Title: Enzymes as Escorts in Organometallic Cofactor Trafficking
Abstract:Many coenzymes are vitamins that are assimilated in mammals into their active form from precursors obtained from the diet. They are often both rare and reactive rendering the likelihood that the cell ...Many coenzymes are vitamins that are assimilated in mammals into their active form from precursors obtained from the diet. They are often both rare and reactive rendering the likelihood that the cell uses a collision‐based strategy for their delivery to dependent enzymes, low. The problem is especially acute for B 12 , an organometallic cofactor that is reactive in all three of its biologically relevant oxidation states, is usually present at very low concentrations, and is only used by a limited group of enzymes. To avert problems of cofactor dilution and inactivation in an intracellular milieu, we have proposed that enzymes that catalyze the ultimate step in cofactor assimilation pathways may also function as escorts for targeted delivery of their products. We will discuss recent insights into this problem is handled for coenzyme B 12 , which is synthesized and delivered to its target enzyme by adenosyltransferase.Read More
Publication Year: 2008
Publication Date: 2008-03-01
Language: en
Type: article
Indexed In: ['crossref']
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