Title: PS184. Biophysical Alterations of the Brain in First-Episode, Drug-Naïve Patients with Major Depressive Disorder: A Magnetization Transfer Imaging Study
Abstract: p=0.923) were significantly reduced in MDD.SPM with regionof-interest (ROI) analysis revealed that the gray-matter of right hippocampus (PFWE-correct=0.001)was significantly reduced.Results from the analysis of hippocampal subfields showed the reduction of areas included total Cornu Ammonis (CA) 2/3, subiculum, CA4/DG (Dentate Gyrus), presubiculum, hippocampus, CA1, and fimbria.No any other areas showed significantly changed.Importantly, the reduction of CA2/3 (r=-0.367,p=0.023), and CA4/DG (r=-0.403,p=0.012) areas were significantly correlated with the clinical severity of depressive symptoms. Conclusion:Our data indicate that the hippocampal volumes were reduced in patients with first-episode, drug-naïve MDD.The reduced hippocampal CA2/3 and CA4/DG, which were well correlated with the clinical severity of depressive symptoms, reflect the important role of these areas in the pathophysiology of MDD.