Abstract: In article number 2100035, Ramakrishnan Kannan, Xiaoqing Pan, Miaofang Chi, and co-workers developed a robust, unsupervised machine learning data analysis method to reveal encapsulation of metal catalysts that are otherwise overlooked in microscopy datasets. Therefore, providing a reliable tool for analyzing the nano-environment of catalysts and being generally applicable to any spectroscopic analysis where revealing a trace signal is challenging.