Title: Fluorescence in situ hybridization (FISH) : applications in haematological cytogenetics
Abstract: Fluorescence in situ hybridization (FISH) is a powerful tool for the cytogenetic analysis of haematological malignancies. The availability of several types of DNA probes that can be chemically labelled and detected by fluorescence methods has provided widely ranging applications. FISH is a rapid and sensitive technique allowing detection of numerical and structural chromosome changes in metaphase and interphase cells. Interphase cytogenetics provides an important mean to analyse cells that exhibit a low mitotic rate or are present in a low number (minimal residual disease). FISH on metaphase cells improves the accuracy of conventional cytogenetics particularly when caryotypes are complex or when chromosomal abnormalities are submicroscopic. In this review, examples of these applications are presented and discussed.
Publication Year: 1995
Publication Date: 1995-06-15
Language: en
Type: article
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