity,': [723], 'expensive': [724], 'substrates,': [728, 888], 'multistep': [730], 'processes.': [731], '2018,': [733, 4114], 'Zhou': [734, 2687, 3051, 3233, 3713, 3717], 'al.51': [736], 'developed': [737, 845], '1,4-hydrophosphonylation': [739], 'benzofuran': [741], 'azadienes': [743], 'γ-aminophosphonates.': [746], 'well-designed': [749], 'substrate,': [750], 'aromatization': [752], 'driving': [753], 'force': [754], 'played': [755], 'vital': [757], 'role,': [758], 'therefore': [760], 'did': [763], 'not': [764, 1386], 'work': [765], 'acyclic': [767], 'azadiene': [768], 'substrates.': [769, 1388], 'response': [771], 'growing': [774], 'it': [785], 'would': [786, 2084, 2105, 2115], 'desirable': [789], 'develop': [791], 'them': [801], 'based': [802], 'transformation': [805], 'available': [808, 2227], 'bench': [810], 'stable': [811], 'materials.': [813], 'alkenes,': [818], 'pioneered': [819], 'Buchwald,': [821], 'Hirano': [822, 3739, 3841, 3890, 4100], 'Miura': [824, 900, 3743, 3845, 3892, 4102], '2013,52,53': [826], 'one': [828], 'tools': [833], 'preparation': [836, 2173], 'amine': [839], 'derivatives.54–64': [840], 'Recently,': [841], 'Buchwald': [842, 3766, 3786, 3808, 3869, 3919, 3940, 4038], 'al.65': [844], 'reversal': [847], 'α,β-unsaturated': [852], '1,2-benzisoxazole,': [856], 'gives': [859], 'primary': [860], 'amines': [861], '(Scheme': [862, 915, 960, 1749, 1865, 1954, 1976], '1a).': [863], 'Simultaneously,': [864], 'Zhang': [865, 2842, 3270, 3497, 3986, 4061, 4073, 4122], 'al.66': [867], 'similar': [870, 2011], 'regio-reversed': [871], 'hydroamination,': [872], 'capable': [873], 'directly': [875], 'producing': [876], 'series': [878], 'β-amino': [880, 976], 'amides,': [883], 'nitriles.': [885], 'only': [890, 1397, 1979], 'example': [891], 'regioselective': [894], 'vinylphosphines': [897], 'al.,67': [902], 'providing': [903, 1436], 'new': [905], 'approach': [906], 'α-aminophosphines;': [908], 'version': [911, 2231], 'still': [913], 'preliminary': [914], '1b).': [916], 'Inspired': [917], 'previous': [920], 'works65–67': [922], 'our': [924, 1520, 1702], 'interest': [926], 'organophosphorus': [930], 'compounds68,69': [931], 'esters,70,71': [934], 'we': [935, 1499, 1518, 1916, 2070, 2145], 'herein': [936], 'present': [937], 'attain': [942], 'esters': [944, 1064, 1335, 1384, 1392, 1413, 1438, 1555, 1706, 1814, 1924, 1933], 'diastereo-': [951], 'electrophilic': [955], 'amination': [956, 1075, 1893], '1c).': [961], 'Scheme': [962, 1793, 2130], '(a': [965], 'b)': [967], 'Examples': [968], 'α-aminophosphines.': [980], '(c)': [981], 'Synthesis': [982, 2484, 2522, 2593, 2611, 2672, 2821, 2899, 2935, 2988, 3018, 3166, 3237, 3275, 3368, 3481, 3650, 3679, 3872, 3894, 3947, 3968, 4041, 4082, 4225, 4247], 'Results': [994], 'Discussion': [996], 'To': [997, 1514, 1701, 1823], 'begin': [998], 'investigation,': [1000], 'β,γ-unsaturated': [1001, 1383, 1391], 'ester': [1002, 1006, 1272, 1964], '1a': [1003, 1241], 'hydroxylamine': [1005, 1063, 1412, 1422, 1428, 1554, 1705, 1963, 2024, 2097], '2a': [1007], 'were': [1008, 1128, 1385, 1430, 1500, 1564, 1624, 1707, 1938], 'chosen': [1009, 1018], 'model': [1012], 'substrates': [1013, 1363], 'dimethoxymethylsilane': [1015], '(DMMS)': [1016], 'hydride': [1021, 1134], 'source.': [1022], 'An': [1023, 4218], 'evaluation': [1024], 'revealed': [1027, 1094], '(R)-DTBM-SegPhos': [1028, 1473, 1774], '(': [1029, 1329], 'L7)': [1030], '(DTBM,': [1031], '3,5-tBu-4-MeO-C6H2)': [1032], 'superior': [1035], 'all': [1037, 1431, 1939], 'others': [1038], 'tested': [1039], '(Table': [1040, 1058, 1083, 1102, 1312, 1531], '1,': [1041, 1059, 1084, 1103, 2415], 'entry': [1042, 1060, 1085], '7': [1043, 1197], 'vs': [1044, 1087, 1331], 'entries': [1045, 1104], '1–6),': [1046], 'provided': [1048, 1567], '3aa': [1049, 1330], '91%': [1051], 'yield': [1052, 1079, 1115, 1325, 1544, 1652, 1887], '95%': [1054], 'enantiomeric': [1055], 'excess': [1056], '(ee)': [1057], '7).': [1061, 1088], 'When': [1062, 1122, 1389], 'para-Et2N': [1067], 'phenyl': [1068, 1993], '2b': [1070, 1273], 'reagent,': [1076], 'ee': [1081, 1159, 1327, 1485, 1547, 1631, 1718, 1786], 'decreased': [1082, 1113, 1141], '8': [1086, 1844, 1850], 'investigation': [1090, 1521], 'solvent': [1093], 'tetrahydrofuran': [1095], '(THF)': [1096], 'best': [1100, 1324], 'choice': [1101], '8–10).': [1105], 'Interestingly,': [1106], 'adding': [1107], 'PPh3': [1108, 1282], 'ligand': [1112, 1251], 'without': [1116, 1905], 'loss': [1117, 1907], 'enantioselectivity': [1119], '(entry': [1120], '11).': [1121], 'diethoxymethylsilane': [1123], '(DEMS)': [1124, 1286], 'polymethylhydrosiloxane': [1126], '(PMHS)': [1127, 1293], 'instead': [1130, 1276, 1289, 1296, 1961], 'DMMS': [1132, 1255, 1477, 1778], 'sources,': [1135], 'product': [1137, 1321, 1402, 1648, 1726, 1738, 1833, 1870, 1883, 1980], 'enantioselectivities': [1140], '(entries': [1142], '12': [1143], '13).': [1145], 'Table': [1146, 1450, 1751], 'Optimization': [1149], 'Reaction': [1151, 2800], 'Conditionsa': [1152], 'Entry': [1153, 3423], 'Ligand': [1154], 'R': [1155], 'Solvent': [1156], 'Yield': [1157], '(%)b': [1158], '(%)c': [1160], 'L1': [1162], 'Me2N': [1163, 1169, 1175, 1181, 1187, 1193, 1199, 1211, 1217, 1223, 1229, 1235], 'THF': [1164, 1170, 1176, 1182, 1188, 1194, 1200, 1206, 1224, 1230, 1236, 1258, 1480, 1781], '35': [1165, 1184], '45': [1166, 1178], '2': [1167, 1451, 1466, 1767, 1794], 'L2': [1168], '53': [1171, 1219], '85': [1172], '3': [1173, 1752, 2131], 'L3': [1174], '27': [1177], '4': [1179, 1764], 'L4': [1180], '13': [1183, 1981], '5': [1185], 'L5': [1186], '10': [1189, 1215, 1904], '-': [1190], '6': [1191], 'L6': [1192], '65': [1195], '90': [1196, 1208], 'L7': [1198, 1204, 1210, 1216, 1222, 1228, 1234], '91': [1201, 1238], '95': [1202, 1226], '8d': [1203], 'Et2N': [1205], '70': [1207], '9': [1209, 1884], 'Toluene': [1212], '83': [1213], '82': [1214], 'MTBE': [1218], '98': [1220], '11e': [1221], '79': [1225], '12f': [1227], '73': [1231], '93': [1232], '13g': [1233], '80': [1237], 'aReaction': [1239, 1461, 1762], 'conditions:': [1240, 1462, 1763], '(0.15': [1242, 1464], 'mmol),': [1243, 1246, 1257, 1465, 1468, 1479, 1766, 1769, 1780], '2a–2b': [1244], '(0.18': [1245, 1467], 'Cu(OAc)2': [1247, 1469, 1770], '(5': [1248, 1470, 1771], 'mol': [1249, 1253, 1280, 1471, 1475, 1772, 1776], '%),': [1250, 1254, 1472, 1476, 1773, 1777], '(6': [1252, 1474, 1775], '(0.6': [1256, 1478], '(0.75': [1259, 1481], 'mL).': [1260, 1482, 1783], 'MTBE,': [1261], 'methyl': [1262], 'tert-butyl': [1263], 'ether.': [1264], 'bIsolated': [1265], 'yields.': [1266, 1721, 1785], 'cDetermined': [1267], 'HPLC': [1269, 1490, 1791], 'analysis.': [1270, 1491, 1792], 'dHydroxylamine': [1271], '2a.': [1278], 'e6': [1279], '%': [1281], 'added.': [1284], 'fDiethoxymethylsilane': [1285], 'DMMS.': [1291, 1298], 'gPolymethylhydrosiloxane': [1292], 'With': [1299], 'optimized': [1301, 1550], 'conditions': [1303, 1953], 'hand,': [1305], 'substrate': [1307, 1530, 1586, 1919], 'scope': [1308, 1410, 1587, 1920], 'then': [1310, 2116], 'explored': [1311], '2).': [1313], 'Generally,': [1314, 1580], 'ethyl': [1316], '(E)-4-phenylbut-3-enoate': [1317], 'gave': [1318, 1371], 'value': [1328, 1486, 1787], '3ba,': [1332], '3ca).': [1333], 'β,γ-Unsaturated': [1334, 1456], 'substituents': [1337, 1657], '–Me,': [1338, 1659], '–F,': [1339], '–Cl,': [1340], '–Br,': [1341], '–OMe': [1343], 'aromatic': [1346, 1365, 1608, 1665], 'rings': [1347, 1609, 1666], 'converted': [1349, 1709], 'efficiently': [1350, 1673], 'into': [1351, 1674, 1710, 2077, 4270], '3da–': [1354], '3ja': [1355], 'enantioselectivities.': [1361, 1579], 'Additionally,': [1362], 'heterocycles,': [1366], 'furan': [1367], 'thiophene,': [1369], 'expected': [1373, 1401, 1569], '90–91%': [1376], '91–95%': [1379], 'ee.': [1380, 1407, 1655, 1890], 'Unfortunately,': [1381], 'alkyl-substituted': [1382], 'suitable': [1387], 'γ-cyclohexyl': [1390], 'reacted': [1393, 1642], 'under': [1394, 1951], 'standard': [1395, 1952], 'conditions,': [1396], 'trace': [1398], 'amounts': [1399], 'obtained': [1404, 1541, 1625, 1741, 1940], '40%': [1406], 'investigated.': [1416], 'Both': [1417, 1593], 'electron-rich': [1419, 1557], '-deficient': [1421, 1559], 'well': [1425], 'heterocyclic': [1427], 'applicable': [1432], 'transformation,': [1435], '3ac–': [1439], '3aj': [1440], 'enantiocontrol.': [1449, 1686], 'Scope': [1454, 1755], 'Esters': [1457, 2769, 2848], 'Hydroxylamine': [1459, 4288], 'Estersa': [1460], 'Isolated': [1483, 1784], 'yield.': [1484], 'determined': [1488, 1729, 1789], 'Encouraged': [1492], 'success': [1495], 'next': [1501], 'particularly': [1502], 'interested': [1503], 'whether': [1505], 'strategy': [1507, 2153], 'works': [1509], 'address': [1515], 'question,': [1517], 'began': [1519], 'using': [1522, 1959], '4a': [1526], 'prototypical': [1529], '3).': [1532, 1977], 'Strikingly,': [1533], 'desired': [1535, 1617, 1676, 1882], '5aa': [1539, 1727, 1740, 1871], '85%': [1543, 1912], '99%': [1546, 1889], 'slightly': [1549], 'conditions.': [1552], 'Several': [1553], 'groups': [1560, 1595, 1602], '(–OMe': [1561], '–Br)': [1563], 'screened': [1565], '5ad–': [1572], '5ah': [1573], 'moderate-to-good': [1575, 1720], 'excellent': [1578], 'catalyst': [1582], 'showed': [1584], 'functional': [1590], 'compatibility.': [1592], 'electron-donating': [1594], '(–CH3,': [1596], '–OCH3,': [1597], '–tBu)': [1599], 'electron-withdrawing': [1601], '(–F': [1603], '–Cl)': [1605], 'worked': [1613], 'well,': [1614], '5ba–': [1622], '5ha': [1623], 'good-to-excellent': [1627], 'values': [1632], 'cases.': [1635], 'addition,': [1637, 1915], 'dibenzyl': [1638], 'smoothly': [1643], 'give': [1645], '5ia': [1649], '80%': [1651], '93%': [1654], 'Various': [1656], 'including': [1658], '–OMe,': [1660], '–Cl': [1662], 'transformed': [1672, 1839, 1874], '5ja–': [1680], '5oa': [1681], 'These': [1687], 'promising': [1688], 'results': [1689, 2044], 'prompted': [1694], 'us': [1695], 'continue': [1697], 'examining': [1698], 'phosphonates.': [1700], 'delight,': [1703], 'representative': [1704], 'phosphonate': [1712], '5pa–': [1713], '5ph': [1714], 'over': [1716], '90%': [1717], 'absolute': [1723], 'configuration': [1724], 'S': [1732], 'comparison': [1735], '(S)-': [1739, 1834], 'two': [1744], 'steps': [1745], '(S)-3-amino-3-phenylpropan-1-ol': [1748], '2a).': [1750], 'Cinnamyl': [1759], 'Phosphine': [1760, 3549, 4139], 'Derivativesa': [1761], '(0.2': [1765], '(0.3': [1768], '(0.8': [1779], '(2': [1782], '(a–c)': [1796], 'Configuration': [1797], 'determination': [1798], '5aa,': [1800], 'application': [1801], 'δ-amino': [1813, 1816, 1932, 1935], 'show': [1824], 'potential': [1827], 'chiral-aminated': [1830], 'products,': [1831], '3ba': [1835], 'further': [1838, 1873, 2206], 'alcohol': [1843], 'method.18': [1848], 'Alcohol': [1849], 'key': [1853], 'intermediate': [1854], 'drug': [1860], 'cis-(+)-sertraline,': [1861], 'effective': [1863, 2047], 'antidepressant': [1864], '2b).72': [1866], 'resulting': [1868], 'reduction': [1876], 'HSiCl3': [1878], 'produce': [1880], '82%': [1886], 'Buchwald–Hartwig': [1892], '5na': [1900], 'led': [1901], 'diphenylamine': [1903], 'any': [1906], 'chirality': [1909], '(82%': [1910], 'yield,': [1911], 'ee).': [1913], 'expanded': [1917], 'γ,δ-unsaturated': [1922, 1926], 'moderate': [1942], 'but': [1944], 'maintain': [1945], 'level': [1948], '2c).': [1955], 'A': [1956, 2083, 2318, 3036, 4077, 4290], 'protonation': [1957], 'CD3OD': [1960], 'conducted': [1966], 'probe': [1968], 'regioselectivity': [1970, 2001, 2034], 'generated': [1973], 'organocopper': [1974], 'species': [1975, 2082, 2113, 2128], 'labeled': [1983], '72%': [1985], 'deuterium': [1986], 'at': [1987, 2365], 'carbon': [1989], 'adjacent': [1990], 'ring': [1994], '(γ-position': [1995], 'oxide).': [1999], 'hydrocupration': [2004], 'largely': [2006], 'dictated': [2007], 'electronic': [2009], 'properties,': [2010], 'alkenyl-arenes.73': [2013], 'By': [2014], 'detailed': [2016], 'computational': [2017], 'study': [2018], 'styrene': [2022], 'Tobisch': [2026, 4282], 'confirmed': [2027], 'migratory': [2028], 'olefin': [2029], 'insertion': [2030, 2073], 'proceeds': [2031], 'afford': [2036], 'alkyl': [2038, 2063, 2087], 'copper': [2039, 2054, 2064, 2088], 'intermediate.': [2040], 'π-electron-withdrawing': [2042], 'arene': [2043], 'depletion': [2048], 'electron': [2050], 'density': [2051], 'center,': [2055], 'enhances': [2058], 'stability': [2060], 'intermediate.74': [2065], 'According': [2066], 'reports,': [2069], 'propose': [2071], 'alkene': [2076], 'ligand-bound': [2080], 'LCu(I)H': [2081, 2127], 'generate': [2085], 'complex': [2089], 'B.': [2090, 2391, 2517, 3250], 'Subsequent': [2091], 'intramolecular': [2092], 'SN2': [2093], 'cleavage': [2094], "ester's": [2098], 'N–O': [2099], 'linkage': [2100], 'followed': [2101], 'elimination': [2104], 'form': [2106], 'C−N': [2108], 'bond': [2109], 'enantioselectively.': [2110], 'copper(I)': [2112], 'C': [2114], 'undergo': [2117], 'transmetalation': [2118], 'external': [2121], 'hydride-transfer': [2122], 'reagent': [2123], 'reform': [2125], 'A.': [2129, 2305, 2343, 2511, 2819, 2986, 4207], 'Deuterium-labeling': [2133], 'experiment': [2134], 'proposed': [2136], 'cycle.': [2138], 'Conclusion': [2143], 'demonstrate': [2146], 'unified': [2151], 'regio-': [2165], 'fashion,': [2168], 'thus': [2169], 'allowing': [2170], 'essential': [2175], 'We': [2183], 'believe': [2184], 'enriched': [2192], 'will': [2201], 'lay': [2202], 'foundation': [2204], 'discovery': [2207], 'bioactivity': [2211], 'medicinal': [2213], 'chemistry': [2214], 'synthesis.': [2217], 'Supporting': [2218, 2220], 'Information': [2219, 2221, 2277, 4312], 'chemical': [2223], 'compound': [2224], 'information': [2225], 'online': [2230], 'paper.': [2234], 'nuclear': [2236], 'magnetic': [2237], 'resonance': [2238], '(NMR)': [2239], 'spectra': [2240, 2246], 'high-performance': [2242], 'liquid': [2243], 'chromatography': [2244], '(HPLC)': [2245], 'describe,': [2250], 'see': [2251], 'supplementary': [2252], 'figures.': [2253], 'Correspondence': [2254], 'requests': [2256], 'should': [2259], 'addressed': [2261], 'author.': [2265], 'Conflict': [2266], 'Interest': [2268], 'authors': [2270, 2279], 'declare': [2271], 'no': [2272], 'competing': [2273], 'financial': [2274, 2297], 'interests.': [2275], 'Funding': [2276], 'gratefully': [2280], 'thank': [2281], 'National': [2283], 'Natural': [2284, 3105], 'Foundation': [2286], 'China': [2288], '(NSFC': [2289], '21971102)': [2290], 'Guangdong': [2292], 'Innovative': [2293], 'Program': [2294], '(2019BT02Y335)': [2295], 'support.': [2298], 'References': [2299], '1.': [2300], 'Purdy': [2301], 'R.': [2302, 2421, 2718, 3033, 3049, 3784], 'H.;': [2303, 2309, 2577, 3102, 3294, 3312, 3355, 3444, 3504, 4123, 4260], 'Morrow': [2304], 'L.;': [2306, 2344, 2507, 2640, 2785, 3415, 4010, 4129, 4258], 'Moore': [2307], 'P.': [2308, 2759], 'Paul': [2310], 'S.': [2311, 2329, 2520, 3054, 3253, 3767, 3787, 3809, 3870, 3920, 3941, 4039, 4208], 'M.Stress-Induced': [2312], 'Elevations': [2313], 'Type': [2317], 'Receptor-Active': [2319], 'Steroids': [2320], 'Rat': [2323], 'Brain.Proc.': [2324], 'Natl.': [2325], 'Acad.': [2326], 'Sci.': [2327], 'U.': [2328], 'A.1991,': [2330], '88,': [2331], '4553–4557.': [2332], 'Google': [2333, 2372, 2417, 2437, 2467, 2503, 2542, 2565, 2603, 2632, 2663, 2684, 2714, 2753, 2779, 2808, 2833, 2857, 2892, 2916, 2946, 2976, 3006, 3026, 3045, 3073, 3098, 3117, 3154, 3180, 3228, 3246, 3265, 3290, 3308, 3323, 3349, 3375, 3407, 3438, 3467, 3490, 3520, 3554, 3576, 3601, 3637, 3660, 3688, 3708, 3734, 3759, 3780, 3800, 3822, 3836, 3862, 3885, 3908, 3933, 3959, 3979, 4004, 4031, 4058, 4093, 4117, 4147, 4170, 4195, 4237, 4254, 4279, 4301], 'Scholar': [2334, 2373, 2418, 2438, 2468, 2504, 2543, 2566, 2604, 2633, 2664, 2685, 2715, 2754, 2780, 2809, 2834, 2858, 2893, 2917, 2947, 2977, 3007, 3027, 3046, 3074, 3099, 3118, 3155, 3181, 3229, 3247, 3266, 3291, 3309, 3324, 3350, 3376, 3408, 3439, 3468, 3491, 3521, 3555, 3577, 3602, 3638, 3661, 3689, 3709, 3735, 3760, 3781, 3801, 3823, 3837, 3863, 3886, 3909, 3934, 3960, 3980, 4005, 4032, 4059, 4094, 4118, 4148, 4171, 4196, 4238, 4255, 4280, 4302], '2.': [2335], 'Bowery': [2336], 'N.': [2337], 'G.;': [2338, 3012, 3413, 3530, 3532, 4062], 'Hill': [2339], 'D.': [2340, 2348, 2379], 'R.;': [2341, 2873, 3185, 3535], 'Hudson': [2342], 'Doble': [2345], 'A.;': [2346, 2383, 2386, 2515, 2721, 3446], 'Middlemiss': [2347], 'N.;': [2349, 2723, 2867, 2870, 3448, 3765, 3866, 4127], 'Shaw': [2350], 'J.;': [2351, 2401, 2471, 2636, 2638, 2692, 2719, 2789, 2839, 3234, 3251, 3357, 3506, 3562, 3714, 4037, 4199], 'Turnbull': [2352], 'M.': [2353, 2376, 2382, 3030, 3529, 3804, 4174], '(–)-Baclofen': [2354], 'Decreases': [2355], 'Neurotransmitter': [2356], 'Release': [2357], 'Mammalian': [2360], 'CNS': [2361], 'Action': [2364], 'Novel': [2367, 3461], 'Receptor.Nature1980,': [2369], '283,': [2370], '92–94.': [2371], '3.': [2374], 'Hoekstra': [2375], 'S.;': [2377, 2395, 2443, 2575, 2817, 3052, 3187, 3442, 3763, 3868, 3937, 3939, 3965, 4035, 4070, 4241], 'Sobieray': [2378], 'M.;': [2380, 2389, 2512, 2644, 2760, 2981, 2984, 3031, 3050, 3419, 3474, 3558, 3666, 4012, 4179], 'Schwindt': [2381], 'Mulhern': [2384], 'T.': [2385, 2388, 2872, 4264], 'Grote': [2387], 'Huckabee': [2390], 'K.;': [2392, 2518, 2548, 2582, 2642, 2728, 3525, 3740, 3842, 3891, 4101, 4203], 'Hendrickson': [2393], 'V.': [2394, 2869], 'Franklin': [2396], 'L.': [2397], 'C.;': [2398, 2580, 2725, 2837, 3297, 3472, 3560, 4181], 'Granger': [2399], 'E.': [2400, 2762, 2865, 3189, 3330], 'Karrick': [2402], 'G.': [2403, 2730, 3327, 3524], 'L.Chemical': [2404], 'Development': [2405], 'CI-1008,': [2407], 'Enantiomerically': [2409, 3339], 'Pure': [2410], 'Anticonvulsant.Org.': [2411], 'Proc.': [2412], 'Res.': [2413], 'Dev.1997,': [2414], '26–38.': [2416], '4.': [2419], 'Silverman': [2420], 'B.From': [2422], 'Basic': [2423], 'Blockbuster': [2426], 'Drug:': [2427], 'Discovery': [2429], 'Lyrica.Angew.': [2431], 'Chem.': [2432, 2463, 2538, 2598, 2627, 2658, 2710, 2748, 2775, 2828, 2911, 2942, 2971, 3002, 3150, 3175, 3345, 3403, 3515, 3632, 3730, 3754, 3776, 3796, 3817, 3880, 3904, 3954, 3999, 4027, 4053], 'Int.': [2433, 2599, 2628, 2659, 2749, 2829, 2912, 2972, 3176, 3516, 3633, 3755, 3818, 3881, 3955, 4000, 4054], 'Ed.2008,': [2434, 3177], '47,': [2435, 3178], '3500–3504.': [2436], '5.': [2439], 'Ooi': [2440], 'T.;': [2441, 3353, 3500, 3502, 3742, 3805, 3844, 4066, 4068, 4097], 'Fujioka': [2442], 'Maruoka': [2444], 'K.Highly': [2445], 'Conjugate': [2447, 2551], 'Addition': [2448, 2619, 2993, 3568, 4211], 'Nitroalkanes': [2450], 'Alkylidenemalonates': [2452], 'Using': [2453, 3431], 'Efficient': [2454, 2934, 3080, 4219], 'Phase-Transfer': [2455, 3432], 'Catalysis': [2456, 3255, 3433], 'N-Spiro': [2458], 'Chiral': [2459, 2558, 2845, 2886, 2937, 3085, 3279, 3396, 3628, 3652, 3681, 3720, 3970, 4018, 4084, 4227], 'Ammonium': [2460], 'Bromides.J.': [2461], 'Am.': [2462, 2537, 2709, 2774, 2941, 3001, 3149, 3344, 3402, 3775, 3903], 'Soc.2004,': [2464, 3346], '126,': [2465, 3347], '11790–11791.': [2466], '6.': [2469], 'Deng': [2470, 2608, 2668, 4178], 'Hu': [2472, 2606, 2666, 3212, 3693], 'X.-P.;': [2473], 'J.-D.;': [2475], 'Yu': [2476, 4204], 'S.-B.;': [2477], 'D.-Y.;': [2479], 'Z.-C.;': [2481], 'Zheng': [2482, 2786, 2895], 'Z.Enantioselective': [2483], 'β-Aryl-γ-Amino': [2486], 'Cu-Catalyzed': [2490, 3829, 4023], 'Asymmetric': [2491, 2592, 2610, 2671, 2732, 2797, 2851, 3317, 3367, 3567, 3671, 3695, 3922, 4075, 4142, 4158, 4210], '1,4-Reductions': [2492], 'γ-Phthalimido-Substituted': [2494], 'α,β-Unsaturated': [2495, 2554, 2846], 'Carboxylic': [2496, 2624], 'Esters.J.': [2498], 'Org.': [2499, 2680], 'Chem.2008,': [2500], '73,': [2501], '6022–6024.': [2502], '7.': [2505], 'Guo': [2506, 2814, 3293, 4034], 'Chi': [2508], 'Y.;': [2509, 3301, 3498, 3527, 3738, 3785, 3840, 3912, 4064, 4175], 'Almeida': [2510], 'Guzei': [2513], 'I.': [2514], 'Parker': [2516], 'Gellman': [2519], 'H.Stereospecific': [2521], 'Conformationally': [2524], 'Constrained': [2525], 'Acids:': [2527], 'New': [2528, 3037], 'Foldamer': [2529], 'Building': [2530], 'Blocks': [2531], 'Support': [2533], 'Helical': [2534], 'Secondary': [2535, 3623], 'Structure.J.': [2536], 'Soc.2009,': [2539], '131,': [2540], '16018–16020.': [2541], '8.': [2544], 'Hatano': [2545], 'M.,': [2546], 'Yamakawa': [2547], 'Ishihara': [2549], 'K.Enantioselective': [2550], 'Hydrocyanation': [2552], 'N-Acylpyrroles': [2555], 'Catalyzed': [2556, 2588, 2770, 2883, 2962, 3362, 3511, 3589], 'Lithium(I)': [2559], 'Phosphoryl': [2560], 'Phenoxide.ACS': [2561], 'Catal.2017,': [2562, 3095], '7,': [2563, 3096, 3373], '6686–6690.': [2564], '9.': [2567], 'Chen': [2568, 2949, 3198, 3200, 3499, 3604], 'X.-Y.;': [2569, 2950], 'Xiong': [2570, 4067], 'J.-W.;': [2571], 'Liu': [2572, 2840, 3503, 3783, 3917, 3984, 4069], 'Q.;': [2573, 2783, 3077, 3584, 3963], 'Li': [2574, 2691, 2788, 3268, 3531, 3559, 3964, 4011], 'Sheng': [2576], 'von': [2578], 'Essen': [2579], 'Rissanen': [2581], 'Enders': [2583], 'D.Control': [2584], 'N-Heterocyclic': [2586, 2960], 'Carbene': [2587, 2961], 'Reactions': [2589, 2700], 'Enals:': [2591], 'Oxindole-γ-Amino': [2595], 'Derivatives.Angew.': [2597, 2626], 'Ed.2018,': [2600, 2629, 2660, 3956, 4001], '57,': [2601, 2630, 2661, 3957, 4002], '300–304.': [2602], '10.': [2605], 'B.;': [2607, 2667, 3190], 'L.Catalytic': [2609, 3921], 'Trifluoromethylated': [2613, 2674], 'through': [2616, 2654, 3722, 3951], 'Umpolung': [2618, 2678], 'Trifluoromethyl': [2621], 'Imines': [2622], '2233–2237.': [2631], '11.': [2634], 'Ma': [2635, 2724, 3501, 3581], 'Lin': [2637, 3206, 3667, 4261], 'Zhao': [2639, 4259], 'Harms': [2641], 'Marsch': [2643], 'Xie': [2645], 'X.;': [2646, 3494, 3641, 3987, 4008, 4153, 4177], 'Meggers': [2647], 'E.Synthesis': [2648], 'β-Substituted': [2650], 'Photoredox': [2656], 'Catalysis.Angew.': [2657, 3631], '11193–11197.': [2662], '12.': [2665], 'L.Direct': [2669], 'Catalytic': [2670], 'Esters/Lactones': [2676], 'Strategy.J.': [2679], 'Chem.2019,': [2681], '84,': [2682], '994–1005.': [2683], '13.': [2686], 'Y.-Y.;': [2688], 'L.-J.;': [2690], 'Sun': [2693, 2862, 2921, 3298, 3606], 'X.-L.;': [2694], 'Tang': [2695, 2790, 3235], 'Y.Side-Arm-Promoted': [2696], 'Highly': [2697, 3700], 'Ring-Opening': [2699, 2876], 'Kinetic': [2702], 'Resolution': [2703], 'Donor-Acceptor': [2705, 2802, 2878], 'Cyclopropanes': [2706, 2879], 'Amines.J.': [2708], 'Soc.2012,': [2711], '134,': [2712], '9066–9069.': [2713], '14.': [2716], 'Lundgren': [2717], 'Wilsily': [2720], 'Marion': [2722], 'Chung': [2726], 'Y.': [2727, 3296], 'Fu': [2729, 3493, 3640], 'C.Catalytic': [2731], 'C-N': [2733], 'Bond': [2734], 'Formation:': [2735], 'Phosphine-Catalyzed': [2736], 'Intra-': [2737], 'Intermolecular': [2739, 2765, 3745], 'γ-Addition': [2740], 'Nitrogen': [2742], 'Nucleophiles': [2743], 'Allenoates': [2745], 'Alkynoates.Angew.': [2747], 'Ed.2013,': [2750, 2973, 3756], '52,': [2751, 2974, 3757], '2525–2528.': [2752], '15.': [2755], 'Fang': [2756, 3122, 3159, 3210], 'Y.-Q.;': [2757], 'Tadross': [2758], 'Jacobsen': [2761, 3329], 'N.Highly': [2763], 'Enantioselective,': [2764], 'Allenyl': [2768], 'Bifunctional': [2772], 'Phosphinothioureas.J.': [2773], 'Soc.2014,': [2776], '136,': [2777], '17966–17968.': [2778], '16.': [2781], 'Kang': [2782], 'Z.;': [2787, 2863, 3299, 3643, 3712, 3826, 4121, 4125, 4151, 4201, 4262], 'Y.Sidearm': [2791], 'Control': [2794], 'Ring': [2798, 3990], 'Opening': [2799, 3991], 'Cyclopropane.Chin.': [2803], 'J.': [2804, 2812, 3471, 3476, 3537, 4113], 'Chem.2014,': [2805], '32,': [2806], '669–672.': [2807], '17.': [2810], 'Gomez': [2811], 'E.;': [2813, 3130, 3195], 'W.;': [2815, 2861, 3269, 4072], 'Gaspa': [2816], 'Kleij': [2818], 'W.Copper-Catalyzed': [2820], 'Featuring': [2825], 'Quaternary': [2826], 'Stereocenters.Angew.': [2827], 'Ed.2017,': [2830], '56,': [2831, 4193, 4252], '15035–15038.': [2832], '18.': [2835], 'Xia': [2836, 2951], 'Shen': [2838, 2919], 'D.;': [2841, 2896, 3328, 3417, 3889, 3916, 4099], 'W.Synthesis': [2843], 'Pd-Catalyzed': [2850], 'Allylic': [2852], 'Amination.Org.': [2853], 'Lett.2017,': [2854], '19,': [2855], '4251–4254.': [2856], '19.': [2859], 'Luo': [2860], 'Fernando': [2864], 'H.': [2866], 'Nesterov': [2868], 'Cundari': [2871], 'H.Asymmetric': [2875], 'Primary': [2881], 'Arylamines': [2882], 'Heterobimetallic': [2887], 'Catalyst.ACS': [2888], 'Catal.2019,': [2889, 4144], '9,': [2890, 4145], '8285–8293.': [2891], '20.': [2894], 'Studer': [2897], 'A.Asymmetric': [2898], 'Heterocyclic': [2901], 'γ-Amino-Acid': [2902], 'Diamine': [2904], 'Three-Component': [2907], 'Radical': [2908], 'Cascade': [2909], 'Reactions.Angew.': [2910, 3514], 'Ed.2019,': [2913], '58,': [2914], '15803–15807.': [2915], '21.': [2918], 'L.-T.;': [2920], 'L.-H.;': [2922], 'Ye': [2923, 2955, 3231], 'S.Highly': [2924, 2956], 'γ-Amination': [2926, 2958], 'α,': [2928], 'β-Unsaturated': [2929], 'Acyl': [2930], 'Chlorides': [2931], 'Azodicarboxylates:': [2933], 'Derivatives.J.': [2940], 'Soc.2011,': [2943], '133,': [2944], '15894–15897.': [2945], '22.': [2948], 'F.;': [2952, 3010, 3411], 'Cheng': [2953, 3128, 3183, 3193, 3579], 'J.-T.;': [2954, 3192], '[4+2]': [2963], 'Annulation': [2964], 'Oxidized': [2966], 'Enals': [2967], 'Azo': [2969], 'Dicarboxylates.Angew.': [2970], '10644–10647.': [2975], '23.': [2978], 'Yager': [2979], 'K.': [2980, 3384], 'Taylor': [2982], 'C.': [2983], 'Smith': [2985], 'B.Asymmetric': [2987], 'α-Aminophosphonates': [2990], 'Diastereoselective': [2992], 'Lithium': [2995], 'Diethyl': [2996], 'Phosphite': [2997], 'Chelating': [2999], 'Imines.J.': [3000], 'Soc.1994,': [3003], '116,': [3004], '9377–9378.': [3005], '24.': [3008], 'Orsini': [3009], 'Sello': [3011], 'Sisti': [3013], 'M.Aminophosphonic': [3014], 'Biological': [3020], 'Applications.Curr.': [3021], 'Med.': [3022, 3224], 'Chem.2010,': [3023], '17,': [3024], '264–289.': [3025], '25.': [3028], 'Slaughter': [3029], 'Miller': [3032, 3252], 'F.2-Amino-4-Phosphonobutyric': [3034], 'Acid:': [3035], 'Pharmacological': [3038], 'Tool': [3039], 'Retina': [3041], 'Research.Science1981,': [3042], '211,': [3043], '182–184.': [3044], '26.': [3047], 'Govea': [3048], 'Carlton': [3053], 'M.Group': [3055], 'III': [3056], 'Metabotropic': [3057], 'Glutamate': [3058], 'Receptors': [3059], 'Transient': [3061], 'Receptor': [3062], 'Potential': [3063], 'Vanilloid': [3064], 'Co-Localize': [3066], 'Interact': [3068], 'Nociceptors.Neuroscience2012,': [3070], '217,': [3071], '130–139.': [3072], '27.': [3075], 'Yang': [3076, 3078, 3131, 3583, 3585, 3911, 3962, 4124, 4150], 'S.-D.Highly': [3079], 'Divergent': [3082], 'Construction': [3083], 'γ-Phosphono-α-Amino': [3086], 'Palladium-Catalyzed': [3089], 'Alkylation': [3090], 'Unactivated': [3092, 3832, 3925], 'C(sp3)–H': [3093], 'Bonds.ACS': [3094], '5220–5224.': [3097], '28.': [3100], 'Seto': [3101], 'Kuzuyama': [3103], 'T.Bioactive': [3104], 'Products': [3106], 'Carbon–Phosphorus': [3108], 'Bonds': [3109, 4272], 'Their': [3111], 'Biosynthesis.Nat.': [3112], 'Prod.': [3113], 'Rep.1999,': [3114], '16,': [3115, 3860], '589–596.': [3116], '29.': [3119], 'Shie': [3120, 3157, 3196], 'J.-J.;': [3121, 3197, 3664], 'J.-M.;': [3123, 3160, 3211], 'S.-Y.;': [3125, 3209], 'Tsai': [3126], 'K.-C.;': [3127], 'Y.-S.': [3129, 3194], 'A.-S.;': [3132], 'Hsiao': [3133], 'S.-C.;': [3134], 'Su': [3135], 'C.-Y.;': [3136], 'Wong': [3137, 3161, 3215], 'C.-H.Synthesis': [3138], 'Tamiflu': [3140, 3172], 'Its': [3142, 4088], 'Phosphonate': [3143, 3219], 'Congeners': [3144, 3220], 'Possessing': [3145], 'Potent': [3146, 3169], 'Anti-Influenza': [3147, 3170, 3222], 'Activity.J.': [3148], 'Soc.2007,': [3151], '129,': [3152], '11892–11893.': [3153], '30.': [3156], 'J.-J.,': [3158], 'C.-H.A': [3162], 'Concise': [3163], 'Flexible': [3165], 'Agents': [3171], 'Tamiphosphor.Angew.': [3174], '5788–5791.': [3179], '31.': [3182], 'T.-J.': [3184], 'Weinheimer': [3186], 'Tarbet': [3188], 'Jan': [3191], 'C.-L.;': [3199], 'C.-A.;': [3201], 'Hsieh': [3202], 'W.-C.;': [3203], 'P.-W.;': [3205], 'W.-H.;': [3207], 'O.': [3213], 'Y.-P.;': [3214], 'C.-H.Development': [3216], 'Oseltamivir': [3218], 'Agents.J.': [3223], 'Chem.2012,': [3225], '55,': [3226, 3820], '8657–8670.': [3227], '32.': [3230], 'L.-W.;': [3232], 'Y.Phosphine-Triggered': [3236], 'Functionalized': [3239], 'Cyclic': [3240], 'Compounds.Chem.': [3241], 'Soc.': [3242, 3261, 3286], 'Rev.2008,': [3243], '37,': [3244], '1140–1152.': [3245], '33.': [3248], 'Cowen': [3249], 'J.Enantioselective': [3254], 'Complexity': [3257], 'Generation': [3258], 'Allenoates.Chem.': [3260], 'Rev.2009,': [3262], '38,': [3263], '3102–3116.': [3264], '34.': [3267], 'J.Recent': [3271], 'Developments': [3272], 'Utilization': [3277], 'β-Aminophosphine': [3280, 3653], 'Catalysts': [3283], 'Ligands.Chem.': [3285], 'Rev.2016,': [3287], '45,': [3288], '1657–1677.': [3289], '35.': [3292], 'Fan': [3295], 'Wu': [3300, 3612], 'Kwon': [3302], 'O.Phosphine': [3303], 'Organocatalysis.Chem.': [3304], 'Rev.2018,': [3305, 3320], '118,': [3306, 3321], '10049–10293.': [3307], '36.': [3310], 'Ni': [3311], 'Chan': [3313, 4206], 'W.-L.;': [3314, 3564], 'Lu': [3315, 3610, 4120], 'Y.Phosphine-Catalyzed': [3316], 'Organic': [3318], 'Reactions.Chem.': [3319], '9344–9411.': [3322], '37.': [3325], 'Joly': [3326], 'N.Thiourea-Catalyzed': [3331], 'Hydrophosphonylation': [3333, 3364, 3452, 3725], 'Imines:': [3335, 3366, 3544], 'Practical': [3336], 'Enriched': [3340], 'α-Amino': [3341, 3370, 3391, 3427, 3548], 'Acids.J.': [3343], '4102–4103.': [3348], '38.': [3351], 'Akiyama': [3352], 'Morita': [3354], 'Itoh': [3356], 'Fuchibe': [3358], 'K.Chiral': [3359], 'Bronsted': [3360, 3587], 'Phosphonates.Org.': [3371], 'Lett.2005,': [3372], '2583–2585.': [3374], '39.': [3377], 'Bernardi': [3378, 3414], 'L.,': [3379], 'Zhuang': [3380], 'W.': [3381], '&': [3382, 4314], 'Jorgensen': [3383], 'A.An': [3385, 3421], 'Easy': [3386, 3422], 'Approach': [3387], 'Optically': [3389, 3425], 'Active': [3390, 3426], 'Zn(II)-Catalyzed': [3397], 'Amination': [3399], 'Phosphonates.J.': [3401], 'Soc.2005,': [3404], '127,': [3405], '5772–5773.': [3406], '40.': [3409], 'Fini': [3410], 'Micheletti': [3412], 'Pettersen': [3416], 'Fochi': [3418], 'Ricci': [3420], '(PTC).Chem.': [3434], 'Commun.2008,': [3435, 3487], '44,': [3436, 3488], '4345–4347.': [3437], '41.': [3440], 'Nakamura': [3441], 'Nakashima': [3443], 'Yamamura': [3445], 'Shibata': [3447], 'Toru': [3449], 'T.Organocatalytic': [3450], 'Sulfonylimines': [3454], 'Having': [3455], 'Heteroarenesulfonyl': [3457], 'Group': [3458], 'Stereocontroller.Adv.': [3462], 'Synth.': [3463, 3684, 4233], 'Catal.2008,': [3464], '350,': [3465], '1209–1212.': [3466], '42.': [3469], 'Wilt': [3470], 'Pink': [3473], 'Johnston': [3475], 'N.A': [3477], 'Diastereo-': [3478], 'α-Substituted': [3483], 'Anti-α,β-Diaminophosphonic': [3484], 'Derivatives.Chem.': [3486], '4177–4179.': [3489], '43.': [3492], 'Loh': [3495], 'W.-T.;': [3496, 3607], 'C.-H.Chiral': [3508], 'Guanidinium': [3509], 'Salt': [3510], 'Phospha-Mannich': [3513], 'Ed.2009,': [3517], '48,': [3518, 3574], '7387–7390.': [3519], '44.': [3522], 'Ingle': [3523], 'Liang': [3526, 4063], 'Mormino': [3528], 'Fronczek': [3533], 'F.': [3534], 'Antilla': [3536], 'C.Chiral': [3538], 'Magnesium': [3539], 'BINOL': [3540], 'Phosphate-Catalyzed': [3541], 'Phosphination': [3542], 'Enantioenriched': [3547, 3949], 'Oxides.Org.': [3550], 'Lett.2011,': [3551], '13,': [3552], '2054–2057.': [3553], '45.': [3556], 'Xu': [3565], 'S.Palladium-Catalyzed': [3566], 'Diarylphosphines': [3570, 3674], 'N-Tosylimines.Chem.': [3572], 'Commun.2012,': [3573], '11148–11150.': [3575], '46.': [3578], 'M.-X.;': [3580], 'R.-S.;': [3582], 'S.-D.Chiral': [3586], 'Phosphonylation': [3591, 3621], 'Allylamine': [3593], 'Oxidative': [3595], 'Dehydrogenation': [3596], 'Coupling.Org.': [3597], 'Lett.2016,': [3598], '18,': [3599], '3262–3265.': [3600], '47.': [3603], 'D.-H.;': [3605], 'Zhu': [3608, 3762, 3867, 3938, 4036], 'C.-J.;': [3609], 'G.-S.;': [3611], 'D.-P.;': [3613], 'A.-E.;': [3615], 'P.-Q.Enantioselective': [3617], 'Reductive': [3618], 'Cyanation': [3619], 'Amides': [3624], 'Iridium': [3626], 'Thiourea': [3629], 'Sequential': [3630], 'Ed.2021,': [3634], '60,': [3635], '8827–8831.': [3636], '48.': [3639], 'C.-H.Bicyclic': [3645], 'Guanidine-Catalyzed': [3646], 'Phospha-Michael': [3648], 'Reaction:': [3649, 4186], 'Oxides': [3654], 'β-Aminophosphines.Chem.': [3656], 'Commun.2007,': [3657], '43,': [3658], '5058–5060.': [3659], '49.': [3662], 'Feng': [3663], 'Z.-Q.;': [3668], 'W.-L.Palladium-Catalyzed': [3670], '1,4-Addition': [3672], 'Nitroalkenes': [3676], 'P,': [3682], 'N-Compounds.Adv.': [3683], 'Catal.2012,': [3685], '354,': [3686], '3122–3126.': [3687], '50.': [3690], 'Du': [3691], 'H.-Q.;': [3692], 'X.-P.Rh-Catalyzed': [3694], 'Hydrogenation': [3696], '(Z)-β-Phosphorylated': [3698], 'Enamides:': [3699], 'β-Aminophosphines.Org.': [3704], 'Lett.2019,': [3705], '21,': [3706], '8921–8924.': [3707], '51.': [3710], 'Gu': [3711, 4007, 4152, 4176], 'G.-F.;': [3716], 'Y.-G.Synthesis': [3718], 'γ-Aminophosphonates': [3721], 'Organocatalytic': [3724], 'Azadienes': [3727], 'Phosphites.Org.': [3729], 'Front.2018,': [3731], '5,': [3732], '1148–1151.': [3733], '52.': [3736], 'Miki': [3737, 3839], 'Satoh': [3741, 3843], 'M.Copper-Catalyzed': [3744, 3846], 'Styrenes': [3749], 'Polymethylhydrosiloxane': [3751], 'Hydroxylamines.Angew.': [3753], '10830–10834.': [3758], '53.': [3761], 'Niljianskul': [3764, 3865], 'L.Enantio-': [3768], 'CuH-Catalyzed': [3771], 'Alkenes.J.': [3774], 'Soc.2013,': [3777], '135,': [3778], '15746–15749.': [3779], '54.': [3782], 'L.CuH-Catalyzed': [3788], 'Olefin': [3789], 'Functionalization:': [3790], 'From': [3791], 'Carbonyl': [3794], 'Addition.Acc.': [3795], 'Res.2000,': [3797], '53,': [3798], '1229–1243.': [3799], '55.': [3802], 'Pirnot': [3803], 'Y.-M.;': [3807], 'L.Copper': [3810], 'Hydride-Catalyzed': [3811], 'Alkenes': [3814, 3854], 'Alkynes.Angew.': [3816], 'Ed.2016,': [3819], '48–57.': [3821], '56.': [3824], 'Sorádová': [3825], 'Šebesta': [3827], 'R.Enantioselective': [3828], 'Functionalizations': [3830], 'Alkenes.ChemCatChem2016,': [3833], '8,': [3834, 4029], '2581–2588.': [3835], '57.': [3838], 'Formal': [3848], 'Oxa-': [3851], 'Azabicyclic': [3853], 'Hydrosilanes': [3856], 'Hydroxylamines.Org.': [3858], 'Lett.2014,': [3859], '1498–1501.': [3861], '58.': [3864], 'L.Enantioselective': [3871, 4040], 'α-Aminosilanes': [3874], 'Vinylsilanes.Angew.': [3879], 'Ed.2015,': [3882], '54,': [3883], '1638–1641.': [3884], '59.': [3887], 'Nishikawa': [3888, 4098], 'M.Asymmetric': [3893], 'α-Aminoboronic': 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'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 2}], 'updated_date': '2024-12-12T02:31:38.692153', 'created_date': '2021-07-19'}
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