Abstract: Plasma cell myeloma is a malignant disease of plasma cells producing specific proteins, which typically involves the bone marrow but involves other soft tissues as well. The bony lesions tend to occur as multiple myeloma, but about 2-10% consist of a solitary type and some authors insist that solitary lesion would develop to disseminated myeloma in 8-10 years. Criteria used for solitary osseous myeloma were 1. presentation with biopsy-proven plasma cell myeloma in a single osseous site 2. negative bone marrow examination at the time of diagnosis 3. no laboratory or radiographic evidence, of dissemination far 2 years following the initial diagnosis . 4. no Bence-Jones protein in urine. We experienced the solitary plasma cell myeloma in 42 year old male occuring m the mandible. On the panoramic view, the expansive osteolytic lesion with invasion of mandibular inferior border was noted. No osteolytic defect was found on the other bone series. Histologically, the osteolytic lesion of the mandible was heavily infiltrated with atypical plasma cells. The bone marrow showed slightly increased cellularity without malignant cells or plasmacytosis. Laboratory results presented slight increase of gamma-globulin in serum without monoclonal gammopathy. No Bence-Jone`s protein was found in urine. Other blood tests were within normal limit.
Publication Year: 1987
Publication Date: 1987-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot