Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3174545927', 'doi': 'https://doi.org/10.4155/fmc-2021-0097', 'title': 'Mitochondrial Dysfunctions Associated With Chronic Respiratory Diseases and Their Targeted Therapies: an Update', 'display_name': 'Mitochondrial Dysfunctions Associated With Chronic Respiratory Diseases and Their Targeted Therapies: an Update', 'publication_year': 2021, 'publication_date': '2021-06-29', 'ids': {'openalex': 'https://openalex.org/W3174545927', 'doi': 'https://doi.org/10.4155/fmc-2021-0097', 'mag': '3174545927', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34184585'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.4155/fmc-2021-0097', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S122867665', 'display_name': 'Future Medicinal Chemistry', 'issn_l': '1756-8919', 'issn': ['1756-8919', '1756-8927'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320316', 'host_organization_name': 'Future Science Ltd', 'host_organization_lineage': ['https://openalex.org/P4310320316'], 'host_organization_lineage_names': ['Future Science Ltd'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073251236', 'display_name': 'Dinesh Kumar Chellappan', 'orcid': 'https://orcid.org/0000-0001-5567-6663'}, 'institutions': [{'id': 'https://openalex.org/I62370553', 'display_name': 'International Medical University', 'ror': 'https://ror.org/04d4wjw61', 'country_code': 'MY', 'type': 'education', 'lineage': ['https://openalex.org/I62370553']}], 'countries': ['MY'], 'is_corresponding': False, 'raw_author_name': 'Dinesh Kumar Chellappan', 'raw_affiliation_strings': ['Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia'], 'affiliations': [{'raw_affiliation_string': 'Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia', 'institution_ids': ['https://openalex.org/I62370553']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009187844', 'display_name': 'Vivek Dharwal', 'orcid': 'https://orcid.org/0000-0002-9645-3797'}, 'institutions': [{'id': 'https://openalex.org/I114017466', 'display_name': 'University of Technology Sydney', 'ror': 'https://ror.org/03f0f6041', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I114017466']}, {'id': 'https://openalex.org/I2800664540', 'display_name': 'Centenary Institute', 'ror': 'https://ror.org/05gvja138', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I2800664540']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Vivek Dharwal', 'raw_affiliation_strings': ['Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia', 'School of Life Sciences, University of Technology Sydney, Sydney, NSW, 2007, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, University of Technology Sydney, Sydney, NSW, 2007, Australia', 'institution_ids': ['https://openalex.org/I114017466']}, {'raw_affiliation_string': 'Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia', 'institution_ids': ['https://openalex.org/I2800664540']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063798252', 'display_name': 'Keshav Raj Paudel', 'orcid': 'https://orcid.org/0000-0002-3591-2080'}, 'institutions': [{'id': 'https://openalex.org/I114017466', 'display_name': 'University of Technology Sydney', 'ror': 'https://ror.org/03f0f6041', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I114017466']}, {'id': 'https://openalex.org/I2800664540', 'display_name': 'Centenary Institute', 'ror': 'https://ror.org/05gvja138', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I2800664540']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Keshav Raj Paudel', 'raw_affiliation_strings': ['Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia', 'School of Life Sciences, University of Technology Sydney, Sydney, NSW, 2007, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, University of Technology Sydney, Sydney, NSW, 2007, Australia', 'institution_ids': ['https://openalex.org/I114017466']}, {'raw_affiliation_string': 'Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia', 'institution_ids': ['https://openalex.org/I2800664540']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006548312', 'display_name': 'Niraj Kumar Jha', 'orcid': 'https://orcid.org/0000-0001-9486-4069'}, 'institutions': [{'id': 'https://openalex.org/I74885063', 'display_name': 'Sharda University', 'ror': 'https://ror.org/03b6ffh07', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I74885063']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Niraj Kumar Jha', 'raw_affiliation_strings': ['Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No. 32–34, Knowledge Park IIIGreater Noida, 201310, Uttar Pradesh, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No. 32–34, Knowledge Park IIIGreater Noida, 201310, Uttar Pradesh, India', 'institution_ids': ['https://openalex.org/I74885063']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054898346', 'display_name': 'Ronan MacLoughlin', 'orcid': 'https://orcid.org/0000-0002-3164-1607'}, 'institutions': [{'id': 'https://openalex.org/I4210100542', 'display_name': 'Aerogen (Ireland)', 'ror': 'https://ror.org/019g1wb57', 'country_code': 'IE', 'type': 'company', 'lineage': ['https://openalex.org/I4210100542']}, {'id': 'https://openalex.org/I142762351', 'display_name': 'Royal College of Surgeons in Ireland', 'ror': 'https://ror.org/01hxy9878', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I142762351']}, {'id': 'https://openalex.org/I205274468', 'display_name': 'Trinity College Dublin', 'ror': 'https://ror.org/02tyrky19', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I205274468']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Ronan MacLoughlin', 'raw_affiliation_strings': ['Aerogen, IDA Business Park, Dangan, Galway, H91 HE94, Ireland', 'School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland', 'School of Pharmacy & Pharmaceutical Sciences, Trinity College, Dublin, D02 PN40, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Aerogen, IDA Business Park, Dangan, Galway, H91 HE94, Ireland', 'institution_ids': ['https://openalex.org/I4210100542']}, {'raw_affiliation_string': 'School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland', 'institution_ids': ['https://openalex.org/I142762351']}, {'raw_affiliation_string': 'School of Pharmacy & Pharmaceutical Sciences, Trinity College, Dublin, D02 PN40, Ireland', 'institution_ids': ['https://openalex.org/I205274468']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074742233', 'display_name': 'Brian G. Oliver', 'orcid': 'https://orcid.org/0000-0002-7122-9262'}, 'institutions': [{'id': 'https://openalex.org/I129604602', 'display_name': 'University of Sydney', 'ror': 'https://ror.org/0384j8v12', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I129604602']}, {'id': 'https://openalex.org/I114017466', 'display_name': 'University of Technology Sydney', 'ror': 'https://ror.org/03f0f6041', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I114017466']}, {'id': 'https://openalex.org/I2800858616', 'display_name': 'Woolcock Institute of Medical Research', 'ror': 'https://ror.org/04hy0x592', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I2799732068', 'https://openalex.org/I2800858616', 'https://openalex.org/I99043593']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Brian G Oliver', 'raw_affiliation_strings': ['School of Life Sciences, University of Technology Sydney, Sydney, NSW, 2007, Australia', 'Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia'], 'affiliations': [{'raw_affiliation_string': 'Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia', 'institution_ids': ['https://openalex.org/I129604602', 'https://openalex.org/I2800858616']}, {'raw_affiliation_string': 'School of Life Sciences, University of Technology Sydney, Sydney, NSW, 2007, Australia', 'institution_ids': ['https://openalex.org/I114017466']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076048446', 'display_name': 'Philip M. Hansbro', 'orcid': 'https://orcid.org/0000-0002-4741-3035'}, 'institutions': [{'id': 'https://openalex.org/I2800664540', 'display_name': 'Centenary Institute', 'ror': 'https://ror.org/05gvja138', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I2800664540']}, {'id': 'https://openalex.org/I114017466', 'display_name': 'University of Technology Sydney', 'ror': 'https://ror.org/03f0f6041', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I114017466']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Philip M Hansbro', 'raw_affiliation_strings': ['Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia', 'School of Life Sciences, University of Technology Sydney, Sydney, NSW, 2007, Australia'], 'affiliations': [{'raw_affiliation_string': 'Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia', 'institution_ids': ['https://openalex.org/I2800664540']}, {'raw_affiliation_string': 'School of Life Sciences, University of Technology Sydney, Sydney, NSW, 2007, Australia', 'institution_ids': ['https://openalex.org/I114017466']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040015789', 'display_name': 'Kamal Dua', 'orcid': 'https://orcid.org/0000-0002-7507-1159'}, 'institutions': [{'id': 'https://openalex.org/I114017466', 'display_name': 'University of Technology Sydney', 'ror': 'https://ror.org/03f0f6041', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I114017466']}, {'id': 'https://openalex.org/I2800664540', 'display_name': 'Centenary Institute', 'ror': 'https://ror.org/05gvja138', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I2800664540']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Kamal Dua', 'raw_affiliation_strings': ['Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia', 'Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, 2007, Australia'], 'affiliations': [{'raw_affiliation_string': 'Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, 2007, Australia', 'institution_ids': ['https://openalex.org/I114017466']}, {'raw_affiliation_string': 'Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia', 'institution_ids': ['https://openalex.org/I2800664540']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 9, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.047, 'has_fulltext': False, 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.999974, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '13', 'issue': '15', 'first_page': '1249', 'last_page': '1251'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10322', 'display_name': 'Respiratory Support and Mechanisms', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10322', 'display_name': 'Respiratory Support and Mechanisms', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10143', 'display_name': 'Chronic Obstructive Pulmonary Disease (COPD) Research', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C104863432', 'wikidata': 'https://www.wikidata.org/wiki/Q614304', 'display_name': 'Pharmacy', 'level': 2, 'score': 0.5135072}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.47634295}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41039094}, {'id': 'https://openalex.org/C74909509', 'wikidata': 'https://www.wikidata.org/wiki/Q10387', 'display_name': 'Gerontology', 'level': 1, 'score': 0.342897}, {'id': 'https://openalex.org/C512399662', 'wikidata': 'https://www.wikidata.org/wiki/Q3505712', 'display_name': 'Family medicine', 'level': 1, 'score': 0.22240081}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008171', 'descriptor_name': 'Lung Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001569', 'descriptor_name': 'Benzodiazepines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001569', 'descriptor_name': 'Benzodiazepines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D001569', 'descriptor_name': 'Benzodiazepines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005905', 'descriptor_name': 'Glyburide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005905', 'descriptor_name': 'Glyburide', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D005905', 'descriptor_name': 'Glyburide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008171', 'descriptor_name': 'Lung Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008171', 'descriptor_name': 'Lung Diseases', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008171', 'descriptor_name': 'Lung Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.4155/fmc-2021-0097', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S122867665', 'display_name': 'Future Medicinal Chemistry', 'issn_l': '1756-8919', 'issn': ['1756-8919', '1756-8927'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320316', 'host_organization_name': 'Future Science Ltd', 'host_organization_lineage': ['https://openalex.org/P4310320316'], 'host_organization_lineage_names': ['Future Science Ltd'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34184585', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1561835222', 'https://openalex.org/W1951227278', 'https://openalex.org/W2016808085', 'https://openalex.org/W2038085138', 'https://openalex.org/W2055775240', 'https://openalex.org/W2076598575', 'https://openalex.org/W2140014506', 'https://openalex.org/W2153924942', 'https://openalex.org/W2157751043', 'https://openalex.org/W2166478007', 'https://openalex.org/W2291366038', 'https://openalex.org/W2527325622', 'https://openalex.org/W2756252761', 'https://openalex.org/W2791082632', 'https://openalex.org/W2853559064', 'https://openalex.org/W2904838957', 'https://openalex.org/W2977839607', 'https://openalex.org/W3006429557', 'https://openalex.org/W3012344944', 'https://openalex.org/W3115851070'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2899084033', 'https://openalex.org/W2748952813', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'Future': [0], 'Medicinal': [1], 'ChemistryVol.': [2], '13,': [3, 898], 'No.': [4, 118, 827, 860, 873, 899], '15': [5, 900], 'CommentaryMitochondrial': [6], 'dysfunctions': [7], 'associated': [8, 613], 'with': [9, 614, 951, 956, 964], 'chronic': [10, 352, 465, 832], 'respiratory': [11, 354, 501, 833], 'diseases': [12], 'and': [13, 324, 469, 564, 580, 610, 694, 728, 753, 765, 795, 812, 837, 855, 893], 'their': [14], 'targeted': [15], 'therapies:': [16], 'an': [17, 356, 434], 'updateDinesh': [18], 'Kumar': [19, 27, 40, 104, 603], 'Chellappan‡,': [20], 'Vivek': [21, 58], 'Dharwal‡,': [22], 'Keshav': [23, 80], 'Raj': [24, 81], 'Paudel‡,': [25], 'Niraj': [26, 103], 'Jha,': [28], 'Ronan': [29, 129], 'MacLoughlin,': [30], 'Brian': [31, 166], 'G': [32, 167], 'Oliver,': [33], 'Philip': [34, 193], 'M': [35, 194], 'Hansbro': [36, 195], '&': [37, 112, 142, 157, 221, 939], 'Kamal': [38, 222], 'DuaDinesh': [39], 'Chellappan‡': [41], 'https://orcid.org/0000-0001-5567-6663Department': [42], 'of': [43, 47, 61, 65, 84, 88, 107, 110, 140, 147, 155, 170, 174, 182, 186, 202, 206, 239, 243, 246, 302, 351, 433, 464, 498, 659, 700, 763, 847, 862, 868, 881, 1000], 'Life': [44, 62, 85, 171, 203], 'Sciences,': [45, 63, 86, 144, 159, 172, 204], 'School': [46, 109, 242], 'Pharmacy,': [48, 240], 'International': [49], 'Medical': [50, 183], 'University,': [51, 116], 'Bukit': [52], 'Jalil,': [53], '57000,': [54], 'Kuala': [55], 'Lumpur,': [56], 'Malaysia,': [57], 'Dharwal‡': [59], 'https://orcid.org/0000-0002-9645-3797School': [60], 'University': [64, 87, 173, 185, 205, 245], 'Technology': [66, 89, 113, 175, 207, 247], 'Sydney,': [67, 68, 76, 90, 91, 99, 176, 177, 187, 188, 208, 209, 217, 235, 248, 249], 'NSW,': [69, 77, 92, 100, 178, 210, 218, 236, 250], '2007,': [70, 93, 179, 211, 251], 'AustraliaCentre': [71, 94, 212], 'for': [72, 95, 197, 213, 225, 231, 413, 586, 906], 'Inflammation,': [73, 96, 214, 232], 'Centenary': [74, 97, 215, 233], 'Institute,': [75, 98, 216, 234], '2050,': [78, 101, 219, 237], 'Australia,': [79, 102, 192], 'Paudel‡': [82], 'https://orcid.org/0000-0002-3591-2080School': [83], 'Jha': [105], 'https://orcid.org/0000-0001-9486-4069Department': [106], 'Biotechnology,': [108], 'Engineering': [111], '(SET),': [114], 'Sharda': [115], 'Plot': [117], '32–34,': [119], 'Knowledge': [120], 'Park': [121], 'III,': [122], 'Greater': [123], 'Noida,': [124], '201310,': [125], 'Uttar': [126], 'Pradesh,': [127], 'India,': [128], 'MacLoughlin': [130], 'https://orcid.org/0000-0002-3164-1607Aerogen,': [131], 'IDA': [132], 'Business': [133], 'Park,': [134], 'Dangan,': [135], 'Galway,': [136], 'H91': [137], 'HE94,': [138], 'IrelandSchool': [139, 154], 'Pharmacy': [141, 156], 'Biomolecular': [143], 'Royal': [145], 'College': [146], 'Surgeons': [148], 'in': [149, 279, 372, 391, 437, 533, 562, 583, 669, 703, 730, 759, 816, 831, 844, 865, 878, 890, 929, 960, 971, 997], 'Ireland,': [150, 165], 'Dublin,': [151, 162], 'D02': [152, 163], 'YN77,': [153], 'Pharmaceutical': [158], 'Trinity': [160], 'College,': [161], 'PN40,': [164], 'Oliver': [168], 'https://orcid.org/0000-0002-7122-9262School': [169], 'AustraliaWoolcock': [180], 'Institute': [181], 'Research,': [184, 857], 'New': [189], 'South': [190], 'Wales,': [191], '**Author': [196], 'correspondence:': [198, 226], 'E-mail': [199, 227], 'Address:': [200, 228], '[email protected]://orcid.org/0000-0002-4741-3035School': [201], 'Australia': [220], 'Dua': [223], '*Author': [224], '[email protected],': [229], 'https://orcid.org/0000-0002-7507-1159Centre': [230], 'AustraliaDiscipline': [238], 'Graduate': [241], 'Health,': [244], 'AustraliaPublished': [252], 'Online:29': [253], 'Jun': [254], '2021https://doi.org/10.4155/fmc-2021-0097AboutSectionsView': [255], 'ArticleView': [256], 'Full': [257], 'TextPDF/EPUB': [258], 'ToolsAdd': [259], 'to': [260, 633, 637], 'favoritesDownload': [261], 'CitationsTrack': [262], 'CitationsPermissionsReprints': [263], 'ShareShare': [264], 'onFacebookTwitterLinkedInReddit': [265], 'View': [266], 'articleKeywords:': [267], 'inflammationmitochondriarespiratory': [268], 'diseasestargeted': [269, 937], 'therapiesReferences1.': [270], 'Frantz': [271], 'MC,': [272], 'Wipf': [273], 'P.': [274], 'Mitochondria': [275, 390], 'as': [276, 460], 'a': [277, 299, 376, 461, 760, 957], 'target': [278], 'treatment.': [280], 'Environ.': [281], 'Mol.': [282, 515], 'Mutagen': [283], '51(5),': [284], '462–475': [285], '(2010).Medline,': [286], 'CAS,': [287, 334, 447, 551, 573, 596, 624, 648, 680, 714, 738, 776], 'Google': [288, 311, 335, 363, 384, 401, 422, 448, 482, 521, 552, 574, 597, 625, 649, 681, 715, 739, 777, 803], 'Scholar2.': [289], 'Panth': [290], 'N,': [291], 'Paudel': [292, 341, 405], 'KR,': [293, 406], 'Parajuli': [294], 'K.': [295, 559], 'Reactive': [296], 'oxygen': [297, 321], 'species:': [298], 'key': [300], 'hallmark': [301], 'cardiovascular': [303], 'disease.': [304, 393], 'Adv.': [305], 'Med.': [306], '2016,': [307], '9152732': [308], '(2016).Crossref,': [309, 399], 'Medline,': [310, 333, 362, 383, 400, 446, 481, 520, 550, 572, 595, 623, 647, 679, 713, 737, 775, 802], 'Scholar3.': [312], 'Zorov': [313], 'DB,': [314], 'Juhaszova': [315], 'M,': [316, 338, 404, 487], 'Sollott': [317], 'SJ.': [318], 'Mitochondrial': [319, 458, 531, 578, 607, 787], 'reactive': [320], 'species': [322], '(ROS)': [323], 'ROS-induced': [325], 'ROS': [326], 'release.': [327], 'Physiol.': [328, 512, 516, 542, 546], 'Rev.': [329, 641], '94(3),': [330], '909–950': [331], '(2014).Crossref,': [332, 774], 'Scholar4.': [336], 'Mehta': [337, 403], 'Dhanjal': [339], 'DS,': [340], 'KR': [342], 'et': [343, 409, 430, 456, 493, 529, 605, 689, 747, 785], 'al.': [344, 410, 431, 457, 494, 530, 606, 690, 748, 786], 'Cellular': [345], 'signalling': [346], 'pathways': [347], 'mediating': [348], 'the': [349, 499, 698, 755, 829, 842, 845, 866, 879, 907, 965, 972, 998], 'pathogenesis': [350, 867], 'inflammatory': [353, 374, 882], 'diseases:': [355], 'update.': [357], 'Inflammopharmacology': [358], '28(4),': [359], '795–817': [360], '(2020).Crossref,': [361, 801], 'Scholar5.': [364], 'Sethi': [365], 'GS,': [366], 'Dharwal': [367, 717], 'V,': [368, 718], 'Naura': [369, 719], 'AS.': [370, 720], 'Poly(ADP-Ribose)polymerase-1': [371], 'lung': [373, 392, 504, 726, 883], 'disorders:': [375], 'review.': [377], 'Front.': [378], 'Immunol.': [379, 442, 619], '8,': [380], '1172': [381], '(2017).Crossref,': [382], 'Scholar6.': [385], 'Cloonan': [386], 'SM,': [387], 'Choi': [388, 743], 'AM.': [389], 'J.': [394, 418, 441, 541, 618, 674, 769], 'Clin.': [395], 'Invest.': [396], '126(3),': [397], '809–820': [398], 'Scholar7.': [402], 'Shukla': [407], 'SD': [408], 'Interferon': [411], 'therapy': [412], 'preventing': [414], 'COPD': [415, 563], 'exacerbations.': [416], 'EXCLI.': [417], '19,': [419], '1477–1480': [420], '(2020).Medline,': [421], 'Scholar8.': [423], 'Monick': [424], 'MM,': [425], 'Powers': [426], 'LS,': [427], 'Walters': [428], 'K': [429], 'Identification': [432], 'autophagy': [435], 'defect': [436], "smokers'": [438], 'alveolar': [439], 'macrophages.': [440], '185(9),': [443], '5425–5435': [444], '(2010).Crossref,': [445], 'Scholar9.': [449], 'Ryter': [450], 'SW,': [451], 'Rosas': [452], 'IO,': [453], 'Owen': [454], 'CA': [455], 'dysfunction': [459, 579, 611], 'pathogenic': [462], 'mediator': [463], 'obstructive': [466], 'pulmonary': [467, 471], 'disease': [468], 'idiopathic': [470], 'fibrosis.': [472], 'Ann.': [473], 'Am.': [474, 540], 'Thorac.': [475], 'Soc.': [476], '15(Suppl.': [477], '4),': [478], 'S266–S272': [479], '(2018).Crossref,': [480, 571, 736], 'Scholar10.': [483], 'van': [484], 'der': [485], 'Toorn': [486], 'Slebos': [488], 'DJ,': [489], 'de': [490], 'Bruin': [491], 'HG': [492], 'Cigarette': [495, 809], 'smoke-induced': [496, 535], 'blockade': [497], 'mitochondrial': [500, 664, 796, 838], 'chain': [502], 'switches': [503], 'epithelial': [505, 537], 'cell': [506, 538], 'apoptosis': [507], 'into': [508], 'necrosis.': [509], 'Am': [510], 'J': [511], 'Lung': [513, 543], 'Cell': [514, 544], '292(5),': [517], 'L1211–1218': [518], '(2007).Crossref,': [519, 646], 'Scholar11.': [522], 'Hara': [523], 'H,': [524], 'Araya': [525, 556], 'J,': [526, 557], 'Ito': [527], 'S': [528, 604], 'fragmentation': [532], 'cigarette': [534], 'bronchial': [536, 848], 'senescence.': [539], 'Mol': [545], '305(10),': [547], 'L737–746': [548], '(2013).Crossref,': [549], 'Scholar12.': [553], 'Tsubouchi': [554], 'K,': [555], 'Kuwano': [558], 'PINK1-PARK2-mediated': [560], 'mitophagy': [561], 'IPF': [565], 'pathogeneses.': [566], 'Inflamm.': [567], 'Regen.': [568], '38,': [569], '18': [570], 'Scholar13.': [575], 'Reddy': [576], 'PH.': [577], 'oxidative': [581, 695, 839, 863], 'stress': [582, 696, 864], 'asthma:': [584], 'implications': [585], 'mitochondria-targeted': [587], 'antioxidant': [588], 'therapeutics.': [589], 'Pharmaceuticals': [590], '(Basel)': [591], '4(3),': [592], '429–456': [593], '(2011).Crossref,': [594], 'Scholar14.': [598], 'Mabalirajan': [599], 'U,': [600], 'Dinda': [601], 'AK,': [602], 'structural': [608], 'changes': [609], 'are': [612], 'experimental': [615], 'allergic': [616], 'asthma.': [617], '181(5),': [620], '3540–3548': [621], '(2008).Crossref,': [622], 'Scholar15.': [626], 'Murphy': [627], 'MP,': [628], 'Smith': [629], 'RA.': [630], 'Targeting': [631], 'antioxidants': [632], 'mitochondria': [634, 830], 'by': [635, 663], 'conjugation': [636], 'lipophilic': [638], 'cations.': [639], 'Annu.': [640], 'Pharmacol.': [642, 675, 733], 'Toxicol.': [643], '47,': [644], '629–656': [645], 'Scholar16.': [650], 'Thu': [651], 'le': [652], 'T,': [653, 782], 'Ahn': [654], 'JR,': [655], 'Woo': [656], 'SH.': [657], 'Inhibition': [658], 'L-type': [660], 'Ca2+': [661], 'channel': [662], 'Na+-Ca2+': [665], 'exchange': [666], 'inhibitor': [667, 789], 'CGP-37157': [668], 'rat': [670], 'atrial': [671], 'myocytes.': [672], 'Eur.': [673], '552(1–3),': [676], '15–19': [677], '(2006).Crossref,': [678], 'Scholar17.': [682], 'Mo': [683], 'Y,': [684], 'Deng': [685], 'S,': [686], 'Zhang': [687], 'L': [688, 746], 'SS-31': [691], 'reduces': [692], 'inflammation': [693, 727], 'through': [697], 'inhibition': [699, 722], 'Fis1': [701], 'expression': [702], 'lipopolysaccharide-stimulated': [704], 'microglia.': [705], 'Biochem.': [706, 732, 771], 'Biophys.': [707], 'Res.': [708], 'Commun.': [709], '520(1),': [710], '171–178': [711], '(2019).Crossref,': [712], 'Scholar18.': [716], 'PARP-1': [721], 'ameliorates': [723], 'elastase': [724], 'induced': [725], 'emphysema': [729], 'mice.': [731], '150,': [734], '24–34': [735], 'Scholar19.': [740], 'Yang': [741], 'SJ,': [742], 'JM,': [744], 'Kim': [745], 'Nicotinamide': [749], 'improves': [750], 'glucose': [751], 'metabolism': [752], 'affects': [754], 'hepatic': [756], 'NAD-sirtuin': [757], 'pathway': [758], 'rodent': [761], 'model': [762], 'obesity': [764], 'type': [766], '2': [767], 'diabetes.': [768], 'Nutr.': [770], '25(1),': [772], '66–72': [773], 'Scholar20.': [778], 'Ruiz': [779], 'A,': [780], 'Quintela-Lopez': [781], 'Sanchez-Gomez': [783], 'MV': [784], 'division': [788], '1': [790], 'disrupts': [791], 'oligodendrocyte': [792], 'Ca(2+)': [793], 'homeostasis': [794], 'function.': [797], 'Glia': [798], '68(9),': [799], '1743–1756': [800], 'ScholarFiguresReferencesRelatedDetailsCited': [804], 'ByAgarwood': [805], 'Oil': [806], 'Nanoemulsion': [807], 'Attenuates': [808], 'Smoke-Induced': [810], 'Inflammation': [811], 'Oxidative': [813], 'Stress': [814], 'Markers': [815], 'BCi-NS1.1': [817], 'Airway': [818], 'Epithelial': [819], 'Cells17': [820], 'February': [821], '2023': [822], '|': [823, 852, 887], 'Nutrients,': [824], 'Vol.': [825, 835, 858, 871, 895, 897], '15,': [826], '4Targeting': [828], 'diseasesMitochondrion,': [834], '67Nutraceuticals': [836], 'stress:': [840], 'bridging': [841], 'gap': [843], 'management': [846], 'asthma7': [849], 'July': [850], '2022': [851], 'Environmental': [853], 'Science': [854, 892], 'Pollution': [856], '29,': [859], '42Role': [861], 'COPDMinerva': [869], 'Medica,': [870], '113,': [872], '3Nutraceuticals:': [874], 'unlocking': [875], 'newer': [876], 'paradigms': [877], 'mitigation': [880], 'diseases6': [884], 'October': [885], '2021': [886, 918, 922, 927, 932, 934], 'Critical': [888], 'Reviews': [889], 'Food': [891], 'Nutrition,': [894], '19': [896], 'Follow': [901], 'us': [902], 'on': [903], 'social': [904], 'media': [905], 'latest': [908], 'updates': [909], 'Metrics': [910], 'Downloaded': [911], '81': [912], 'times': [913], 'History': [914], 'Received': [915], '7': [916], 'April': [917], 'Accepted': [919], '26': [920], 'May': [921], 'Published': [923, 928], 'online': [924], '29': [925], 'June': [926], 'print': [930], 'August': [931], 'Information©': [933], 'Newlands': [935], 'PressKeywordsinflammationmitochondriarespiratory': [936], 'therapiesFinancial': [938], 'competing': [940], 'interests': [941], 'disclosureThe': [942], 'authors': [943], 'have': [944], 'no': [945], 'relevant': [946], 'affiliations': [947], 'or': [948, 954, 961, 968, 981, 986, 989, 991], 'financial': [949, 958, 962], 'involvement': [950], 'any': [952], 'organization': [953], 'entity': [955], 'interest': [959], 'conflict': [963], 'subject': [966], 'matter': [967], 'materials': [969], 'discussed': [970], 'manuscript.': [973], 'This': [974], 'includes': [975], 'employment,': [976], 'consultancies,': [977], 'honoraria,': [978], 'stock': [979], 'ownership': [980], 'options,': [982], 'expert': [983], 'testimony,': [984], 'grants': [985], 'patents': [987], 'received': [988], 'pending,': [990], 'royalties.No': [992], 'writing': [993], 'assistance': [994], 'was': [995], 'utilized': [996], 'production': [999], 'this': [1001], 'manuscript.PDF': [1002], 'download': [1003]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3174545927', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-31T05:52:31.133673', 'created_date': '2021-07-05'}