Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3173015742', 'doi': 'https://doi.org/10.3390/biomedicines9060650', 'title': 'Inhibition of Hsp90 Counteracts the Established Experimental Dermal Fibrosis Induced by Bleomycin', 'display_name': 'Inhibition of Hsp90 Counteracts the Established Experimental Dermal Fibrosis Induced by Bleomycin', 'publication_year': 2021, 'publication_date': '2021-06-07', 'ids': {'openalex': 'https://openalex.org/W3173015742', 'doi': 'https://doi.org/10.3390/biomedicines9060650', 'mag': '3173015742', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34200311', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8226767'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biomedicines9060650', 'pdf_url': 'https://www.mdpi.com/2227-9059/9/6/650/pdf?version=1623154314', 'source': {'id': 'https://openalex.org/S2737005842', 'display_name': 'Biomedicines', 'issn_l': '2227-9059', 'issn': ['2227-9059'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2227-9059/9/6/650/pdf?version=1623154314', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019621028', 'display_name': 'Hana Štorkánová', 'orcid': 'https://orcid.org/0000-0002-6416-8385'}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}, {'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Hana Štorkánová', 'raw_affiliation_strings': ['Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}, {'raw_affiliation_string': 'Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I21250087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078948771', 'display_name': 'Lenka Štorkánová', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Lenka Štorkánová', 'raw_affiliation_strings': ['Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035726960', 'display_name': 'Adéla Navrátilová', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}, {'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Adéla Navrátilová', 'raw_affiliation_strings': ['Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}, {'raw_affiliation_string': 'Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I21250087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048868986', 'display_name': 'Viktor Bečvář', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Viktor Bečvář', 'raw_affiliation_strings': ['Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010887266', 'display_name': 'Hana Hulejová', 'orcid': 'https://orcid.org/0000-0002-2335-6996'}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Hana Hulejová', 'raw_affiliation_strings': ['Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064499724', 'display_name': 'S. Oreská', 'orcid': 'https://orcid.org/0000-0002-9912-725X'}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}, {'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Sabína Oreská', 'raw_affiliation_strings': ['Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}, {'raw_affiliation_string': 'Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I21250087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062096932', 'display_name': 'Barbora Heřmánková', 'orcid': 'https://orcid.org/0000-0002-1314-1123'}, 'institutions': [{'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Barbora Heřmánková', 'raw_affiliation_strings': ['Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, 16252 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, 16252 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I21250087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057948163', 'display_name': 'Maja Špiritović', 'orcid': 'https://orcid.org/0000-0002-9114-2172'}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}, {'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Maja Špiritović', 'raw_affiliation_strings': ['Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, 16252 Prague, Czech Republic.', 'Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}, {'raw_affiliation_string': 'Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, 16252 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I21250087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069564967', 'display_name': 'Radim Bečvář', 'orcid': 'https://orcid.org/0000-0003-0022-3135'}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}, {'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Radim Bečvář', 'raw_affiliation_strings': ['Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}, {'raw_affiliation_string': 'Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I21250087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089477356', 'display_name': 'Karel Pavelká', 'orcid': 'https://orcid.org/0000-0003-1952-8422'}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}, {'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Karel Pavelka', 'raw_affiliation_strings': ['Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}, {'raw_affiliation_string': 'Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I21250087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079921904', 'display_name': 'Jiří Vencovský', 'orcid': 'https://orcid.org/0000-0002-0851-0713'}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}, {'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Jiří Vencovský', 'raw_affiliation_strings': ['Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}, {'raw_affiliation_string': 'Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I21250087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032641681', 'display_name': 'Jörg H. W. Distler', 'orcid': 'https://orcid.org/0000-0001-7408-9333'}, 'institutions': [{'id': 'https://openalex.org/I181369854', 'display_name': 'Friedrich-Alexander-Universität Erlangen-Nürnberg', 'ror': 'https://ror.org/00f7hpc57', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I181369854']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jörg H W Distler', 'raw_affiliation_strings': ['Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.', 'institution_ids': ['https://openalex.org/I181369854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031588644', 'display_name': 'Ladislav Šenolt', 'orcid': 'https://orcid.org/0000-0001-5500-7312'}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}, {'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Ladislav Šenolt', 'raw_affiliation_strings': ['Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}, {'raw_affiliation_string': 'Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I21250087']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059312680', 'display_name': 'Michal Tomčík', 'orcid': 'https://orcid.org/0000-0002-8616-7850'}, 'institutions': [{'id': 'https://openalex.org/I4210092695', 'display_name': 'Institute of Rheumatology', 'ror': 'https://ror.org/00jk0vn85', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092695']}, {'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Michal Tomčík', 'raw_affiliation_strings': ['Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'Institute of Rheumatology, 12800 Prague, Czech Republic.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Rheumatology, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I4210092695']}, {'raw_affiliation_string': 'Department of Rheumatology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.', 'institution_ids': ['https://openalex.org/I21250087']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'apc_paid': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'fwci': 0.97, 'has_fulltext': False, 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.799158, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 82}, 'biblio': {'volume': '9', 'issue': '6', 'first_page': '650', 'last_page': '650'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11330', 'display_name': 'Pathogenesis and Treatment of Systemic Sclerosis', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11330', 'display_name': 'Pathogenesis and Treatment of Systemic Sclerosis', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11172', 'display_name': 'Skin Scarring and Remodeling Mechanisms', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/2708', 'display_name': 'Dermatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11068', 'display_name': 'Adaptation of Tendon and Skeletal Muscle to Mechanical Loading', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/2732', 'display_name': 'Orthopedics and Sports Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hsp90-inhibitor', 'display_name': 'Hsp90 inhibitor', 'score': 0.58036065}, {'id': 'https://openalex.org/keywords/myofibroblast', 'display_name': 'Myofibroblast', 'score': 0.532455}, {'id': 'https://openalex.org/keywords/dermal-remodeling', 'display_name': 'Dermal Remodeling', 'score': 0.487821}], 'concepts': [{'id': 'https://openalex.org/C2776232574', 'wikidata': 'https://www.wikidata.org/wiki/Q415571', 'display_name': 'Bleomycin', 'level': 3, 'score': 0.8293984}, {'id': 'https://openalex.org/C2780559512', 'wikidata': 'https://www.wikidata.org/wiki/Q605709', 'display_name': 'Fibrosis', 'level': 2, 'score': 0.6795443}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5887065}, {'id': 'https://openalex.org/C2777560012', 'wikidata': 'https://www.wikidata.org/wiki/Q5924361', 'display_name': 'Hsp90 inhibitor', 'level': 5, 'score': 0.58036065}, {'id': 'https://openalex.org/C207865475', 'wikidata': 'https://www.wikidata.org/wiki/Q1467330', 'display_name': 'Myofibroblast', 'level': 3, 'score': 0.532455}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.51021266}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.4943452}, {'id': 'https://openalex.org/C205260736', 'wikidata': 'https://www.wikidata.org/wiki/Q418939', 'display_name': 'Heat shock protein', 'level': 3, 'score': 0.46725887}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.4156621}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.40690824}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.40173206}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.36901927}, {'id': 'https://openalex.org/C2775932338', 'wikidata': 'https://www.wikidata.org/wiki/Q24772687', 'display_name': 'Hsp90', 'level': 4, 'score': 0.33193898}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19248614}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.19084713}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.09335017}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biomedicines9060650', 'pdf_url': 'https://www.mdpi.com/2227-9059/9/6/650/pdf?version=1623154314', 'source': {'id': 'https://openalex.org/S2737005842', 'display_name': 'Biomedicines', 'issn_l': '2227-9059', 'issn': ['2227-9059'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/4ff5b7e455b94a139f7f9a2d3de9e59d', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://dx.doi.org/10.3390/biomedicines9060650', 'pdf_url': 'https://www.mdpi.com/2227-9059/9/6/650/pdf?version=1696849856', 'source': {'id': 'https://openalex.org/S4306400947', 'display_name': 'MDPI (MDPI AG)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210097602', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute (Switzerland)', 'host_organization_lineage': ['https://openalex.org/I4210097602'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute (Switzerland)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://opus4.kobv.de/opus4-fau/files/16748/biomedicines-09-00650-v2.pdf', 'pdf_url': 'https://opus4.kobv.de/opus4-fau/files/16748/biomedicines-09-00650-v2.pdf', 'source': {'id': 'https://openalex.org/S4306402340', 'display_name': 'OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universitätsbibliothek Erlangen-Nürnberg)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226767', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34200311', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biomedicines9060650', 'pdf_url': 'https://www.mdpi.com/2227-9059/9/6/650/pdf?version=1623154314', 'source': {'id': 'https://openalex.org/S2737005842', 'display_name': 'Biomedicines', 'issn_l': '2227-9059', 'issn': ['2227-9059'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.63}], 'grants': [{'funder': 'https://openalex.org/F4320321005', 'funder_display_name': 'Ministerstvo Školství, Mládeže a Tělovýchovy', 'award_id': 'SVV 260523'}, {'funder': 'https://openalex.org/F4320321798', 'funder_display_name': 'Ministerstvo Zdravotnictví Ceské Republiky', 'award_id': '16-33542A'}, {'funder': 'https://openalex.org/F4320321798', 'funder_display_name': 'Ministerstvo Zdravotnictví Ceské Republiky', 'award_id': '00023728'}], 'datasets': [], 'versions': [], 'referenced_works_count': 76, 'referenced_works': ['https://openalex.org/W1526728179', 'https://openalex.org/W1528062235', 'https://openalex.org/W1965334681', 'https://openalex.org/W1965586395', 'https://openalex.org/W1966238197', 'https://openalex.org/W1966492828', 'https://openalex.org/W1976547976', 'https://openalex.org/W1987777204', 'https://openalex.org/W1989600727', 'https://openalex.org/W1990842725', 'https://openalex.org/W1996385150', 'https://openalex.org/W1997004264', 'https://openalex.org/W2002044132', 'https://openalex.org/W2005020313', 'https://openalex.org/W2005430586', 'https://openalex.org/W2012993485', 'https://openalex.org/W2024007670', 'https://openalex.org/W2025071836', 'https://openalex.org/W2025287936', 'https://openalex.org/W2028406163', 'https://openalex.org/W2030982690', 'https://openalex.org/W2032259307', 'https://openalex.org/W2032383027', 'https://openalex.org/W2034462747', 'https://openalex.org/W2037658248', 'https://openalex.org/W2044304089', 'https://openalex.org/W2054254671', 'https://openalex.org/W2055198492', 'https://openalex.org/W2070741283', 'https://openalex.org/W2071410302', 'https://openalex.org/W2073063750', 'https://openalex.org/W2104061566', 'https://openalex.org/W2104755183', 'https://openalex.org/W2107419852', 'https://openalex.org/W2115974767', 'https://openalex.org/W2120791222', 'https://openalex.org/W2130500555', 'https://openalex.org/W2131121772', 'https://openalex.org/W2134164289', 'https://openalex.org/W2136376193', 'https://openalex.org/W2137417707', 'https://openalex.org/W2144562554', 'https://openalex.org/W2151739538', 'https://openalex.org/W2157261840', 'https://openalex.org/W2159148154', 'https://openalex.org/W2289891298', 'https://openalex.org/W2300678113', 'https://openalex.org/W2347093301', 'https://openalex.org/W2413915964', 'https://openalex.org/W2519768493', 'https://openalex.org/W2567214425', 'https://openalex.org/W2588889117', 'https://openalex.org/W2750186979', 'https://openalex.org/W2751876410', 'https://openalex.org/W2766145635', 'https://openalex.org/W2772664042', 'https://openalex.org/W2774773192', 'https://openalex.org/W2782314122', 'https://openalex.org/W2802494300', 'https://openalex.org/W2889154002', 'https://openalex.org/W2889573754', 'https://openalex.org/W2901760304', 'https://openalex.org/W2913172834', 'https://openalex.org/W2945521814', 'https://openalex.org/W2953044679', 'https://openalex.org/W2982597658', 'https://openalex.org/W2985676661', 'https://openalex.org/W2994323364', 'https://openalex.org/W3024311541', 'https://openalex.org/W3029637737', 'https://openalex.org/W3034773147', 'https://openalex.org/W3038969721', 'https://openalex.org/W3096336171', 'https://openalex.org/W3118577024', 'https://openalex.org/W4211001791', 'https://openalex.org/W867807832'], 'related_works': ['https://openalex.org/W3008425152', 'https://openalex.org/W2510135606', 'https://openalex.org/W2387080865', 'https://openalex.org/W2254692507', 'https://openalex.org/W2143657744', 'https://openalex.org/W2137206941', 'https://openalex.org/W2010809759', 'https://openalex.org/W1966492828', 'https://openalex.org/W1965487585', 'https://openalex.org/W1559186561'], 'abstract_inverted_index': {'Our': [0], 'previous': [1], 'study': [2], 'demonstrated': [3, 89], 'that': [4], 'heat': [5], 'shock': [6], 'protein': [7], '90': [8], '(Hsp90)': [9], 'is': [10], 'overexpressed': [11], 'in': [12, 23, 48, 75, 126, 166, 194], 'the': [13, 32, 43, 55, 59, 67, 76, 127, 161, 167, 179, 188], 'involved': [14, 125], 'skin': [15], 'of': [16, 29, 35, 45, 52, 58, 69, 78, 104, 122, 129, 144, 160, 164, 169, 181, 190], 'patients': [17], 'with': [18, 87, 183], 'systemic': [19, 120], 'sclerosis': [20], '(SSc)': [21], 'and': [22, 42, 92, 110, 119, 140, 171], 'experimental': [24, 80], 'dermal': [25, 46, 81, 97, 147], 'fibrosis.': [26], 'Pharmacological': [27], 'inhibition': [28], 'Hsp90': [30, 71, 165, 192], 'prevented': [31, 137], 'stimulatory': [33], 'effects': [34], 'transforming': [36, 105], 'growth': [37, 106], 'factor-beta': [38], 'on': [39], 'collagen': [40, 99], 'synthesis': [41], 'development': [44], 'fibrosis': [47, 82, 148, 182], 'three': [49], 'preclinical': [50, 60], 'models': [51], 'SSc.': [53], 'In': [54], 'next': [56], 'step': [57], 'analysis,': [61], 'herein,': [62], 'we': [63], 'aimed': [64], 'to': [65, 132, 149, 153, 187], 'evaluate': [66], 'efficacy': [68], 'an': [70, 150], 'inhibitor,': [72], '17-dimethylaminoethylamino-17-demethoxygeldanamycin': [73], '(17-DMAG),': [74], 'treatment': [77, 180], 'established': [79, 145], 'induced': [83], 'by': [84], 'bleomycin.': [85], 'Treatment': [86], '17-DMAG': [88, 135], 'potent': [90], 'antifibrotic': [91], 'anti-inflammatory': [93], 'properties:': [94], 'it': [95, 173], 'decreased': [96], 'thickening,': [98], 'content,': [100], 'myofibroblast': [101], 'count,': [102], 'expression': [103], 'factor': [107], 'beta': [108], 'receptors,': [109], 'pSmad3-positive': [111], 'cell': [112], 'counts,': [113], 'as': [114, 116, 174], 'well': [115], 'leukocyte': [117], 'infiltration': [118], 'levels': [121], 'crucial': [123], 'cytokines/chemokines': [124], 'pathogenesis': [128], 'SSc,': [130], 'compared': [131], 'vehicle-treated': [133], 'mice.': [134], 'effectively': [136], 'further': [138, 158], 'progression': [139], 'may': [141], 'induce': [142], 'regression': [143], 'bleomycin-induced': [146], 'extent': [151], 'comparable': [152], 'nintedanib.': [154], 'These': [155], 'findings': [156], 'provide': [157], 'evidence': [159], 'vital': [162], 'role': [163], 'pathophysiology': [168], 'SSc': [170], 'characterize': [172], 'a': [175], 'potential': [176], 'target': [177], 'for': [178, 197], 'translational': [184], 'implications': [185], 'due': [186], 'availability': [189], 'several': [191], 'inhibitors': [193], 'clinical': [195], 'trials': [196], 'other': [198], 'indications.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3173015742', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}], 'updated_date': '2024-09-19T18:59:24.477201', 'created_date': '2021-06-22'}