Title: Clinical Implications of Genetic Profiling, Polygenic Risk Scores, LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease (ASCVD) – What is New?
Abstract: Elevated levels of circulating Low-density lipoprotein (LDL) is now considered as the predominant putative cause of Atherosclerotic Cardiovascular Disease (ASCVD) 1 We now recognise that LDL-cholesterol is central to the atherosclerotic process.The Lipid-Atherosclerosis hypothesis has been well established.Yet there is confusion and controversy as to its causative role with many physicians still implying that inflammatory processes may play a bigger role. 2