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2431, 2578, 2613, 2624, 2667, 2676, 2681, 2718, 2781, 2839, 2870, 3039, 3054, 3115, 3123, 3137, 3159, 3239, 3244, 3314, 3388, 3410, 3423, 3431, 3518, 3530, 3534, 3627, 3713, 3831, 3873, 3910, 4056], 'cause': [16, 160], 'current': [19, 163, 482], 'pandemic,': [20, 164, 2992], 'produces': [21, 165], 'multiform': [22, 166], 'manifestations': [23, 167], 'throughout': [24, 168], 'body,': [26, 170], 'causing': [27, 171, 1987, 2378, 2678], 'indiscriminate': [28, 172], 'damage': [29, 173, 471, 534, 1408, 2680], 'to': [30, 48, 94, 139, 174, 192, 238, 283, 318, 332, 423, 472, 485, 590, 656, 675, 751, 906, 911, 933, 1077, 1208, 1234, 1240, 1352, 1743, 1942, 2048, 2236, 2341, 2546, 2674, 2776, 2800, 2835, 2899, 2978, 3145, 3450, 3582, 3673, 3839], 'multiple': [31, 175, 2895], 'organ': [32, 176, 2679], 'systems,': [33, 177], 'particularly': [34, 178], 'lungs,': [36, 180], 'heart,': [37, 181], 'brain,': [38, 182], 'kidney,': [39, 183], 'vasculature.': [41, 185], 'The': [42, 117, 186, 261, 481, 583, 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[626, 3171], 'Corti': [627], 'Veesler': [629], 'Unexpected': [631], 'receptor': [632, 691, 1152, 1271, 1618, 2331, 2577], 'functional': [633, 1023, 1298], 'mimicry': [634], 'elucidates': [635], 'activation': [636, 1388, 1411, 2380, 2387, 2627], 'fusion.Cell.': [639], '2019;': [640, 2125], '176:': [641], '1026-1039Abstract': [642], '(390)': [650], 'gains': [654], 'access': [655], 'engaging': [660], 'protein': [662, 750, 814, 2619], 'ACE2,': [663, 907, 972], 'carboxypeptidase': [666, 1072, 1347], 'expressed': [667, 2427], 'nearly': [669], 'all': [670], 'human': [671, 698, 1016, 1291], 'varying': [676], 'degrees.4Ziegler': [677], 'C.G.K.': [678], 'Allon': [679], 'S.J.': [680, 2184, 3866], 'Nyquist': [681], 'S.K.': [682], 'Mbano': [683], 'I.M.': [684], 'Miao': [685], 'V.N.': [686], 'Tzouanas': [687], 'C.N.': [688], 'et': [689, 2746, 3889], 'al.SARS-CoV-2': [690, 2747], 'ACE2': [692, 724, 820, 874, 979, 1098, 1180, 1206, 1373], 'interferon-stimulated': [695], 'gene': [696], 'airway': [699], 'epithelial': [700], 'detected': [704], 'specific': [706, 974], 'subsets': [708], 'across': [709], 'tissues.Cell.': [710], '181:': [712], '1016-1035.e19Abstract': [713], '(1542)': [721], 'exists': [725], 'two': [727, 784, 1263], 'forms,': [728], 'membrane-bound': [730, 753], 'form': [731], 'soluble': [734], 'form,': [735], 'mediated': [744], 'S': [749, 801], 'form.5Verdecchia': [754], 'P.': [755, 1471, 1531, 2014, 2449, 2707, 3339, 3785, 4136], 'Cavallini': [756, 1472], 'C.': [757, 834, 1473, 1492, 1559, 1561, 1887, 1907, 1996, 2006, 2008, 2012, 2174, 2451, 2689, 2699, 2701, 2705, 2922, 2932, 3075, 3265, 3277, 3303, 3345, 3694, 3856, 3891, 3994, 4004], 'Spanevello': [758, 1474], 'Angeli': [760, 1476], 'F.': [761, 1047, 1322, 1477, 1525, 2170, 2459, 3269, 3403, 3588, 3766, 3783, 3852], 'COVID-19:': [762, 1478, 2296, 2484, 3119, 3210, 3320, 3507, 3948, 4064], 'ACE2centric': [763, 1479], 'infective': [764, 1480], 'disease?.Hypertension.': [765, 1481], '76:': [767, 1483], '294-299Crossref': [768, 1484], '(63)': [771, 1487], 'down-regulates': [775, 819], 'receptors': [777], 'taking': [779], 'advantage': [780], 'proteases:': [786], 'type': [787, 1269, 1276, 2157, 3835], 'II': [788, 1190, 1218, 1236, 1247, 1268, 1275, 1440, 2158], 'serine': [790, 1923, 1979], 'protease': [791], '(ie,': [792, 816], 'TMPRSS2),': [793], 'facilitates': [795], 'ingress': [797], 'cleaving': [799, 1192], 'antigen': [802], '(the': [805], 'active': [806, 1251, 1952], 'site),': [808], 'disintegrin': [810], 'metalloproteinase': [812], 'domain-containing': [813], '17': [815], 'ADAM17),': [817], 'spreading': [822], 'together': [824], 'attached': [827], 'through': [829, 1409], 'blood': [830, 1116, 1717, 2837, 3034], 'circulation.6Sfera': [831], 'Osorio': [833, 1491], 'Jafri': [835, 1493], 'N.': [836, 1055, 1330, 1494, 1668, 1998, 2691, 3343], 'Diaz': [837, 1495], 'E.L.': [838, 1496], 'Campo': [839, 1497], 'Maldonado': [840, 1498], 'J.E.': [841, 1499, 2740], 'Intoxication': [842, 1500], 'endogenous': [844, 1502, 1958], 'angiotensin': [845, 1075, 1078, 1185, 1350, 1353, 1503, 1568], 'II:': [846, 1504], 'hypothesis.Front': [849, 1507], 'Immunol.': [850, 1508, 1764, 1844, 2302, 2857], '11:': [852, 1510, 1580, 1700], '1472Crossref': [853, 1511], '(29)': [856, 1514], 'Scholar,7Heurich': [858], 'Hofmann-Winkler': [860], 'H.': [861, 1523, 1670, 2176, 2208, 2352, 3095, 3099, 3101, 3194, 3271, 3288, 3290, 3401, 3612, 3622, 3858], 'Gierer': [862], 'S.': [863, 869, 1067, 1342, 1521, 1649, 1754, 1834, 1876, 1885, 1903, 1905, 2463, 2465, 2467, 2847, 2926, 3263, 3286, 3297, 3301, 3311, 3490, 3618, 3660, 3666, 3702, 3772, 3899, 3998, 4142], 'Liepold': [864], 'T.': [865, 1553, 2016, 2168, 2709, 3009, 3103, 3382, 3590, 3850, 4103], 'Jahn': [866], 'O.': [867, 3470], 'Pöhlmann': [868], 'TMPRSS2': [870, 880], 'ADAM17': [872], 'cleave': [873], 'differentially': [875], 'proteolysis': [878], 'augments': [881], 'driven': [883], 'protein.J': [892], 'Virol.': [893], '2014;': [894], '88:': [895], '1293-1307Crossref': [896], '(606)': [899], 'SARS-CoV': [903], 'also': [904, 3961], 'binds': [905], '10-fold': [910], '20-fold': [912], 'greater': [913], 'affinity': [915], 'than': [916], 'SARS-CoV.8Liu': [917], 'Y.': [918, 1519, 1529, 1533, 1547, 2477, 3067, 3596, 3602, 3610, 3620], 'Gayle': [919], 'A.A.': [920, 3093], 'Wilder-Smith': [921], 'Rocklöv': [923], 'reproductive': [926], 'number': [927], 'higher': [931], 'compared': [932], 'SARS': [934, 1574], 'coronavirus.J': [935], 'Travel': [936], 'Med.': [937, 1103, 1378, 1425, 1578, 1925, 2032, 2197, 2489, 2725, 2756, 2815, 3024, 3326, 3369, 3684, 3879, 4072], '27:': [939], 'taaa021Crossref': [940], '(1879)': [943], 'Therefore,': [946, 1434, 2970], 'mechanism': [949, 1798], 'infection,': [951], 'what': [952, 3939], 'makes': [953], 'novel': [955, 1069, 1344], '(compared': [956], 'common': [959], 'pathogens': [961, 1748, 1803], 'such': [962], 'influenza': [964], 'parainfluenza': [966], 'viruses)': [967], 'use': [970], 'protein,': [975], 'receptor.': [978], 'key': [982], 'modulator': [983], 'RAAS,': [986, 1257], 'intricate': [988], 'interlinked': [989], 'regulates': [992], 'physiological': [993], 'pathologic': [995, 1401], 'functions': [996, 1259], 'cardiovascular,': [999], 'renal,': [1000], 'pulmonary': [1002, 3240, 3586, 3820, 3947, 3968, 4109], 'systems.9Tipnis': [1003], 'S.R.': [1004, 1279], 'Hooper': [1005, 1280], 'N.M.': [1006, 1281, 2604], 'Hyde': [1007, 1282], 'Karran': [1009, 1284], 'Christie': [1011, 1286], 'G.': [1012, 1287, 1541, 1672, 2946, 3280, 3498, 3594, 3700, 3774, 3897, 4018, 4048], 'Turner': [1013, 1140, 1288, 1606, 2565], 'A.J.': [1014, 1141, 1289, 1607, 2566, 3059], 'A': [1015, 1068, 1290, 1343, 1564, 1587, 2143, 2512], 'homolog': [1017, 1292], 'enzyme.': [1020, 1295], 'Cloning': [1021, 1296], 'expression': [1024, 1299, 2318], 'captopril-insensitive': [1027, 1302], 'carboxypeptidase.J': [1028, 1303], 'Biol': [1029, 1304], 'Chem.': [1030, 1305], '2000;': [1031, 1081, 1306, 1356], '275:': [1032, 1307], '33238-33243Abstract': [1033, 1308], '(1730)': [1041, 1316], 'Scholar,': [1043, 1086, 1318, 1361, 1666, 1686, 1852, 1874, 3656, 3692, 4085, 4124], '10Donoghue': [1044, 1319], 'Hsieh': [1046, 1321], 'Baronas': [1048, 1323], 'Godbout': [1050, 1325], 'K.': [1051, 1061, 1133, 1326, 1336, 1517, 1599, 1893, 1901, 2210, 2354, 2558, 2788, 2928, 2930, 3097, 3309, 3337, 3347, 4000, 4002], 'Gosselin': [1052, 1327], 'Stagliano': [1054, 1329], 'Donovan': [1056, 1331], 'Woolf': [1058, 1333], 'B.': [1059, 1334, 1527, 1539, 1752, 1832, 1913, 2257, 2845, 3604, 3624], 'Robison': [1060, 1335], 'Jeyaseelan': [1062, 1337], 'Breitbart': [1064, 1339], 'R.E.': [1065, 1340, 2088, 2469], 'Acton': [1066, 1341], 'enzyme-related': [1071, 1346], 'converts': [1074, 1349], 'I': [1076, 1187, 1215, 1233, 1351], '1-9.Circ': [1079, 1354], 'Res.': [1080, 1168, 1355, 1634, 2095, 2222, 2366, 2515, 2593, 3214, 3727, 3924], '87:': [1082, 1357], 'E1-E9Crossref': [1083, 1358], '11Oudit': [1087, 1362], 'G.Y.': [1088, 1147, 1363, 1613, 2572], 'Crackower': [1089, 1364], 'Backx': [1091, 1366], 'P.H.': [1092, 1367], 'Penninger': [1093, 1368, 1562], 'cardiovascular': [1100, 1375], 'physiology.Trends': [1101, 1376], 'Cardiovasc': [1102, 1377], '2003;': [1104, 1379], '13:': [1105, 1380, 1766, 1846, 2859], '93-101Crossref': [1106, 1381], '(210)': [1109, 1384], 'Aside': [1112], 'regulating': [1114], 'arterial': [1115, 3138, 3353], 'pressure,': [1117], 'cardiac': [1118, 4057], 'function,': [1119], 'fluid': [1121], 'balance,': [1122], 'RAAS': [1124, 1395], 'plays': [1125], 'major': [1127, 2066], 'immunity.12Gheblawi': [1130], 'Wang': [1132, 1542, 1598, 2256, 2557, 2789, 3601], 'Viveiros': [1134, 1600, 2559], 'Nguyen': [1136, 1602, 2561], 'Q.': [1137, 1603, 2255, 2562, 2786], 'Zhong': [1138, 1604, 2563], 'J.C.': [1139, 1605, 2564, 3528], 'Raizada': [1142, 1608, 2567], 'M.K.': [1143, 1609, 2568], 'Grant': [1144, 1610, 2569], 'M.B.': [1145, 1611, 2570], 'Oudit': [1146, 1612, 2571], 'Angiotensin-converting': [1148, 1614, 2573], '2:': [1150, 1616, 2575], 'regulator': [1154, 1620, 2579], 'renin-angiotensin': [1157, 1419, 1623, 2582], 'system:': [1158, 1624, 2583], 'celebrating': [1159, 1625, 2584], '20th': [1161, 1627, 2586], 'anniversary': [1162, 1628, 2587], 'discovery': [1165, 1631, 2590, 3560], 'ACE2.Circ': [1167, 1633, 2592], '126:': [1170, 1636, 2595], '1456-1474Crossref': [1171, 1637, 2596], '(1272)': [1174, 1640, 2599], 'Under': [1177], 'normal': [1178, 2425], 'circumstances,': [1179], 'terminates': [1181], 'action': [1183], '(Ang)': [1186], 'Ang': [1189, 1196, 1199, 1214, 1217, 1232, 1235, 1244, 1246, 1267, 1274, 1391, 1439], 'peptides': [1194], '1-9': [1197], '1-7,': [1200], 'respectively.': [1201], 'absence': [1204], '(due': [1207], 'blockade': [1210], 'down-regulation),': [1212], 'both': [1213], 'accumulate.': [1219], 'because': [1221], 'ACE': [1222], 'not': [1224, 3671], 'engaged': [1225], 'virus,': [1228], 'conversion': [1230], 'continues': [1237], 'unabated,': [1238], 'unopposed': [1241], 'accumulation': [1242], 'II.': [1245], 'biologically': [1250], 'mediator': [1252], 'effects': [1254], 'whose': [1258], 'controlled': [1261], 'G': [1264], 'protein–coupled': [1265], 'receptors,': [1266], '1': [1270], '(AT1R)': [1272], 'receptor.9Tipnis': [1278], 'Abnormal': [1387], 'II/AT1R': [1392], 'component': [1393], 'implicated': [1398], 'several': [1400], 'conditions,': [1402], 'including': [1403, 2326], 'development': [1405, 1826], 'end-organ': [1407, 1422], 'proinflammatory': [1413, 2248, 2411], 'profibrotic': [1415], 'cascades.13Luft': [1416], 'F.C.': [1417], 'Tissue': [1418], 'damage.J': [1423], 'Mol': [1424, 2629], '2002;': [1426], '80:': [1427, 2272], '325-326Crossref': [1428], '(4)': [1431], 'COVID-19–induced': [1435, 2770], 'ACE/ACE2': [1436], 'imbalance': [1437], 'upregulation': [1441], 'favor': [1447], 'local': [1448, 1949], 'inflammation,': [1449, 2405, 2677], 'capillary': [1450], 'leakage,': [1451], 'procoagulant': [1453, 1972], 'state,': [1454], 'mitochondrial': [1455], 'oxidative': [1456], 'damage,': [1457], 'reactive': [1458], 'oxygen': [1459], 'species': [1460], 'production,': [1461], 'IL-6': [1463], 'up-regulation,': [1464], 'inducing': [1465], 'coagulation': [1466, 1718, 1822, 1917, 2119], 'response.5Verdecchia': [1470], 'Scholar,6Sfera': [1489], 'Scholar,14Kuba': [1516], 'Imai': [1518], 'Rao': [1520], 'Gao': [1522], 'Guo': [1524], 'Guan': [1526, 3607], 'Huan': [1528], 'Yang': [1530, 2787], 'Zhang': [1532, 1538, 3619], 'Deng': [1534], 'W.': [1535, 2790], 'Bao': [1536], 'L.': [1537, 1878, 2288, 2792, 2918, 3608, 3658, 3768, 3789, 3990, 4126], 'Liu': [1540, 1546, 1556, 3595, 3597], 'Chappell': [1544], 'Zheng': [1548], 'Leibbrandt': [1550], 'Wada': [1552], 'Slutsky': [1554], 'A.S.': [1555, 3275], 'Qin': [1558], 'Jiang': [1560, 2791], 'crucial': [1565, 1730], 'converting': [1569], 'coronavirus-induced': [1575], 'lung': [1576, 2022, 2715, 3573, 3747, 3794], 'injury.Nat': [1577], '2005;': [1579], '875-879Crossref': [1581], '(2533)': [1584], 'detailed': [1588], 'found': [1595, 3235, 3962], 'elsewhere.12Gheblawi': [1596], 'Scholar,15Mahmudpour': [1642], 'Roozbeh': [1644], 'Keshavarz': [1646], 'Farrokhi': [1648], 'Nabipour': [1650], 'I.': [1651, 1897, 2914, 3273, 3986], 'storm:': [1654], 'anger': [1656], 'inflammation.Cytokine.': [1658], '133:': [1660, 2126], 'e155151Crossref': [1661], '(316)': [1664], '16Labò': [1667], 'Ohnuki': [1669], 'Tosato': [1671], 'Vasculopathy': [1673], 'coagulopathy': [1675], 'associated': [1676, 2072, 2503, 3000, 3161, 3442, 3710, 3907], 'infection.Cells.': [1679], '9:': [1681], '1583Crossref': [1682], '(56)': [1684], '17Curran': [1687], 'C.S.': [1688], 'Rivera': [1689], 'D.R.': [1690], 'Kopp': [1691], 'J.B.': [1692], 'usurps': [1694], 'regulatory': [1696], 'networks.Front': [1697], 'Pharmacol.': [1698], '1278Crossref': [1701], '(22)': [1704], 'Immunothrombosis': [1707], 'consequence': [1710], 'evolutionarily': [1713], 'conserved': [1714], 'link': [1715], 'between': [1716, 1808], 'innate': [1720, 1761, 1778, 1809, 1841, 1859, 1919, 2854, 2871], 'immunity,': [1721, 2297], 'regarded': [1725], 'newly': [1728], 'revised,': [1729], 'element': [1731], 'intravascular': [1733, 1758, 1838, 2050, 2851, 2896], 'immunity': [1734, 1810, 1920], 'encompasses': [1736], 'range': [1739], 'strategies': [1742], 'detect': [1744], 'protect': [1746], 'against': [1747, 1802, 2043], 'vasculature.18Engelmann': [1751], 'Massberg': [1753, 1833, 2846], 'Thrombosis': [1755, 1835, 2848], 'effector': [1759, 1811, 1839, 2852], 'immunity.Nat': [1762, 1842, 2855], 'Rev': [1763, 1843, 2301, 2856], '2013;': [1765, 1845, 2858], '34-45Crossref': [1767, 1847, 2860], '(1155)': [1770, 1850, 2863], 'Scholar,19Delvaeye': [1772, 2865], 'Conway': [1774, 1855, 2867], 'E.M.': [1775, 1856, 2868, 4105], 'Coagulation': [1776, 1857, 2869, 3387], 'responses:': [1780, 1861, 2873], 'we': [1782, 1863, 2875], 'view': [1783, 1864, 2876], 'them': [1784, 1865, 2877], 'separately?.Blood.': [1785, 1866, 2878], '2009;': [1786, 1867, 2879], '114:': [1787, 1868, 2880], '2367-2374Crossref': [1788, 1869, 2881], '(230)': [1791, 1872, 2884], 'It': [1794], 'complex': [1797], 'protection': [1801], 'interaction': [1807], 'systems': [1812], '(eg,': [1813], 'monocytes/macrophages,': [1814], 'neutrophils,': [1815], 'complement': [1817, 2348, 2384, 2510], 'system)': [1818], 'platelets': [1820, 1983, 2344, 2666], 'factors,': [1823, 2535], 'favoring': [1824], 'microthrombi': [1828, 3556], 'within': [1829], 'microcirculation.18Engelmann': [1831], '19Delvaeye': [1853], '20Massberg': [1875], 'Grahl': [1877], 'von': [1879, 2320], 'Bruehl': [1880], 'M.L.': [1881], 'Manukyan': [1882], 'Pfeiler': [1884], 'Goosmann': [1886], 'Brinkmann': [1888], 'V.': [1889], 'Lorenz': [1890], 'Bidzhekov': [1892], 'Khandagale': [1894], 'A.B.': [1895], 'Konrad': [1896], 'Kennerknecht': [1898], 'Reges': [1900], 'Holdenrieder': [1902], 'Braun': [1904], 'Reinhardt': [1906], 'Spannagl': [1908], 'Preissner': [1910], 'K.T.': [1911], 'Engelmann': [1912], 'Reciprocal': [1914], 'coupling': [1915], 'via': [1921], 'neutrophil': [1922, 1964, 1978, 2485, 2749, 2952, 4024], 'proteases.Nat': [1924], '2010;': [1926], '16:': [1927], '887-896Crossref': [1928], '(871)': [1931], 'Regardless': [1934], 'initiating': [1937], 'event,': [1938], 'response': [1941], 'and/or': [1944], 'pathogen': [1945, 2045], 'invasion': [1946], 'includes': [1947], 'delivery': [1950], 'factor,': [1954], 'degradation': [1956, 3041], 'anticoagulants,': [1959], 'extracellular': [1965, 2018, 2486, 2711, 2750, 2953, 4025], 'traps': [1966, 2019, 2712, 2751, 2954, 4026], '(NETs)': [1967], 'scaffold': [1971], 'consisting': [1973], 'DNA,': [1975], 'histones,': [1976], 'proteases.': [1980], 'NETosis': [1981], 'sequesters': [1982], 'microcirculation,': [1986], 'increased': [1988, 3963], 'fibrin–platelet': [1989], 'interactions': [1990], 'formation': [1993, 2771, 2830, 2888], 'microthrombi.21Radermecker': [1995], 'Detrembleur': [1997, 2690], 'Guiot': [1999, 2692], 'Cavalier': [2001, 2694], 'Henket': [2003, 2696], "d'Emal": [2005, 2698], 'Vanwinge': [2007, 2700], 'Cataldo': [2009, 2702], 'Oury': [2011, 2704], 'Delvenne': [2013, 2706], 'Marichal': [2015, 2708], 'Neutrophil': [2017, 2710], 'infiltrate': [2020, 2713], 'airway,': [2023, 2716], 'interstitial,': [2024, 2717], 'vascular': [2026, 2188, 2719, 2779, 3870], 'compartments': [2027, 2720], 'COVID-19.J': [2030, 2269, 2723, 4114], 'Exp': [2031, 2488, 2724, 2755], '217:': [2034, 2491, 2727, 2758], 'e20201012Crossref': [2035, 2728], '(227)': [2038, 2731], 'Ordinarily,': [2041], 'remains': [2046], 'restricted': [2047], 'compartment,': [2051], 'triggering': [2052, 2244], 'minimal': [2053], 'parenchymal': [2055], 'damage.': [2056], 'on': [2058, 2423, 2803], 'large': [2060], 'scale,': [2061], 'immunothrombosis': [2062, 2652], 'biological': [2067], 'process': [2068], 'fostering': [2069], 'pathologies': [2071], 'thrombosis': [2074, 2504, 2675, 3238, 3354, 3714, 3911], 'microvasculature': [2077], 'damage.22Bray': [2081], 'Sartain': [2083], 'S.E.': [2084, 2162, 3844, 4042], 'Gollamudi': [2085], 'Rumbaut': [2087], 'Microvascular': [2089, 3792], 'thrombosis:': [2090], 'experimental': [2091], 'implications.Transl': [2094], '225:': [2097], '105-130Abstract': [2098], '(50)': [2106], 'Scholar,23Jackson': [2108], 'S.P.': [2109], 'Darbousset': [2110], 'Schoenwaelder': [2112], 'S.M.': [2113], 'Thromboinflammation:': [2114], 'challenges': [2115], 'therapeutically': [2117], 'targeting': [2118], 'defense': [2123], 'mechanisms.Blood.': [2124], '906-918Crossref': [2127], '(329)': [2130], 'induces': [2138], 'microthrombosis': [2139], 'remain': [2140], 'incompletely': [2141], 'understood.': [2142], 'sequence': [2144], 'events': [2146, 3140, 3448], 'proposed,': [2149], 'described': [2151, 3938], 'here.': [2152], 'directly': [2155, 2672], 'invade': [2156], 'pneumocytes.24Ackermann': [2159], 'Verleden': [2161, 3843], 'Kuehnel': [2163, 3845], 'Haverich': [2165, 3847], 'Welte': [2167, 3849], 'Laenger': [2169, 3851], 'Vanstapel': [2171, 3853], 'Werlein': [2173, 3855], 'Stark': [2175, 3857], 'Tzankov': [2177, 3859], 'Li': [2179, 2181, 3461, 3611, 3861, 3863, 4047], 'W.W.': [2180, 3862], 'V.W.': [2182, 3864], 'Mentzer': [2183, 3865], 'Jonigk': [2185, 3867], 'Pulmonary': [2187, 3352, 3869, 4055, 4155], 'endothelialitis,': [2189, 3871], 'thrombosis,': [2190, 2780, 3872], 'angiogenesis': [2192, 3874], 'Covid-19.N': [2194, 3876], 'Engl': [2195, 3877], '383:': [2199, 3881], '120-128Crossref': [2200, 3882], '(3553)': [2203, 3885], 'Scholar,25McFadyen': [2205], 'J.D.': [2206, 2350, 2471], 'Stevens': [2207, 2351], 'Peter': [2209, 2353], 'emerging': [2212, 2356], 'threat': [2213, 2357], '(micro)thrombosis': [2215, 2359], 'therapeutic': [2220, 2364], 'implications.Circ': [2221, 2365], '127:': [2224, 2368], '571-587Crossref': [2225, 2369], '(371)': [2228, 2372], 'Infected': [2231], 'undergo': [2233], 'pyroptosis,': [2234], 'danger-associated': [2240], 'patterns': [2242], 'cytokines': [2249, 2412], 'chemokines': [2251], 'environment.26Ye': [2254], 'Mao': [2258], '"cytokine': [2266], "storm'": [2267], 'Infect.': [2270], '607-613Abstract': [2273], '(1912)': [2281], 'Scholar,27Tay': [2283], 'M.Z.': [2284], 'Poh': [2285], 'C.M.': [2286, 2738], 'Rénia': [2287], 'MacAry': [2289], 'P.A.': [2290], 'Ng': [2291], 'L.F.P.': [2292], 'trinity': [2294], 'inflammation': [2298], 'intervention.Nat': [2300], '20:': [2304], '363-374Crossref': [2305], '(2694)': [2308], 'activated': [2312], 'alveolar': [2313], 'endothelium': [2314], 'then': [2315], 'up-regulates': [2316], 'Willebrand': [2321], 'factor': [2322, 2397, 2540], 'adhesion': [2324, 2328], 'molecules,': [2325], 'inter-cellular': [2327], 'molecule-1,': [2329], 'vitronectin': [2330], '(alpha': [2332], 'v': [2333], 'beta': [2334], '3': [2335], 'integrin),': [2336], 'P-selectin,': [2337], 'E-selectin,': [2339], 'recruitment': [2342], 'leukocytes': [2346], 'activation.25McFadyen': [2349], 'Neutrophils': [2375], 'NETs,': [2377], 'direct': [2379], 'classical': [2383], 'pathway.': [2385], 'Complement': [2386, 3709, 3906], 'potentiates': [2388], 'increasing': [2392, 2682], 'endothelial': [2393, 2404, 2538], 'monocyte': [2395, 2432], 'further': [2399], 'platelet': [2400], 'activation,': [2401, 2424], 'amplifying': [2403], 'increases': [2407], 'production': [2409], 'endothelium.': [2415], 'These': [2416, 2542], 'include': [2417], 'following:': [2419], 'IL-1;': [2420], 'IL-8;': [2421], 'regulated': [2422], 'T-cell': [2426], 'secreted;': [2429], 'IL-6;': [2430], 'chemoattractant': [2433], 'protein-1.28Barnes': [2434], 'B.J.': [2435], 'Adrover': [2436], 'Baxter-Stoltzfus': [2438, 3705, 3902], 'Borczuk': [2440], 'Cools-Lartigue': [2442], 'Crawford': [2444], 'Daßler-Plenker': [2446], 'Guerci': [2448], 'Huynh': [2450], 'Knight': [2452], 'J.S.': [2453, 2606], 'Loda': [2454], 'Looney': [2456], 'M.R.': [2457], 'McAllister': [2458], 'Rayes': [2460], 'Renaud': [2462], 'Rousseau': [2464], 'Salvatore': [2466, 3701, 3898], 'Schwartz': [2468], 'Spicer': [2470], 'Yost': [2472], 'C.C.': [2473], 'Weber': [2474], 'Zuo': [2476], 'Egeblad': [2478], 'Targeting': [2480], 'potential': [2481], 'drivers': [2482], 'traps.J': [2487], 'e20200652Crossref': [2492], '(985)': [2495], 'Scholar,29Fletcher-Sandersjöö': [2497], 'Bellander': [2499], 'B.M.': [2500], 'Is': [2501], 'caused': [2505], 'overactivation': [2507], 'cascade?': [2511], 'literature': [2513], 'review.Thromb': [2514], '194:': [2517], '36-41Abstract': [2518], '(97)': [2526], 'hypoxic': [2530], 'induce': [2533], 'hypoxia-inducible': [2534], 'up-regulate': [2537], 'expression.': [2541], 'ultimately': [2544], 'lead': [2545, 3672], 'unchecked': [2548], 'generation': [2549], 'thrombin,': [2551], 'thrombus': [2554], 'formation.12Gheblawi': [2555], 'Scholar,30Jaimes': [2601], 'J.A.': [2602, 3061, 3085], 'André': [2603], 'Chappie': [2605], 'Millet': [2607], 'J.K.': [2608], 'Whittaker': [2609], 'G.R.': [2610], 'Phylogenetic': [2611], 'structural': [2614], 'modeling': [2615], 'reveals': [2620], 'evolutionary': [2622], 'distinct': [2623], 'proteolytically': [2625], 'sensitive': [2626], 'loop.J': [2628], 'Biol.': [2630], '432:': [2632], '3309-3325Crossref': [2633], '(297)': [2636], 'Scholar,31Jayarangaiah': [2638], 'Kariyanna': [2640], 'P.T.': [2641], 'Chen': [2642, 3621], 'Jayarangaiah': [2644], 'Kumar': [2646], 'COVID-19-associated': [2648], 'coagulopathy:': [2649], 'exacerbated': [2651], 'response.Clin': [2653], 'Appl': [2654], 'Thromb': [2655, 4115], 'Hemost.': [2656], '26': [2658], '(1076029620943293)Crossref': [2659], '(65)': [2662], 'Activated': [2665], 'neutrophils': [2668], 'releasing': [2669], 'NETs': [2670, 2773], 'mortality': [2683, 2798, 3631], 'COVID-19.21Radermecker': [2688], 'Scholar,32Veras': [2733], 'F.P.': [2734], 'Pontelli': [2735], 'M.C.': [2736], 'Silva': [2737, 4095], 'Toller-Kawahisa': [2739], 'de': [2741, 3278, 3291, 3781, 4090, 4097], 'Lima': [2742], 'Nascimento': [2744], 'D.C.': [2745], 'triggered': [2748], 'mediate': [2752], 'pathology.J': [2754], 'e20201129Crossref': [2759], '(523)': [2762], 'Autopsy': [2765, 3312], 'reports': [2766, 3960], 'suggested': [2768, 3753], 'contribute': [2775], 'storms,': [2778], 'distress': [2784, 3569, 3678, 3764, 3804], 'syndrome.33Ruan': [2785], 'Song': [2793, 3603], 'Clinical': [2795, 3625], 'predictors': [2796, 3055], 'due': [2799, 3581], 'based': [2802], '150': [2809], 'Wuhan,': [2812, 3638], 'China.Intensive': [2813], 'Care': [2814, 3023, 3683, 3808], '46:': [2817], '846-848Crossref': [2818], '(3197)': [2821], 'limited': [2826], 'amount': [2827], 'NET': [2829, 2887], 'inflammatory': [2832], 'sites': [2833], 'serves': [2834], 'limit': [2836], 'loss': [2838], 'prevent': [2840], 'pathogens,18Engelmann': [2844], 'clearly': [2892], 'dysregulated': [2893], 'sites,': [2897], 'rapid': [2900], 'occlusion': [2901, 2950, 4022], 'microvessels.34Leppkes': [2903], 'Knopf': [2905, 3977], 'Naschberger': [2907, 3979], 'Lindemann': [2909, 3981], 'Singh': [2911, 3983], 'Herrmann': [2913, 2947, 3985, 4019], 'Stürzl': [2915, 3987], 'Staats': [2917, 3989], 'Mahajan': [2919, 3991], 'Schauer': [2921, 3993], 'Kremer': [2923, 2939, 3995, 4011], 'A.N.': [2924, 3996, 4089], 'Völkl': [2925, 3997], 'Amann': [2927, 3999], 'Evert': [2929, 4001], 'Falkeis': [2931, 4003], 'Wehrfritz': [2933, 4005], 'Rieker': [2935, 4007], 'R.J.': [2936, 4008], 'Hartmann': [2937, 4009], 'A.E.': [2940, 3492, 4012], 'Neurath': [2941, 4013], 'M.F.': [2942, 4014], 'Muñoz': [2943, 4015], 'L.E.': [2944, 3071, 4016], 'Schett': [2945, 4017], 'Vascular': [2949, 4021], 'COVID-19.EBioMedicine.': [2956, 4028], '58:': [2958, 4030], '102925Abstract': [2959, 4031], '(290)': [2967, 4039], 'unfavorable': [2972], 'milieu': [2973], 'allow': [2975], 'uncontrollably': [2980], 'circulation,': [2983], 'dysfunction.': [2986], 'Since': [2987], 'beginning': [2989], 'was': [2994, 3752], 'recognized': [2995], 'hypercoagulatory': [2998], 'clinically': [3003], 'high': [3004, 3198], 'prevalence': [3005], 'thromboembolic': [3007], 'events.35Iba': [3008], 'Levy': [3010], 'J.H.': [3011, 3429], 'Levi': [3012], 'Connors': [3014], 'Thachil': [3016], 'Coagulopathy': [3018], '2019.Crit': [3022], '48:': [3026], '1358-1364Crossref': [3027], '(344)': [3030], 'Increased': [3033], 'levels': [3035], 'D-dimer,': [3037], 'fibrinogen,': [3038], 'fibrin': [3040], 'products': [3042], 'frequently': [3044], 'useful': [3047], 'biomarkers': [3048], 'severity': [3051, 3577], 'adverse': [3057], 'outcomes.36Rodriguez-Morales': [3058], 'Cardona-Ospina': [3060], 'Gutiérrez-Ocampo': [3062], 'Villamizar-Peña': [3064], 'Holguin-Rivera': [3066], 'Escalera-Antezana': [3068], 'J.P.': [3069, 3259], 'Alvarado-Arnez': [3070], 'Bonilla-Aldana': [3072], 'D.K.': [3073], 'Franco-Paredes': [3074], 'Henao-Martinez': [3076], 'A.F.': [3077], 'Paniz-Mondolfi': [3078], 'Lagos-Grisales': [3080], 'G.J.': [3081, 3091], 'Ramírez-Vallejo': [3082], 'Suárez': [3084], 'Zambrano': [3086], 'L.I.': [3087], 'Villamil-Gómez': [3088], 'W.E.': [3089], 'Balbin-Ramon': [3090], 'Rabaan': [3092], 'Harapan': [3094], 'Dhama': [3096], 'Nishiura': [3098], 'Kataoka': [3100], 'Ahmad': [3102], 'Sah': [3104], 'Latin': [3106], 'American': [3107, 4061], 'Network': [3108], 'Coronavirus': [3110], '2019-COVID-19': [3111], 'Research': [3112], '(LANCOVID-19)Clinical,': [3113], 'laboratory': [3114], 'imaging': [3116, 3504], 'features': [3117], 'systematic': [3121], 'meta-analysis.Travel': [3124], 'Med': [3125], 'Infect': [3126], 'Dis.': [3127], '34:': [3129, 3542], '101623Crossref': [3130], '(1577)': [3133], 'Venous': [3136], 'thrombotic': [3139, 3202, 4110], 'were': [3141, 3160], 'seen': [3142], 'up': [3144], '30%': [3146], 'treated': [3149], 'intensive': [3152], 'care': [3153], 'unit,': [3154], 'even': [3155, 3250], 'pharmacologic': [3157], 'thromboprophylaxis,': [3158], '5.4-fold': [3164], 'increase': [3165], 'risk': [3168, 3628], 'mortality.37Klok': [3170], 'Kruip': [3172], 'M.J.H.A.': [3173], 'van': [3174, 3186], 'der': [3175], 'Meer': [3176], 'N.J.M.': [3177], 'Arbous': [3178], 'M.S.': [3179, 3472], 'Gommers': [3180], 'Kant': [3182], 'K.M.': [3183], 'Kaptein': [3184], 'F.H.J.': [3185], 'Paassen': [3187], 'Stals': [3189], 'M.A.M.': [3190], 'Huisman': [3191], 'M.V.': [3192], 'Endeman': [3193], 'Confirmation': [3195], 'cumulative': [3199], 'incidence': [3200], 'complications': [3203], 'critically': [3205, 3444], 'ill': [3206, 3445], 'ICU': [3207], 'updated': [3212], 'analysis.Thromb': [3213], '148-150Abstract': [3217], '(1301)': [3225], 'An': [3228], 'autopsy': [3229, 4066], 'series': [3230, 4067, 4160], 'deep': [3236], 'vein': [3237], 'embolism': [3241], '58%': [3243], '73%': [3245], 'cases,': [3248], 'respectively,': [3249], 'without': [3251], 'suspicion': [3253, 3564], 'venous': [3255, 3315], 'thromboembolism.38Wichmann': [3256], 'Sperhake': [3258], 'Lütgehetmann': [3260], 'Steurer': [3262], 'Edler': [3264], 'Heinemann': [3266], 'Heinrich': [3268], 'Mushumba': [3270], 'Kniep': [3272], 'Schröder': [3274], 'Burdelski': [3276], 'Heer': [3279], 'Nierhaus': [3281], 'Frings': [3283], 'Pfefferle': [3285], 'Becker': [3287], 'Bredereke-Wiedling': [3289], 'Weerth': [3292], 'Paschen': [3294], 'H.R.': [3295], 'Sheikhzadeh-Eggers': [3296], 'Stang': [3298], 'Schmiedel': [3300], 'Bokemeyer': [3302], 'Addo': [3304], 'M.M.': [3305], 'Aepfelbacher': [3306], 'Püschel': [3308], 'Kluge': [3310], 'findings': [3313, 3505, 4157], 'thromboembolism': [3316], 'prospective': [3322], 'cohort': [3323, 3642], 'study.Ann': [3324], 'Intern': [3325, 3368], '173:': [3328, 3371], '268-277Crossref': [3329], '(1639)': [3332], 'Scholar,39Lax': [3334], 'S.F.': [3335], 'Skok': [3336], 'Zechner': [3338], 'Kessler': [3340], 'H.H.': [3341], 'Kaufmann': [3342], 'Koelblinger': [3344], 'Vander': [3346, 4052], 'Bargfrieder': [3348], 'U.': [3349], 'Trauner': [3350], 'fatal': [3358], 'outcome:': [3359], 'results': [3360], 'prospective,': [3363], 'single-center,': [3364], 'clinicopathologic': [3365], 'case': [3366], 'series.Ann': [3367], '350-361Crossref': [3372], '(542)': [3375], 'Acute': [3378], 'coronary': [3379], 'syndrome/myocardial': [3380], 'infarction40Hadid': [3381], 'Kafri': [3383], 'Al-Katib': [3385], 'anticoagulation': [3389], 'COVID-19.Blood': [3391], 'Rev.': [3392], '47:': [3394], 'e100761Crossref': [3395], '(107)': [3398], 'Scholar,41Amirfakhryan': [3400], 'Safari': [3402], 'Outbreak': [3404], 'SARS-CoV2:': [3406], 'Infection': [3409], 'Cardiovascular': [3411], 'Involvement.Hellenic': [3412], 'Cardiol.': [3414], '62:': [3416], '13-23Crossref': [3417], '(30)': [3420], 'strokes42Qi': [3424], 'Keith': [3426], 'K.A.': [3427], 'Huang': [3428], 'stroke:': [3432], 'review.Brain': [3434], 'Hemorrhages.': [3435], '14:': [3437], '337-339Google': [3438], 'patients.': [3446], 'Other': [3447, 3959], 'related': [3449, 3838], 'macrothromboses': [3451], 'bowels43Bhayana': [3457], 'Som': [3459], 'M.D.': [3462], 'Carey': [3463], 'D.E.': [3464], 'Anderson': [3465], 'Blake': [3467], 'Catalano': [3469], 'Gee': [3471], 'Hahn': [3473], 'P.F.': [3474], 'Harisinghani': [3475], 'Kilcoyne': [3477], 'Lee': [3479], 'S.I.': [3480], 'Mojtahed': [3481], 'Pandharipande': [3483], 'P.V.': [3484], 'Pierce': [3485], 'T.T.': [3486], 'Rosman': [3487], 'D.A.': [3488, 3496], 'Saini': [3489], 'Samir': [3491], 'Simeone': [3493], 'J.F.': [3494], 'Gervais': [3495], 'Velmahos': [3497], 'Misdraji': [3499], 'Kambadakone': [3501], 'Abdominal': [3503], 'preliminary': [3508], 'observations.Radiology.': [3509], '297:': [3511], 'E207-E215Crossref': [3512], '(212)': [3515], 'extremities,44Calvão': [3519], 'Relvas': [3521], 'Pinho': [3523], 'Brinca': [3525], 'Cardoso': [3527], 'Acro-ischaemia': [3529], 'infection:': [3532, 3721, 3918], 'histopathological': [3535], 'features.J': [3536], 'Eur': [3537], 'Acad': [3538], 'Dermatol': [3539], 'Venereol.': [3540], 'e653-e754Crossref': [3543], '(19)': [3546], 'sometimes': [3549], 'consequences.': [3553], 'Furthermore,': [3554], 'COVID-19–related': [3555, 3566], 'typical.': [3558], 'Their': [3559], 'began': [3561], 'syndrome,': [3570], 'preserved': [3572], 'mechanics': [3574], 'despite': [3575], 'hypoxemia,': [3579], 'occurred': [3580], 'micro-obstructions': [3583], 'vasculature.45Zhou': [3587], 'Yu': [3589], 'Du': [3591], 'Fan': [3593], 'Xiang': [3599], 'Gu': [3605], 'Wei': [3609], 'Wu': [3613], 'Xu': [3615], 'Tu': [3617], 'Cao': [3623], 'course': [3626], 'factors': [3629], 'adult': [3633], 'inpatients': [3634], 'retrospective': [3641], 'study.Lancet.': [3643], '395:': [3645], '1054-1062Abstract': [3646], '(17670)': [3654], '46Gattinoni': [3657], 'Coppola': [3659], 'Cressoni': [3661], 'Busana': [3663], 'Rossi': [3665, 4131], 'Chiumello': [3667], 'does': [3670], '"typical"': [3675], 'syndrome.Am': [3679], 'Respir': [3681, 4071], 'Crit': [3682], '201:': [3686], '1299-1300Crossref': [3687], '(916)': [3690], '47Magro': [3693], 'Mulvey': [3695, 3892], 'J.J.': [3696, 3893], 'Berlin': [3697, 3894], 'Nuovo': [3699, 3896], 'Harp': [3703, 3900], 'Laurence': [3707, 3904], 'microvascular': [3711, 3821, 3840, 3908], 'five': [3725, 3922], 'cases.Transl': [3726, 3923], '220:': [3729, 3926], '1-13Abstract': [3730, 3927], '(1549)': [3738, 3935], 'Indeed,': [3741], 'acronym': [3743], 'MicroCLOTS': [3744], '(microvascular': [3745], 'vessel': [3748], 'obstructive': [3749, 3796], 'thromboinflammatory': [3750, 3797], 'syndrome)': [3751], 'name': [3756], 'phenotype': [3760], 'syndrome/SARS-CoV-2.48Ciceri': [3765], 'Beretta': [3767], 'Scandroglio': [3769], 'A.M.': [3770], 'Colombo': [3771, 4139], 'Landoni': [3773], 'Ruggeri': [3775], 'Peccatori': [3777], "D'Angelo": [3779], 'Cobelli': [3782], 'Rovere-Querini': [3784], 'Tresoldi': [3786], 'Dagna': [3788], 'Zangrillo': [3790], 'vessels': [3795], '(MicroCLOTS):': [3799], 'atypical': [3801], 'working': [3806], 'hypothesis.Crit': [3807], 'Resusc.': [3809], '22:': [3811], '95-97PubMed': [3812], 'Scanning': [3815], 'electron': [3816], 'micrographs': [3817], 'bed': [3822], 'exhibited': [3827], 'substantial': [3828], 'architectural': [3829], 'distortion': [3830], 'significant': [3832], 'intussusception': [3833], '(a': [3834], 'neoangiogenesis)': [3837], 'occlusion.24Ackermann': [3841], 'Magro': [3888], 'al47Magro': [3890], 'probably': [3941], 'earliest': [3943], 'histopathologic': [3944], 'event': [3945], 'microthrombotic': [3950], 'interstitial': [3951], 'pneumonitis': [3952], 'accompanied': [3953], 'slight/moderate': [3956], 'intra-alveolar': [3957], 'exudate.': [3958], 'fibrinous': [3964], 'thrombi': [3965], 'microcirculation': [3969], 'who': [3972], 'died': [3973], 'COVID-19.34Leppkes': [3975], 'Scholar,49Fox': [4041], 'Akmatbekov': [4043], 'Harbert': [4045], 'J.L.': [4046], 'Quincy': [4049], 'Brown': [4050], 'Heide': [4053], 'R.S.': [4054, 4132], 'pathology': [4058], 'African': [4060], 'New': [4069], 'Orleans.Lancet': [4070], '8:': [4074], '681-686Abstract': [4075], '(842)': [4083], '50Dolhnikoff': [4086], 'Duarte-Neto': [4088], 'Almeida': [4091], 'Monteiro': [4092], 'R.A.': [4093], 'da': [4094], 'L.F.F.': [4096], 'Oliveira': [4098], 'E.P.': [4099], 'Saldiva': [4100], 'P.H.N.': [4101], 'Mauad': [4102], 'Negri': [4104], 'Pathological': [4106], 'evidence': [4107], 'Haemost.': [4116], '18:': [4118], '1517-1519Crossref': [4119], '(376)': [4122], '51Carsana': [4125], 'Sonzogni': [4127], 'Nasr': [4129], 'Pellegrinelli': [4133], 'Zerbi': [4135], 'Rech': [4137], 'Antinori': [4141], 'Corbellino': [4143], 'Galli': [4145], 'Catena': [4147], 'Tosoni': [4149], 'Gianatti': [4151], 'Nebuloni': [4153], 'post-mortem': [4156], 'northern': [4165], 'Italy:': [4166], 'two-centre': [4168], 'des': [4169]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3158205267', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 4}], 'updated_date': '2025-01-05T06:24:21.130654', 'created_date': '2021-05-10'}