Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3167062982', 'doi': 'https://doi.org/10.1101/2021.06.10.447952', 'title': 'A reference-quality, fully annotated genome from a Puerto Rican individual', 'display_name': 'A reference-quality, fully annotated genome from a Puerto Rican individual', 'publication_year': 2021, 'publication_date': '2021-06-11', 'ids': {'openalex': 'https://openalex.org/W3167062982', 'doi': 'https://doi.org/10.1101/2021.06.10.447952', 'mag': '3167062982'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2021.06.10.447952', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2021/10/06/2021.06.10.447952.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2021/10/06/2021.06.10.447952.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056359638', 'display_name': 'Aleksey V. Zimin', 'orcid': 'https://orcid.org/0000-0001-5091-3092'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Aleksey Zimin', 'raw_affiliation_strings': ['Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063791362', 'display_name': 'Alaina Shumate', 'orcid': 'https://orcid.org/0000-0002-4450-1857'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alaina Shumate', 'raw_affiliation_strings': ['Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD'], 'affiliations': [{'raw_affiliation_string': 'Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059952147', 'display_name': 'Ida Shinder', 'orcid': 'https://orcid.org/0000-0002-1651-9347'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}, {'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ida Shinder', 'raw_affiliation_strings': ['Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'Cross Disciplinary Graduate Program in Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, MD'], 'affiliations': [{'raw_affiliation_string': 'Cross Disciplinary Graduate Program in Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948', 'https://openalex.org/I2799853436']}, {'raw_affiliation_string': 'Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049308552', 'display_name': 'Jakob Heinz', 'orcid': 'https://orcid.org/0000-0002-9218-2643'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jakob Heinz', 'raw_affiliation_strings': ['Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036638042', 'display_name': 'Daniela Puiu', 'orcid': 'https://orcid.org/0000-0002-2386-9265'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniela Puiu', 'raw_affiliation_strings': ['Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD'], 'affiliations': [{'raw_affiliation_string': 'Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009657521', 'display_name': 'Mihaela Pertea', 'orcid': 'https://orcid.org/0000-0003-0762-8637'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mihaela Pertea', 'raw_affiliation_strings': ['Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD'], 'affiliations': [{'raw_affiliation_string': 'Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010384159', 'display_name': 'Steven L. Salzberg', 'orcid': 'https://orcid.org/0000-0002-8859-7432'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven L. Salzberg', 'raw_affiliation_strings': ['Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD', 'Department of Biostatistics, Johns Hopkins University, Baltimore, MD', 'Department of Computer Science, Johns Hopkins University, Baltimore, MD'], 'affiliations': [{'raw_affiliation_string': 'Center for Computational Biology, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Department of Biostatistics, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Department of Computer Science, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5056359638'], 'corresponding_institution_ids': ['https://openalex.org/I145311948'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 57}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10015', 'display_name': 'Genomics and Phylogenetic Studies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10015', 'display_name': 'Genomics and Phylogenetic Studies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10434', 'display_name': 'Chromosomal and Genetic Variations', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sequence-assembly', 'display_name': 'Sequence assembly', 'score': 0.61078995}, {'id': 'https://openalex.org/keywords/gene-annotation', 'display_name': 'Gene Annotation', 'score': 0.50786096}], 'concepts': [{'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.72200036}, {'id': 'https://openalex.org/C2776321320', 'wikidata': 'https://www.wikidata.org/wiki/Q857525', 'display_name': 'Annotation', 'level': 2, 'score': 0.6517643}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.63524234}, {'id': 'https://openalex.org/C197077220', 'wikidata': 'https://www.wikidata.org/wiki/Q720988', 'display_name': 'Human genome', 'level': 4, 'score': 0.62079805}, {'id': 'https://openalex.org/C18949551', 'wikidata': 'https://www.wikidata.org/wiki/Q740578', 'display_name': 'Sequence assembly', 'level': 5, 'score': 0.61078995}, {'id': 'https://openalex.org/C192953774', 'wikidata': 'https://www.wikidata.org/wiki/Q7307127', 'display_name': 'Reference genome', 'level': 4, 'score': 0.5935368}, {'id': 'https://openalex.org/C51679486', 'wikidata': 'https://www.wikidata.org/wiki/Q380546', 'display_name': 'DNA sequencing', 'level': 3, 'score': 0.58264804}, {'id': 'https://openalex.org/C89566754', 'wikidata': 'https://www.wikidata.org/wiki/Q2273828', 'display_name': 'Genome project', 'level': 4, 'score': 0.56737936}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.560629}, {'id': 'https://openalex.org/C2908923196', 'wikidata': 'https://www.wikidata.org/wiki/Q5205742', 'display_name': 'Gene Annotation', 'level': 4, 'score': 0.50786096}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.4803154}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.450154}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C162317418', 'wikidata': 'https://www.wikidata.org/wiki/Q252857', 'display_name': 'Transcriptome', 'level': 4, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2021.06.10.447952', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2021/10/06/2021.06.10.447952.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/genetics/iyab227', 'pdf_url': 'https://academic.oup.com/genetics/article-pdf/220/2/iyab227/43399577/iyab227.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2021.06.10.447952', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2021/10/06/2021.06.10.447952.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1596062789', 'https://openalex.org/W2022910985', 'https://openalex.org/W2095680943', 'https://openalex.org/W2102619694', 'https://openalex.org/W2104549677', 'https://openalex.org/W2107282968', 'https://openalex.org/W2122732537', 'https://openalex.org/W2146108629', 'https://openalex.org/W2158714788', 'https://openalex.org/W2168909179', 'https://openalex.org/W2170079545', 'https://openalex.org/W2170310072', 'https://openalex.org/W2173732482', 'https://openalex.org/W2336818861', 'https://openalex.org/W2481029670', 'https://openalex.org/W2580040938', 'https://openalex.org/W2784788330', 'https://openalex.org/W2788228074', 'https://openalex.org/W2789492402', 'https://openalex.org/W2898598946', 'https://openalex.org/W2901214479', 'https://openalex.org/W2903241977', 'https://openalex.org/W2952870794', 'https://openalex.org/W2991295831', 'https://openalex.org/W3022572641', 'https://openalex.org/W3022783334', 'https://openalex.org/W3029661147', 'https://openalex.org/W3030496926', 'https://openalex.org/W3037487387', 'https://openalex.org/W3037791019', 'https://openalex.org/W3042374389', 'https://openalex.org/W3085758516', 'https://openalex.org/W3097237895', 'https://openalex.org/W3113162057', 'https://openalex.org/W3128198169', 'https://openalex.org/W3148425969', 'https://openalex.org/W3163990482'], 'related_works': ['https://openalex.org/W3088056938', 'https://openalex.org/W3028516693', 'https://openalex.org/W2991935870', 'https://openalex.org/W2793945238', 'https://openalex.org/W2503209723', 'https://openalex.org/W2289136766', 'https://openalex.org/W2133994800', 'https://openalex.org/W2033409266', 'https://openalex.org/W1996370379', 'https://openalex.org/W1975465622'], 'abstract_inverted_index': {'Abstract': [0], 'Until': [1], '2019,': [2, 42], 'the': [3, 16, 44, 58, 79, 89, 114, 117], 'human': [4, 121], 'genome': [5, 34, 45, 93, 122], 'was': [6, 15, 35, 51, 74], 'available': [7, 36], 'in': [8, 29, 105, 157, 168, 171], 'only': [9, 175], 'one': [10], 'fully-annotated': [11], 'version,': [12], 'GRCh38,': [13], 'which': [14, 145], 'result': [17], 'of': [18, 21, 46, 62, 78, 98, 116], '18': [19], 'years': [20], 'continuous': [22], 'improvement': [23], 'and': [24, 60, 108, 111, 132, 159, 177], 'revision.': [25], 'Despite': [26], 'dramatic': [27], 'improvements': [28, 104], 'sequencing': [30, 107], 'technology,': [31, 110], 'no': [32], 'other': [33], 'as': [37, 76, 123], 'an': [38, 47, 96], 'annotated': [39], 'reference': [40, 92], 'until': [41], 'when': [43], 'Ashkenazi': [48], 'individual,': [49], 'Ash1,': [50], 'released.': [52], 'In': [53], 'this': [54], 'study,': [55], 'we': [56], 'describe': [57], 'assembly': [59, 109], 'annotation': [61], 'a': [63, 68, 124], 'second': [64], 'individual': [65, 71, 97], 'genome,': [66, 85], 'from': [67, 95, 161, 182, 187], 'Puerto': [69], 'Rican': [70], 'whose': [72], 'DNA': [73], 'collected': [75], 'part': [77], 'Human': [80], 'Pangenome': [81], 'project.': [82], 'The': [83], 'new': [84], 'called': [86], 'PR1,': [87], 'is': [88, 129], 'first': [90], 'true': [91], 'created': [94], 'African': [99], 'descent.': [100], 'Due': [101], 'to': [102, 113, 126], 'recent': [103], 'both': [106], 'particularly': [112], 'use': [115], 'recently': [118], 'completed': [119], 'CHM13': [120, 183], 'guide': [125], 'assembly,': [127], 'PR1': [128, 158, 169], 'more': [130, 133], 'complete': [131], 'contiguous': [134], 'than': [135, 170], 'either': [136], 'GRCh38': [137], 'or': [138], 'Ash1.': [139], 'Annotation': [140], 'revealed': [141], '37,755': [142], 'genes': [143, 164, 179], '(of': [144], '19,999': [146], 'are': [147, 155, 184], 'protein-coding),': [148], 'including': [149], '12': [150], 'additional': [151], 'gene': [152], 'copies': [153, 167], 'that': [154], 'present': [156], 'missing': [160, 186], 'CHM13.': [162], '57': [163], 'have': [165], 'fewer': [166], 'CHM13,': [172], '9': [173], 'map': [174], 'partially,': [176], '3': [178], '(all': [180], 'non-coding)': [181], 'entirely': [185], 'PR1.': [188]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3167062982', 'counts_by_year': [], 'updated_date': '2024-12-19T23:04:01.130509', 'created_date': '2021-06-22'}