Publication Information

{'id': 'https://openalex.org/W3158054251', 'doi': 'https://doi.org/10.3390/ijms22094624', 'title': 'Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ', 'display_name': 'Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ', 'publication_year': 2021, 'publication_date': '2021-04-28', 'ids': {'openalex': 'https://openalex.org/W3158054251', 'doi': 'https://doi.org/10.3390/ijms22094624', 'mag': '3158054251', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33924880', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8124190'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms22094624', 'pdf_url': 'https://www.mdpi.com/1422-0067/22/9/4624/pdf?version=1619600401', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1422-0067/22/9/4624/pdf?version=1619600401', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067010487', 'display_name': 'Lorena Mazuecos', 'orcid': 'https://orcid.org/0000-0002-7897-1304'}, 'institutions': [{'id': 'https://openalex.org/I79189158', 'display_name': 'University of Castilla-La Mancha', 'ror': 'https://ror.org/05r78ng12', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I79189158']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Lorena Mazuecos', 'raw_affiliation_strings': ['Biochemistry Section, Faculty of Science and Chemical Technologies, University of Castilla-La Mancha, Avda Camilo José Cela 10, 13071 Ciudad Real, Spain', 'Regional Center for Biomedical Research (CRIB), University of Castilla-La Mancha, 13071 Ciudad Real, Spain'], 'affiliations': [{'raw_affiliation_string': 'Regional Center for Biomedical Research (CRIB), University of Castilla-La Mancha, 13071 Ciudad Real, Spain', 'institution_ids': ['https://openalex.org/I79189158']}, {'raw_affiliation_string': 'Biochemistry Section, Faculty of Science and Chemical Technologies, University of Castilla-La Mancha, Avda Camilo José Cela 10, 13071 Ciudad Real, Spain', 'institution_ids': ['https://openalex.org/I79189158']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043480814', 'display_name': 'Cristina Pintado', 'orcid': 'https://orcid.org/0000-0002-9369-8318'}, 'institutions': [{'id': 'https://openalex.org/I79189158', 'display_name': 'University of Castilla-La Mancha', 'ror': 'https://ror.org/05r78ng12', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I79189158']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Cristina Pintado', 'raw_affiliation_strings': ['Biochemistry Section, Faculty of Environmental Sciences and Biochemistry, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain', 'Regional Center for Biomedical Research (CRIB), University of Castilla-La Mancha, 13071 Ciudad Real, Spain'], 'affiliations': [{'raw_affiliation_string': 'Regional Center for Biomedical Research (CRIB), University of Castilla-La Mancha, 13071 Ciudad Real, Spain', 'institution_ids': ['https://openalex.org/I79189158']}, {'raw_affiliation_string': 'Biochemistry Section, Faculty of Environmental Sciences and Biochemistry, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain', 'institution_ids': ['https://openalex.org/I79189158']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071175762', 'display_name': 'Blanca Rubio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79189158', 'display_name': 'University of Castilla-La Mancha', 'ror': 'https://ror.org/05r78ng12', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I79189158']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Blanca Rubio', 'raw_affiliation_strings': ['Biochemistry Section, Faculty of Science and Chemical Technologies, University of Castilla-La Mancha, Avda Camilo José Cela 10, 13071 Ciudad Real, Spain', 'Regional Center for Biomedical Research (CRIB), University of Castilla-La Mancha, 13071 Ciudad Real, Spain'], 'affiliations': [{'raw_affiliation_string': 'Regional Center for Biomedical Research (CRIB), University of Castilla-La Mancha, 13071 Ciudad Real, Spain', 'institution_ids': ['https://openalex.org/I79189158']}, {'raw_affiliation_string': 'Biochemistry Section, Faculty of Science and Chemical Technologies, University of Castilla-La Mancha, Avda Camilo José Cela 10, 13071 Ciudad Real, Spain', 'institution_ids': ['https://openalex.org/I79189158']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075536668', 'display_name': 'Eduardo Guisantes-Batán', 'orcid': 'https://orcid.org/0000-0001-5617-5721'}, 'institutions': [{'id': 'https://openalex.org/I79189158', 'display_name': 'University of Castilla-La Mancha', 'ror': 'https://ror.org/05r78ng12', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I79189158']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Eduardo Guisantes-Batán', 'raw_affiliation_strings': ['Regional Institute for Applied Scientific Research, University of Castilla-La Mancha, 13071 Ciudad Real, Spain'], 'affiliations': [{'raw_affiliation_string': 'Regional Institute for Applied Scientific Research, University of Castilla-La Mancha, 13071 Ciudad Real, Spain', 'institution_ids': ['https://openalex.org/I79189158']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052684659', 'display_name': 'Antonio Andrés', 'orcid': 'https://orcid.org/0000-0002-9892-8338'}, 'institutions': [{'id': 'https://openalex.org/I79189158', 'display_name': 'University of Castilla-La Mancha', 'ror': 'https://ror.org/05r78ng12', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I79189158']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Antonio Andrés', 'raw_affiliation_strings': ['Biochemistry Section, Faculty of Science and Chemical Technologies, University of Castilla-La Mancha, Avda Camilo José Cela 10, 13071 Ciudad Real, Spain', 'Regional Center for Biomedical Research (CRIB), University of Castilla-La Mancha, 13071 Ciudad Real, Spain'], 'affiliations': [{'raw_affiliation_string': 'Regional Center for Biomedical Research (CRIB), University of Castilla-La Mancha, 13071 Ciudad Real, Spain', 'institution_ids': ['https://openalex.org/I79189158']}, {'raw_affiliation_string': 'Biochemistry Section, Faculty of Science and Chemical Technologies, University of Castilla-La Mancha, Avda Camilo José Cela 10, 13071 Ciudad Real, Spain', 'institution_ids': ['https://openalex.org/I79189158']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5027484309', 'display_name': 'Nilda Gallardo', 'orcid': 'https://orcid.org/0000-0003-3211-569X'}, 'institutions': [{'id': 'https://openalex.org/I79189158', 'display_name': 'University of Castilla-La Mancha', 'ror': 'https://ror.org/05r78ng12', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I79189158']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Nilda Gallardo', 'raw_affiliation_strings': ['Biochemistry Section, Faculty of Science and Chemical Technologies, University of Castilla-La Mancha, Avda Camilo José Cela 10, 13071 Ciudad Real, Spain', 'Regional Center for Biomedical Research (CRIB), University of Castilla-La Mancha, 13071 Ciudad Real, Spain'], 'affiliations': [{'raw_affiliation_string': 'Regional Center for Biomedical Research (CRIB), University of Castilla-La Mancha, 13071 Ciudad Real, Spain', 'institution_ids': ['https://openalex.org/I79189158']}, {'raw_affiliation_string': 'Biochemistry Section, Faculty of Science and Chemical Technologies, University of Castilla-La Mancha, Avda Camilo José Cela 10, 13071 Ciudad Real, Spain', 'institution_ids': ['https://openalex.org/I79189158']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5052684659', 'https://openalex.org/A5027484309'], 'corresponding_institution_ids': ['https://openalex.org/I79189158', 'https://openalex.org/I79189158'], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'fwci': 0.956, 'has_fulltext': False, 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.999981, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '22', 'issue': '9', 'first_page': '4624', 'last_page': '4624'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10489', 'display_name': 'Regulation of Appetite and Obesity', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fgf21', 'display_name': 'FGF21', 'score': 0.6921917}, {'id': 'https://openalex.org/keywords/leptin-receptor', 'display_name': 'Leptin receptor', 'score': 0.52486396}], 'concepts': [{'id': 'https://openalex.org/C2780613262', 'wikidata': 'https://www.wikidata.org/wiki/Q223739', 'display_name': 'Leptin', 'level': 3, 'score': 0.9414699}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.87787265}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.86985034}, {'id': 'https://openalex.org/C151955695', 'wikidata': 'https://www.wikidata.org/wiki/Q654528', 'display_name': 'White adipose tissue', 'level': 3, 'score': 0.83220935}, {'id': 'https://openalex.org/C171089720', 'wikidata': 'https://www.wikidata.org/wiki/Q193583', 'display_name': 'Adipose tissue', 'level': 2, 'score': 0.8219359}, {'id': 'https://openalex.org/C106646824', 'wikidata': 'https://www.wikidata.org/wiki/Q5425475', 'display_name': 'FGF21', 'level': 4, 'score': 0.6921917}, {'id': 'https://openalex.org/C2780642333', 'wikidata': 'https://www.wikidata.org/wiki/Q901269', 'display_name': 'Brown adipose tissue', 'level': 3, 'score': 0.5516185}, {'id': 'https://openalex.org/C14372207', 'wikidata': 'https://www.wikidata.org/wiki/Q7072306', 'display_name': 'Leptin receptor', 'level': 4, 'score': 0.52486396}, {'id': 'https://openalex.org/C151279926', 'wikidata': 'https://www.wikidata.org/wiki/Q965695', 'display_name': 'Thermogenesis', 'level': 3, 'score': 0.4535918}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3963077}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3243608}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.31644684}, {'id': 'https://openalex.org/C511355011', 'wikidata': 'https://www.wikidata.org/wiki/Q12174', 'display_name': 'Obesity', 'level': 2, 'score': 0.20233619}, {'id': 'https://openalex.org/C74373430', 'wikidata': 'https://www.wikidata.org/wiki/Q24727126', 'display_name': 'Fibroblast growth factor', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D052436', 'descriptor_name': 'Adipose Tissue, White', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D005346', 'descriptor_name': 'Fibroblast Growth Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007031', 'descriptor_name': 'Hypothalamus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D057967', 'descriptor_name': 'Infusions, Intraventricular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000090265', 'descriptor_name': 'Klotho Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047495', 'descriptor_name': 'PPAR gamma', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D048068', 'descriptor_name': 'PPAR-beta', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013450', 'descriptor_name': 'Sulfones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013876', 'descriptor_name': 'Thiophenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms22094624', 'pdf_url': 'https://www.mdpi.com/1422-0067/22/9/4624/pdf?version=1619600401', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/d374adec10184169b4c400c1ebab9c61', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124190', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33924880', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms22094624', 'pdf_url': 'https://www.mdpi.com/1422-0067/22/9/4624/pdf?version=1619600401', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.76, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 71, 'referenced_works': ['https://openalex.org/W1561443084', 'https://openalex.org/W1590709474', 'https://openalex.org/W1965746769', 'https://openalex.org/W1981583644', 'https://openalex.org/W1982027543', 'https://openalex.org/W1986602268', 'https://openalex.org/W1986938616', 'https://openalex.org/W1988869711', 'https://openalex.org/W1989584881', 'https://openalex.org/W1994049242', 'https://openalex.org/W1994361114', 'https://openalex.org/W2000665430', 'https://openalex.org/W2012834939', 'https://openalex.org/W2027753197', 'https://openalex.org/W2031581878', 'https://openalex.org/W2032619628', 'https://openalex.org/W2042911346', 'https://openalex.org/W2044339817', 'https://openalex.org/W2046402204', 'https://openalex.org/W2048967691', 'https://openalex.org/W2049827705', 'https://openalex.org/W2051674591', 'https://openalex.org/W2060682066', 'https://openalex.org/W2078409165', 'https://openalex.org/W2082269743', 'https://openalex.org/W2087945271', 'https://openalex.org/W2099579483', 'https://openalex.org/W2104711211', 'https://openalex.org/W2111232488', 'https://openalex.org/W2114650931', 'https://openalex.org/W2116103211', 'https://openalex.org/W2131471654', 'https://openalex.org/W2132596222', 'https://openalex.org/W2137173138', 'https://openalex.org/W2138466941', 'https://openalex.org/W2140313261', 'https://openalex.org/W2145142659', 'https://openalex.org/W2146788074', 'https://openalex.org/W2151470490', 'https://openalex.org/W2154555913', 'https://openalex.org/W2158673389', 'https://openalex.org/W2160824260', 'https://openalex.org/W2165414619', 'https://openalex.org/W2190043075', 'https://openalex.org/W2277833502', 'https://openalex.org/W2299666228', 'https://openalex.org/W2559717016', 'https://openalex.org/W2582374195', 'https://openalex.org/W2587591333', 'https://openalex.org/W2598901339', 'https://openalex.org/W2604914239', 'https://openalex.org/W2768045652', 'https://openalex.org/W2786101762', 'https://openalex.org/W2793564315', 'https://openalex.org/W2807414198', 'https://openalex.org/W2885098536', 'https://openalex.org/W2913539314', 'https://openalex.org/W2918488914', 'https://openalex.org/W2918626547', 'https://openalex.org/W2937928544', 'https://openalex.org/W2977688847', 'https://openalex.org/W2984235225', 'https://openalex.org/W2984270504', 'https://openalex.org/W2999200998', 'https://openalex.org/W3007343547', 'https://openalex.org/W3035975209', 'https://openalex.org/W3044164734', 'https://openalex.org/W3044817976', 'https://openalex.org/W3109057840', 'https://openalex.org/W3128407175', 'https://openalex.org/W4236050255'], 'related_works': ['https://openalex.org/W3146532088', 'https://openalex.org/W3134072345', 'https://openalex.org/W3047633609', 'https://openalex.org/W3029291832', 'https://openalex.org/W2763780577', 'https://openalex.org/W2416934161', 'https://openalex.org/W2406660090', 'https://openalex.org/W2167431561', 'https://openalex.org/W2059411416', 'https://openalex.org/W2008060059'], 'abstract_inverted_index': {'The': [0], 'altered': [1], 'function': [2, 27], 'of': [3, 28, 129, 137, 142, 169, 175, 192], 'adipose': [4, 29, 41, 200], 'tissue': [5, 42], 'can': [6], 'result': [7], 'in': [8, 38, 67, 126, 189, 198], 'obesity,': [9], 'insulin': [10], 'resistance,': [11], 'and': [12, 26, 139, 160], 'its': [13], 'metabolic': [14, 62], 'complications.': [15], 'Leptin,': [16, 117], 'acting': [17, 118], 'on': [18, 178], 'the': [19, 24, 33, 61, 94, 123, 134, 147, 166, 172, 190], 'central': [20, 120, 176], 'nervous': [21], 'system,': [22], 'modifies': [23], 'composition': [25], 'tissue.': [30, 201], 'To': [31, 69], 'date,': [32], 'molecular': [34], 'changes': [35], 'that': [36, 185], 'occur': [37], 'epididymal': [39], 'white': [40], '(eWAT)': [43], 'during': [44], 'chronic': [45], 'leptin': [46, 66, 80, 115, 153, 177, 197], 'treatment': [47], 'are': [48], 'not': [49], 'fully': [50], 'understood.': [51], 'Herein': [52], 'we': [53, 104], 'aimed': [54], 'to': [55, 108, 155], 'address': [56], 'whether': [57], 'PPARβ/δ': [58, 96, 170, 186], 'could': [59], 'mediate': [60], 'actions': [63, 174], 'induced': [64, 132, 150, 195], 'by': [65, 151, 196], 'eWAT.': [68, 143, 179], 'this': [70], 'end,': [71], 'male': [72], '3-month-old': [73], 'Wistar': [74], 'rats,': [75], 'infused': [76], 'intracerebroventricularly': [77], '(icv)': [78], 'with': [79, 93], '(0.2': [81], 'μg/day)': [82], 'for': [83], '7': [84], 'days,': [85], 'were': [86], 'daily': [87], 'co-treated': [88], 'intraperitoneally': [89], '(ip)': [90], 'without': [91, 114], 'or': [92], 'specific': [95], 'receptor': [97], 'antagonist': [98], 'GSK0660': [99, 107, 145], '(1': [100], 'mg/kg/day).': [101], 'In': [102, 164, 180], 'parallel,': [103], 'also': [105], 'administered': [106], 'control': [109], 'rats': [110], 'fed': [111], 'ad': [112], 'libitum': [113], 'infusion.': [116], 'at': [119], 'level,': [121], 'prevented': [122], 'starvation-induced': [124], 'increase': [125], 'circulating': [127], 'levels': [128], 'FGF21,': [130], 'while': [131], 'markedly': [133], 'endogenous': [135], 'expression': [136, 194], 'FGF21': [138, 193], 'browning': [140, 162], 'markers': [141], 'Interestingly,': [144], 'abolished': [146], 'anorectic': [148], 'effects': [149], 'icv': [152], 'leading': [154], 'increased': [156], 'visceral': [157, 199], 'fat': [158], 'mass': [159], 'reduced': [161], 'capacity.': [163], 'addition,': [165], 'pharmacological': [167], 'inhibition': [168], 'alters': [171], 'immunomodulatory': [173], 'summary,': [181], 'our': [182], 'results': [183], 'demonstrate': [184], 'is': [187], 'involved': [188], 'up-regulation': [191]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3158054251', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}], 'updated_date': '2024-12-08T14:54:09.997449', 'created_date': '2021-05-10'}