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1339, 1389], 'sensitivity.': [783], 'Both': [784], 'have': [785, 1189, 1420], 'validated': [787], 'against': [788], 'current': [789], 'gold': [790], 'standards': [791], 'commonly': [794], 'accepted': [795], 'surrogates': [796], 'published': [799], 'literature.5': [800], 'Analyses': [801], 'using': [805], 'ANCOVA': [806, 1142], 'models': [807, 1143], 'sex,': [809, 1146], 'age,': [810, 1147], 'value': [813, 827, 1150], 'end': [816, 1071, 1119, 1153], 'point,': [817, 1154], 'treatment': [820, 1115, 1157, 1382, 1425], 'group': [821, 879, 886, 897, 1093, 1098, 1136], 'covariates.': [823], '2-sided': [825], 'P': [826], '<0.05': [828], 'considered': [830], 'statistically': [831], 'significant.In': [832], 'total,': [833], '120': [834], 'enrolled,4': [837], 'including': [838], '108': [839], '(90%)': [840], 'history': [844], 'whom': [848], '19': [849], '(18%)': [850], 'had': [851, 857, 1509], 'new-onset': [852], 'T2D': [853, 1221, 1429], '35': [855], '(32%)': [856], 'impaired': [858], 'based': 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[970, 1290, 1413], 'showed': [971], 'overall': [972], 'similar': [973, 1200], 'results': [974], '(data': [975], 'not': [976, 1274, 1410], 'shown).': [977], 'fasting': [980], 'plasma': [981, 991, 1009, 1236, 1978], '(–5.2%': [983], '[95%': [984, 998, 1016, 1029], '–8.7': [986], '–1.8],': [988], 'P=0.003)': [989], 'area': [993, 1011], 'under': [994, 1012], 'curve': [996, 1014], '(–7.0%': [997], '–2.5': [1000], '–12],': [1002], 'P=0.002).': [1003], 'No': [1004, 1043], 'observed': [1007, 1046, 1336], '(–9.9%': [1015], '–22': [1018], '1.3],': [1020], 'P=0.09)': [1021], 'pancreatic': [1023], 'β-cell': [1024], 'function': [1025], '(Disposition': [1026], 'Index,': [1027], '5.3%': [1028], '–20': [1031], '25],': [1033], 'P=0.7).': [1034], 'total': [1037, 1252, 1404], 'weight': [1039, 1264, 1406], 'mass.': [1042, 1349], 'fat': [1048, 1050, 1412], 'mass,': [1049, 1273, 1409], 'percentage,': [1051], 'visceral': [1053], 'adipose': [1054], 'tissue': [1055], '[C–G]).Download': [1057], 'figureDownload': [1058], 'PowerPointFigure.': [1059], 'Effect': [1060, 1744], 'composition.': [1068], 'For': [1069], 'each': [1070, 1118], 'point': [1072, 1120], '(A–G),': [1073], 'boxplots': [1074], 'represent': [1075, 1108], 'unadjusted': [1076], 'values': [1077], 'baseline,': [1079], '(red)': [1094], '(blue).': [1099], 'The': [1100, 1114, 1194, 1350, 1440, 1448, 1461, 1483, 1497, 1505, 1523, 1536, 1559, 1582, 1706, 1712, 1780], 'box': [1101], 'represents': [1102, 1285, 1315], 'median': [1103], 'interquartile': [1105, 1112], 'range;': [1106], 'whiskers': [1107], '1.5': [1109], 'times': [1110], 'range.': [1113], 'difference': [1124], 'vs': [1137, 2020], 'group,': [1140], 'HOMA2': [1159], 'indicates': [1160], 'Assessment;': [1163], 'pp,': [1165], 'percentage': [1166], 'point.To': [1167], 'our': [1168], 'knowledge,': [1169], 'first': [1173], 'reporting': [1175], 'who': [1188], 'HFrEF': [1190, 1212], 'primarily': [1191, 1230], 'diabetes.': [1193, 1400], 'indicate': [1197], 'improvement': [1201, 1337], 'induced': [1206], 'previously': [1216], 'reported': [1217], 'failure.': [1224], 'Our': [1225], 'suggest': [1227], 'modulates': [1231], 'decreasing': [1235], 'glucose.': [1237], 'Thereby,': [1238], 'adverse': [1240], 'actions': [1241], 'hyperglycemia': [1243], 'several': [1245], 'tissues': [1246], 'potentially': [1248], 'decreased.': [1249], 'weight,': [1254], 'but,': [1255], 'contrast': [1257], 'previous': [1259], 'loss': [1265, 1284, 1317, 1346], 'consisted': [1266], 'mainly': [1267, 1395], 'reduction': [1270], 'fat.': [1275], 'It': [1276], 'remains': [1277], 'unknown': [1278], 'what': [1280], 'extent': [1281], 'early': [1283, 1295], 'decrease': [1287], 'muscle': [1289], 'water.': [1292, 1319], 'sustained': [1297], 'cotransporter-2': [1301], 'outcomes,1': [1305], 'it': [1306], 'be': [1308, 1355, 1365], 'speculated': [1309], 'that,': [1310], 'some': [1312], 'extent,': [1313], 'also': [1322, 1333], 'demonstrated': [1324], 'other': [1326, 1781], 'modalities.4': [1327], 'Reduction': [1328], 'water': [1331], 'could': [1332], 'explain': [1334], 'empagliflozin,': [1343], 'despite': [1344], 'small': [1351], 'sample': [1352], 'size': [1353], 'should': [1354], 'acknowledged': [1356], 'when': [1357], 'interpreting': [1358], 'results,': [1360], 'no': [1362, 1510, 1784], 'conclusions': [1363], 'can': [1364], 'made': [1366], 'regarding': [1367], 'possible': [1368], 'T2D.In': [1375], 'both': [1386], 'cohort': [1394], 'consisting': [1396], 'Moreover,': [1401], 'reductions': [1402], 'indices,': [1414], 'observed.': [1416], 'These': [1417], 'likely': [1419], 'implications': [1421], 'prevention': [1427], 'HFrEF.Sources': [1433], 'FundingThis': [1435], 'research': [1436, 1459, 1481], 'supported': [1438], 'Danish': [1441, 1707], 'Foundation': [1443, 1465, 1486, 1540, 1562, 1709], '(grant': [1444, 1493, 1502], 'numbers': [1445], '17-R116-A7714-22076,': [1446], '18-R124-A8573-22107),': [1447], 'Research': [1449, 1462, 1524, 1537], 'Council': [1450, 1525], '(institutional': [1458, 1480], 'grant),': [1460, 1482], 'Innovation': [1464, 1539], '(FUHAS,': [1471, 1546], 'formerly': [1472, 1547], 'FUKAP),': [1473, 1548], 'A.P.': [1484, 1560], 'Advancement': [1489, 1565], 'Medical': [1491, 1567], 'Science': [1492], 'number': [1494, 1503], '17-l-0002),': [1495], 'Capital': [1498, 1713], 'Region': [1499, 1714], 'A6058).': [1504], 'manufacturer': [1506], 'role': [1511], 'any': [1513], 'aspect': [1514], 'study.Disclosures': [1517], 'Dr': [1518, 1577, 1595, 1625, 1645, 1680, 1701], 'reports': [1520, 1579, 1597, 1627, 1648, 1682, 1703], 'grants': [1521, 1534, 1557, 1580, 1683, 1704], 'Science,': [1568], 'conduct': [1573, 1591, 1719], 'study.': [1576, 1594], 'personal': [1598, 1628, 1649, 1687, 1723, 1765], 'fees': [1599, 1606, 1629, 1650, 1657, 1688, 1724, 1766], 'scientific': [1601, 1652], 'advisory': [1602, 1653], 'panel': [1603, 1654], 'speaker': [1605, 1631, 1656, 1690, 1726, 1768], 'Boehringer': [1608, 1639, 1660, 1774], 'Ingelheim,': [1609, 1640, 1661, 1775], 'Merck,': [1610], 'Sharp': [1611], '&': [1612], 'Dohme,': [1613], 'AstraZeneca,': [1614, 1635, 1659, 1764], 'Amgen,': [1615], 'Novartis,': [1616, 1634, 1667], 'Novo': [1617, 1636, 1771], 'Nordisk,': [1618, 1637], 'Shire,': [1620], 'outside': [1621, 1641, 1676, 1697, 1776], 'submitted': [1623, 1643, 1678, 1699, 1778], 'work.': [1624, 1644, 1679, 1700, 1779], 'honoraria': [1632, 1691, 1727], 'F.': [1646], 'Abbott,': [1662], 'Orion': [1663, 1695], 'Pharma,': [1664, 1696], 'Pfizer,': [1665], 'acting': [1669], 'an': [1671, 1937], 'unpaid': [1672], 'advisor': [1673], 'Corvia,': [1675], 'Abiomed': [1685], 'Inc,': [1686], 'Novartis': [1693], 'study;': [1722], 'nonfinancial': [1729], '(as': [1731], 'national': [1733], 'lead': [1734], 'investigator': [1735], 'DAPA-HF': [1738, 1872, 1916], '[Study': [1740], 'Evaluate': [1742], 'Dapagliflozin': [1746, 1920], 'Incidence': [1749], 'Worsening': [1751], 'Cardiovascular': [1755], 'Death': [1756], 'Chronic': [1760], 'Failure])': [1762], 'honorarium': [1769], 'Nordisk': [1772], 'authors': [1782], 'report': [1783], 'conflicts.FootnotesThe': [1785], 'podcast': [1786], 'transcript': [1788], 'Data': [1792], 'Supplements': [1793], 'https://www.ahajournals.org/doi/suppl/10.1161/CIRCULATIONAHA.120.053463.Registration:': [1795], 'URL:': [1796], 'https://www.clinicaltrials.gov;': [1797], 'Unique': [1798], 'identifier:': [1799], 'NCT03198585.For': [1800], 'Sources': [1801], 'Funding': [1803], 'Disclosures,': [1805], 'see': [1806], 'page': [1807], '2210.https://www.ahajournals.org/journal/circCorrespondence': [1808], 'morten.schou.[email': [1831], 'protected]dkReferences1.': [1832], 'Zannad': [1833], 'F,': [1834, 1961], 'Ferreira': [1835], 'JP,': [1836], 'Pocock': [1837], 'SJ,': [1838], 'Anker': [1839], 'SD,': [1840, 1909], 'Butler': [1841], 'J,': [1842, 1913, 1949, 1963, 2010], 'Filippatos': [1843], 'G,': [1844], 'Brueckmann': [1845], 'M,': [1846, 1951], 'Ofstad': [1847], 'AP,': [1848], 'Pfarr': 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'10.1007/s00125-014-3285-xCrossrefMedlineGoogle': [2029], 'Scholar': [2030], 'Previous': [2031], 'Back': [2032], 'top': [2034], 'Next': [2035], 'FiguresReferencesRelatedDetails': [2036], 'June': [2037], '2021Vol': [2039], 'Issue': [2041], '22Article': [2042], 'InformationMetrics': [2043], 'Download:': [2044], '1,664': [2045], '©': [2046], '2021': [2047, 2056], 'American': [2048], 'Association,': [2050], 'Inc.https://doi.org/10.1161/CIRCULATIONAHA.120.053463PMID:': [2051], '34061581': [2052], 'publishedJune': [2054], 'Keywordsheart': [2057], 'failurebody': [2058], 'compositiondiabetes': [2059], 'mellitus,': [2060], '2insulin': [2062], 'resistancesodium-glucose': [2063], 'transporter': [2064], 'inhibitorsempagliflozinPDF': [2066], 'download': [2067], 'SubjectsHeart': [2068], 'FailureClinical': [2069], 'StudiesMetabolismMechanisms': [2070]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3165122163', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 7}], 'updated_date': '2024-09-01T09:12:17.305086', 'created_date': '2021-06-07'}