Abstract: A disease resembling Rift Valley fever (RVF) and affecting sheep was described by Montgommery in Kenya in 1912-1913 but it was in 1930 that RVF was identified, during a major outbreak in a farm near Lake Naivasha in Kenya. Sheep, cattle, and goats are very susceptible to RVF, very young animals being the most susceptible, with almost 100% mortality rates. The Rift Valley fever virus (RVFV) is enveloped and spherical with a diameter of 80-120nm. Most wild strains of RVFV express a nonstructural NSs protein, which is considered to be one of the main factors responsible for RVFV pathogenesis. The vaccine is a formalin-inactivated virulent strain of RVFV formulated in aluminum hydroxide gel as adjuvant for the prophylactic immunization of cattle, sheep, and goats. The rapid development of countermeasures against RVFV is important to minimize the impact of the disease. The development of safe veterinary vaccines should encourage and stimulate the development of human vaccines.
Publication Year: 2021
Publication Date: 2021-05-07
Language: en
Type: other
Indexed In: ['crossref']
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Cited By Count: 1
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