Title: Lipoprotein lipase (LPL) facilitates the uptake of postprandial vitamin A by the developing tissues
Abstract: Postprandial vitamin A, incorporated in chylomicrons as retinyl ester (RE), is an important source of retinoids for the developing embryo. Lipoprotein lipase (LPL) hydrolyses chylomicrons to smaller chylomicron remnants‐RE and facilitates the uptake of chylomicron remnants containing retinoids in extrahepatic tissues. Although, its expression has been reported in placenta, it is not clear whether LPL facilitates postprandial uptake of vitamin‐A by this tissue. In this study, RE levels in embryos from mice lacking placental LPL (MCKhLPL/LPL−/ −) are reduced both on a vitamin‐A sufficient or excess diet, despite a normal embryonic phenotype. Furthermore, when the dams are maintained on a vitamin A‐sufficient diet and their retinoid stores are adequate, pharmacological systemic inhibition of LPL activity, by means of the lipase inhibitor P‐407, impairs the uptake of chylomicrons RE in yolk sac and embryo, but not in placenta. In contrast, when maternal retinoid stores are depleted, pharmacological systemic inhibition of LPL does not impair neither embryonic nor extraembryonic uptake of RE. These results suggest that LPL facilitates the uptake of postprandial vitamin A by the developing tissues, but it is not the only player that ensures availability of dietary vitamin‐A to the embryo. Research support: NRI Grant no. 2006‐35200‐16580 from the USDA, Bioactive Food Components for Optimal Health Program (31.0)
Publication Year: 2010
Publication Date: 2010-04-01
Language: en
Type: article
Indexed In: ['crossref']
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