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'study.': [85], 'One': [86], 'patient,': [87], 'a': [88, 120, 133, 137, 378, 383, 448], '25': [89], 'y/o': [90], 'DMG,': [94], 'developed': [95, 226, 303], 'rapidly': [96], 'progressive': [97], 'disease': [98, 282], 'after': [99, 222, 241], 'enrollment,': [100], 'resulting': [101], 'complete': [103], 'paraparesis': [104], 'led': [106], 'to': [107, 113, 169, 244, 336, 403, 427, 437, 469], 'removal': [108, 312], 'from': [109, 487], 'study': [111], 'prior': [112], 'cell': [114, 172, 199, 416, 457], 'infusion;': [115], 'she': [116], 'was': [117, 148, 182, 324], 'treated': [118, 376], 'single': [121, 379], 'patient': [122, 302, 375, 380], 'eIND': [123, 381], 'same': [126], 'treatment': [127], 'regimen': [128], 'as': [129, 295], 'utilized': [132], 'retroviral': [134], 'vector': [135], 'expressing': [136], '14g2a.4-1BB.z': [138], 'construct': [140], 'an': [142], 'inducible': [143], 'iCasp9': [144], 'safety': [145, 450], 'switch.': [146], 'Manufacturing': [147], 'performed': [149], 'Miltenyi': [152], 'Prodigy': [153], 'CD4/CD8': [155], 'enriched': [156], 'apheresis': [157], 'product.': [158], 'cultured': [163], 'presence': [166], 'of': [167, 189, 281, 297, 305, 313, 320, 367, 398, 412, 442, 455, 602], 'dasatinib': [168], 'improve': [170], 'fitness': [173], '(Weber': [174], 'Science,': [177], '2021).': [178], 'An': [179], 'Ommaya': [180], 'reservoir': [181], 'placed': [183], 'all': [185, 205], 'patients': [186, 225, 252, 361, 473, 488], 'for': [187, 204, 219, 246, 418, 472, 606], 'monitoring': [188], 'intracranial': [190], 'pressure': [191], '(ICP).': [192], 'Results:': [193], 'generated': [195], 'products': [200], 'meeting': [201], 'release': [202, 228], 'criteria': [203], 'four': [206], 'patients.': [207, 328], 'All': [208, 224], 'lymphodepletion': [211], 'cyclophosphamide': [213], 'fludarabine': [215], 'remained': [217], 'inpatient': [218], '14+': [220], 'days': [221, 240], 'infusion.': [223, 242], 'cytokine': [227], 'syndrome': [229], '(Grade': [230, 272], '1-3)': [231], 'manifested': [232, 294], 'by': [233, 277], 'fever,': [234], 'tachycardia': [235], 'hypotension,': [237], 'beginning': [238], '6-7': [239], 'Due': [243], 'concern': [245], 'tumoral': [247], 'edema': [248], 'increased': [250, 306], 'ICP,': [251], 'managed': [254], 'conservative': [256], 'fluid': [257], 'resuscitation,': [258], 'early': [260], 'intervention': [261], 'tocilizumab': [263], 'anakinra': [265], '+/-': [266], 'corticosteroids.': [267], 'Other': [268], 'toxicities': [269, 331], 'included': [270], 'ICANS': [271], '1-2)': [273], 'neurotoxicity': [275], 'mediated': [276], 'inflammation': [278, 438], 'sites': [280, 441], 'which': [283, 308], 'we': [284], 'have': [285], 'termed': [286], 'Tumor': [287], 'Inflammation-Associated': [288], 'Neurotoxicity': [289], '(TIAN).': [290], 'TIAN': [291], 'most': [292], 'often': [293], 'worsening': [296], 'existing': [298], 'deficits,': [299], 'but': [300], 'one': [301], 'symptoms': [304], 'ICP': [307], 'quickly': [309], 'resolved': [310], 'upon': [311], 'CSF': [314, 345, 357], 'via': [315], 'Ommaya.': [317], 'No': [318, 329], 'evidence': [319], 'on-target,': [321], 'off-tumor': [322], 'toxicity': [323, 586], 'observed': [325], 'any': [327], 'dose-limiting': [330], 'occurred.CAR': [332], 'trafficked': [335], 'CNS': [338, 440], 'detected': [341], 'both': [343], 'peripheral': [347], 'blood.': [348, 359], 'Inflammatory': [349], 'cytokines': [350], 'including': [351, 461, 480], 'IL-6': [352], 'elevated': [354], '3/4': [360], 'exhibited': [362, 382], 'marked': [363], 'improvement': [364], 'or': [365], 'resolution': [366], 'neurological': [368], 'deficits': [369], 'some': [371], 'radiographic': [372], 'improvement.': [373], 'The': [374], '>90%': [384], 'reduction': [385], 'her': [387], 'DMG': [390], 'tumor': [391], 'volume': [392], 'two': [394], 'months': [395], 'post-infusion.': [396], 'Durability': [397], 'therapeutic': [400], 'benefit': [401], 'remains': [402], 'be': [404, 495], 'determined.': [405], 'Conclusions:': [406], 'This': [407, 464], 'first': [410], 'report': [411], 'therapy': [417, 471], 'DMG.': [423], 'Toxicities': [424], 'similar': [426], 'additional,': [433], 'manageable': [434, 585], 'complications': [435], 'due': [436], 'tumor.': [443], 'Treatment': [444], 'DL1': [446], 'tolerable': [449], 'profile': [451], 'clear': [453], 'signs': [454], 'expansion': [458], 'activity': [460, 583], 'clinical': [462, 582], 'responses.': [463], 'approach': [465], 'has': [466], 'potential': [468], 'transform': [470], 'DIPG/DMG.': [476], 'Further': [477], 'correlative': [478], 'studies,': [479], 'single-cell': [481], 'RNAseq,': [482], 'longer-term': [483], 'outcomes': [484], 'results': [486], 'subsequent': [490], 'dose': [491], 'levels': [492], 'will': [493], 'also': [494], 'presented.': [496], 'Citation': [497], 'Format:': [498], 'Robbie': [499], 'G.': [500], 'Majzner,': [501], 'Sneha': [502], 'Ramakrishna,': [503], 'Aaron': [504], 'Mochizuki,': [505], 'Shabnum': [506], 'Patel,': [507], 'Harshini': [508], 'Chinnasamy,': [509], 'Kristen': [510], 'Yeom,': [511], 'Liora': [512], 'Schultz,': [513], 'Rebecca': [514], 'Richards,': [515], 'Cynthia': [516], 'Campen,': [517], 'Agnes': [518], 'Reschke,': [519], 'Jasia': [520], 'Mahdi,': [521], 'Angus': [522], 'Martin': [523], 'Shaw': [524], 'Toland,': [525], 'Christina': [526], 'Baggott,': [527], 'Sharon': [528], 'Mavroukakis,': [529], 'Emily': [530], 'Egeler,': [531], 'Jennifer': [532], 'Moon,': [533], 'Kayla': [534], 'Landrum,': [535], 'Courtney': [536], 'Erickson,': [537], 'Lindsey': [538], 'Rasmussen,': [539], 'Valentin': [540], 'Barsan,': [541], 'John': [542], 'S.': [543], 'Tamaresis,': [544], 'Anne': [545], 'Cunniffe': [546], 'Marcy,': [547], 'Michael': [548], 'Kunicki,': [549], 'Michelle': [550, 575], 'Fujimoto,': [551], 'Zach': [552], 'Ehlinger,': [553], 'Sreevidya': [554], 'Kurra,': [555], 'Timothy': [556], 'Cornell,': [557], 'Sonia': [558], 'Partap,': [559], 'Paul': [560], 'Fisher,': [561], 'Gerald': [562], 'Grant,': [563], 'Hannes': [564], 'Vogel,': [565], 'Bita': [566], 'Sahaf,': [567], 'Kara': [568], 'Davis,': [569], 'Steven': [570], 'Feldman,': [571], 'Crystal': [572], 'L.': [573], 'Mackall,': [574], 'Monje.': [576], 'mediate': [581], 'children': [588], 'young': [590], 'adults': [591], '[abstract].': [599], 'In:': [600], 'Proceedings': [601], 'American': [604], 'Association': [605], 'Cancer': [607, 621], 'Research': [608], 'Annual': [609], 'Meeting': [610], '2021;': [611], '2021': [612], 'Apr': [613], '10-15': [614], 'May': [616], '17-21.': [617], 'Philadelphia': [618], '(PA):': [619], 'AACR;': [620], 'Res': [622], '2021;81(13_Suppl):Abstract': [623], 'nr': [624], 'CT031.': [625]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3177273112', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}], 'updated_date': '2024-09-19T01:08:56.392295', 'created_date': '2021-07-05'}