Publication Information

{'id': 'https://openalex.org/W3178799725', 'doi': 'https://doi.org/10.1158/1538-7445.am2021-1459', 'title': 'Abstract 1459: PTP4A3 phosphatase is a novel drug target for epithelial ovarian cancer', 'display_name': 'Abstract 1459: PTP4A3 phosphatase is a novel drug target for epithelial ovarian cancer', 'publication_year': 2021, 'publication_date': '2021-07-01', 'ids': {'openalex': 'https://openalex.org/W3178799725', 'doi': 'https://doi.org/10.1158/1538-7445.am2021-1459', 'mag': '3178799725'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2021-1459', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042435282', 'display_name': 'John Robert Cornelison', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'John Robert Cornelison', 'raw_affiliation_strings': ['1KeViRx, Inc., Charlottesville, VA;'], 'affiliations': [{'raw_affiliation_string': '1KeViRx, Inc., Charlottesville, VA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071988542', 'display_name': 'Ettore J. Rastelli', 'orcid': 'https://orcid.org/0000-0003-2778-7635'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ettore J. Rastelli', 'raw_affiliation_strings': ['2University of Pittsburgh, Pittsburgh, PA;'], 'affiliations': [{'raw_affiliation_string': '2University of Pittsburgh, Pittsburgh, PA;', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064972037', 'display_name': 'Duncan J. Hart', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I51556381', 'display_name': 'University of Virginia', 'ror': 'https://ror.org/0153tk833', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I51556381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Duncan J. Hart', 'raw_affiliation_strings': ['3University of Virginia, Charlottesville, VA.'], 'affiliations': [{'raw_affiliation_string': '3University of Virginia, Charlottesville, VA.', 'institution_ids': ['https://openalex.org/I51556381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018690790', 'display_name': 'Anna J. Mendelson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I51556381', 'display_name': 'University of Virginia', 'ror': 'https://ror.org/0153tk833', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I51556381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anna J. Mendelson', 'raw_affiliation_strings': ['3University of Virginia, Charlottesville, VA.'], 'affiliations': [{'raw_affiliation_string': '3University of Virginia, Charlottesville, VA.', 'institution_ids': ['https://openalex.org/I51556381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086296534', 'display_name': 'Elizabeth R. Sharlow', 'orcid': 'https://orcid.org/0000-0002-7957-3594'}, 'institutions': [{'id': 'https://openalex.org/I51556381', 'display_name': 'University of Virginia', 'ror': 'https://ror.org/0153tk833', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I51556381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth R. Sharlow', 'raw_affiliation_strings': ['3University of Virginia, Charlottesville, VA.'], 'affiliations': [{'raw_affiliation_string': '3University of Virginia, Charlottesville, VA.', 'institution_ids': ['https://openalex.org/I51556381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018024103', 'display_name': 'Peter Wipf', 'orcid': 'https://orcid.org/0000-0001-7693-5863'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter Wipf', 'raw_affiliation_strings': ['2University of Pittsburgh, Pittsburgh, PA;'], 'affiliations': [{'raw_affiliation_string': '2University of Pittsburgh, Pittsburgh, PA;', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085858115', 'display_name': 'John S. Lazo', 'orcid': 'https://orcid.org/0000-0002-0645-4025'}, 'institutions': [{'id': 'https://openalex.org/I51556381', 'display_name': 'University of Virginia', 'ror': 'https://ror.org/0153tk833', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I51556381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John S. Lazo', 'raw_affiliation_strings': ['3University of Virginia, Charlottesville, VA.'], 'affiliations': [{'raw_affiliation_string': '3University of Virginia, Charlottesville, VA.', 'institution_ids': ['https://openalex.org/I51556381']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 57}, 'biblio': {'volume': '81', 'issue': '13_Supplement', 'first_page': '1459', 'last_page': '1459'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12104', 'display_name': 'Protein Tyrosine Phosphatases', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12104', 'display_name': 'Protein Tyrosine Phosphatases', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6077975}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.47394183}, {'id': 'https://openalex.org/C207103383', 'wikidata': 'https://www.wikidata.org/wiki/Q3930246', 'display_name': 'Hazard ratio', 'level': 3, 'score': 0.46849567}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.46042514}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.45517567}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.44433165}, {'id': 'https://openalex.org/C2780427987', 'wikidata': 'https://www.wikidata.org/wiki/Q172341', 'display_name': 'Ovarian cancer', 'level': 3, 'score': 0.4439015}, {'id': 'https://openalex.org/C150173356', 'wikidata': 'https://www.wikidata.org/wiki/Q6144101', 'display_name': 'Serous fluid', 'level': 2, 'score': 0.42924154}, {'id': 'https://openalex.org/C44249647', 'wikidata': 'https://www.wikidata.org/wiki/Q208498', 'display_name': 'Confidence interval', 'level': 2, 'score': 0.077785194}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2021-1459', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.75, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4322709813', 'https://openalex.org/W4231508397', 'https://openalex.org/W2607392433', 'https://openalex.org/W2605096467', 'https://openalex.org/W2418957561', 'https://openalex.org/W2314460022', 'https://openalex.org/W2014221109', 'https://openalex.org/W1997140422', 'https://openalex.org/W1985790301', 'https://openalex.org/W183804059'], 'abstract_inverted_index': {'Abstract': [0], 'High': [1], 'grade': [2], 'serous': [3], 'ovarian': [4, 11, 105, 348], 'cancer': [5, 12, 106, 349], '(HGSOC)': [6], 'is': [7, 66, 70, 90, 341], 'the': [8, 25, 104, 108, 228, 249, 259, 300, 303, 354], 'deadliest': [9], 'epithelial': [10, 347], '(EOC)': [13], 'variant,': [14], 'with': [15, 60, 119, 139, 145, 254, 289], 'a': [16, 94, 279, 296, 310, 315, 342], 'bleak': [17], 'outcome': [18], 'that': [19, 72, 113], 'kills': [20], '>14,000': [21], 'women': [22], 'annually': [23], 'in': [24, 41, 49, 58, 93, 122, 160, 187, 208, 314], 'US.': [26], 'In': [27, 128], 'past': [28], 'four': [29], 'decades,': [30], 'first': [31], 'line': [32, 253], 'therapies': [33, 45], 'have': [34, 46, 54], 'changed': [35], 'only': [36], 'modestly.': [37], 'While': [38], 'dramatic': [39], 'advances': [40], 'targeted-': [42], 'and': [43, 63, 183, 202, 230, 234, 264, 366], 'immune-based': [44], 'been': [47, 56], 'seen': [48], 'some': [50], 'solid': [51], 'tumors,': [52, 97], 'they': [53], 'not': [55], 'reported': [57], 'patients': [59, 148, 156], 'HGSOC.': [61, 99, 316], 'Recurrent': [62], 'chemoresistant': [64, 233], 'HGSOC': [65, 74, 129, 196, 250], 'common.': [67], 'Therefore,': [68], 'it': [69], 'imperative': [71], 'new': [73], 'drug': [75, 344], 'targets': [76], 'be': [77], 'interrogated.': [78], 'The': [79], 'Protein': [80], 'Tyrosine': [81], 'Phosphatases': [82], 'of': [83, 96, 103, 180, 194, 223, 232, 240, 248, 266, 273, 275, 278, 281, 302, 306, 353], 'Regenerating': [84], 'Liver': [85], '(PRL': [86], 'or': [87, 243], 'PTP4A)': [88], 'family': [89, 305], 'significantly': [91], 'upregulated': [92], 'variety': [95], 'including': [98, 199, 285], 'A': [100, 216], 'bioinformatic': [101], 'analysis': [102], 'using': [107], 'KMplot': [109], 'Survival': [110], 'Database': [111], 'revealed': [112], 'high': [114, 154, 169], 'PTP4A3': [115, 133, 209, 339], 'expression': [116, 134, 162, 170, 211], 'was': [117, 184], 'associated': [118], 'poor': [120], 'survival': [121, 140, 159, 176, 231], 'EOC': [123, 236], '(p<0.0001,': [124], 'hazard': [125], 'ratio': [126], '(HR)=1.35).': [127], 'early': [130], 'stage': [131], 'disease,': [132], 'levels': [135], 'were': [136], 'also': [137], 'correlated': [138], '(stage': [141, 190], 'I/II-': [142], 'p=0.0013,': [143], 'HR=3.2),': [144], 'low': [146, 161], 'expressing': [147, 155], 'surviving': [149], 'twice': [150], 'as': [151, 153, 309], 'long': [152], '(upper': [157], 'quartile': [158], 'cohort': [163, 171], '=': [164, 172], '81.2': [165], 'months': [166], 'compared': [167], 'to': [168], '44.3': [173], 'months).': [174], 'This': [175], 'difference': [177], 'appeared': [178], 'independent': [179, 239], 'myc': [181], 'amplification': [182], 'more': [185], 'pronounced': [186], 'advanced': [188], 'disease': [189], 'III/IV).': [191], 'qPCR': [192], 'profiling': [193], 'established': [195], 'cell': [197, 237, 252], 'lines,': [198], 'Kuramochi,': [200], 'COV362': [201], 'OVCAR4,': [203], 'showed': [204], '5-20': [205], 'fold': [206], 'increases': [207], 'gene': [210], 'versus': [212], 'nonmalignant': [213], 'control': [214], 'cells.': [215], 'potent,': [217], 'specific,': [218], 'allosteric': [219], 'small': [220], 'molecule': [221], 'inhibitor': [222], 'PTP4A3,': [224], 'KVX-053,': [225], 'markedly': [226], 'reduced': [227], 'growth': [229], 'chemosensitive': [235], 'lines': [238], 'their': [241], 'BRCA': [242], 'p53': [244], 'status.': [245], 'Moreover,': [246], 'treatment': [247], 'OVCAR4': [251], 'KVX-053': [255], '(1': [256], 'μM)': [257], 'inhibited': [258], 'oncogenic': [260], 'Janus': [261], 'kinase-signal': [262], 'transducer': [263], 'activator': [265], 'transcription': [267], '(JAK-STAT)': [268], 'signaling': [269], 'pathway': [270], 'through': [271], 'loss': [272], 'phosphorylation': [274], 'STAT3.': [276], 'Evaluation': [277], 'series': [280], 'next-generation': [282], 'KVX-053-based': [283], 'analogs': [284], 'chemodegraders': [286], 'yielded': [287], 'chemotypes': [288], 'enhanced': [290], 'cytotoxic': [291], 'effects.': [292], 'These': [293], 'results': [294], 'demonstrate': [295], 'clear': [297], 'path': [298], 'for': [299, 346, 357], 'development': [301], 'PTP4A': [304], 'tyrosine': [307], 'phosphatases': [308], 'novel': [311, 343], 'therapeutic': [312], 'target': [313, 345], 'Citation': [317], 'Format:': [318], 'John': [319, 336], 'Robert': [320], 'Cornelison,': [321], 'Ettore': [322], 'J.': [323, 326, 329], 'Rastelli,': [324], 'Duncan': [325], 'Hart,': [327], 'Anna': [328], 'Mendelson,': [330], 'Elizabeth': [331], 'R.': [332], 'Sharlow,': [333], 'Peter': [334], 'Wipf,': [335], 'S.': [337], 'Lazo.': [338], 'phosphatase': [340], '[abstract].': [350], 'In:': [351], 'Proceedings': [352], 'American': [355], 'Association': [356], 'Cancer': [358, 372], 'Research': [359], 'Annual': [360], 'Meeting': [361], '2021;': [362], '2021': [363], 'Apr': [364], '10-15': [365], 'May': [367], '17-21.': [368], 'Philadelphia': [369], '(PA):': [370], 'AACR;': [371], 'Res': [373], '2021;81(13_Suppl):Abstract': [374], 'nr': [375], '1459.': [376]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3178799725', 'counts_by_year': [], 'updated_date': '2025-01-28T06:00:14.949848', 'created_date': '2021-07-19'}