Publication Information

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'https://openalex.org/W2911919235', 'https://openalex.org/W2921530519', 'https://openalex.org/W2974482276', 'https://openalex.org/W2980417415', 'https://openalex.org/W4229487902', 'https://openalex.org/W606118208'], 'related_works': ['https://openalex.org/W4245440762', 'https://openalex.org/W2801635219', 'https://openalex.org/W2374375360', 'https://openalex.org/W2291867146', 'https://openalex.org/W2123185042', 'https://openalex.org/W2081585241', 'https://openalex.org/W2060407540', 'https://openalex.org/W2040327458', 'https://openalex.org/W1991335876', 'https://openalex.org/W1797343337'], 'abstract_inverted_index': {'Voltage-gated': [0, 246, 492, 590, 772], 'sodium': [1, 158, 247, 404, 493, 551, 555, 591, 773, 836, 940, 1052, 1081, 1117, 1144, 1179, 1221, 1968, 2007, 2067, 2115, 2267, 2413, 2477, 2615, 2642, 2764, 3039, 3112, 3227, 3236, 3257, 3290, 3404, 3823, 3933, 4101], 'channels': [2, 248, 494, 592, 774, 1222, 2573, 2643, 3824, 4048], '(Nav1s)': [3, 249, 495], 'are': [4, 39, 238, 250, 285, 484, 516, 569, 1424, 1547, 1553, 1569, 2561, 2960, 3373, 3753, 3784, 4246, 4252], 'responsible': [5, 251], 'for': [6, 240, 252, 486, 550, 554, 561, 799, 892, 974, 1300, 1346, 1985, 2476, 2880, 2927, 2942, 2957, 2980, 3010, 3099, 3144, 3795, 4204], 'the': [7, 49, 61, 94, 116, 124, 142, 171, 174, 184, 191, 205, 213, 230, 241, 253, 295, 307, 340, 362, 370, 388, 417, 420, 430, 437, 451, 459, 476, 487, 506, 613, 651, 664, 690, 717, 731, 735, 827, 937, 983, 1016, 1048, 1084, 1148, 1152, 1185, 1206, 1229, 1243, 1255, 1364, 1429, 1532, 1550, 1564, 1575, 1579, 1584, 1622, 1625, 1641, 1645, 1655, 1723, 1777, 1784, 1802, 1865, 1891, 1899, 1937, 1944, 1992, 2046, 2231, 2238, 2254, 2286, 2293, 2340, 2347, 2368, 2376, 2396, 2407, 2450, 2457, 2481, 2515, 2523, 2537, 2544, 2550, 2555, 2568, 2584, 2595, 2645, 2700, 2707, 2735, 2739, 2819, 2827, 2881, 2909, 2914, 2929, 2977, 2984, 2991, 2997, 3008, 3015, 3043, 3075, 3249, 3253, 3312, 3382, 3390, 3442, 3449, 3460, 3479, 3534, 3634, 3646, 3707, 3835, 3843, 3857, 3877, 3892, 3905, 3956, 3971, 3988, 4000, 4031, 4090, 4133, 4158, 4161, 4167, 4174, 4211, 4343, 4362, 4370], 'initiation': [8, 254], 'and': [9, 17, 28, 32, 53, 74, 87, 98, 123, 166, 232, 255, 263, 274, 278, 299, 320, 333, 344, 369, 412, 478, 512, 523, 543, 563, 584, 597, 619, 631, 636, 659, 673, 694, 779, 833, 861, 877, 905, 1192, 1250, 1285, 1358, 1496, 1507, 1568, 1621, 1648, 1708, 1834, 1894, 1997, 2275, 2398, 2593, 2784, 2874, 2889, 2923, 2969, 3006, 3079, 3096, 3173, 3241, 3338, 3380, 3402, 3411, 3421, 3471, 3491, 3497, 3499, 3511, 3536, 3763, 3815, 3882, 3961, 3974, 3992, 3994, 4137, 4251, 4296, 4314, 4329], 'propagation': [10, 256], 'of': [11, 35, 48, 64, 76, 82, 105, 121, 129, 137, 145, 164, 217, 235, 243, 257, 281, 294, 310, 322, 328, 351, 367, 375, 383, 391, 410, 463, 481, 489, 518, 533, 628, 667, 692, 702, 719, 730, 749, 829, 835, 849, 863, 936, 977, 1015, 1047, 1078, 1115, 1141, 1151, 1220, 1228, 1248, 1257, 1367, 1393, 1421, 1466, 1492, 1521, 1525, 1534, 1549, 1566, 1582, 1624, 1644, 1702, 1722, 1729, 1776, 1787, 1804, 1864, 1890, 1898, 1936, 1947, 1966, 1995, 2005, 2021, 2048, 2065, 2086, 2098, 2113, 2153, 2175, 2185, 2230, 2241, 2256, 2273, 2278, 2289, 2339, 2350, 2381, 2401, 2449, 2460, 2507, 2517, 2549, 2570, 2586, 2590, 2613, 2640, 2699, 2710, 2762, 2787, 2811, 2821, 2935, 2948, 2951, 2990, 3081, 3110, 3138, 3171, 3180, 3188, 3200, 3288, 3316, 3331, 3385, 3392, 3444, 3452, 3463, 3483, 3518, 3538, 3606, 3633, 3650, 3756, 3798, 3818, 3838, 3846, 3860, 3876, 3885, 3896, 3908, 3931, 3958, 3990, 4036, 4040, 4045, 4076, 4099, 4139, 4160, 4207, 4233, 4244, 4254, 4294, 4317, 4319, 4346, 4353, 4366], 'action': [12, 258, 4055, 4069], 'potentials': [13, 259, 4056, 4070], 'in': [14, 43, 93, 152, 204, 260, 289, 339, 398, 450, 500, 505, 576, 582, 612, 638, 654, 680, 707, 763, 943, 1055, 1147, 1213, 1272, 1288, 1295, 1310, 1333, 1531, 1555, 1880, 2040, 2088, 2158, 2189, 2260, 2367, 2480, 2522, 2644, 2665, 2826, 2964, 2967, 2983, 3002, 3014, 3038, 3085, 3168, 3175, 3219, 3248, 3272, 3319, 3526, 3611, 3642, 3691, 3706, 3711, 3741, 3773, 3825, 3900, 3916, 3955, 3970, 3987, 3999, 4012, 4030, 4049, 4051, 4067, 4071, 4089, 4143, 4163, 4173, 4291, 4375], 'neurons,': [15, 261, 2041, 3981], 'muscle,': [16, 262], 'endocrine': [18, 264, 513], 'cells.': [19, 265, 514], 'Many': [20, 266], 'clinically': [21, 267], 'used': [22, 268], 'drugs': [23, 269], 'such': [24, 270, 683, 3982], 'as': [25, 271, 684, 687, 689, 2045, 2192, 3000, 3252, 3430, 3522, 3576, 3652, 3977, 3979, 3983, 4016], 'local': [26, 272], 'anesthetics': [27, 273], 'antiarrhythmics': [29, 275], 'inhibit': [30, 276], 'Nav1s,': [31, 83, 236, 277, 329, 482, 668, 1882, 3005], 'a': [33, 118, 132, 224, 279, 364, 378, 470, 497, 519, 540, 544, 714, 1051, 1079, 1116, 1142, 1268, 1347, 1522, 1535, 1556, 1850, 2026, 2066, 2114, 2388, 2563, 2745, 2763, 3176, 3289, 3932, 4064, 4183, 4376], 'variety': [34, 280], 'inherited': [36, 282, 3207], 'human': [37, 185, 283, 431, 850, 938, 978, 2279, 3354, 3422], 'disorders': [38, 284, 852], 'caused': [40, 286], 'by': [41, 287, 617, 831, 982, 2095, 2136, 3322, 3437, 3454, 3524, 3614, 4018, 4026, 4180, 4230, 4248], 'mutations': [42, 288], 'Nav1': [44, 65, 148, 290, 311, 394, 571, 750, 1870, 1987, 2031, 2187, 2572, 2958, 3201, 3211, 3800, 3848, 4372, 4384], 'genes.': [45, 291, 2539], 'Nav1s': [46, 106, 292, 352, 515, 608, 1038, 2052, 2731, 4082], 'consist': [47, 293], 'main': [50, 296, 520], 'α': [51, 297, 529, 572, 3386], 'subunit': [52, 187, 298, 433, 522, 530, 573, 1182, 1872, 2282, 2304, 3394], 'several': [54, 300], 'auxiliary': [55, 301, 525, 3801], 'β': [56, 182, 302, 428, 2303, 3371, 3393], 'subunits.': [57, 303, 527, 3387, 3439], 'Detailed': [58, 304], 'information': [59, 305, 758, 1658, 2786], 'on': [60, 306, 1659, 2025, 3395, 3459, 3834], 'structure–function': [62, 308], 'relationships': [63, 309], 'subunits': [66, 312, 3372], 'has': [67, 110, 313, 356, 1210, 1233, 2177, 4086], 'been': [68, 111, 314, 357, 678, 1211, 1234, 2178, 4387], 'obtained': [69, 315, 759, 2920], 'through': [70, 316, 760], 'heterologous': [71, 102, 317, 348, 764, 1214, 2172, 4377], 'expression': [72, 104, 318, 350, 765, 1114, 1215, 1219, 2064, 2085, 2112, 2157, 2174, 2761, 3287, 3379, 3451, 3610, 3845, 3894, 3906, 3930, 3951, 4028, 4378], 'experiments': [73, 319], 'analyses': [75, 321, 848, 879], 'protein': [77, 323, 1848, 4321], 'structures.': [78, 324], 'The': [79, 325, 528, 796, 889, 1390, 1463, 1518, 2576, 2944, 3487], 'basic': [80, 326, 665, 2137, 3204], 'properties': [81, 144, 193, 234, 327, 390, 439, 480, 666, 2184, 2288, 2400, 3384], 'including': [84, 330, 669, 1226, 1259, 1883, 2588], 'their': [85, 331, 579, 670, 703], 'gating': [86, 162, 192, 332, 408, 438, 671, 866, 2272, 2287, 3383], 'ion': [88, 334, 674, 864, 1788, 1948, 2155, 2242, 2351, 2461, 2711, 2981], 'permeation,': [89, 335, 675], 'were': [90, 336, 609, 697, 3165, 3428, 3502, 3953], 'classically': [91, 337], 'described': [92, 338], 'squid': [95, 341, 614, 1153, 1230], 'giant': [96, 342, 615, 1149, 1231], 'axon': [97, 214, 343, 460, 616, 1150, 2377, 3076, 4134, 4212], 'other': [99, 345, 681, 1580, 2577, 3003], 'invertebrates.': [100, 346], 'However,': [101, 347, 2171], 'functional': [103, 349, 1218, 2173, 3363, 3450, 3780, 4364], 'from': [107, 353, 1019, 1083, 1184, 1223, 1254, 1640, 2406, 2601, 2743, 2903, 2987, 3260, 3648, 3709, 4080], 'marine': [108, 354, 1224, 4367, 4382], 'invertebrates': [109, 355], 'unsuccessful.': [112, 358, 2179], 'Ascidians': [113, 359], 'belong': [114, 360, 1562, 3183], 'to': [115, 135, 180, 212, 226, 361, 381, 426, 458, 472, 634, 699, 753, 1242, 1328, 1360, 1563, 1574, 1801, 1821, 2301, 2375, 2391, 2519, 2567, 2583, 2729, 2738, 2823, 2907, 3184, 3208, 3225, 3268, 3348, 3361, 3375, 3434, 3768, 3778, 3788, 3791, 3872, 3904, 4351], 'Urochordata,': [117, 363], 'sister': [119, 365], 'group': [120, 366, 1581, 3187], 'vertebrates,': [122, 368], 'larval': [125, 371, 2647, 3917, 3959], 'central': [126, 372, 1508, 3960, 3968], 'nervous': [127, 373, 507, 1431, 1509, 2648, 3963, 4002], 'system': [128, 374, 508, 1271, 1327, 1510, 4003], 'ascidians': [130, 376, 1996, 3783], 'shows': [131, 377], 'similar': [133, 379], 'plan': [134, 380], 'that': [136, 173, 382, 419, 546, 1227, 1252, 1278, 1292, 1427, 1982, 2132, 2295, 2554, 3193, 3202, 3230, 3343, 4061, 4084, 4342], 'vertebrates.': [138, 384], 'Here,': [139, 385, 2180], 'we': [140, 386, 2181, 2900, 2919, 3222, 3397, 3446, 3793, 4165, 4360], 'report': [141, 387], 'biophysical': [143, 233, 389, 479, 2183, 2399], 'ascidian': [146, 392, 1263, 1311, 1778, 1938, 2159, 2232, 2341, 2451, 2603, 2646, 2701, 3256, 4072, 4371], 'Ciona': [147, 175, 393, 421, 1322, 1526, 1646, 1660, 1703, 1724, 1866, 2186, 2296, 2408, 2483, 2508, 2788, 2812, 2883, 2904, 4037], '(CiNav1a)': [149, 395, 4374], 'heterologously': [150, 396, 2258], 'expressed': [151, 397, 1146, 1649, 2038, 2259, 3231, 3318, 3915, 4011, 4032, 4166], 'Xenopus': [153, 399, 2261, 3220, 3320, 3612, 4052], 'oocytes.': [154, 400], 'CiNav1a': [155, 199, 401, 445, 2263, 2363, 2661, 2911, 2949, 2965, 3194, 3217, 3232, 3245, 3317, 3344, 3350, 3410, 3414, 3484, 3510, 3519, 3558, 3714, 3729, 3770, 3861, 3886, 3897, 3950, 4008, 4041, 4062, 4085, 4347], 'exhibited': [156, 402, 3233], 'tetrodotoxin-insensitive': [157, 403], 'currents': [159, 405, 729, 2268, 3237, 3330, 3405], 'with': [160, 170, 196, 406, 416, 442, 537, 578, 756, 767, 945, 1275, 1654, 1874, 2269, 2292, 2996, 3238, 3415, 3514, 3578, 3585, 3693, 3715, 3743, 3771, 3867, 4042, 4171, 4191, 4235, 4335], 'rapid': [161, 407, 2271, 3239], 'kinetics': [163, 409, 672, 3482, 3884], 'activation': [165, 411, 2274, 3240, 3492, 3880], 'inactivation.': [167, 413, 2276], 'Furthermore,': [168, 414], 'consistent': [169, 415, 2291], 'fact': [172, 418, 2294], 'genome': [176, 422, 1620, 1647, 1701, 1725, 1779, 1867, 1939, 2233, 2297, 2342, 2409, 2452, 2484, 2506, 2702, 2810, 2872], 'lacks': [177, 423, 2298], 'orthologous': [178, 424, 2299], 'genes': [179, 425, 574, 1989, 2305, 2415, 2479, 2552], 'vertebrate': [181, 427, 1365, 1493, 1577, 1709, 1881, 2050, 2302, 2571, 2730, 3210, 4292], 'subunits,': [183, 429], 'β1': [186, 432, 2280, 3438, 3615], 'did': [188, 434, 2283, 3476, 3854, 3869], 'not': [189, 435, 501, 1279, 2284, 2723, 3367, 3477, 3503, 3855, 3870, 4021], 'influence': [190, 436], 'when': [194, 440], 'coexpressed': [195, 441], 'CiNav1a.': [197, 443, 3839], 'Interestingly,': [198, 444], 'contains': [200, 446, 2364, 2725], 'an': [201, 447, 1262, 1324, 1822, 2365, 3196, 4087], 'ankyrin-binding': [202, 448, 1895], 'motif': [203, 449, 1896, 3036], 'II–III': [206, 452, 1901, 2369, 3016, 4091, 4168, 4189, 4344], 'linker,': [207, 453, 1893, 2370], 'which': [208, 237, 454, 483, 696, 1246, 1546, 2042, 2371, 3265, 3465, 3912, 3965, 4325, 4340], 'can': [209, 455, 2133, 2372, 4348], 'be': [210, 456, 2134, 2373, 3269, 3435, 4349], 'targeted': [211, 244, 457, 490, 2374, 4350], 'initial': [215, 461, 2378, 3045, 3077, 4135, 4213], 'segment': [216, 462, 2379, 3078, 4136], 'mammalian': [218, 464, 2382], 'cortical': [219, 465, 2383, 4178, 4355], 'neurons.': [220, 466, 2384, 4073, 4356], 'Our': [221, 467, 747], 'findings': [222, 468, 2386], 'provide': [223, 469, 2387, 4361], 'platform': [225, 471, 2390], 'gain': [227, 473, 1361, 2392], 'insight': [228, 474, 1362, 2886], 'into': [229, 475, 1363, 1706, 1783, 1943, 2237, 2346, 2395, 2456, 2706, 2887, 3353], 'evolutionary': [231, 477, 1193, 1490, 2397], 'important': [239, 485], 'development': [242, 488, 1309], 'therapeutics.': [245, 491], 'play': [496], 'crucial': [498], 'role': [499, 4066, 4159], 'only': [502, 1280, 2724, 3409, 3508], 'membrane': [503, 629, 655], 'excitability': [504], 'but': [509, 1298, 2732, 3776], 'also': [510, 677, 1299, 1359, 2733, 3007, 3166, 3425, 3529, 3766], 'muscle': [511], 'composed': [517], '(α)': [521], 'associated': [524], '(β1–4)': [526], 'is': [531, 547, 1240, 1267, 1323, 1849, 2580, 2917, 3246, 3345, 4024], 'comprised': [532], 'four': [534, 2411, 2538, 2992], 'homologous': [535, 2728], 'domains,': [536], 'each': [538, 2988, 3757], 'containing': [539], 'voltage': [541, 709, 1730, 1824, 1846, 3011], 'sensor,': [542], 'pore': [545, 975, 2978], 'highly': [548, 2727], 'selective': [549], 'ions—a': [552], 'selectivity': [553, 2982], 'over': [556], '1000': [557], 'times': [558], 'higher': [559], 'than': [560, 1578, 2966, 3324, 3790], 'potassium': [562], 'calcium': [564], 'ions.': [565], 'To': [566, 3388, 3440, 4156], 'date,': [567], 'there': [568], 'ten': [570], 'identified': [575, 1868, 2030, 2410, 2551, 2597, 2741, 4229], 'mammals': [577], 'expressions': [580], 'regulated': [581], 'tissue-specific': [583], 'cell': [585, 705, 1290, 1334, 1406, 2093, 3377, 4327], 'type–specific': [586], 'manner': [587], '(1Catterall': [588, 770], 'W.A.': [589, 771, 791, 884, 3135, 3604], 'at': [593, 775, 2562, 3042, 3074, 3654, 4132, 4210], '60:': [594, 776], 'Structure,': [595, 777], 'function': [596, 778, 3580, 3696, 3746], 'pathophysiology.J.': [598, 780], 'Physiol.': [599, 640, 738, 781, 2162], '2012;': [600, 782], '590:': [601, 783], '2577-2589Crossref': [602, 784], 'PubMed': [603, 644, 742, 785, 807, 843, 872, 900, 949, 989, 1030, 1063, 1098, 1129, 1165, 1201, 1353, 1399, 1436, 1472, 1502, 1540, 1631, 1714, 1738, 1795, 1829, 1857, 1955, 1975, 2014, 2079, 2127, 2166, 2249, 2358, 2468, 2531, 2622, 2656, 2718, 2776, 2835, 2895, 3050, 3091, 3119, 3157, 3302, 3627, 3831, 3945, 4108, 4149, 4220, 4267, 4309], 'Scopus': [604, 645, 743, 786, 808, 844, 873, 901, 950, 990, 1031, 1064, 1099, 1130, 1166, 1202, 1318, 1354, 1400, 1437, 1473, 1503, 1541, 1632, 1715, 1739, 1796, 1830, 1858, 1956, 1976, 2015, 2080, 2128, 2167, 2250, 2359, 2469, 2532, 2623, 2657, 2719, 2777, 2836, 2896, 3051, 3092, 3120, 3158, 3303, 3628, 3946, 4109, 4150, 4221, 4268, 4310], '(429)': [605, 787], 'Google': [606, 647, 745, 788, 810, 846, 875, 903, 952, 992, 1033, 1066, 1101, 1132, 1168, 1204, 1320, 1356, 1402, 1439, 1475, 1505, 1543, 1634, 1717, 1741, 1798, 1832, 1860, 1958, 1978, 2017, 2082, 2130, 2169, 2252, 2361, 2471, 2534, 2625, 2659, 2721, 2779, 2838, 2898, 3053, 3094, 3122, 3160, 3305, 3630, 3832, 3948, 4111, 4152, 4223, 4270, 4312], 'Scholar).': [607, 746, 1034, 1321, 1544, 1635, 1718, 1861, 1979, 2018, 2083, 2170, 2362, 2472, 2660, 2780, 3161, 3306], 'first': [610, 3447, 4363], 'characterized': [611, 679, 3255], 'Hodgkin': [618], 'Huxley': [620, 623], '(2Hodgkin': [621], 'A.L.': [622, 3133], 'A.F.': [624], 'A': [625, 1176, 1719, 1845, 2019, 2503, 2511, 2807, 2815, 3034, 3136, 3820, 4288], 'quantitative': [626], 'description': [627], 'current': [630, 3315, 3365, 3461, 3480, 3844, 3858], 'its': [632, 1282, 3456], 'application': [633], 'conduction': [635], 'excitation': [637], 'nerve.J.': [639], '1952;': [641], '117:': [642], '500-544Crossref': [643], '(13430)': [646], 'Scholar),': [648, 847, 876, 1205, 1403, 1440, 1506, 2899, 3095, 3631, 3833, 3949], 'who': [649], 'established': [650], 'fundamental': [652], 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'Kaczmarczyk': [1374, 1447], 'Winchell': [1376, 1449], 'C.J.': [1377, 1450], 'Hudson': [1378, 1451], 'C.': [1379, 1452, 1484], 'Kamata': [1380, 1453], 'Nakagawa': [1382, 1455], 'Tsuda': [1384, 1457], 'Kusakabe': [1386, 1413, 1459], 'T.G.': [1387, 1414, 1460], 'pre-vertebrate': [1391, 1464], 'placodes.Nature.': [1395, 1468, 1498], '2015;': [1396, 1469, 4306], '524:': [1397, 1470], '462-465Crossref': [1398, 1471], '(63)': [1401, 1474], 'neural': [1404, 1494, 3274], 'stem': [1405], '(18Horie': [1407], 'T.': [1408, 1488, 1590, 1598, 1762, 1922, 2143, 2216, 2325, 2435, 2630, 2685, 3129, 3602], 'Shinki': [1409], 'Ogura': [1411], 'Sasakura': [1417, 2846], 'Ependymal': [1419], 'cells': [1420, 1426, 3275, 3359, 3407, 3412, 3507, 3712, 3775, 3957], 'larvae': [1423], 'stem-like': [1425], 'form': [1428], 'adult': [1430], 'system.Nature.': [1432], '2011;': [1433], '469:': [1434], '525-528Crossref': [1435], '(64)': [1438], 'neuronal': [1441, 2051, 2089, 2154, 2747, 4298], 'subtypes': [1442], '19Horie': [1477], 'Hazbun': [1479], 'Cao': [1483], 'Horie': [1487], 'Shared': [1489], 'origin': [1491], 'crest': [1495], 'cranial': [1497], '560:': [1500], '228-232Crossref': [1501], '(46)': [1504], 'connectome': [1511, 1520], '(20Ryan': [1512], 'Lu': [1514], 'Meinertzhagen': [1516, 1769, 1929, 2223, 2332, 2442, 2692], 'I.A.': [1517, 1770, 1930, 2224, 2333, 2443, 2693], 'CNS': [1519], 'tadpole': [1523, 2905], 'larva': [1524, 2906], 'intestinalis': [1527, 1663, 2509, 2813], '(L.)': [1528], 'highlights': [1529], 'sidedness': [1530], 'brain': [1533, 3972, 4187], 'sibling.Elife.': [1537], '2016;': [1538, 4217], '5e16962Crossref': [1539], '(99)': [1542, 4269], 'Ascidians,': [1545], 'members': [1548], 'subphylum': [1551], 'Tunicata,': [1552], 'located': [1554, 3998], 'unique': [1557], 'phylogenetic': [1558, 2541], 'position,': [1559], 'where': [1560], 'they': [1561], 'lineage': [1565], 'chordates': [1567], 'considered': [1570, 2044], 'more': [1571, 2961, 3785], 'closely': [1572, 2581, 3786], 'related': [1573, 2582, 3787], 'ancestral': [1576, 2049], 'chordates,': [1583], 'cephalochordates': [1585], '(amphioxus)': [1586], '(21Putnam': [1587], 'N.H.': [1588], 'Butts': [1589], 'Ferrier': [1591], 'D.E.': [1592, 3127], 'Furlong': [1593], 'R.F.': [1594], 'Hellsten': [1595], 'Kawashima': [1597], 'Robinson-Rechavi': [1599], 'Shoguchi': [1601, 2848], 'E.': [1602, 2849, 3023], 'Terry': [1603], 'Yu': [1605, 2489, 2793], 'J.K.': [1606], 'Benito-Gutierrez': [1607], 'E.L.': [1608], 'Dubchak': [1609], 'I.': [1610, 1693], 'Garcia-Fernandez': [1611], 'Gibson-Brown': [1613], 'Grigoriev': [1615], 'I.V.': [1616], 'et': [1617, 1698, 1773, 1933, 2227, 2336, 2446, 2696, 2870], 'al.The': [1618, 1699], 'amphioxus': [1619], 'evolution': [1623, 1786, 1946, 2240, 2349, 2459, 2521, 2709, 2825, 4293], 'karyotype.Nature.': [1627], '2008;': [1628, 2893, 3089, 4147], '453:': [1629], '1064-1071Crossref': [1630], '(1176)': [1633], 'Of': [1636], 'note,': [1637], 'extensive': [1638], 'work': [1639], 'global': [1642, 2876], 'tag': [1651, 4034], 'provides': [1652], 'us': [1653], 'nucleic': [1656], 'robusta': [1661], '(Ciona': [1662], 'type': [1664, 2510, 2814, 3199], 'A)': [1665], '(22Dehal': [1666], 'Campbell': [1670], 'R.K.': [1671], 'Chapman': [1672], 'Degnan': [1674], 'De': [1676], 'Tomaso': [1677], 'Davidson': [1679], 'Di': [1681], 'Gregorio': [1682], 'Gelpke': [1684], 'Goodstein': [1686], 'D.M.': [1687], 'Harafuji': [1688], 'Hastings': [1690, 2868], 'K.E.': [1691, 2869], 'Ho': [1692], 'Hotta': [1694], 'draft': [1700], 'intestinalis:': [1704, 2884], 'Insights': [1705], 'origins.Science.': [1710], '2002;': [1711, 4264], '298:': [1712], '2157-2167Crossref': [1713], '(1313)': [1716], 'comprehensive': [1720, 2474], '(23Okamura': [1726], 'Biodiversity': [1728], 'sensor': [1731], 'domain': [1732], 'proteins.Pflugers': [1733], 'Arch.': [1734], '2007;': [1735], '454:': [1736], '361-371Crossref': [1737], '(42)': [1740], '24Okamura': [1743], 'Nishino': [1745, 1905, 2199, 2308, 2418, 2668, 3057, 4115], 'Murata': [1747, 1907, 2201, 2310, 2420, 2670], 'Nakajo': [1749, 1909, 2203, 2312, 2422, 2672, 3059, 4117], 'Iwasaki': [1751, 1809, 1911, 2205, 2314, 2424, 2674], 'Ohtsuka': [1753, 1913, 2207, 2316, 2426, 2676], 'Tanaka-Kunishima': [1755, 1915, 2209, 2318, 2428, 2678], 'Hara': [1759, 1919, 2213, 2322, 2432, 2682], 'Yoshida': [1761, 1921, 2215, 2324, 2434, 2491, 2684, 2795], 'Nishida': [1763, 1923, 2217, 2326, 2436, 2686], 'Okado': [1765, 1925, 2219, 2328, 2438, 2688], 'Watari': [1767, 1927, 2221, 2330, 2440, 2690], 'al.Comprehensive': [1774, 1934, 2228, 2337, 2447, 2697], 'reveals': [1780, 1940, 2234, 2343, 2453, 2514, 2703, 2818], 'novel': [1781, 1941, 2235, 2344, 2393, 2454, 2704], 'insights': [1782, 1942, 2236, 2345, 2394, 2455, 2705], 'molecular': [1785, 1945, 2239, 2348, 2458, 2708, 3205, 3816, 3836], 'genes.Physiol.': [1790, 1950, 2244, 2353, 2463, 2713], 'Genomics.': [1791, 1951, 2245, 2354, 2464, 2714], '2005;': [1792, 1826, 1952, 2246, 2355, 2465, 2715], '22:': [1793, 1953, 2247, 2356, 2466, 2716], '269-282Crossref': [1794, 1954, 2248, 2357, 2467, 2717], '(75)': [1797, 1957, 2251, 2360, 2470, 2720], 'led': [1800], 'identification': [1803], 'voltage-sensing': [1805], 'phosphatase': [1806, 1818], '(25Murata': [1807], 'Sasaki': [1811], 'Inaba': [1813], 'Okamura': [1815, 1843, 1962, 2001, 2144, 2609, 2637, 3067, 3106, 4095, 4125], 'Phosphoinositide': [1817], 'activity': [1819], 'coupled': [1820], 'intrinsic': [1823], 'sensor.Nature.': [1825], '435:': [1827], '1239-1243Crossref': [1828], '(522)': [1831], 'proton': [1836, 1852], '(Hv1/VSOP)': [1838], '(26Sasaki': [1839], 'Takagi': [1841], 'sensor-domain': [1847], 'channel.Science.': [1853], '589-592Crossref': [1856], '(395)': [1859], 'Previous': [1862, 2403], 'three': [1869, 2556], 'α-like': [1871], 'genes,': [1873], 'one': [1875], 'harboring': [1876], 'characteristics': [1878, 3191], 'conserved': [1879, 2963, 3167], 'ion-selectivity': [1884], 'signature': [1885, 2998], '(D/E/K/A),': [1886], 'inactivation': [1887, 3101, 3242, 3517, 3649, 3710], 'latch': [1888], 'III–IV': [1892, 3097], '(ABM)': [1897], 'cytoplasmic': [1900], 'linker': [1902, 3098, 4092, 4169, 4190, 4345], '(24Okamura': [1903, 2197, 2306, 2416, 2666], '27Nishino': [1960], 'Evolutionary': [1964, 2003, 2611, 3108, 4097], 'history': [1965, 2004, 2612, 3109, 4098], 'channels.Handb.': [1969, 2008, 2616, 3113, 4102], '246:': [1973, 2012, 2620, 3117, 4106], '3-32Crossref': [1974, 2013, 2621, 3118, 4107], '(6)': [1977, 2016, 2624, 3121, 4110], 'This': [1980, 3340, 4023], 'suggests': [1981], 'diversification': [1984], 'multiple': [1986], 'occurred': [1990], 'after': [1991], 'branching': [1993], 'point': [1994], '(27Nishino': [1999, 2607, 3104, 4093], 'series': [2020], 'different': [2027, 3505], 'ascidian,': [2028], 'Halocynthia,': [2029, 2744], 'complementary': [2032], 'DNA': [2033], '(cDNA)': [2034], '(originally': [2035], 'called': [2036, 3419, 3426], 'TuNa1)': [2037], 'exclusively': [2039, 3914], 'was': [2043, 2950, 3266, 3466, 3704, 3913, 4010, 4225, 4228], 'prototype': [2047], '(12Okamura': [2053, 2101, 2750, 3276, 3919], 'Gene': [2084], 'TuNa1': [2087, 2176, 2742, 3169, 3259], 'precursors': [2090], 'early': [2092, 3086, 4144], 'contact': [2094], 'neighboring': [2096], 'blastomere': [2097], 'inductive': [2099], 'potential': [2100], 'mimicked': [2135], 'fibroblast': [2138, 2149], 'growth': [2139, 2150], 'factor': [2140, 2151], 'signal': [2141, 4232, 4316, 4333, 4337], '(28Inazawa': [2142], 'Basic': [2148], 'induction': [2152], 'ectodermal': [2160], 'blastomeres.J.': [2161], '511:': [2164], '347-359Crossref': [2165], '(35)': [2168], 'describe': [2182], '(renamed': [2188], 'article': [2191], 'CiNav1a;': [2193], 'previously': [2194, 2596, 2740, 3254, 3586], 'named': [2195], 'Ci-Nav1': [2196, 2664], 'Scholar)),': [2253], 'ortholog': [2255, 3178], 'TuNa1,': [2257, 3911], 'oocyte.': [2262], 'showed': [2264, 2734, 3530, 4054], '(TTX)-insensitive': [2266], 'very': [2270], 'Coexpression': [2277, 4039], '(hβ1)': [2281], 'affect': [2285], 'CiNav1a,': [2290, 2558, 3396, 4164], 'ABM': [2366, 3013, 4088, 4162], '(AIS)': [2380], 'These': [2385, 3190, 4059], 'new': [2389], 'Nav1s.': [2402], 'homology': [2404, 2737], 'search': [2405, 2475], 'Subsequent': [2473], 'updated': [2482], '(29Satou': [2485, 2789], 'Nakamura': [2487, 2791], 'D.': [2490, 2794, 3031], 'Hamada': [2493, 2797], 'Fujie': [2495, 2799], 'Hisata': [2497, 2801], 'Takeda': [2499, 2803], 'nearly': [2504, 2808], 'complete': [2505, 2809], '(C.': [2512, 2816], 'robusta)': [2513, 2817], 'contribution': [2516, 2820], 'inversion': [2518, 2822], 'chromosomal': [2520, 2824], 'genus': [2524, 2828], 'Ciona.Genome': [2525, 2829], 'Evol.': [2527, 2831], '11:': [2529, 2833], '3144-3157Crossref': [2530, 2834], '(28)': [2533, 2837], 'reconfirmed': [2536], 'predicted': [2545], 'sequences': [2548, 2726, 4079], 'revealed': [2553], 'paralogs,': [2557], 'CiNav1b,': [2559], 'CiNav1c,': [2560], 'relatively': [2564], 'close': [2565], 'position': [2566], 'clade': [2569, 2585, 3251], '(Fig.': [2574, 2605, 2971, 3102, 3213, 3243, 3263, 3335, 3485, 3494, 3520, 3760, 3850, 3862, 3887, 4004, 4057, 4154, 4338], '1A).': [2575], 'one,': [2578], 'CiNav2,': [2579], 'Nav2': [2587], 'BSC1': [2589], 'cockroach': [2591], 'Blattella': [2592], 'TuNa2,': [2594], 'Nav': [2598, 2748, 3364], 'channel–like': [2599], 'another': [2602, 3185], 'Halocynthia': [2604, 3172, 3261], '1A)': [2606], '30Nagahora': [2627], 'Okada': [2629], 'Yahagi': [2631], 'Diversity': [2639], 'system.Biochem.': [2649], '2000;': [2653], '275:': [2654], '558-564Crossref': [2655], '(27)': [2658], '(former': [2662], 'name': [2663], 'Scholar))': [2722], 'highest': [2736], 'TTX-insensitive': [2746], 'Using': [2781], 'cDNA': [2783, 2925, 2931, 3351], 'genomic': [2785], '31Satou': [2840], 'Mineta': [2842], 'Ogasawara': [2844], 'Ueno': [2850], 'Yamada': [2852], 'Matsumoto': [2854], 'Wasserscheid': [2856], 'Dewar': [2858], 'Wiley': [2860], 'G.B.': [2861], 'Macmil': [2862], 'S.L.': [2863, 4277], 'Roe': [2864], 'B.A.': [2865], 'Zeller': [2866], 'R.W.': [2867], 'al.Improved': [2871], 'assembly': [2873], 'evidence-based': [2875], 'set': [2879], 'New': [2885], 'intron': [2888], 'operon': [2890], 'populations.Genome': [2891], '9R152Crossref': [2894], '(156)': [2897], 'performed': [2901, 3223, 3398], 'RT-PCR': [2902, 4019], 'obtain': [2908], 'full-length': [2910, 2930, 3216], 'cDNA.': [2912], 'Because': [2913], 'full': [2915], 'length': [2916], 'long,': [2918], 'two': [2921, 2933, 3639], "(5'": [2922], "3')": [2924], 'fragments': [2926], 'covering': [2928], 'sets': [2934], 'PCR': [2936], 'primers': [2937], '(see': [2938], 'Experimental': [2939], 'procedures': [2940], 'section': [2941], 'details).': [2943], 'deduced': [2945], 'primary': [2946, 4175], 'structure': [2947], '2323': [2952], 'acids.': [2954], 'Critical': [2955], 'regions': [2956, 2975, 3164], 'functions': [2959, 3206, 3837], 'evidently': [2962], 'CiNav1b': [2968], 'CiNav1c': [2970], '1B).': [2972, 4155], 'Those': [2973, 3162], 'critical': [2974, 3163, 4289], 'include': [2976, 3966], 'turrets': [2979], 'S5–S6': [2985], 'loop': [2986, 3017], 'quadrant': [2989], 'repetitive': [2993], 'domains': [2994], '(I–IV)': [2995], 'D/E/K/A': [2999], 'found': [3001, 3954], 'typical': [3004, 3234], 'S4': [3009], 'sensing,': [3012], '(32Garrido': [3018], 'Giraud': [3020], 'Carlier': [3022], 'Fernandes': [3024], 'Moussif': [3026], 'Fache': [3028], 'M.P.': [3029], 'Debanne': [3030], 'Dargent': [3032], 'targeting': [3035], 'involved': [3037], 'clustering': [3041, 3073, 4131, 4250], 'axonal': [3044], 'segment.Science.': [3046], '2003;': [3047], '300:': [3048], '2091-2094Crossref': [3049], '(270)': [3052], '33Hill': [3055, 4113], 'A.S.': [3056, 4114, 4197], 'Fineman': [3063, 4121], 'J.R.': [3064, 4122], 'Selzer': [3065, 4123], 'M.E.': [3066, 4124], 'Cooper': [3069, 4127], 'E.C.': [3070, 4128], 'Ion': [3071, 4129], 'node': [3080, 4138], 'Ranvier': [3082, 4140, 4245], 'evolved': [3083, 4141], 'sequentially': [3084, 4142], 'chordates.PLoS': [3087, 4145], 'Genet.': [3088, 4146], '4e1000317Crossref': [3090, 4148], '(98)': [3093, 4151], 'fast': [3100, 3145, 4295], '1B)': [3103], '34West': [3124], 'J.W.': [3125], 'Patton': [3126], 'Scheuer': [3128, 3601], 'Goldin': [3132], 'Catterall': [3134, 3603], 'cluster': [3137], 'hydrophobic': [3139], 'residues': [3142], 'required': [3143, 3638], 'Na+-channel': [3146], 'inactivation.Proc.': [3147], '1992;': [3154], '89:': [3155], '10910-10914Crossref': [3156], '(646)': [3159], '(BAA04133)': [3170], 'mostly': [3174], '(CBY22707)': [3179], 'Oikopleura': [3181], '(which': [3182], 'ascidians).': [3189], 'suggest': [3192, 4060, 4083, 4341], 'represents': [3195], 'original': [3197], 'retains': [3203], 'all': [3209], 'isoforms': [3212], '1).': [3214], 'Expressing': [3215], 'mRNA': [3218, 4009, 4027], 'oocytes,': [3221], 'TEVC': [3224], 'record': [3226], 'currents.': [3228, 3781], 'Cells': [3229], '2).': [3244], 'grouped': [3247], 'same': [3250], 'channel,': [3258], 'roretzi': [3262, 3910], '1A),': [3264], 'reported': [3267, 3587, 4388], 'TTX': [3270, 3310], 'insensitive': [3271, 3347], 'native': [3273], 'Applying': [3307], '10': [3308], 'μM': [3309], 'suppressed': [3311], 'peak': [3313], 'inward': [3314], 'oocytes': [3321, 3613], 'less': [3323], '5%,': [3325], 'whereas': [3326, 3700, 3852], 'it': [3327, 3853], 'completely': [3328], 'inhibited': [3329], 'rat': [3332, 4177, 4186, 4354], '(rNav1.4)': [3334], '2,': [3336], 'B': [3337, 3496], 'C).': [3339], 'result': [3341], 'indicates': [3342], 'almost': [3346], 'TTX.': [3349], 'transfected': [3352], 'kidney': [3356], '293T': [3357], '(HEK293T)': [3358], 'failed': [3360, 3777], 'express': [3362], '(data': [3366, 4020], 'shown).': [3368, 4022], 'In': [3369, 3473, 3864, 4006, 4357], 'mammals,': [3370], 'known': [3374, 3433, 3457], 'increase': [3376], 'surface': [3378, 3989], 'modify': [3381], 'examine': [3389], 'effects': [3391, 3443, 3797], 'cut-open': [3399, 3527], 'oocyte': [3400, 3528, 4053], 'recording': [3401, 3525], 'compared': [3403], 'between': [3406, 3506, 3533], 'expressing': [3408, 3509, 3713], 'coexpressing': [3413, 3513], 'hβ1.': [3416, 3515], 'rNav1.4': [3417], '(also': [3418], 'μ1)': [3420], 'Nav1.5': [3423], '(hNav1.5,': [3424], 'hH1)': [3427], 'tested': [3429, 3794], 'positive': [3431, 4184, 4231], 'controls': [3432], 'modulated': [3436], 'test': [3441], 'hβ1,': [3445], 'verified': [3448], 'hβ1': [3453, 3475, 3539, 3644, 3718, 3772], 'observing': [3455], 'influences': [3458], 'decay': [3462, 3481, 3883], 'rNav1.4,': [3464], 'remarkedly': [3467], 'accelerated': [3468, 3645], '(Figs.': [3469], '3A': [3470], '4B).': [3472, 3486], 'contrast,': [3474], 'alter': [3478], 'current–voltage': [3488], '(I–V)': [3489], 'curve': [3490], 'speed': [3493], '3,': [3495], 'C': [3498, 3762], 'Fig.': [3500], 'S1)': [3501], 'significantly': [3504], 'those': [3512], 'Steady-state': [3516], '4A)': [3521], 'examined': [3523, 3653, 3891, 4017], 'no': [3531, 3701], 'difference': [3532, 3703], 'presence': [3535], 'absence': [3537], '(CiNav1a:': [3540, 3719], 'V_half': [3541, 3561], '=': [3542, 3550, 3556, 3562, 3568, 3574, 3659, 3665, 3671, 3677, 3683, 3689, 3721, 3727, 3733, 3739], '−46.39': [3543], '±': [3544, 3552, 3564, 3570, 3582, 3661, 3667, 3679, 3685, 3698, 3723, 3735, 3748], '0.2931': [3545], '[mV];': [3546, 3554, 3566, 3572], 'k': [3547, 3567], '[slope': [3548], 'factor]': [3549], '4.001': [3551], '0.2253': [3553], 'N': [3555, 3573, 3670, 3688, 3726, 3738], '5;': [3557, 3672], '+': [3559, 3674, 3730], 'hβ1:': [3560, 3675, 3731], '−49.03': [3563], '0.4525': [3565], '3.958': [3569], '0.4790': [3571], '7,': [3575, 3690], 'fitted': [3577], 'Boltzmann': [3579], '[mean': [3581, 3697, 3747], 'SD]).': [3583], 'Consistent': [3584], 'data': [3588], '(35Qu': [3589], 'Isom': [3591], 'L.L.': [3592], 'Westenbroek': [3593], 'R.E.': [3594], 'Rogers': [3595], 'J.C.': [3596], 'Tanada': [3597], 'T.N.': [3598], 'McCormick': [3599], 'K.A.': [3600], 'Modulation': [3605], 'cardiac': [3607], 'subunits.J.': [3616], '1995;': [3619, 3828], '270:': [3620], '25696-25701Abstract': [3621], '(113)': [3629], 'fits': [3632], 'recovery': [3635, 3647, 3708], 'course': [3637], 'exponential': [3640, 3695, 3745, 3758], 'components': [3641], 'rNav1.4.': [3643], 'hNav1.5': [3651, 3673], '−100': [3655], 'mV': [3656], '(hNav1.5:': [3657], 'tau1': [3658, 3676], '20.64': [3660], '11.443': [3662], 'ms,': [3663, 3669, 3681, 3687, 3725, 3737], 'tau2': [3664, 3682], '868.666': [3666], '1057.546': [3668], '9.861': [3678], '1.455': [3680], '821.217': [3684], '442.856': [3686], 'fitting': [3692, 3742], 'double': [3694], 'SD]),': [3699], 'significant': [3702, 3874], 'observed': [3705], 'or': [3716], 'without': [3717], 'tau': [3720, 3732, 3752], '2.151': [3722], '0.702': [3724], '10;': [3728], '2.401': [3734], '0.687': [3736], '9,': [3740], 'single': [3744], 'SD])': [3749], '(tau1,': [3750], 'tau2,': [3751], 'constant': [3755], 'component)': [3759], '4,': [3761], 'D).': [3764], 'We': [3765, 3890], 'tried': [3767], 'coexpress': [3769], 'HEK293T': [3774], 'observe': [3779], 'Although': [3782, 4380], 'insects,': [3792], 'possible': [3796], 'insect': [3799], 'subunit,': [3802], 'TipE': [3803, 3840, 3868], '(36Feng': [3804], 'Deak': [3806], 'Kasbekar': [3808], 'D.P.': [3809], 'Gil': [3810], 'D.W.': [3811], 'Hall': [3812], 'L.M.': [3813], 'Cytogenetic': [3814], 'localization': [3817], 'tipE:': [3819], 'affecting': [3822], 'Drosophila': [3826, 3847], 'melanogaster.Genetics.': [3827], '139:': [3829], '1679-1688Crossref': [3830], 'drastically': [3841], 'enhanced': [3842], 'Para': [3849], '5A),': [3851], 'change': [3856, 3875], 'amplitude': [3859], '5B).': [3863], 'addition,': [3865, 4007], 'coexpression': [3866], 'lead': [3871], 'any': [3873], 'I–V': [3878], 'curve,': [3879], 'speed,': [3881], '5,': [3888], 'B–D).': [3889], 'pattern': [3895, 3907], 'whole-mount': [3899], 'situ': [3901], 'hybridization.': [3902], 'Corresponding': [3903], 'signals': [3952], 'peripheral': [3962, 3980, 4001], 'systems,': [3964], 'presumptive': [3967], 'vesicle': [3973], 'motor': [3975], 'ganglion,': [3976], 'epidermal': [3984], 'sensory': [3985], 'trunk': [3991], 'tail': [3993, 3996], 'bipolar': [3995], '6).': [4005], 'juvenile': [4013], 'cerebral': [4014], 'ganglion': [4015], 'supported': [4025], 'profile': [4029], 'database': [4035], '(http://ghost.zool.kyoto-u.ac.jp/cgi-bin/fordetailht1.cgi?name=KY.Chr9.756.v1.SL1-1).': [4038], 'CiKv1b': [4043], '(one': [4044], 'shaker-related': [4046], 'K+': [4047], 'Ciona)': [4050], '7).': [4058], 'plays': [4063], 'substantial': [4065], 'generating': [4068], 'Phylogenetic': [4074], 'investigate': [4157], 'fused': [4170], 'YFP': [4172, 4192], 'cultured': [4176], 'lentivirus.': [4181], 'As': [4182], 'control,': [4185], '(Addgene;': [4193], 'no.': [4194], '91426)': [4195], '(37Dumitrescu': [4196], 'Evans': [4198], 'M.D.': [4199], 'Grubb': [4200], 'M.S.': [4201], 'Evaluating': [4202], 'tools': [4203], 'live': [4205], 'imaging': [4206], 'plasticity': [4209], 'segment.Front.': [4214], 'Cell.': [4215], 'Neurosci.': [4216], '10:': [4218], '268Crossref': [4219], '(11)': [4222], 'transfected.': [4226], 'AIS': [4227, 4352], 'immunostaining': [4234, 4318], 'anti–ankyrin-G': [4236], 'antibody': [4237], '(38Jenkins': [4238], 'S.M.': [4239], 'Bennett': [4240, 4284], 'V.': [4241, 4285], 'Developing': [4242], 'nodes': [4243], 'defined': [4247], 'ankyrin-G': [4249, 4336], 'independent': [4253], 'paranodal': [4255], 'axoglial': [4256], 'adhesion.Proc.': [4257], '99:': [4265], '2303-2308Crossref': [4266], '39Jenkins': [4272], 'P.M.': [4273], 'Kim': [4274], 'Jones': [4276], 'Tseng': [4278], 'W.C.': [4279], 'Svitkina': [4280], 'T.M.': [4281], 'Yin': [4282], 'H.H.': [4283], 'Giant': [4286], 'ankyrin-G:': [4287], 'innovation': [4290], 'integrated': [4297], 'signaling.Proc.': [4299], '112:': [4307], '957-964Crossref': [4308], '(96)': [4311], 'negative': [4315], 'anti–microtubule-associated': [4320], '2': [4322], '(anti-MAP2)': [4323], 'antibody,': [4324], 'marks': [4326], 'body': [4328], 'dendrites.': [4330], 'CiNav1a–II–III': [4331], 'linker–YFP': [4332], 'overlapped': [4334], '8),': [4339], 'study,': [4359], 'characterization': [4365], 'Nav1,': [4369], 'system.': [4379], 'many': [4381], 'cDNAs': [4385], 'analy': [4396]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3160755434', 'counts_by_year': [{'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-24T05:56:47.500180', 'created_date': '2021-05-24'}