Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3178697376', 'doi': 'https://doi.org/10.2147/dddt.s308610', 'title': 'A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects', 'display_name': 'A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects', 'publication_year': 2021, 'publication_date': '2021-07-01', 'ids': {'openalex': 'https://openalex.org/W3178697376', 'doi': 'https://doi.org/10.2147/dddt.s308610', 'mag': '3178697376', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34262260', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8273902'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2147/dddt.s308610', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2496126384', 'display_name': 'Drug Design Development and Therapy', 'issn_l': '1177-8881', 'issn': ['1177-8881'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.dovepress.com/getfile.php?fileID=71340', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101079960', 'display_name': 'Hongjie Qian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210117527', 'display_name': 'Shanghai Xuhui Central Hospital', 'ror': 'https://ror.org/01whmzn59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117527']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hongjie Qian', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210117527']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100428454', 'display_name': 'Qian Chen', 'orcid': 'https://orcid.org/0000-0002-1487-5479'}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210117527', 'display_name': 'Shanghai Xuhui Central Hospital', 'ror': 'https://ror.org/01whmzn59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117527']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qian Chen', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210117527']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060575663', 'display_name': 'Liyu Liang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117527', 'display_name': 'Shanghai Xuhui Central Hospital', 'ror': 'https://ror.org/01whmzn59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117527']}, {'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liyu Liang', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210117527']}, {'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102778331', 'display_name': 'Yang Zou', 'orcid': 'https://orcid.org/0000-0003-0887-7096'}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210117527', 'display_name': 'Shanghai Xuhui Central Hospital', 'ror': 'https://ror.org/01whmzn59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117527']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Zou', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210117527']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112661183', 'display_name': 'Huahua Pu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210117527', 'display_name': 'Shanghai Xuhui Central Hospital', 'ror': 'https://ror.org/01whmzn59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117527']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huahua Pu', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210117527']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110443425', 'display_name': 'Liang Xin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210117527', 'display_name': 'Shanghai Xuhui Central Hospital', 'ror': 'https://ror.org/01whmzn59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117527']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liang Xin', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210117527']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046786528', 'display_name': 'Rong Song', 'orcid': 'https://orcid.org/0000-0003-3662-116X'}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210117527', 'display_name': 'Shanghai Xuhui Central Hospital', 'ror': 'https://ror.org/01whmzn59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117527']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Rong Song', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210117527']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100416475', 'display_name': 'Tingting Li', 'orcid': 'https://orcid.org/0000-0002-6113-1624'}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210117527', 'display_name': 'Shanghai Xuhui Central Hospital', 'ror': 'https://ror.org/01whmzn59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117527']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tingting Li', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210117527']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100554265', 'display_name': 'Huijuan Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210117527', 'display_name': 'Shanghai Xuhui Central Hospital', 'ror': 'https://ror.org/01whmzn59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117527']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huijuan Zhu', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210117527']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100672874', 'display_name': 'Yu Wang', 'orcid': 'https://orcid.org/0000-0002-8528-3227'}, 'institutions': [{'id': 'https://openalex.org/I4210112820', 'display_name': 'Shanghai Institute of Materia Medica', 'ror': 'https://ror.org/022syn853', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210112820']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yu Wang', 'raw_affiliation_strings': ["CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210112820', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007878143', 'display_name': 'Guanghui Tian', 'orcid': 'https://orcid.org/0000-0002-7988-5715'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Guanghui Tian', 'raw_affiliation_strings': ["Vigonvita Life Science Co., Ltd., Suzhou, 215123, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Vigonvita Life Science Co., Ltd., Suzhou, 215123, People's Republic of China", 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008792226', 'display_name': 'Jingshan Shen', 'orcid': 'https://orcid.org/0000-0001-9679-9934'}, 'institutions': [{'id': 'https://openalex.org/I4210112820', 'display_name': 'Shanghai Institute of Materia Medica', 'ror': 'https://ror.org/022syn853', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210112820']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jingshan Shen', 'raw_affiliation_strings': ["CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210112820', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001392142', 'display_name': 'Hualiang Jiang', 'orcid': 'https://orcid.org/0000-0003-0656-6315'}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210112820', 'display_name': 'Shanghai Institute of Materia Medica', 'ror': 'https://ror.org/022syn853', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210112820']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hualiang Jiang', 'raw_affiliation_strings': ["CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210112820', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105413731', 'display_name': 'Chen Yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210117527', 'display_name': 'Shanghai Xuhui Central Hospital', 'ror': 'https://ror.org/01whmzn59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117527']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chen Yu', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210117527']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100422287', 'display_name': 'Zhen Wang', 'orcid': 'https://orcid.org/0000-0001-9450-2260'}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210112820', 'display_name': 'Shanghai Institute of Materia Medica', 'ror': 'https://ror.org/022syn853', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210112820']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhen Wang', 'raw_affiliation_strings': ["CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210112820', 'https://openalex.org/I19820366']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038725556', 'display_name': 'Jingying Jia', 'orcid': 'https://orcid.org/0000-0002-2492-3219'}, 'institutions': [{'id': 'https://openalex.org/I4210157781', 'display_name': 'Shanghai Clinical Research Center', 'ror': 'https://ror.org/057tkkm33', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157781']}, {'id': 'https://openalex.org/I4210117527', 'display_name': 'Shanghai Xuhui Central Hospital', 'ror': 'https://ror.org/01whmzn59', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117527']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Jingying Jia', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Shanghai Engineering Research Center of Phase I Clinical Research & Quality Consistency Evaluation for Drugs, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210157781']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, 200031, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210117527']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5038725556'], 'corresponding_institution_ids': ['https://openalex.org/I4210157781', 'https://openalex.org/I4210117527'], 'apc_list': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.512, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.800828, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 72, 'max': 76}, 'biblio': {'volume': 'Volume 15', 'issue': None, 'first_page': '2947', 'last_page': '2959'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10728', 'display_name': 'Pulmonary Hypertension Research and Treatments', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10728', 'display_name': 'Pulmonary Hypertension Research and Treatments', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12434', 'display_name': 'Phosphodiesterase function and regulation', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10198', 'display_name': 'Heart Failure Treatment and Management', 'score': 0.995, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tolerability', 'display_name': 'Tolerability', 'score': 0.8994502}], 'concepts': [{'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.90886605}, {'id': 'https://openalex.org/C2778375690', 'wikidata': 'https://www.wikidata.org/wiki/Q7814214', 'display_name': 'Tolerability', 'level': 3, 'score': 0.8994502}, {'id': 'https://openalex.org/C22979827', 'wikidata': 'https://www.wikidata.org/wiki/Q5137311', 'display_name': 'Cmax', 'level': 3, 'score': 0.8601876}, {'id': 'https://openalex.org/C2777288759', 'wikidata': 'https://www.wikidata.org/wiki/Q4164182', 'display_name': 'Dosing', 'level': 2, 'score': 0.678739}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6649163}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.6080144}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.59785646}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.52288955}, {'id': 'https://openalex.org/C2777056448', 'wikidata': 'https://www.wikidata.org/wiki/Q285166', 'display_name': 'Oral administration', 'level': 2, 'score': 0.41732946}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32061833}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018565', 'descriptor_name': 'Food-Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D058986', 'descriptor_name': 'Phosphodiesterase 5 Inhibitors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D011744', 'descriptor_name': 'Pyrimidinones', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019540', 'descriptor_name': 'Area Under Curve', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018592', 'descriptor_name': 'Cross-Over Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006207', 'descriptor_name': 'Half-Life', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058986', 'descriptor_name': 'Phosphodiesterase 5 Inhibitors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D058986', 'descriptor_name': 'Phosphodiesterase 5 Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058986', 'descriptor_name': 'Phosphodiesterase 5 Inhibitors', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D011744', 'descriptor_name': 'Pyrimidinones', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D011744', 'descriptor_name': 'Pyrimidinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011744', 'descriptor_name': 'Pyrimidinones', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2147/dddt.s308610', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2496126384', 'display_name': 'Drug Design Development and Therapy', 'issn_l': '1177-8881', 'issn': ['1177-8881'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/9e6625fc650f4fc5a67e6b10d73cdef8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.dovepress.com/a-phase-i-study-to-evaluate-the-safety-tolerability-and-pharmacokineti-peer-reviewed-fulltext-article-DDDT', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=71340', 'source': {'id': 'https://openalex.org/S4306401012', 'display_name': 'Dove Medical Press (Taylor and Francis Group)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273902', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34262260', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.dovepress.com/a-phase-i-study-to-evaluate-the-safety-tolerability-and-pharmacokineti-peer-reviewed-fulltext-article-DDDT', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=71340', 'source': {'id': 'https://openalex.org/S4306401012', 'display_name': 'Dove Medical Press (Taylor and Francis Group)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.44, 'id': 'https://metadata.un.org/sdg/16', 'display_name': 'Peace, justice, and strong institutions'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 18, 'referenced_works': ['https://openalex.org/W1558292706', 'https://openalex.org/W1567859570', 'https://openalex.org/W1960650662', 'https://openalex.org/W2004405846', 'https://openalex.org/W2011477996', 'https://openalex.org/W2037180336', 'https://openalex.org/W2121376498', 'https://openalex.org/W2148038451', 'https://openalex.org/W2148797779', 'https://openalex.org/W2158862125', 'https://openalex.org/W2159885935', 'https://openalex.org/W2166964193', 'https://openalex.org/W2313326603', 'https://openalex.org/W2342923657', 'https://openalex.org/W2905582258', 'https://openalex.org/W2942145199', 'https://openalex.org/W3088705025', 'https://openalex.org/W3113102400'], 'related_works': ['https://openalex.org/W2413891776', 'https://openalex.org/W2380986117', 'https://openalex.org/W2374254312', 'https://openalex.org/W2373403320', 'https://openalex.org/W2371426955', 'https://openalex.org/W2360876458', 'https://openalex.org/W2355979670', 'https://openalex.org/W2348752634', 'https://openalex.org/W22938106', 'https://openalex.org/W1978721469'], 'abstract_inverted_index': {'TPN171H': [0, 34, 90, 138, 149, 179, 192, 199, 238], 'is': [1], 'a': [2, 181, 233], 'novel,': [3], 'potent': [4], 'and': [5, 31, 40, 52, 73, 117, 123, 175, 209, 214, 226, 246], 'selective': [6], 'phosphodiesterase': [7], 'type': [8], '5': [9], '(PDE5)': [10], 'inhibitor': [11], 'for': [12, 108, 173], 'the': [13, 28, 47, 88, 104, 131, 168, 222], 'treatment': [14], 'of': [15, 22, 33, 54, 60, 81, 137, 229, 237], 'pulmonary': [16], 'arterial': [17], 'hypertension': [18], '(PAH).': [19], 'The': [20], 'objective': [21], 'this': [23], 'study': [24, 57], 'was': [25, 58, 94, 112, 139, 200, 212], 'to': [26, 45, 127, 202], 'evaluate': [27], 'safety,': [29], 'tolerability,': [30], 'pharmacokinetics': [32, 51], 'in': [35, 43, 87, 217, 239, 243], 'healthy': [36, 83, 218, 244], 'subjects': [37, 84, 245], 'after': [38, 191], 'single': [39], 'multiple': [41], 'dosing,': [42], 'addition,': [44], 'investigate': [46], 'food': [48, 224], 'effect': [49, 71, 162], 'on': [50, 163, 206, 221], 'safety': [53, 227], 'TPN171H.The': [55], 'entire': [56], 'comprised': [59], 'three': [61], 'parts:': [62], 'Part': [63, 68, 74, 120, 143, 166], 'I': [64], '(single': [65], 'ascending-dose': [66, 77], 'study),': [67, 72], 'II': [69], '(food': [70], 'III': [75], '(multiple': [76], 'study).': [78], 'A': [79], 'total': [80], '63': [82], 'were': [85, 101, 125, 188], 'enrolled': [86], 'study.': [89], 'tablet': [91], 'or': [92], 'placebo': [93], 'administered': [95], 'per': [96], 'protocol': [97], 'requirements.': [98], 'Blood': [99], 'samples': [100], 'collected': [102], 'at': [103, 171], 'designated': [105], 'time': [106], 'points': [107], 'pharmacokinetic': [109], 'analysis.': [110], 'Safety': [111], 'assessed': [113], 'by': [114], 'clinical': [115, 241], 'examinations': [116], 'adverse': [118], 'events.In': [119], 'I,': [121], 'AUC': [122, 174], 'Cmax': [124, 176], 'proved': [126], 'be': [128], 'linear': [129], 'within': [130], '5-30': [132], 'mg': [133], 'dose': [134], 'range.': [135], 'T1/2': [136], '8.02-10.88': [140], 'h.': [141], 'In': [142, 165], 'II,': [144], 'we': [145, 231], 'figured': [146], 'out': [147], 'that': [148, 178], 'administration': [150, 236], 'under': [151], 'fed': [152], 'condition': [153], 'could': [154], 'decrease': [155], 'Cmax,': [156], 'prolong': [157], 'Tmax,': [158], 'but': [159], 'had': [160], 'no': [161, 204], 'AUC.': [164], 'III,': [167], 'accumulation': [169, 183], 'ratio': [170], 'steady-state': [172], 'indicated': [177], 'has': [180], 'slight': [182], 'upon': [184], 'repeated': [185], 'dosing.': [186], 'Subjects': [187], 'generally': [189, 215], 'tolerable': [190], 'administration.': [193], 'Compared': [194], 'with': [195, 248], 'other': [196], 'PDE5': [197], 'inhibitors,': [198], 'found': [201], 'have': [203], 'impact': [205], 'blood': [207], 'pressure': [208], 'color': [210], 'discrimination.TPN171H': [211], 'safe': [213], 'tolerated': [216], 'subjects.': [219], 'Based': [220], 'half-life,': [223], 'effect,': [225], 'profile': [228], 'TPN171H,': [230], 'recommend': [232], 'once-daily,': [234], 'post-meal': [235], 'subsequent': [240], 'studies': [242], 'patients': [247], 'PAH.': [249]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3178697376', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-24T05:47:29.905979', 'created_date': '2021-07-19'}