Title: PE-063: Incidence of Hepatocellular Carcinoma in Subjects with Hepatitis B Virus Positive in Korean National Liver Cancer Screening Program
Abstract: Aims: To optimize efficacy of National Liver Cancer Screening Program (NLCSP) for subjects with hepatitis B surface antigen (HBsAg) positive, it is crucial to know the incidence of hepatocellular carcinoma (HCC) development and its predisposing factors in the program. Methods: From January 2010 to December 2014, all the HBsAg positive participants who received at least two or more abdominal ultrasonography under NLCSP were retrospectively enrolled in a single tertiary hospital. Annual incidence of HBV-related HCC was calculated and related clinical factors were investigated. Results: During 5 years, 541 subjects were enrolled. Mean age was 53 years old and 310 (57.3%) were male. Most subjects (86.5%) were patients of current hospital. Two hundred ninety two subjects (54%) were receiving antiviral agents at the moment. Liver cirrhosis (LC) was diagnosed in 212 (39.2%) by ultrasonography or upper endoscopy. Esophageal varices were found in 63 (14.8%). Total bilirubin, albumin, platelets, and aminotransferases were normal in most subjects. HBV DNA were less than 2,000 IU/mL in 356 subjects (79.6%). Mean follow-up time was 2.4 years and 16 new HCCs were diagnosed. Annual incidence of HBV-related HCCs were 980 per 100,000 patient year (1% per year). Subjects more than 60 years old (2.2% per year) had higher risk of HCC development than those under 60 years (0.6% per year, P<0.005 by Log Rank test). Presence of LC (2.2% per year) also showed higher risk of HCC than LC-free state (0.2% per year, P<0.0001 by Log Rank test). In cirrhotic patients older than 60 years old, the incidence increased up to 3.8% per year. Conclusions: Despite of high rate of antiviral therapy, incidence of HBV-related HCC is not low in participant of NLCSP in Korea. Old age and presence of liver cirrhosis are associated with higher risk of HCC development.
Publication Year: 2016
Publication Date: 2016-01-01
Language: en
Type: article
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