Title: Interaksi Metabolisme INH & Rifampisin Menggunakan Hepatosit Tikus
Abstract: Research on the interaction isoniazid metabolism and rifampicin using rat hepatocytes suspension has been done. As the system metabolism. hepatocytes suspension was prepared by perfusion in the calcium binding media containing EDTA, citrate and glycine was used.
Treatment at the hepatocytes suspension devided into two groups. One group research on the influence of isoniazid on rifampicin metabolism. Second research on the influence of rifampicin on isoniazid metabolism. Each group devided into five subgroups. Result calculated on the base of variation of rifampicin AUC-value beginning from 0 up to 180 minutes showed that isoniazid wilh concentration 5 µg, 10 µg, 15 µg, and 20 µg, did not influence metabolism of rifampicin (10 µg/ml) as showed by no significant changes of AVC values of rifampicin for α= 0.005 on the otherhand result calculated on the based variation of isoniazid AUC-value beginning from 0 up to 180minutes showed that rifampicin with concentration 5 µg, 10 µg, 15 µg, and 20 µg did influence the mctabolism of isoniazid ( 10 µg/ml) as
showed by significant changes of AVC values of isoniazid for α=0.005. Showed that isoniazid mctabolism decrease used as combination of rifampicin
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot